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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T1 25-33 SP_7 denotes COVID-19
T2 116-117 GO:0000805 denotes X
T3 160-169 GO:0005764 denotes lysosomal
T4 350-357 UBERON:0000948 denotes cardiac
T5 359-367 UBERON:0001893 denotes cerebral
T6 372-377 UBERON:0002113 denotes renal
T7 405-414 UBERON:0002048 denotes pulmonary
T8 483-487 UBERON:0002048 denotes lung
T9 546-557 NCBITaxon:11118 denotes Coronavirus
T10 570-578 SP_7 denotes COVID-19
T11 595-605 SP_7 denotes SARS-CoV-2
T12 606-611 NCBITaxon:10239 denotes virus
T13 758-766 SP_7 denotes COVID-19
T14 1046-1055 GO:0005764 denotes lysosomal
T15 1331-1338 CHEBI:33695;CHEBI:33695 denotes message
T16 1536-1537 GO:0000805 denotes X
T17 1555-1564 GO:0005764 denotes lysosomal
T18 1627-1631 SO:0000704 denotes gene
T19 1753-1759 CHEBI:18059;CHEBI:18059 denotes lipids
T20 1794-1797 PR:Q9SMQ6 denotes Gb3
T21 1807-1817 MOP:0001479 denotes deacylated
T22 1829-1853 CHEBI:30087;CHEBI:30087 denotes globotriaosylsphingosine
T23 1860-1863 PR:Q9SMQ6 denotes Gb3
T24 1987-1996 UBERON:0000916 denotes abdominal
T25 2003-2009 UBERON:0000964 denotes cornea
T26 2096-2101 UBERON:0000062 denotes organ
T27 2159-2163 UBERON:0000104 denotes life
T28 2212-2216 UBERON:0000104 denotes life
T29 2235-2242 UBERON:0000948 denotes Cardiac
T30 2256-2261 UBERON:0002113 denotes renal
T31 2485-2495 PR:000008015 denotes Agalsidase
T32 2536-2540 CHEBI:33290;CHEBI:33290 denotes Food
T33 2545-2549 CHEBI:23888;CHEBI:23888 denotes Drug
T34 2755-2761 UBERON:0007023 denotes adults
T35 2805-2814 UBERON:0002048 denotes pulmonary
T36 2883-2887 UBERON:0002048 denotes lung
T37 2917-2922 UBERON:0002108 denotes small
T38 2923-2930 UBERON:0001005 denotes airways
T39 3056-3073 UBERON:0000065 denotes respiratory tract
T40 3093-3097 GO:0016265 denotes died
T41 3111-3115 UBERON:0002048 denotes lung
T42 3176-3185 UBERON:0002048 denotes pulmonary
T43 3351-3358 UBERON:0000948 denotes cardiac
T44 3426-3435 UBERON:0002048 denotes pulmonary
T45 3436-3451 GO:0007596 denotes thromboembolism
T46 3517-3525 CHEBI:10545;CHEBI:10545 denotes electron
T47 3573-3581 UBERON:0003215 denotes alveolar
T48 3582-3588 UBERON:0001796 denotes lavage
T49 3589-3594 UBERON:0006314 denotes fluid
T50 3617-3623 UBERON:0001005 denotes airway
T51 3624-3634 UBERON:0000483 denotes epithelium
T52 3666-3677 GO:0005737 denotes cytoplasmic
T53 3678-3694 GO:0016234 denotes inclusion bodies
T54 3707-3717 UBERON:0000483;CL:0000067 denotes epithelial
T55 3718-3723 CL:0000067 denotes cells
T56 3728-3740 CL:0000160 denotes goblet cells
T57 3756-3762 UBERON:0007311 denotes Sputum
T58 3792-3808 GO:0016234 denotes inclusion bodies
T59 3829-3849 UBERON:0002031;CL:0002328 denotes bronchial epithelial
T60 3850-3855 CL:0002328 denotes cells
T61 3906-3912 UBERON:0007311 denotes sputum
T62 3986-3996 GO:0016234 denotes inclusions
T63 4030-4034 UBERON:0002048 denotes lung
T64 4098-4101 PR:Q9SMQ6 denotes Gb3
T65 4136-4142 CHEBI:18059;CHEBI:18059 denotes lipids
T66 4195-4205 GO:0016234 denotes inclusions
