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PMC:7278327 / 3387-5075 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T19 34-38 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T20 169-172 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T21 217-249 Body_part denotes nicotinic acetylcholine receptor http://purl.org/sig/ont/fma/fma61796
T22 481-484 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T23 565-568 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T24 581-596 Body_part denotes olfactory nerve http://purl.org/sig/ont/fma/fma46787
T25 619-626 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T26 711-731 Body_part denotes olfactory epithelium http://purl.org/sig/ont/fma/fma64803
T27 721-731 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T28 880-887 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T29 962-965 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T30 1633-1636 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 581-596 Body_part denotes olfactory nerve http://purl.obolibrary.org/obo/UBERON_0001579
T7 591-596 Body_part denotes nerve http://purl.obolibrary.org/obo/UBERON_0001021
T8 711-731 Body_part denotes olfactory epithelium http://purl.obolibrary.org/obo/UBERON_0001997
T9 721-731 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
143 251-256 Gene denotes nAChR Gene:1137
144 540-545 Gene denotes nAChR Gene:1137
145 808-813 Gene denotes nAChR Gene:1137
146 1029-1034 Gene denotes nAChR Gene:1137
147 1265-1270 Gene denotes nAChR Gene:1137
148 1674-1679 Gene denotes nAChR Gene:1137
149 122-134 Species denotes rabies virus Tax:11292
150 381-391 Species denotes SARS-CoV-2 Tax:2697049
151 529-539 Species denotes SARS-CoV-2 Tax:2697049
152 927-937 Species denotes SARS-CoV-2 Tax:2697049
153 1018-1028 Species denotes SARS-CoV-2 Tax:2697049
154 1254-1264 Species denotes SARS-CoV-2 Tax:2697049
155 1410-1421 Species denotes coronavirus Tax:11118
156 1573-1583 Species denotes SARS-CoV-2 Tax:2697049
157 136-140 Species denotes RABV Tax:11292
158 1509-1513 Species denotes RABV Tax:11292
159 227-240 Chemical denotes acetylcholine MESH:D000109
160 142-152 Disease denotes infections MESH:D007239
161 1135-1143 Disease denotes COVID-19 MESH:C000657245
162 1144-1153 Disease denotes infection MESH:D007239
163 1299-1307 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T41 122-128 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T42 142-152 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T43 381-389 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 529-537 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 927-935 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 1018-1026 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 1135-1143 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T48 1144-1153 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49 1254-1262 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 1299-1307 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T51 1573-1581 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T35 20-21 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 60-63 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T37 129-134 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T38 169-172 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T39 169-172 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T40 190-195 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T41 262-265 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T42 303-304 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 481-484 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T44 481-484 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T45 565-568 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T46 565-568 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T47 591-596 http://purl.obolibrary.org/obo/UBERON_0001021 denotes nerve
T48 721-731 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T49 779-783 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T50 962-965 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T51 962-965 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T52 976-977 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 1059-1060 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 1234-1235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55 1352-1354 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T56 1444-1445 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 1552-1553 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 1571-1572 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 1633-1636 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T60 1633-1636 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T61 1652-1653 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T8 227-240 Chemical denotes acetylcholine http://purl.obolibrary.org/obo/CHEBI_15355
T9 871-879 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T10 880-887 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T11 1222-1230 Chemical denotes nicotine http://purl.obolibrary.org/obo/CHEBI_18723

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T8 173-195 http://purl.obolibrary.org/obo/GO_0046794 denotes transport of the virus
T9 173-182 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T10 251-256 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T11 462-471 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T12 516-525 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T13 540-545 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T14 808-813 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T15 904-913 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T16 1029-1034 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T17 1265-1270 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T18 1674-1679 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T18 0-258 Sentence denotes As discussed below, a significant body of empirical studies has demonstrated that the destructive neurological effects of rabies virus (RABV) infections are mediated by CNS transport of the virus tightly bound to the nicotinic acetylcholine receptor (nAChR).
T19 259-493 Sentence denotes It has also been recently hypothesized that a similar mechanism may exist to explain the multiple neurological effects of SARS-CoV-2 via binding to peripheral nAChRs followed by orthograde or retrograde transport into the CNS [10,11].
T20 494-740 Sentence denotes Potential portals for transport of SARS-CoV-2/nAChR complexes into the CNS include the olfactory nerve and primary olfactory neurons [9,12], and/or peripheral trigeminal sensory terminal structures located within the olfactory epithelium [13,14].
T21 741-972 Sentence denotes Further studies are required to fully test the hypothesis that the nAChR receptor represents an obligate biochemical chaperone or effector protein responsible for transport of infective SARS-CoV-2 particles into discrete CNS areas.
T22 973-1159 Sentence denotes As a corollary, pharmacological targeting of SARS-CoV-2/nAChR complexes may represent a novel vehicle for prevention and control of neurological comorbidities of COVID-19 infection [10].
T23 1160-1423 Sentence denotes There is the potential for new clinical trials to investigate nicotine as a means of blocking SARS-CoV-2-nAChR binding to prevent or treat COVID-19 (https://www.theguardian.com/world/2020/apr/22/french-study-suggests-smokers-at-lower-risk-of-getting-coronavirus).
T24 1424-1688 Sentence denotes As such, we present a critical discussion that integrates lessons learned from prior RABV research and vaccine development into a working model of a SARS-CoV-2 vaccine that selectively targets and neutralizes CNS penetration of a tightly bound viral nAChR complex.

2_test

Id Subject Object Predicate Lexical cue
32463026-32283006-69142628 628-629 32283006 denotes 9
32463026-15210938-69142629 630-632 15210938 denotes 12
32463026-10667995-69142630 733-735 10667995 denotes 13
32463026-9853116-69142631 736-738 9853116 denotes 14