> top > docs > PMC:7275137 > spans > 2784-8488 > annotations

PMC:7275137 / 2784-8488 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T6 103-107 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T7 112-118 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T8 196-213 Body_part denotes cellular membrane http://purl.org/sig/ont/fma/fma63841
T9 282-297 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T10 435-439 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T11 663-675 Body_part denotes compartments http://purl.org/sig/ont/fma/fma76577
T12 774-783 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T13 784-795 Body_part denotes compartment http://purl.org/sig/ont/fma/fma76577
T14 962-971 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T15 1031-1040 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T16 1213-1222 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T17 1412-1425 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T18 1431-1440 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T19 1532-1541 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T20 1590-1599 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T21 1613-1622 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T22 1693-1702 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T23 2004-2013 Body_part denotes Endosomal http://purl.org/sig/ont/fma/fma67180
T24 2099-2108 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T25 2266-2270 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 2323-2332 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T27 2977-2986 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T28 3097-3109 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T29 3115-3124 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T30 3201-3205 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T31 3234-3239 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 3245-3257 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T33 3271-3278 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T34 3533-3542 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T35 3667-3679 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T36 3801-3806 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T37 3962-3977 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T38 4070-4074 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T39 4528-4547 Body_part denotes cytoplasmic vesicle http://purl.org/sig/ont/fma/fma63175
T40 5094-5102 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T41 5215-5219 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T42 5221-5229 Body_part denotes Lysosome http://purl.org/sig/ont/fma/fma63836
T43 5328-5337 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T44 5366-5375 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T12 2597-2613 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T13 2661-2685 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T14 2687-2695 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 2818-2826 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 3311-3344 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T17 3358-3366 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 3372-3419 Disease denotes severe acute respiratory syndrome coronavirus-2 http://purl.obolibrary.org/obo/MONDO_0100096
T19 3372-3405 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T20 3421-3429 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 3781-3789 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 4045-4053 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T23 4368-4376 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 4629-4637 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 4802-4810 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 5149-5182 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T27 5198-5206 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 5679-5703 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T10 25-34 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T11 42-49 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T12 103-107 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13 166-171 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T14 178-181 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T15 205-213 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T16 245-252 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T17 282-288 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T18 289-297 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T19 365-372 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T20 435-439 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T21 462-465 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T22 514-519 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T23 745-750 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T24 751-754 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T25 865-866 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 1137-1140 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T27 1194-1201 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T28 1289-1296 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T29 1314-1322 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T30 1372-1373 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 1490-1491 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 1677-1685 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T33 1721-1722 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 2213-2220 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T35 2266-2270 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T36 2412-2419 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T37 2557-2558 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 2828-2830 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T39 2920-2928 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T40 2977-2986 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T41 3004-3005 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T42 3115-3124 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T43 3201-3205 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T44 3234-3239 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T45 3801-3806 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T46 3962-3968 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T47 3969-3977 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T48 4070-4074 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T49 4678-4687 http://purl.obolibrary.org/obo/OBI_0000245 denotes organized
T50 5094-5102 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T51 5213-5219 http://purl.obolibrary.org/obo/CLO_0001020 denotes a cell
T52 5221-5229 http://purl.obolibrary.org/obo/GO_0005764 denotes Lysosome
T53 5628-5629 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T30 1412-1425 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T31 1559-1563 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T32 2369-2383 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T33 2369-2378 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T34 2379-2383 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T35 2728-2739 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T36 2741-2743 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T37 2749-2767 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T38 2910-2919 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T39 2932-2934 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T40 3097-3109 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T41 3245-3257 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T42 3271-3278 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 3489-3500 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T44 3667-3679 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T45 4155-4157 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T46 4752-4761 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T47 4777-4782 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T48 4932-4937 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T49 5113-5118 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T50 5240-5245 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T51 5265-5270 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T52 5280-5291 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T4 450-461 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T5 1314-1329 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T6 1825-1834 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T7 1838-1855 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T8 1838-1855 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T9 1911-1935 http://purl.obolibrary.org/obo/GO_0017157 denotes regulation of exocytosis
T10 1911-1921 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11 1925-1935 http://purl.obolibrary.org/obo/GO_0006887 denotes exocytosis
T12 2475-2500 http://purl.obolibrary.org/obo/GO_0045806 denotes inhibition of endocytosis
T13 2489-2500 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T14 2522-2547 http://purl.obolibrary.org/obo/GO_0045806 denotes inhibition of endocytosis
T15 2536-2547 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T16 2597-2613 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T17 3842-3853 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T18 4205-4216 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T19 4540-4559 http://purl.obolibrary.org/obo/GO_0016192 denotes vesicle trafficking
T20 5456-5473 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T21 5456-5473 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T14 0-15 Sentence denotes 1 Introduction
T15 16-144 Sentence denotes The main objective of all viruses is to hijack the intracellular machinery of the host cell for genome replication and assembly.
T16 145-222 Sentence denotes To achieve this, the virus first has to bypass the cellular membrane barrier.
T17 223-340 Sentence denotes The structure of some viruses enables direct fusion at the plasma membrane after recognition of the binding site [1].
