PMC:7275137 / 3984-4377 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T16","span":{"begin":13,"end":22},"obj":"Body_part"},{"id":"T17","span":{"begin":212,"end":225},"obj":"Body_part"},{"id":"T18","span":{"begin":231,"end":240},"obj":"Body_part"},{"id":"T19","span":{"begin":332,"end":341},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma67180"}],"text":"s to monitor endosomal maturation [7]. Two important sensing strategies are used by most viruses for induction of membrane fusion mechanisms: direct pH sensing mediated by a conformational change of the envelope glycoproteins, and endosomal protease-mediated proteolytic cleavage [7]. From a pharmacological perspective, this makes endosomal pH an attractive drug target. Neutralization of end"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T28","span":{"begin":89,"end":96},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T29","span":{"begin":114,"end":122},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T30","span":{"begin":172,"end":173},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T31","span":{"begin":290,"end":291},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"s to monitor endosomal maturation [7]. Two important sensing strategies are used by most viruses for induction of membrane fusion mechanisms: direct pH sensing mediated by a conformational change of the envelope glycoproteins, and endosomal protease-mediated proteolytic cleavage [7]. From a pharmacological perspective, this makes endosomal pH an attractive drug target. Neutralization of end"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T30","span":{"begin":212,"end":225},"obj":"Chemical"},{"id":"T31","span":{"begin":359,"end":363},"obj":"Chemical"}],"attributes":[{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"s to monitor endosomal maturation [7]. Two important sensing strategies are used by most viruses for induction of membrane fusion mechanisms: direct pH sensing mediated by a conformational change of the envelope glycoproteins, and endosomal protease-mediated proteolytic cleavage [7]. From a pharmacological perspective, this makes endosomal pH an attractive drug target. Neutralization of end"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T5","span":{"begin":114,"end":129},"obj":"http://purl.obolibrary.org/obo/GO_0061025"}],"text":"s to monitor endosomal maturation [7]. Two important sensing strategies are used by most viruses for induction of membrane fusion mechanisms: direct pH sensing mediated by a conformational change of the envelope glycoproteins, and endosomal protease-mediated proteolytic cleavage [7]. From a pharmacological perspective, this makes endosomal pH an attractive drug target. Neutralization of end"}

{"project":"LitCovid-sentences","denotations":[{"id":"T23","span":{"begin":39,"end":284},"obj":"Sentence"},{"id":"T24","span":{"begin":285,"end":371},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"s to monitor endosomal maturation [7]. Two important sensing strategies are used by most viruses for induction of membrane fusion mechanisms: direct pH sensing mediated by a conformational change of the envelope glycoproteins, and endosomal protease-mediated proteolytic cleavage [7]. From a pharmacological perspective, this makes endosomal pH an attractive drug target. Neutralization of end"}

{"project":"LitCovid-PubTator","denotations":[{"id":"105","span":{"begin":342,"end":344},"obj":"Gene"},{"id":"106","span":{"begin":149,"end":151},"obj":"Gene"}],"attributes":[{"id":"A105","pred":"tao:has_database_id","subj":"105","obj":"Gene:5053"},{"id":"A106","pred":"tao:has_database_id","subj":"106","obj":"Gene:5053"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"s to monitor endosomal maturation [7]. Two important sensing strategies are used by most viruses for induction of membrane fusion mechanisms: direct pH sensing mediated by a conformational change of the envelope glycoproteins, and endosomal protease-mediated proteolytic cleavage [7]. From a pharmacological perspective, this makes endosomal pH an attractive drug target. Neutralization of end"}