PMC:7275193 / 7469-8049 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7275193","sourcedb":"PMC","sourceid":"7275193","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7275193","text":"Chronic myeloid or myelogenous leukemia (CML) is a myeloproliferative neoplasm which is defined as uncontrolled and dysregulated production of mature myeloid cells, mainly granulocytes. It results from acquired abnormal chromosomal translocation, t(9; 22), known as the Philadelphia chromosome, which contains the BCR-ABL1 fused gene and produces BCR-ABL1 fusion protein with abnormal tyrosine kinase activity [6]. It has three phases: chronic, accelerated, and blast. 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