T67 4213-4234 UBERON:0001915 denotes capillary endothelium
T68 4239-4258 CL:0002063 denotes type II pneumocytes
T69 4315-4323 CHEBI:10545;CHEBI:10545 denotes electron
T70 4359-4380 UBERON:0000102 denotes pulmonary vasculature
T71 4398-4401 NCBITaxon:9606 denotes man
T72 4435-4445 GO:0016234 denotes inclusions
T73 4468-4479 UBERON:0001986;CL:0000115 denotes endothelial
T74 4480-4485 CL:0000115 denotes cells
T75 4489-4500 UBERON:0001982 denotes capillaries
T76 4502-4512 UBERON:0001980 denotes arterioles
T77 4517-4522 UBERON:0001638 denotes veins
T78 4534-4547 UBERON:0001135;CL:0000192 denotes smooth muscle
T79 4548-4553 CL:0000192 denotes cells
T80 4563-4581 UBERON:0002012 denotes pulmonary arteries
T81 4659-4674 UBERON:0008946 denotes lung parenchyma
T82 4690-4698 UBERON:0003215 denotes alveolar
T83 4699-4711 UBERON:0005169 denotes interstitium
T84 4722-4731 UBERON:0001982;CL:0002144 denotes capillary
T85 4732-4743 CL:0002144;UBERON:0001986 denotes endothelial
T86 4744-4749 CL:0002144 denotes cells
T87 4798-4804 UBERON:0001005 denotes airway
T88 4850-4854 UBERON:0002048 denotes lung
T89 4903-4909 UBERON:0001005 denotes airway
T90 4927-4933 UBERON:0001005 denotes airway
T91 4971-4988 CHEBI:24402;CHEBI:24402 denotes glycosphingolipid
T92 5008-5014 UBERON:0001005 denotes airway
T93 5015-5025 UBERON:0000483;CL:0000066 denotes epithelial
T94 5030-5043 UBERON:0001135;CL:0000192 denotes smooth muscle
T95 5044-5049 CL:0000192 denotes cells
T96 5110-5116 UBERON:0001005 denotes airway
T97 5216-5228 CHEBI:6804;CHEBI:6804 denotes methacholine
T98 5309-5318 UBERON:0002048 denotes pulmonary
T99 5338-5347 UBERON:0002048 denotes pulmonary
T100 5401-5407 UBERON:0002048 denotes breath
T101 5884-5893 UBERON:0002048 denotes pulmonary
T102 6043-6054 UBERON:0001004 denotes respiratory
T103 6127-6131 UBERON:0002048 denotes lung
T104 6196-6202 UBERON:0001005 denotes airway
T105 6309-6313 UBERON:0002048 denotes lung
T106 6398-6402 UBERON:0002048 denotes lung
T107 6569-6578 UBERON:0002048 denotes pulmonary
T108 6817-6826 UBERON:0002048 denotes pulmonary
T109 6893-6898 GO:0030431 denotes sleep
T110 7057-7061 UBERON:0002048 denotes Lung
T111 7678-7681 PR:Q9SMQ6 denotes Gb3
T112 7692-7698 UBERON:0001969 denotes plasma
T113 7954-7961 UBERON:0000948 denotes cardiac
T114 8046-8050 PR:000007465 denotes FEV1
T115 8159-8163 PR:000007465 denotes FEV1
T116 8185-8194 UBERON:0002048 denotes pulmonary
T117 8205-8216 NCBITaxon:11118 denotes Coronavirus
T118 8229-8237 SP_7 denotes COVID-19
T119 8254-8264 SP_7 denotes SARS-CoV-2
T120 8265-8270 NCBITaxon:10239 denotes virus
T121 8395-8405 GO:0008152 denotes metabolism
T122 8575-8583 SP_7 denotes COVID-19
T123 8881-8902 CHEBI:37395;CHEBI:37395 denotes mucopolysaccharidosis
T124 9031-9035 UBERON:0000165 denotes oral
T125 9117-9121 UBERON:0000165 denotes oral
T126 9630-9637 UBERON:0000948 denotes cardiac
T127 9658-9670 UBERON:0002316 denotes white matter
T128 9682-9687 UBERON:0000955 denotes brain
T129 9764-9770 UBERON:0000062 denotes organs