T18 341-444 Sentence denotes However, most enveloped viruses depend on the endocytic pathway prior to fusion with the host cell [2].
T19 445-709 Sentence denotes Once endocytosis has been initiated, survival and replication of the virus depend on successful delivery of the viral nucleocapsid into the correct intracellular department, as different viral families target distinct compartments as primary replication sites [3].
T20 710-861 Sentence denotes Moreover, in order to survive, the virus has to escape from the endosomal compartment silently, without triggering the cellular defence mechanisms [4].
T21 862-1003 Sentence denotes As a result, viral evolution involves highly complex escape strategies relying on different cues of endosomal maturation and trafficking [5].
T22 1004-1238 Sentence denotes Establishment of an acidic endosomal lumen is the key requirement for normal functioning of the endocytic pathway [6], so pH sensing has evolved as one of the fundamental strategies used by viruses to monitor endosomal maturation [7].
T23 1239-1484 Sentence denotes Two important sensing strategies are used by most viruses for induction of membrane fusion mechanisms: direct pH sensing mediated by a conformational change of the envelope glycoproteins, and endosomal protease-mediated proteolytic cleavage [7].
T24 1485-1571 Sentence denotes From a pharmacological perspective, this makes endosomal pH an attractive drug target.
T25 1572-1717 Sentence denotes Neutralization of endosomal pH obstructs endosomal trafficking, impedes sorting mechanisms, and inhibits activity of the endosomal proteases [6].
T26 1718-1866 Sentence denotes As a consequence, pharmacological modulation of endolysosomal pH could prevent viral fusion and impair the formation of viral replication complexes.
T27 1867-2003 Sentence denotes Moreover, as pH modulation is important for regulation of exocytosis, vesicular pH modulation could also affect viral dissemination [8].
T28 2004-2178 Sentence denotes Endosomal trafficking is necessary for normal cellular functioning, so long-term disruption of endosomal function could have considerable pathophysiological consequences [9].
T29 2179-2346 Sentence denotes Moreover, the infectivity of some viruses that use alternative strategies to enter the cell could be increased by pH-mediated inhibition of the endosomal pathway [10].
T30 2347-2501 Sentence denotes For this reason, most antiviral drug development strategies have focused on more specific fusion mechanisms rather than general inhibition of endocytosis.
T31 2502-2697 Sentence denotes However, short-term inhibition of endocytosis could be a viable strategy for the management of viral infections with no alternative treatment options, such as coronavirus disease 2019 (COVID-19).
T32 2698-2850 Sentence denotes Recent evidence suggests that chloroquine (CQ) and hydroxychloroquine (HCQ) may be effective therapeutic strategies for COVID-19 [11], [12], [13], [14].
T33 2851-3020 Sentence denotes Although the exact mechanism of action responsible for the antiviral activity of CQ and HCQ remains unclear, the elevation of lysosomal pH seems to play a key role [14].
T34 3021-3210 Sentence denotes This is in concordance with previous findings, as proteolytic processing of glycoprotein S by lysosomal proteases seems to be necessary for the fusion of coronavirus with the host cell [2].
T35 3211-3557 Sentence denotes Moreover, treatment of cells with glycoprotein S – the main protein responsible for viral fusion of severe acute respiratory syndrome coronavirus (SARS-CoV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) – resulted in translocation of the main viral receptor, angiotensin-converting enzyme 2 (ACE-2), to endosomal vesicles [15].
T36 3558-3704 Sentence denotes Furthermore, the same effect was demonstrated for spike-bearing pseudoviruses, emphasizing the importance of glycoprotein S for viral fusion [15].
T37 3705-3983 Sentence denotes It is important to mention that although many groups have demonstrated that SARS-CoV enters the cells by receptor-mediated, pH-sensitive endocytosis [15], some groups have reported that viral fusion might also occur by pH-independent direct fusion with the plasma membrane [16].
T38 3984-4377 Sentence denotes Although the exact mechanism responsible for the entrance of SARS-CoV-2 into the host cell remains to be elucidated, the authors believe that data from clinical trials on CQ and HCQ support the importance of pH-dependent endocytosis, and that other widely available pharmacological agents with lysosomotropic properties may also demonstrate clinical effectiveness in the treatment of COVID-19.
T39 4378-4571 Sentence denotes This review discusses commonly used pharmacological agents in the context of their lysosomotropic effects and pH-modulation-mediated interaction with cytoplasmic vesicle trafficking (Fig. 1 .).
T40 4572-4840 Sentence denotes Although almost 5 million people had been diagnosed with COVID-19 at the time of writing (20th May 2020), organized clinical data that would facilitate the evaluation of potential antiviral effects of the drugs discussed below on SARS-CoV-2 are unavailable at present.
T41 4841-5036 Sentence denotes Colleagues in possession of such data are urged to evaluate the possible benefits of these drugs, as they might offer new hope in terms of prevention and/or treatment of this devastating disease.
T42 5037-5220 Sentence denotes Fig. 1 Possible interaction of lysosomotropic agents and lysosome targeting drugs with the replication cycle of severe acute respiratory syndrome corovavirus-2 (SARS-CoV-2) in a cell.
