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PMC:7275133 / 20849-23991
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
424 | 3024-3026 | Gene | denotes | of | Gene:6688 |
425 | 3013-3015 | Gene | denotes | of | Gene:6688 |
426 | 3005-3007 | Gene | denotes | of | Gene:6688 |
427 | 2854-2856 | Gene | denotes | of | Gene:6688 |
428 | 2652-2654 | Gene | denotes | of | Gene:6688 |
429 | 2374-2376 | Gene | denotes | of | Gene:6688 |
430 | 2342-2344 | Gene | denotes | of | Gene:6688 |
431 | 1965-1967 | Gene | denotes | of | Gene:6688 |
432 | 1718-1720 | Gene | denotes | of | Gene:6688 |
433 | 1572-1574 | Gene | denotes | of | Gene:6688 |
434 | 1400-1402 | Gene | denotes | of | Gene:6688 |
435 | 1346-1348 | Gene | denotes | of | Gene:6688 |
436 | 1184-1186 | Gene | denotes | of | Gene:6688 |
437 | 140-145 | Species | denotes | Apple | Tax:3750 |
438 | 631-636 | Species | denotes | Apple | Tax:3750 |
439 | 902-907 | Species | denotes | Apple | Tax:3750 |
440 | 989-996 | Species | denotes | patient | Tax:9606 |
441 | 1061-1068 | Species | denotes | patient | Tax:9606 |
442 | 1943-1950 | Species | denotes | patient | Tax:9606 |
443 | 2183-2191 | Species | denotes | patients | Tax:9606 |
444 | 2549-2557 | Species | denotes | patients | Tax:9606 |
445 | 84-90 | Disease | denotes | asthma | MESH:D001249 |
446 | 588-594 | Disease | denotes | asthma | MESH:D001249 |
447 | 814-829 | Disease | denotes | asthma symptoms | MESH:D051271 |
448 | 853-859 | Disease | denotes | asthma | MESH:D001249 |
449 | 1492-1507 | Disease | denotes | asthma symptoms | MESH:D051271 |
450 | 1762-1768 | Disease | denotes | asthma | MESH:D001249 |
451 | 2209-2215 | Disease | denotes | asthma | MESH:D001249 |
452 | 2719-2725 | Disease | denotes | asthma | MESH:D001249 |
453 | 2781-2787 | Disease | denotes | asthma | MESH:D001249 |
455 | 45-51 | Disease | denotes | asthma | MESH:D001249 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T11 | 161-166 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
T12 | 332-337 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
T13 | 796-800 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T14 | 2813-2817 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T9 | 161-166 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
T10 | 332-337 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
T11 | 796-800 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T12 | 2813-2817 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T53 | 45-51 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T54 | 84-90 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T55 | 578-594 | Disease | denotes | pediatric asthma | http://purl.obolibrary.org/obo/MONDO_0005405 |
T56 | 588-594 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T57 | 814-820 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T58 | 853-859 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T59 | 1363-1369 | Disease | denotes | Asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T60 | 1427-1430 | Disease | denotes | GPS | http://purl.obolibrary.org/obo/MONDO_0007686 |
T61 | 1492-1498 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T62 | 1762-1768 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T63 | 2209-2215 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T64 | 2658-2664 | Disease | denotes | Asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T65 | 2719-2725 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T66 | 2781-2787 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T167 | 161-166 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
T168 | 161-166 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
T169 | 161-166 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
T170 | 161-166 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
T171 | 232-240 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T172 | 332-337 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
T173 | 332-337 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
T174 | 332-337 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
T175 | 332-337 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
T176 | 369-377 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T177 | 521-523 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
T178 | 796-800 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T179 | 796-800 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T180 | 833-842 | http://www.ebi.ac.uk/efo/EFO_0000881 | denotes | digitally |
T181 | 1099-1106 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
T182 | 1132-1139 | http://www.ebi.ac.uk/efo/EFO_0000881 | denotes | digital |
T183 | 1705-1711 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | device |
T184 | 1968-1974 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | device |
T185 | 1979-1986 | http://www.ebi.ac.uk/efo/EFO_0000881 | denotes | digital |
T186 | 2238-2239 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T187 | 2240-2247 | http://www.ebi.ac.uk/efo/EFO_0000881 | denotes | digital |
T188 | 2349-2356 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
T189 | 2377-2384 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
T190 | 2813-2817 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T191 | 2813-2817 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T29 | 683-690 | Chemical | denotes | Android | http://purl.obolibrary.org/obo/CHEBI_27436 |
T30 | 1525-1533 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
T31 | 2132-2140 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
T32 | 2297-2305 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
T33 | 2538-2546 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T25 | 289-294 | http://purl.obolibrary.org/obo/GO_0030431 | denotes | sleep |
T26 | 448-453 | http://purl.obolibrary.org/obo/GO_0030431 | denotes | sleep |
T27 | 541-546 | http://purl.obolibrary.org/obo/GO_0030431 | denotes | sleep |