T130 9896-9905 GO:0005764 denotes lysosomal
T131 9955-9976 CHEBI:37395;CHEBI:37395 denotes mucopolysaccharidoses
T132 10035-10041 CL:0002211 denotes type I
T133 10093-10101 UBERON:0004288 denotes skeletal
T134 10251-10263 UBERON:0002106 denotes splenomegaly
T135 10482-10490 UBERON:0004288 denotes skeletal
T136 10942-10958 UBERON:0005409 denotes gastrointestinal
T137 10988-10992 UBERON:0000104 denotes life
T138 11001-11007 UBERON:0001969 denotes plasma
T139 11013-11016 PR:Q9SMQ6 denotes Gb3
T140 11034-11037 PR:Q9SMQ6 denotes Gb3
T141 11038-11048 GO:0016234 denotes inclusions
T142 11054-11059 UBERON:0002113;CL:1000497 denotes renal
T143 11060-11065 CL:1000497 denotes cells
T144 11102-11111 CL:0000653 denotes podocytes
T145 11244-11249 UBERON:0000062 denotes organ
T146 11486-11494 SP_7 denotes COVID-19
T147 11662-11670 SP_7 denotes COVID-19
T148 11679-11687 SP_7 denotes COVID-19
T46335 25-33 SP_7 denotes COVID-19
T14944 116-117 GO:0000805 denotes X
T12628 160-169 GO:0005764 denotes lysosomal
T151 350-357 UBERON:0000948 denotes cardiac
T63646 359-367 UBERON:0001893 denotes cerebral
T12987 372-377 UBERON:0002113 denotes renal
T76726 405-414 UBERON:0002048 denotes pulmonary
T80418 483-487 UBERON:0002048 denotes lung
T82531 546-557 NCBITaxon:11118 denotes Coronavirus
T86002 570-578 SP_7 denotes COVID-19
T34415 595-605 SP_7 denotes SARS-CoV-2
T95476 606-611 NCBITaxon:10239 denotes virus
T81259 758-766 SP_7 denotes COVID-19
T77793 1046-1055 GO:0005764 denotes lysosomal
T91386 1331-1338 CHEBI:33695;CHEBI:33695 denotes message
T41907 1536-1537 GO:0000805 denotes X
T48067 1555-1564 GO:0005764 denotes lysosomal
T82620 1627-1631 SO:0000704 denotes gene
T7827 1753-1759 CHEBI:18059;CHEBI:18059 denotes lipids
T52422 1794-1797 PR:Q9SMQ6 denotes Gb3
T70815 1807-1817 MOP:0001479 denotes deacylated
T68709 1829-1853 CHEBI:30087;CHEBI:30087 denotes globotriaosylsphingosine
T92531 1860-1863 PR:Q9SMQ6 denotes Gb3
T45454 1987-1996 UBERON:0000916 denotes abdominal
T95453 2003-2009 UBERON:0000964 denotes cornea
T23173 2096-2101 UBERON:0000062 denotes organ
T27671 2159-2163 UBERON:0000104 denotes life
T65885 2212-2216 UBERON:0000104 denotes life
T31116 2235-2242 UBERON:0000948 denotes Cardiac
T76687 2256-2261 UBERON:0002113 denotes renal
T70752 2485-2495 PR:000008015 denotes Agalsidase
T86774 2536-2540 CHEBI:33290;CHEBI:33290 denotes Food
T28077 2545-2549 CHEBI:23888;CHEBI:23888 denotes Drug
T21527 2755-2761 UBERON:0007023 denotes adults
T54049 2805-2814 UBERON:0002048 denotes pulmonary
T70903 2883-2887 UBERON:0002048 denotes lung
T22323 2917-2922 UBERON:0002108 denotes small
T78722 2923-2930 UBERON:0001005 denotes airways
T93825 3056-3073 UBERON:0000065 denotes respiratory tract
T55247 3093-3097 GO:0016265 denotes died
T15410 3111-3115 UBERON:0002048 denotes lung
T66152 3176-3185 UBERON:0002048 denotes pulmonary
T67930 3351-3358 UBERON:0000948 denotes cardiac
T17765 3426-3435 UBERON:0002048 denotes pulmonary
T50739 3436-3451 GO:0007596 denotes thromboembolism
T27978 3517-3525 CHEBI:10545;CHEBI:10545 denotes electron
