PMC:7276840 / 962-7247 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7276840","sourcedb":"PMC","sourceid":"7276840","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7276840","text":"1 CASE REPORT\nA 48‐year‐old male presented to the emergency room (ER) with a 2‐day history of persistent chest pain. Electrocardiogram revealed an ST‐elevation myocardial infarction (STEMI) in the inferolateral distribution. Per the American College of Cardiology (ACC) guidelines, the patient underwent a timely and successful percutaneous revascularization of the dominant right coronary artery that was occluded. The left coronary circulation did not have significant disease. A large amount of clot was also removed from the artery during the procedure in which two drug‐eluting stents were deployed in the mid to distal right coronary artery.\nOvernight the patient's condition worsened as he developed cardiogenic shock with tachycardia, hypotension and a loud holosystolic murmur was noted. His chest X‐ray revealed worsening pulmonary congestion. A stat echocardiogram revealed a large ventricular septal defect (VSD) (Figure 1) and the patient was taken back to the catheterization laboratory for a right heart catheterization and placement of intra‐aortic balloon pump (IABP). The final diagnosis was a postinfarction VSD measuring 2 cm in dimension and a shunt fraction of 3. Since the patient's hemodynamics improved with the IABP, we waited a few days to let the myocardium heal somewhat before surgical repair. He also tested negative for COVID‐19.\nFigure 1 Transthoracic echocardiography revealing a large ventricular septal defect (white arrow) extending from mid septum to the apex Five days after his hospital presentation and 7 days after his chest pain started, he was taken to the operating room, where a large 3‐cm VSD was repaired using the exclusion technique with a pericardial patch. Except for the upper 1 to 1.5 cm, the rest of the septum could not hold any stitches and, therefore, the pericardial patch was subtended through the anterior wall of the left ventricle, parallel to the left anterior descending artery (interrupted horizontal mattress sutures tied outside the heart on pledgets), through the inferior ventriculotomy (sandwiched between the two layers of muscle closure) and moving up along the lateral wall adjacent to the septolateral junction and extending up to the origin of the anterolateral papillary muscle (interrupted horizontal mattress sutures tied outside the heart over a pledget). The left atrial appendage was excluded with an epicardial clip and epicardial bipolar leads were placed on the lateral wall of the left ventricle and the right atrium. The origin of the anterolateral papillary muscle was reinforced with a pledgeted stitch through and through the ventricular wall. Intraoperative transesophageal echocardiography showed a competent repair with trace residual shunting (Figure 2). The IABP was removed on postoperative day 1 and he was extubated and weaned off inotropes on the second postoperative day. He was discharged home on postoperative day number 7 with a life vest, since his left ventricular ejection fraction was noted to be 25%.\nFigure 2 Intraoperative post‐repair transesophageal echocardiography demonstrating a competent repair of the ventricular septal defect On a separate but very important note, in keeping with the policy of “No visitation” to prevent the spread of COVID‐19, his wife and family did not visit him since his admission to the hospital until his discharge.\n\n2 DISCUSSION\nThis case highlights the issues that have been raised before by others regarding the coronavirus, stay‐at‐home regulations, and demand for emergency care for non‐COVID conditions. A recent article published in the Washington Post, 1 has reported that physicians in the United States, Spain, and the UK have all noticed a serious decline in the number of patients coming to the ER not only for typical problems like appendicitis, bowel obstructions, gall bladder problems but also for the more critical heart attacks and strokes. Metzler reports a 40% decline in the number of admissions for STEMI and non‐STEMI in Austria during the COVID‐19 pandemic. 2 In a soon to be published report by Garcia, 3 number of cardiac catheterization laboratory activations for STEMI have been reduced by almost 40% in nine high‐volume centers in the United States.\nThe reasons for this decline are many and include fear for catching a deadly virus in the hospital, the instruction to strictly stay in‐house, consideration of many heart‐related symptoms of shortness of breath and chest discomfort by patients to be related to respiratory infections and best dealt with at home and so forth.\nThis patient's pain started 2 days earlier, but he did not seek attention until later. From the conversation with him and his wife, they were concerned about the risk of catching the deadly COVID‐19 in the hospital. The patient was not a smoker or a known diabetic and did not have any family history of coronary artery disease. A heart attack was not on their mind but respiratory infection and fear of COVID‐19 was the first and foremost concern of theirs. It was not until his chest pain had persisted for 2 days that he finally came to ER. Had he come when the pain had started, this patient would likely have had an uneventful recovery after treatment of the right coronary artery occlusion per the ACC guidelines. His avoidance of an ER visit in a timely fashion because of the fear of COVID‐19 led to the catastrophic complication of STEMI that surgeons rarely see today because of successful results of timely percutaneous revascularization.\nWhatever the reason for this patient's or that of others to delay seeking medical attention during this pandemic, the concern remains that this delay will lead to increased morbidity and mortality in the coming weeks and months. There most certainly are many others like this patient, who have suffered or will suffer a catastrophic complication due to delay in treatment. Metzler et al 2 posits that if 40% of people are not seeking care for acute coronary syndromes, and assuming 40% of those untreated people suffer a significant complication or death, the effect of COVID‐19 pandemic on non‐COVID related health of our population may be even more devastating than COVID‐19 itself. And this case just highlights the fact that this assumption may not be too far from the 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