T28 | 878-883 | http://purl.obolibrary.org/obo/GO_0030431 | denotes | sleep |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T138 | 0-51 | Sentence | denotes | Table 2 Current and emerging technologies in asthma |
T139 | 52-107 | Sentence | denotes | Technology Measures Outcomes in asthma studies Comments |
T140 | 108-127 | Sentence | denotes | Wearable technology |
T141 | 128-137 | Sentence | denotes | − Fitbit™ |
T142 | 138-318 | Sentence | denotes | − Apple™ Watch Fitbit: heart rate (available on most but not all models), steps/day, physical activity (light, moderate and vigorous), sedentary time, sleep efficiency, wake counts |
T143 | 319-523 | Sentence | denotes | Apple Watch: heart rate, EKG, steps/day, physical activity (light, moderate and vigorous), sedentary time − Fitbit overestimated sleep efficiency and underestimated wake counts compared with actigraphy.18 |
T144 | 524-630 | Sentence | denotes | − Fitbit-derived sleep quality correlated with PROMIS pediatric asthma impact score.21 Corresponding Apps: |
T145 | 631-690 | Sentence | denotes | Apple Watch App on iPhone, Fitbit App on iPhone and Android |
T146 | 691-868 | Sentence | denotes | Pros: portable; commercially available; may be useful when used with other measures such as air quality, lung function and asthma symptoms to digitally phenotype asthma patients |
T147 | 869-874 | Sentence | denotes | Cons: |
T148 | 875-935 | Sentence | denotes | No sleep data available on Apple Watch without 3rd party App |
T149 | 936-949 | Sentence | denotes | Data sharing: |
T150 | 950-1076 | Sentence | denotes | Data does not sync to EMR directly but patient can access file and send to provider via mail, secure email, or patient portal. |
T151 | 1077-1168 | Sentence | denotes | Electronic monitoring devices (e.g., inhaler sensors ± digital health platform) Digihaler™: |
T152 | 1169-1280 | Sentence | denotes | − Inhaler time of inhaler use, peak inspiratory flow rate (PIFR), time to PIFR, inhalation volume and duration. |
T153 | 1281-1305 | Sentence | denotes | Propeller Health System: |
T154 | 1306-1360 | Sentence | denotes | − Inhaler sensor: date, time and number of doses taken |
T155 | 1361-1390 | Sentence | denotes | − Asthma Health Platform App: |
T156 | 1391-1516 | Sentence | denotes | Location of inhaler use using phone GPS, current weather/pollen counts/air pollution and self-report asthma symptoms/triggers |
T157 | 1517-1534 | Sentence | denotes | Hailie™ solution: |
T158 | 1535-1610 | Sentence | denotes | − Inhaler sensor: date, time, number of inhaler actuations and missed doses |
T159 | 1611-1674 | Sentence | denotes | − Hailie™ App: medication adherence, daily medication reminders |
T160 | 1675-1712 | Sentence | denotes | Inhaler compliance assessment device: |
T161 | 1713-1808 | Sentence | denotes | Time of dose, inhaler technique errors − Greater asthma control31,38–39 and symptom-free days33 |
T162 | 1809-1898 | Sentence | denotes | − Reduction in daily symptoms31, rescue medication use29,32–33, and exacerbations34,38–39 |
T163 | 1899-1935 | Sentence | denotes | − Improved medication adherence36–40 |
T164 | 1936-2008 | Sentence | denotes | − High patient acceptability of device and digital health platform36–37. |
T165 | 2009-2028 | Sentence | denotes | Corresponding Apps: |
T166 | 2029-2067 | Sentence | denotes | Digihaler™, Propeller Health, Hailie™. |
T167 | 2068-2141 | Sentence | denotes | Web-based platform also available for Propeller Health, Hailie™ solution. |
T168 | 2142-2307 | Sentence | denotes | Pros: portable, high acceptability among patients, improvements in asthma control in those with a digital health platform (e.g., Propeller Health, Hailie™ solution). |
T169 | 2308-2313 | Sentence | denotes | Cons: |
T170 | 2314-2434 | Sentence | denotes | Additional efficacy studies of the devices are needed, cost of devices are not always covered by insurance reimbursement |
T171 | 2435-2448 | Sentence | denotes | Data sharing: |
T172 | 2449-2609 | Sentence | denotes | Provider platform available to share results (e.g. Digihaler™, Propeller Health, Hailie™ solution), patients may share data from Digihaler™ also via file share. |
T173 | 2610-2655 | Sentence | denotes | Mobile-based applications Self-monitoring of: |
T174 | 2656-2673 | Sentence | denotes | − Asthma symptoms |
T175 | 2674-2684 | Sentence | denotes | − Triggers |
T176 | 2685-2763 | Sentence | denotes | − Medication use -Improvements in asthma control though low-quality evidence45 |
T177 | 2764-2886 | Sentence | denotes | -Improvements in asthma control in five studies, lung function in two studies and quality of life in three studies46 Pros: |
T178 | 2887-2917 | Sentence | denotes | Acceptable and feasible to use |
T179 | 2918-2923 | Sentence | denotes | Cons: |
T180 | 2924-3045 | Sentence | denotes | Vary in quality; data are self-reported, most apps have not been validated; risk of loss of privacy of health information |
T181 | 3046-3059 | Sentence | denotes | Data sharing: |
T182 | 3060-3142 | Sentence | denotes | Vary in ability to share with provider, most are up to user to share with provider |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T50 | 45-51 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T51 | 84-90 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T52 | 588-594 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T53 | 814-820 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T54 | 853-859 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T55 | 1363-1369 | Phenotype | denotes | Asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T56 | 1492-1498 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T57 | 1762-1768 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T58 | 2209-2215 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T59 | 2658-2664 | Phenotype | denotes | Asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T60 | 2719-2725 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
T61 | 2781-2787 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |