PMC:7274970 / 3843-4792 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"93","span":{"begin":0,"end":8},"obj":"Species"},{"id":"94","span":{"begin":313,"end":321},"obj":"Species"},{"id":"95","span":{"begin":661,"end":669},"obj":"Species"},{"id":"96","span":{"begin":926,"end":934},"obj":"Species"},{"id":"97","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"98","span":{"begin":295,"end":300},"obj":"Disease"},{"id":"99","span":{"begin":304,"end":312},"obj":"Disease"},{"id":"100","span":{"begin":370,"end":381},"obj":"Disease"},{"id":"101","span":{"begin":432,"end":440},"obj":"Disease"},{"id":"102","span":{"begin":648,"end":657},"obj":"Disease"},{"id":"103","span":{"begin":675,"end":683},"obj":"Disease"},{"id":"104","span":{"begin":796,"end":807},"obj":"Disease"},{"id":"105","span":{"begin":940,"end":948},"obj":"Disease"}],"attributes":[{"id":"A93","pred":"tao:has_database_id","subj":"93","obj":"Tax:9606"},{"id":"A94","pred":"tao:has_database_id","subj":"94","obj":"Tax:9606"},{"id":"A95","pred":"tao:has_database_id","subj":"95","obj":"Tax:9606"},{"id":"A96","pred":"tao:has_database_id","subj":"96","obj":"Tax:9606"},{"id":"A97","pred":"tao:has_database_id","subj":"97","obj":"MESH:C000657245"},{"id":"A98","pred":"tao:has_database_id","subj":"98","obj":"MESH:D003643"},{"id":"A99","pred":"tao:has_database_id","subj":"99","obj":"MESH:C000657245"},{"id":"A100","pred":"tao:has_database_id","subj":"100","obj":"MESH:D008231"},{"id":"A101","pred":"tao:has_database_id","subj":"101","obj":"MESH:C000657245"},{"id":"A102","pred":"tao:has_database_id","subj":"102","obj":"MESH:D003643"},{"id":"A103","pred":"tao:has_database_id","subj":"103","obj":"MESH:C000657245"},{"id":"A104","pred":"tao:has_database_id","subj":"104","obj":"MESH:D008231"},{"id":"A105","pred":"tao:has_database_id","subj":"105","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Patients with COVID-19 typically present a decrease in absolute lymphocyte count (ALC) (Huang et al., 2020a, Wang et al., 2020). The dynamic profile of total circulating lymphocytes indicated that a continuous and sustained decrease in the ALC is closely associated with disease aggravation and death in COVID-19 patients (Wang et al., 2020, Zhou et al., 2020). Indeed, lymphopenia was associated with increased disease severity in COVID-19 (Tan et al., 2020). In addition, the neutrophil-to-lymphocyte ratio (NLR) can also serve as a simple complementary indicator to predict clinical severity and prognosis, and is an independent risk factor for mortality in patients with COVID-19 (Lagunas-Rangel, 2020, Qin et al., 2020, Liu et al., 2020). These studies indicate that promoting recovery from lymphopenia and slowing the deterioration based on an increased NLR may reduce the need for ICU care and improve the prognosis of patients with COVID-19."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T5","span":{"begin":64,"end":74},"obj":"Body_part"},{"id":"T6","span":{"begin":170,"end":181},"obj":"Body_part"},{"id":"T7","span":{"begin":478,"end":488},"obj":"Body_part"},{"id":"T8","span":{"begin":492,"end":502},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma62863"}],"text":"Patients with COVID-19 typically present a decrease in absolute lymphocyte count (ALC) (Huang et al., 2020a, Wang et al., 2020). The dynamic profile of total circulating lymphocytes indicated that a continuous and sustained decrease in the ALC is closely associated with disease aggravation and death in COVID-19 patients (Wang et al., 2020, Zhou et al., 2020). Indeed, lymphopenia was associated with increased disease severity in COVID-19 (Tan et al., 2020). In addition, the neutrophil-to-lymphocyte ratio (NLR) can also serve as a simple complementary indicator to predict clinical severity and prognosis, and is an independent risk factor for mortality in patients with COVID-19 (Lagunas-Rangel, 2020, Qin et al., 2020, Liu et al., 2020). These studies indicate that promoting recovery from lymphopenia and slowing the deterioration based on an increased NLR may reduce the need for ICU care and improve the prognosis of patients with COVID-19."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T24","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"T25","span":{"begin":304,"end":312},"obj":"Disease"},{"id":"T26","span":{"begin":370,"end":381},"obj":"Disease"},{"id":"T27","span":{"begin":432,"end":440},"obj":"Disease"},{"id":"T28","span":{"begin":675,"end":683},"obj":"Disease"},{"id":"T29","span":{"begin":796,"end":807},"obj":"Disease"},{"id":"T30","span":{"begin":940,"end":948},"obj":"Disease"}],"attributes":[{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0003783"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0003783"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Patients with COVID-19 typically present a decrease in absolute lymphocyte count (ALC) (Huang et al., 2020a, Wang et al., 2020). The dynamic profile of total circulating lymphocytes indicated that a continuous and sustained decrease in the ALC is closely associated with disease aggravation and death in COVID-19 patients (Wang et al., 2020, Zhou et al., 2020). Indeed, lymphopenia was associated with increased disease severity in COVID-19 (Tan et al., 2020). In addition, the neutrophil-to-lymphocyte ratio (NLR) can also serve as a simple complementary indicator to predict clinical severity and prognosis, and is an independent risk factor for mortality in patients with COVID-19 (Lagunas-Rangel, 2020, Qin et al., 2020, Liu et al., 2020). These studies indicate that promoting recovery from lymphopenia and slowing the deterioration based on an increased NLR may reduce the need for ICU care and improve the prognosis of patients with COVID-19."