PMC:7275137 / 17378-17728 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T49","span":{"begin":166,"end":174},"obj":"Disease"}],"attributes":[{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Considering everything mentioned above and the recent in-silico finding that clarithromycin and erythromycin could have a direct antiviral effect by interfering with COVID-19 protease [38], macrolides should be investigated further as a treatment option, including the route of administration, with inhalatory macrolides being of particular interest."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T106","span":{"begin":120,"end":121},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T107","span":{"begin":235,"end":236},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Considering everything mentioned above and the recent in-silico finding that clarithromycin and erythromycin could have a direct antiviral effect by interfering with COVID-19 protease [38], macrolides should be investigated further as a treatment option, including the route of administration, with inhalatory macrolides being of particular interest."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T121","span":{"begin":77,"end":91},"obj":"Chemical"},{"id":"T122","span":{"begin":96,"end":108},"obj":"Chemical"},{"id":"T124","span":{"begin":129,"end":138},"obj":"Chemical"},{"id":"T125","span":{"begin":190,"end":200},"obj":"Chemical"},{"id":"T126","span":{"begin":310,"end":320},"obj":"Chemical"}],"attributes":[{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_3732"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_42355"},{"id":"A123","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_48923"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_25106"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_25106"}],"text":"Considering everything mentioned above and the recent in-silico finding that clarithromycin and erythromycin could have a direct antiviral effect by interfering with COVID-19 protease [38], macrolides should be investigated further as a treatment option, including the route of administration, with inhalatory macrolides being of particular interest."}

{"project":"LitCovid-sentences","denotations":[{"id":"T87","span":{"begin":0,"end":350},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Considering everything mentioned above and the recent in-silico finding that clarithromycin and erythromycin could have a direct antiviral effect by interfering with COVID-19 protease [38], macrolides should be investigated further as a treatment option, including the route of administration, with inhalatory macrolides being of particular interest."}

{"project":"LitCovid-PubTator","denotations":[{"id":"294","span":{"begin":77,"end":91},"obj":"Chemical"},{"id":"295","span":{"begin":96,"end":108},"obj":"Chemical"},{"id":"296","span":{"begin":190,"end":200},"obj":"Chemical"},{"id":"297","span":{"begin":310,"end":320},"obj":"Chemical"},{"id":"307","span":{"begin":166,"end":174},"obj":"Disease"}],"attributes":[{"id":"A294","pred":"tao:has_database_id","subj":"294","obj":"MESH:D017291"},{"id":"A295","pred":"tao:has_database_id","subj":"295","obj":"MESH:D004917"},{"id":"A296","pred":"tao:has_database_id","subj":"296","obj":"MESH:D018942"},{"id":"A297","pred":"tao:has_database_id","subj":"297","obj":"MESH:D018942"},{"id":"A307","pred":"tao:has_database_id","subj":"307","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Considering everything mentioned above and the recent in-silico finding that clarithromycin and erythromycin could have a direct antiviral effect by interfering with COVID-19 protease [38], macrolides should be investigated further as a treatment option, including the route of administration, with inhalatory macrolides being of particular interest."}