T5031 3573-3581 UBERON:0003215 denotes alveolar
T23916 3582-3588 UBERON:0001796 denotes lavage
T49253 3589-3594 UBERON:0006314 denotes fluid
T70974 3617-3623 UBERON:0001005 denotes airway
T13303 3624-3634 UBERON:0000483 denotes epithelium
T91501 3666-3677 GO:0005737 denotes cytoplasmic
T12729 3678-3694 GO:0016234 denotes inclusion bodies
T42400 3707-3717 UBERON:0000483;CL:0000067 denotes epithelial
T77410 3718-3723 CL:0000067 denotes cells
T49489 3728-3740 CL:0000160 denotes goblet cells
T99704 3756-3762 UBERON:0007311 denotes Sputum
T36371 3792-3808 GO:0016234 denotes inclusion bodies
T8706 3829-3849 UBERON:0002031;CL:0002328 denotes bronchial epithelial
T81731 3850-3855 CL:0002328 denotes cells
T9866 3906-3912 UBERON:0007311 denotes sputum
T67576 3986-3996 GO:0016234 denotes inclusions
T6758 4030-4034 UBERON:0002048 denotes lung
T2282 4098-4101 PR:Q9SMQ6 denotes Gb3
T44047 4136-4142 CHEBI:18059;CHEBI:18059 denotes lipids
T50511 4195-4205 GO:0016234 denotes inclusions
T95816 4213-4234 UBERON:0001915 denotes capillary endothelium
T7275 4239-4258 CL:0002063 denotes type II pneumocytes
T14607 4315-4323 CHEBI:10545;CHEBI:10545 denotes electron
T71714 4359-4380 UBERON:0000102 denotes pulmonary vasculature
T18869 4398-4401 NCBITaxon:9606 denotes man
T22144 4435-4445 GO:0016234 denotes inclusions
T89118 4468-4479 UBERON:0001986;CL:0000115 denotes endothelial
T14032 4480-4485 CL:0000115 denotes cells
T66397 4489-4500 UBERON:0001982 denotes capillaries
T53518 4502-4512 UBERON:0001980 denotes arterioles
T77123 4517-4522 UBERON:0001638 denotes veins
T70231 4534-4547 UBERON:0001135;CL:0000192 denotes smooth muscle
T38592 4548-4553 CL:0000192 denotes cells
T55326 4563-4581 UBERON:0002012 denotes pulmonary arteries
T41690 4659-4674 UBERON:0008946 denotes lung parenchyma
T58665 4690-4698 UBERON:0003215 denotes alveolar
T30569 4699-4711 UBERON:0005169 denotes interstitium
T21656 4722-4731 UBERON:0001982;CL:0002144 denotes capillary
T49732 4732-4743 CL:0002144;UBERON:0001986 denotes endothelial
T25131 4744-4749 CL:0002144 denotes cells
T26789 4798-4804 UBERON:0001005 denotes airway
T26506 4850-4854 UBERON:0002048 denotes lung
T8053 4903-4909 UBERON:0001005 denotes airway
T79832 4927-4933 UBERON:0001005 denotes airway
T78838 4971-4988 CHEBI:24402;CHEBI:24402 denotes glycosphingolipid
T43574 5008-5014 UBERON:0001005 denotes airway
T23483 5015-5025 UBERON:0000483;CL:0000066 denotes epithelial
T67279 5030-5043 UBERON:0001135;CL:0000192 denotes smooth muscle
T69043 5044-5049 CL:0000192 denotes cells
T65473 5110-5116 UBERON:0001005 denotes airway
T20997 5216-5228 CHEBI:6804;CHEBI:6804 denotes methacholine
T9080 5309-5318 UBERON:0002048 denotes pulmonary
T19270 5338-5347 UBERON:0002048 denotes pulmonary
T20061 5401-5407 UBERON:0002048 denotes breath
T82232 5884-5893 UBERON:0002048 denotes pulmonary
T40276 6043-6054 UBERON:0001004 denotes respiratory
T94550 6127-6131 UBERON:0002048 denotes lung
T82243 6196-6202 UBERON:0001005 denotes airway
T71068 6309-6313 UBERON:0002048 denotes lung
