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PMC:7278327 / 5077-8295 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T31 225-228 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T32 454-459 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T33 460-465 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T34 545-548 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T35 736-744 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T36 788-791 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T37 998-1001 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T38 1151-1171 Body_part denotes olfactory epithelium http://purl.org/sig/ont/fma/fma64803
T39 1161-1171 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T40 1183-1195 Body_part denotes nasal cavity http://purl.org/sig/ont/fma/fma54378
T41 1318-1335 Body_part denotes non-neuronal cell http://purl.org/sig/ont/fma/fma54536
T42 1331-1335 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T43 1422-1425 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T44 1457-1460 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T45 1604-1624 Body_part denotes olfactory epithelium http://purl.org/sig/ont/fma/fma64803
T46 1614-1624 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T47 1741-1744 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T48 1848-1864 Body_part denotes trigeminal nerve http://purl.org/sig/ont/fma/fma50866
T49 1886-1906 Body_part denotes olfactory epithelium http://purl.org/sig/ont/fma/fma64803
T50 1896-1906 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T51 1929-1936 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T52 2026-2036 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T53 2059-2071 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T54 2073-2076 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T55 2145-2148 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T56 2256-2259 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T57 2504-2511 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T58 2549-2560 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T59 2806-2813 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T60 2818-2821 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T61 2906-2909 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T62 3126-3134 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T63 3188-3195 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 3205-3217 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T10 454-473 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T11 454-459 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T12 460-465 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T13 1151-1171 Body_part denotes olfactory epithelium http://purl.obolibrary.org/obo/UBERON_0001997
T14 1161-1171 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T15 1183-1195 Body_part denotes nasal cavity http://purl.obolibrary.org/obo/UBERON_0001707
T16 1399-1416 Body_part denotes olfactory pathway http://purl.obolibrary.org/obo/UBERON_0013201
T17 1604-1624 Body_part denotes olfactory epithelium http://purl.obolibrary.org/obo/UBERON_0001997
T18 1614-1624 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T19 1848-1864 Body_part denotes trigeminal nerve http://purl.obolibrary.org/obo/UBERON_0001645
T20 1859-1864 Body_part denotes nerve http://purl.obolibrary.org/obo/UBERON_0001021
T21 1886-1906 Body_part denotes olfactory epithelium http://purl.obolibrary.org/obo/UBERON_0001997
T22 1896-1906 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T23 2090-2101 Body_part denotes snake venom http://purl.obolibrary.org/obo/UBERON_0013076
T24 2096-2101 Body_part denotes venom http://purl.obolibrary.org/obo/UBERON_0007113
T25 2362-2373 Body_part denotes snake venom http://purl.obolibrary.org/obo/UBERON_0013076
T26 2368-2373 Body_part denotes venom http://purl.obolibrary.org/obo/UBERON_0007113

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
168 56-61 Gene denotes nAChR Gene:1137
169 4-8 Gene denotes Case
170 41-51 Species denotes SARS-CoV-2 Tax:2697049
171 88-96 Disease denotes COVID-19 MESH:C000657245
183 150-155 Gene denotes nAChR Gene:1137
184 756-786 Species denotes human immunodeficiency virus 1 Tax:11676
185 788-793 Species denotes HIV-1 Tax:11676
186 804-812 Species denotes MERS-CoV Tax:1335626
187 830-847 Species denotes hepatitis C virus Tax:11103
188 192-196 Species denotes RABV Tax:11292
189 404-408 Species denotes RABV Tax:11292
190 493-497 Species denotes RABV Tax:11292
191 614-618 Species denotes RABV Tax:11292
192 694-698 Species denotes RABV Tax:11292
193 849-852 Species denotes HCV Tax:11103
207 1286-1290 Gene denotes ACE2 Gene:59272
208 1481-1486 Gene denotes nAChR Gene:1137
209 1778-1783 Gene denotes nAChR Gene:1137
210 1003-1011 Species denotes Patients Tax:9606
211 1470-1480 Species denotes SARS-CoV-2 Tax:2697049
212 1715-1719 Species denotes RABV Tax:11292
213 1773-1777 Species denotes RABV Tax:11292
214 966-986 Disease denotes SARS-CoV-2 infection MESH:C000657245
215 1017-1025 Disease denotes COVID-19 MESH:C000657245
216 1048-1077 Disease denotes sensory neurological symptoms MESH:D009422
217 1091-1098 Disease denotes anosmia MESH:D000857
218 1232-1252 Disease denotes SARS-CoV-2 infection MESH:C000657245
219 1720-1729 Disease denotes infection MESH:D007239
240 2079-2084 Gene denotes gp120 Gene:3700
241 2161-2166 Gene denotes gp120 Gene:3700
242 2455-2460 Gene denotes nAChR Gene:1137
243 2498-2503 Gene denotes spike Gene:43740568
244 2800-2805 Gene denotes spike Gene:43740568
245 2824-2829 Gene denotes gp120 Gene:3700
246 3182-3187 Gene denotes spike Gene:43740568
247 2073-2078 Species denotes HIV-1 Tax:11676
248 2145-2150 Species denotes HIV-1 Tax:11676
249 2242-2250 Species denotes patients Tax:9606
250 2487-2497 Species denotes SARS-CoV-2 Tax:2697049
251 2789-2799 Species denotes SARS-CoV-2 Tax:2697049
252 2818-2823 Species denotes HIV-1 Tax:11676
253 3171-3181 Species denotes SARS-CoV-2 Tax:2697049
254 2054-2058 Species denotes RABV Tax:11292
255 3084-3088 Species denotes RABV Tax:11292
256 3200-3204 Species denotes RABV Tax:11292
257 2756-2761 Gene denotes nAChR Gene:1137
258 1987-1992 Gene denotes nAChR Gene:1137
259 2256-2297 Disease denotes HIV-1-associated neurocognitive disorders MESH:D019965