T43 5221-5411 Sentence denotes Lysosome targeting drugs and lysosomotropic drugs, such as chloroquine, have the ability to interfere with endosomal trafficking, affecting both endosomal maturation and exocytotic pathways.
T44 5412-5704 Sentence denotes Taking into consideration the dependence of viral replication on the normal functioning of endocytic trafficking, commonly used pharmacological agents that demonstrate lysosomotropic properties should be examined as a possible therapeutic option for the treatment of coronavirus disease 2019.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
52 5198-5208 Species denotes SARS-CoV-2 Tax:2697049
53 5162-5173 Species denotes respiratory Tax:12814
54 5280-5291 Chemical denotes chloroquine MESH:D002738
55 5679-5703 Disease denotes coronavirus disease 2019 MESH:C000657245
94 3489-3520 Gene denotes angiotensin-converting enzyme 2 Gene:59272
95 3522-3527 Gene denotes ACE-2 Gene:59272
96 4488-4490 Gene denotes pH Gene:5053
97 4192-4194 Gene denotes pH Gene:5053
98 3924-3926 Gene denotes pH Gene:5053
99 3829-3831 Gene denotes pH Gene:5053
100 2293-2295 Gene denotes pH Gene:5053
101 1947-1949 Gene denotes pH Gene:5053
102 1880-1882 Gene denotes pH Gene:5053
103 1780-1782 Gene denotes pH Gene:5053
104 1600-1602 Gene denotes pH Gene:5053
105 1542-1544 Gene denotes pH Gene:5053
106 1349-1351 Gene denotes pH Gene:5053
107 1126-1128 Gene denotes pH Gene:5053
108 3175-3186 Species denotes coronavirus Tax:11118
109 3311-3356 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
110 3358-3366 Species denotes SARS-CoV Tax:694009
111 3372-3419 Species denotes severe acute respiratory syndrome coronavirus-2 Tax:2697049
112 3421-3431 Species denotes SARS-CoV-2 Tax:2697049
113 3781-3789 Species denotes SARS-CoV Tax:694009
114 4045-4055 Species denotes SARS-CoV-2 Tax:2697049
115 4598-4604 Species denotes people Tax:9606
116 4802-4812 Species denotes SARS-CoV-2 Tax:2697049
117 1937-1946 Species denotes vesicular Tax:11276
118 2728-2739 Chemical denotes chloroquine MESH:D002738
119 2741-2743 Chemical denotes CQ MESH:D002738
120 2749-2767 Chemical denotes hydroxychloroquine MESH:D006886
121 2769-2772 Chemical denotes HCQ MESH:D006886
122 2932-2934 Chemical denotes CQ MESH:D002738
123 2939-2942 Chemical denotes HCQ MESH:D006886
124 4155-4157 Chemical denotes CQ MESH:D002738
125 4162-4165 Chemical denotes HCQ MESH:D006886
126 2597-2613 Disease denotes viral infections MESH:D001102
127 2661-2685 Disease denotes coronavirus disease 2019 MESH:C000657245
128 2687-2695 Disease denotes COVID-19 MESH:C000657245
129 2818-2826 Disease denotes COVID-19 MESH:C000657245
130 4368-4376 Disease denotes COVID-19 MESH:C000657245
131 4629-4637 Disease denotes COVID-19 MESH:C000657245

2_test

Id Subject Object Predicate Lexical cue
32522674-15656780-48147827 706-707 15656780 denotes 3
32522674-16497584-48147828 1000-1001 16497584 denotes 5
32522674-21140470-48147829 1119-1120 21140470 denotes 6
32522674-21140470-48147830 1714-1715 21140470 denotes 6
32522674-18511251-48147831 2000-2001 18511251 denotes 8
32522674-26448863-48147832 2175-2176 26448863 denotes 9
32522674-12388705-48147833 2342-2344 12388705 denotes 10
32522674-32074550-48147834 2828-2830 32074550 denotes 11
32522674-32173110-48147835 2834-2836 32173110 denotes 12
32522674-32147628-48147836 2840-2842 32147628 denotes 13
32522674-18227861-48147837 3553-3555 18227861 denotes 15
32522674-18227861-48147838 3700-3702 18227861 denotes 15
32522674-18227861-48147839 3855-3857 18227861 denotes 15
32522674-15010527-48147840 3979-3981 15010527 denotes 16
T75160 706-707 15656780 denotes 3
T81000 1000-1001 16497584 denotes 5
T42367 1119-1120 21140470 denotes 6
T17246 1714-1715 21140470 denotes 6
T75945 2000-2001 18511251 denotes 8
T43848 2175-2176 26448863 denotes 9
T8 2342-2344 12388705 denotes 10
T35059 2828-2830 32074550 denotes 11
T17382 2834-2836 32173110 denotes 12
T56821 2840-2842 32147628 denotes 13
T8269 3553-3555 18227861 denotes 15
T29065 3700-3702 18227861 denotes 15
T78033 3855-3857 18227861 denotes 15
T3809 3979-3981 15010527 denotes 16