T44732 6398-6402 UBERON:0002048 denotes lung
T99838 6569-6578 UBERON:0002048 denotes pulmonary
T88697 6817-6826 UBERON:0002048 denotes pulmonary
T47649 6893-6898 GO:0030431 denotes sleep
T42626 7057-7061 UBERON:0002048 denotes Lung
T90709 7678-7681 PR:Q9SMQ6 denotes Gb3
T66110 7692-7698 UBERON:0001969 denotes plasma
T17975 7954-7961 UBERON:0000948 denotes cardiac
T79801 8046-8050 PR:000007465 denotes FEV1
T74301 8159-8163 PR:000007465 denotes FEV1
T8462 8185-8194 UBERON:0002048 denotes pulmonary
T50094 8205-8216 NCBITaxon:11118 denotes Coronavirus
T28844 8229-8237 SP_7 denotes COVID-19
T31834 8254-8264 SP_7 denotes SARS-CoV-2
T52523 8265-8270 NCBITaxon:10239 denotes virus
T15285 8395-8405 GO:0008152 denotes metabolism
T21166 8575-8583 SP_7 denotes COVID-19
T47035 8881-8902 CHEBI:37395;CHEBI:37395 denotes mucopolysaccharidosis
T27552 9031-9035 UBERON:0000165 denotes oral
T33735 9117-9121 UBERON:0000165 denotes oral
T85420 9630-9637 UBERON:0000948 denotes cardiac
T74386 9658-9670 UBERON:0002316 denotes white matter
T3599 9682-9687 UBERON:0000955 denotes brain
T3963 9764-9770 UBERON:0000062 denotes organs
T23169 9896-9905 GO:0005764 denotes lysosomal
T56588 9955-9976 CHEBI:37395;CHEBI:37395 denotes mucopolysaccharidoses
T54608 10035-10041 CL:0002211 denotes type I
T6169 10093-10101 UBERON:0004288 denotes skeletal
T95725 10251-10263 UBERON:0002106 denotes splenomegaly
T88523 10482-10490 UBERON:0004288 denotes skeletal
T9604 10942-10958 UBERON:0005409 denotes gastrointestinal
T14185 10988-10992 UBERON:0000104 denotes life
T5065 11001-11007 UBERON:0001969 denotes plasma
T88556 11013-11016 PR:Q9SMQ6 denotes Gb3
T99402 11034-11037 PR:Q9SMQ6 denotes Gb3
T63298 11038-11048 GO:0016234 denotes inclusions
T77613 11054-11059 UBERON:0002113;CL:1000497 denotes renal
T37944 11060-11065 CL:1000497 denotes cells
T76245 11102-11111 CL:0000653 denotes podocytes
T26927 11244-11249 UBERON:0000062 denotes organ
T25428 11486-11494 SP_7 denotes COVID-19
T37112 11662-11670 SP_7 denotes COVID-19
T85471 11679-11687 SP_7 denotes COVID-19

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 0-13 Disease denotes Fabry disease MESH:D000795
3 25-33 Disease denotes COVID-19 MESH:C000657245
22 595-605 Species denotes SARS-CoV-2 Tax:2697049
23 649-657 Species denotes patients Tax:9606
24 770-778 Species denotes patients Tax:9606
25 858-866 Species denotes patients Tax:9606
26 96-109 Disease denotes Fabry disease MESH:D000795
27 116-132 Disease denotes X-linked disease MESH:D040181
28 256-271 Disease denotes acroparesthesia MESH:D010292
29 273-301 Disease denotes anhydrosis and angiokeratoma MESH:D000794
30 372-391 Disease denotes renal complications MESH:D007674
31 405-426 Disease denotes pulmonary involvement MESH:D008171
32 483-495 Disease denotes lung disease MESH:D008171
33 518-544 Disease denotes component of Fabry disease MESH:D000795
34 546-568 Disease denotes Coronavirus Disease-19 MESH:C000657245
35 570-578 Disease denotes COVID-19 MESH:C000657245
36 663-676 Disease denotes Fabry disease MESH:D000795