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T52 41-49 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 88-96 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T54 762-778 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T55 830-841 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T56 830-839 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T57 966-974 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 977-986 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59 1017-1025 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T60 1091-1098 Disease denotes anosmia http://purl.obolibrary.org/obo/MONDO_0010528
T61 1232-1240 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 1243-1252 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T63 1470-1478 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 1720-1729 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T65 2487-2495 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 2789-2797 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 3171-3179 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T62 13-14 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63 167-168 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T64 225-228 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T65 225-228 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T66 454-459 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T67 454-459 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T68 460-465 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T69 460-465 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T70 545-548 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T71 545-548 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T72 619-622 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T73 756-761 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T74 779-784 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T75 842-847 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T76 896-897 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77 998-1001 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T78 998-1001 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T79 1124-1127 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T80 1161-1171 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T81 1189-1195 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavity
T82 1305-1306 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 1331-1341 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T84 1422-1425 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T85 1422-1425 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T86 1457-1460 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T87 1457-1460 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T88 1614-1624 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T89 1699-1700 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 1741-1744 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T91 1741-1744 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T92 1859-1864 http://purl.obolibrary.org/obo/UBERON_0001021 denotes nerve
T93 1896-1906 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T94 1948-1949 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 1975-1976 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 2114-2117 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T97 2168-2171 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T98 2344-2346 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T99 2545-2548 http://purl.obolibrary.org/obo/CLO_0053799 denotes 4-5
T100 2714-2716 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T101 2906-2909 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T102 2906-2909 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T103 2925-2927 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T104 3021-3028 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T12 532-537 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T13 736-744 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T14 2026-2036 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T15 2026-2031 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T16 2032-2036 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T17 2059-2071 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T18 2096-2101 Chemical denotes venom http://purl.obolibrary.org/obo/CHEBI_78505
T19 2102-2113 Chemical denotes neurotoxins http://purl.obolibrary.org/obo/CHEBI_50910
T20 2368-2373 Chemical denotes venom http://purl.obolibrary.org/obo/CHEBI_78505
T21 2374-2380 Chemical denotes toxins http://purl.obolibrary.org/obo/CHEBI_27026
T22 2436-2447 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T23 2504-2511 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T24 2549-2560 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T25 2549-2554 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T26 2555-2560 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T27 2587-2592 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T28 2610-2615 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T29 2806-2813 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T30 3126-3134 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T31 3188-3195 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T32 3205-3217 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T19 56-61 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T20 150-155 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T21 229-238 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T22 1114-1119 http://purl.obolibrary.org/obo/GO_0050909 denotes taste
T23 1370-1379 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T24 1481-1486 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T25 1520-1529 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T26 1760-1769 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T27 1778-1783 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T28 1987-1992 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T29 2337-2342 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T30 2455-2460 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T31 2756-2761 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T25 0-96 Sentence denotes The Case for a Functional Association of SARS-CoV-2-and nAChR in the Pathophysiology of COVID-19
T26 97-354 Sentence denotes Several empirical studies have demonstrated that the nAChR represents a major receptor for the RABV that mechanistically drives CNS transport of infective viral particles, leading to classic neurological sequelae associated with disease progression [15–17].
T27 355-573 Sentence denotes Due to the efficient neuroinvasive properties of RABV [18,19], including the ability to bypass the blood-brain barrier, studies have used RABV-based vectors for the delivery of drugs to the CNS, with some success [20].