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T6","span":{"begin":41,"end":42},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7","span":{"begin":197,"end":198},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":533,"end":534},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Patients with COVID-19 typically present a decrease in absolute lymphocyte count (ALC) (Huang et al., 2020a, Wang et al., 2020). The dynamic profile of total circulating lymphocytes indicated that a continuous and sustained decrease in the ALC is closely associated with disease aggravation and death in COVID-19 patients (Wang et al., 2020, Zhou et al., 2020). Indeed, lymphopenia was associated with increased disease severity in COVID-19 (Tan et al., 2020). In addition, the neutrophil-to-lymphocyte ratio (NLR) can also serve as a simple complementary indicator to predict clinical severity and prognosis, and is an independent risk factor for mortality in patients with COVID-19 (Lagunas-Rangel, 2020, Qin et al., 2020, Liu et al., 2020). These studies indicate that promoting recovery from lymphopenia and slowing the deterioration based on an increased NLR may reduce the need for ICU care and improve the prognosis of patients with COVID-19."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T14","span":{"begin":556,"end":565},"obj":"Chemical"}],"attributes":[{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_47867"}],"text":"Patients with COVID-19 typically present a decrease in absolute lymphocyte count (ALC) (Huang et al., 2020a, Wang et al., 2020). The dynamic profile of total circulating lymphocytes indicated that a continuous and sustained decrease in the ALC is closely associated with disease aggravation and death in COVID-19 patients (Wang et al., 2020, Zhou et al., 2020). Indeed, lymphopenia was associated with increased disease severity in COVID-19 (Tan et al., 2020). In addition, the neutrophil-to-lymphocyte ratio (NLR) can also serve as a simple complementary indicator to predict clinical severity and prognosis, and is an independent risk factor for mortality in patients with COVID-19 (Lagunas-Rangel, 2020, Qin et al., 2020, Liu et al., 2020). These studies indicate that promoting recovery from lymphopenia and slowing the deterioration based on an increased NLR may reduce the need for ICU care and improve the prognosis of patients with COVID-19."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T7","span":{"begin":370,"end":381},"obj":"Phenotype"},{"id":"T8","span":{"begin":796,"end":807},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0001888"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0001888"}],"text":"Patients with COVID-19 typically present a decrease in absolute lymphocyte count (ALC) (Huang et al., 2020a, Wang et al., 2020). The dynamic profile of total circulating lymphocytes indicated that a continuous and sustained decrease in the ALC is closely associated with disease aggravation and death in COVID-19 patients (Wang et al., 2020, Zhou et al., 2020). Indeed, lymphopenia was associated with increased disease severity in COVID-19 (Tan et al., 2020). In addition, the neutrophil-to-lymphocyte ratio (NLR) can also serve as a simple complementary indicator to predict clinical severity and prognosis, and is an independent risk factor for mortality in patients with COVID-19 (Lagunas-Rangel, 2020, Qin et al., 2020, Liu et al., 2020). These studies indicate that promoting recovery from lymphopenia and slowing the deterioration based on an increased NLR may reduce the need for ICU care and improve the prognosis of patients with COVID-19."}

{"project":"LitCovid-sentences","denotations":[{"id":"T26","span":{"begin":0,"end":128},"obj":"Sentence"},{"id":"T27","span":{"begin":129,"end":361},"obj":"Sentence"},{"id":"T28","span":{"begin":362,"end":460},"obj":"Sentence"},{"id":"T29","span":{"begin":461,"end":743},"obj":"Sentence"},{"id":"T30","span":{"begin":744,"end":949},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Patients with COVID-19 typically present a decrease in absolute lymphocyte count (ALC) (Huang et al., 2020a, Wang et al., 2020). The dynamic profile of total circulating lymphocytes indicated that a continuous and sustained decrease in the ALC is closely associated with disease aggravation and death in COVID-19 patients (Wang et al., 2020, Zhou et al., 2020). Indeed, lymphopenia was associated with increased disease severity in COVID-19 (Tan et al., 2020). In addition, the neutrophil-to-lymphocyte ratio (NLR) can also serve as a simple complementary indicator to predict clinical severity and prognosis, and is an independent risk factor for mortality in patients with COVID-19 (Lagunas-Rangel, 2020, Qin et al., 2020, Liu et al., 2020). These studies indicate that promoting recovery from lymphopenia and slowing the deterioration based on an increased NLR may reduce the need for ICU care and improve the prognosis of patients with COVID-19."}

{"project":"2_test","denotations":[{"id":"32512133-32171076-16126964","span":{"begin":355,"end":359},"obj":"32171076"},{"id":"32512133-32296069-16126965","span":{"begin":454,"end":458},"obj":"32296069"}],"text":"Patients with COVID-19 typically present a decrease in absolute lymphocyte count (ALC) (Huang et al., 2020a, Wang et al., 2020). The dynamic profile of total circulating lymphocytes indicated that a continuous and sustained decrease in the ALC is closely associated with disease aggravation and death in COVID-19 patients (Wang et al., 2020, Zhou et al., 2020). Indeed, lymphopenia was associated with increased disease severity in COVID-19 (Tan et al., 2020). In addition, the neutrophil-to-lymphocyte ratio (NLR) can also serve as a simple complementary indicator to predict clinical severity and prognosis, and is an independent risk factor for mortality in patients with COVID-19 (Lagunas-Rangel, 2020, Qin et al., 2020, Liu et al., 2020). These studies indicate that promoting recovery from lymphopenia and slowing the deterioration based on an increased NLR may reduce the need for ICU care and improve the prognosis of patients with COVID-19."}