37 758-766 Disease denotes COVID-19 MESH:C000657245
38 784-797 Disease denotes Fabry disease MESH:D000795
39 953-962 Disease denotes infection MESH:D007239
42 1469-1477 Species denotes patients Tax:9606
43 1483-1496 Disease denotes Fabry disease MESH:D000795
53 1753-1759 Chemical denotes lipids MESH:D008055
54 1771-1792 Chemical denotes globotriaosylceramide MESH:C018549
55 1794-1797 Chemical denotes Gb3
56 1829-1853 Chemical denotes globotriaosylsphingosine
57 1855-1863 Chemical denotes lyso-Gb3 MESH:C063288
58 1499-1512 Disease denotes Fabry disease MESH:D000795
59 1514-1516 Disease denotes FD MESH:D004402
60 1536-1581 Disease denotes X-linked inherited lysosomal storage disorder MESH:D016464
61 1659-1699 Disease denotes deficiency of the enzyme α-Galactosidase MESH:D000795
72 1945-1960 Disease denotes acroparesthesia MESH:D010292
73 1974-1982 Disease denotes diarrhea MESH:D003967
74 1987-2001 Disease denotes abdominal pain MESH:D015746
75 2024-2035 Disease denotes dyshidrosis
76 2037-2045 Disease denotes tinnitus MESH:D014012
77 2047-2061 Disease denotes angiokeratomas MESH:D000794
78 2067-2083 Disease denotes microalbuminuria
79 2235-2254 Disease denotes Cardiac hypertrophy MESH:D006332
80 2256-2273 Disease denotes renal dysfunction MESH:D007674
81 2279-2285 Disease denotes stroke MESH:D020521
86 2581-2591 Chemical denotes Migalastat MESH:C090092
87 2593-2601 Chemical denotes Galafold MESH:C090092
88 2379-2409 Disease denotes agalsidase alfa and agalsidase
89 2749-2751 Disease denotes FD MESH:D004402
104 2995-3002 Species denotes patient Tax:9606
105 2805-2826 Disease denotes pulmonary involvement MESH:D008171
106 2871-2895 Disease denotes obstructive lung disease MESH:D008173
107 2954-2980 Disease denotes component of Fabry disease MESH:D000795
108 3035-3041 Disease denotes asthma MESH:D001249
109 3056-3084 Disease denotes respiratory tract infections MESH:D012141
110 3093-3097 Disease denotes died MESH:D003643
111 3111-3123 Disease denotes lung disease MESH:D008171
112 3176-3197 Disease denotes pulmonary involvement MESH:D008171
113 3206-3213 Disease denotes dyspnea MESH:D004417
114 3229-3238 Disease denotes dry cough MESH:D003371
115 3242-3255 Disease denotes Fabry disease MESH:D000795
116 3409-3421 Disease denotes pneumothorax MESH:D011030
117 3426-3451 Disease denotes pulmonary thromboembolism MESH:D011655
121 3640-3648 Species denotes patients Tax:9606
122 3872-3879 Species denotes patient Tax:9606
123 3940-3953 Disease denotes Fabry disease MESH:D000795
128 4060-4067 Species denotes patient Tax:9606
129 4098-4101 Chemical denotes Gb3
130 4136-4142 Chemical denotes lipids MESH:D008055
131 4407-4420 Disease denotes Fabry disease MESH:D000795
141 5194-5202 Species denotes patients Tax:9606
142 5216-5228 Chemical denotes methacholine MESH:D016210
143 4798-4816 Disease denotes airway obstruction MESH:D000402
144 4820-4833 Disease denotes Fabry disease MESH:D000795
145 4842-4854 Disease denotes loss of lung MESH:D008171
146 4888-4900 Disease denotes bronchospasm MESH:D001986