T28 574-872 Sentence denotes Furthermore, genetic engineering of the RABV has been employed to generate novel vaccines consisting of non-replicating RABV particles expressing chimeric capsid proteins containing human immunodeficiency virus 1 (HIV-1) [21,22], MERS-CoV, Ebolavirus, and hepatitis C virus (HCV) sequences [23–25].
T29 873-1002 Sentence denotes In light of the above, a similar mechanism may underlie the multiple neurological effects of SARS-CoV-2 infection within the CNS.
T30 1003-1120 Sentence denotes Patients with COVID-19 commonly present with sensory neurological symptoms that include anosmia and/or loss of taste.
T31 1121-1442 Sentence denotes It has been proposed that the olfactory epithelium within the nasal cavity represents an early-stage locus for SARS-CoV-2 infection and replication, as reflected by ACE2 expression by a variety of non-neuronal cell types [9], followed by orthograde transport within the primary olfactory pathway into CNS structures [12].
T32 1443-1639 Sentence denotes Additionally, CNS entry of SARS-CoV-2/nAChR complexes may involve retrograde transport from peripheral trigeminal sensory terminal structures located within the olfactory epithelium [13,14,26,27].
T33 1640-1942 Sentence denotes Interestingly, similar lines of empirical evidence support a mechanism for RABV infection within the CNS via retrograde transport of RABV/nAChR complexes from sensory terminals of trigeminal ganglia [28,29], trigeminal nerve terminals within the olfactory epithelium, or primary olfactory neurons [30].
T34 1943-2140 Sentence denotes From a biochemical perspective, a conserved nAChR-binding motif within the primary amino acid sequences of the RABV glycoprotein, HIV-1 gp120, and snake venom neurotoxins has been observed [31–33].
T35 2141-2348 Sentence denotes The HIV-1 envelope, gp120, has been reported to induce neuropathological changes similar to those in patients with HIV-1-associated neurocognitive disorders and triggers an upregulation of the α7-nAChR [34].
T36 2349-2461 Sentence denotes Importantly, snake venom toxins have been demonstrated to be high-affinity competitive antagonists of the nAChR.
T37 2462-2718 Sentence denotes Sequence analysis of the SARS-CoV-2 spike protein identified homologous regions of 4-5 amino acids with aligned sequences in alpha-bungarotoxin and alpha-cobratoxin, thereby suggesting potential binding affinity and antagonism of the α7-nACh receptor [11].
T38 2719-2929 Sentence denotes Sequence homologies between putative nAChR-binding domains within the SARS-CoV-2 spike protein and HIV-1 gp120 have yet to be determined, although there are recent indications for shared CNS comorbidities [35].
T39 2930-3218 Sentence denotes In sum, convergent lines of evidence presented here support the potential construction and testing of novel homologous vaccines employing non-replicating RABV particles expressing chimeric capsid proteins containing antigenic sequences from SARS-CoV-2 spike protein and RABV glycoprotein.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T8 762-778 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T9 830-839 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T10 1091-1098 Phenotype denotes anosmia http://purl.obolibrary.org/obo/HP_0000458
T11 1106-1119 Phenotype denotes loss of taste http://purl.obolibrary.org/obo/HP_0000223

2_test

Id Subject Object Predicate Lexical cue
32463026-3448605-69142632 347-349 3448605 denotes 15
32463026-8887475-69142632 347-349 8887475 denotes 15
32463026-30772332-69142632 347-349 30772332 denotes 15
32463026-19946287-69142633 410-412 19946287 denotes 18
32463026-23602163-69142634 413-415 23602163 denotes 19
32463026-27581650-69142635 569-571 27581650 denotes 20
32463026-10706640-69142636 796-798 10706640 denotes 21
32463026-14610200-69142637 799-801 14610200 denotes 22
32463026-26063224-69142638 865-867 26063224 denotes 23
32463026-11878905-69142638 865-867 11878905 denotes 23
32463026-32283006-69142639 1343-1344 32283006 denotes 9
32463026-15210938-69142640 1438-1440 15210938 denotes 12
32463026-10667995-69142641 1626-1628 10667995 denotes 13
32463026-9853116-69142642 1629-1631 9853116 denotes 14
32463026-16885765-69142643 1632-1634 16885765 denotes 26
32463026-17150985-69142644 1635-1637 17150985 denotes 27
32463026-7941329-69142645 1840-1842 7941329 denotes 28
32463026-2016778-69142646 1843-1845 2016778 denotes 29
32463026-2053286-69142647 1938-1940 2053286 denotes 30
32463026-9345046-69142648 2133-2135 9345046 denotes 31
32463026-2241576-69142648 2133-2135 2241576 denotes 31
32463026-1397297-69142648 2133-2135 1397297 denotes 31
32463026-29379089-69142649 2344-2346 29379089 denotes 34