147 4910-4922 Disease denotes inflammation MESH:D007249
148 4971-5004 Disease denotes glycosphingolipid and hyperplasia MESH:D006965
149 5137-5149 Disease denotes bronchospasm MESH:D001986
155 5383-5386 Species denotes men Tax:9606
156 5522-5530 Species denotes patients Tax:9606
157 5755-5763 Species denotes patients Tax:9606
158 5388-5407 Disease denotes Shortness of breath MESH:D004417
159 5477-5482 Disease denotes cough MESH:D003371
167 5963-5971 Species denotes patients Tax:9606
168 6030-6038 Species denotes patients Tax:9606
169 6447-6455 Species denotes patients Tax:9606
170 6594-6602 Species denotes patients Tax:9606
171 6386-6410 Disease denotes obstructive lung disease MESH:D008173
172 6461-6474 Disease denotes Fabry disease MESH:D000795
173 6642-6663 Disease denotes bronchial obstruction MESH:D001982
190 6945-6953 Species denotes patients Tax:9606
191 7028-7036 Species denotes patients Tax:9606
192 7089-7097 Species denotes patients Tax:9606
193 7188-7196 Species denotes patients Tax:9606
194 7324-7331 Species denotes patient Tax:9606
195 7483-7491 Species denotes patients Tax:9606
196 7567-7574 Species denotes tobacco Tax:4097
197 7828-7836 Species denotes patients Tax:9606
198 7918-7925 Species denotes tobacco Tax:4097
199 7988-7995 Species denotes patient Tax:9606
200 7673-7681 Chemical denotes lyso-Gb3 MESH:C063288
201 6817-6838 Disease denotes pulmonary involvement MESH:D008171
202 6842-6855 Disease denotes Fabry disease MESH:D000795
203 6874-6885 Disease denotes obstruction MESH:D000402
204 6899-6904 Disease denotes apnea MESH:D001049
205 7954-7973 Disease denotes cardiac involvement MESH:D006331
214 8254-8264 Species denotes SARS-CoV-2 Tax:2697049
215 8552-8560 Species denotes patients Tax:9606
216 8205-8227 Disease denotes Coronavirus Disease-19 MESH:C000657245
217 8229-8237 Disease denotes COVID-19 MESH:C000657245
218 8378-8405 Disease denotes inborn errors of metabolism MESH:D008661
219 8575-8583 Disease denotes COVID-19 MESH:C000657245
220 8685-8703 Disease denotes inherited diseases MESH:D030342
221 8736-8749 Disease denotes Fabry disease MESH:D000795
227 8813-8821 Species denotes patients Tax:9606
228 9093-9101 Species denotes patients Tax:9606
229 9135-9143 Species denotes patients Tax:9606
230 9229-9237 Species denotes patients Tax:9606
231 8928-8938 Disease denotes cystinosis MESH:D003554
240 9512-9519 Species denotes patient Tax:9606
241 9550-9557 Species denotes Patient Tax:9606
242 9375-9388 Disease denotes Fabry disease MESH:D000795
243 9445-9460 Disease denotes agalsidase beta MESH:D012497
244 9600-9604 Disease denotes pain MESH:D010146
245 9606-9613 Disease denotes fatigue MESH:D005221
246 9630-9649 Disease denotes cardiac involvement MESH:D006331
247 9658-9678 Disease denotes white matter lesions MESH:D056784
260 10042-10050 Species denotes patients Tax:9606
261 10292-10300 Species denotes children Tax:9606
262 10405-10413 Species denotes children Tax:9606
263 10421-10429 Species denotes children Tax:9606
264 10735-10742 Species denotes patient Tax:9606
265 9906-9950 Disease denotes storage diseases like Gaucher disease type I MESH:D005776
266 9978-9981 Disease denotes MPS MESH:D009084
267 10027-10041 Disease denotes Gaucher type I MESH:D005776
268 10251-10263 Disease denotes splenomegaly MESH:D013163
269 10302-10314 Disease denotes hepatomegaly MESH:D006529
270 10442-10460 Disease denotes growth retardation MESH:D006130
271 10556-10559 Disease denotes MPS MESH:D009084
277 11168-11176 Species denotes patients Tax:9606
278 11008-11016 Chemical denotes lyso-Gb3 MESH:C063288
279 10888-10901 Disease denotes Fabry disease MESH:D000795
280 10921-10937 Disease denotes neuropathic pain MESH:D009437
281 10942-10967 Disease denotes gastrointestinal symptoms MESH:D012817
286 11688-11696 Species denotes patients Tax:9606
287 11486-11494 Disease denotes COVID-19 MESH:C000657245
288 11662-11670 Disease denotes COVID-19 MESH:C000657245
289 11679-11687 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 160-169 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T2 483-487 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T3 1046-1055 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T4 1555-1564 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T5 1627-1631 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T6 2003-2009 Body_part denotes cornea http://purl.org/sig/ont/fma/fma58238
T7 2096-2101 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T8 2883-2887 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T9 3056-3073 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T10 3111-3115 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T11 3552-3557 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T12 3573-3581 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T13 3624-3634 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T14 3666-3687 Body_part denotes cytoplasmic inclusion http://purl.org/sig/ont/fma/fma63833
T15 3707-3723 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T16 3718-3723 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17 3728-3740 Body_part denotes goblet cells http://purl.org/sig/ont/fma/fma13148
T18 3735-3740 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T19 3756-3762 Body_part denotes Sputum http://purl.org/sig/ont/fma/fma312401
T20 3820-3855 Body_part denotes ciliated bronchial epithelial cells http://purl.org/sig/ont/fma/fma70542
T21 3850-3855 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22 3906-3912 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T23 4030-4034 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T24 4213-4234 Body_part denotes capillary endothelium http://purl.org/sig/ont/fma/fma62114
T25 4247-4258 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T26 4359-4380 Body_part denotes pulmonary vasculature http://purl.org/sig/ont/fma/fma73750
T27 4468-4485 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T28 4480-4485 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T29 4489-4500 Body_part denotes capillaries http://purl.org/sig/ont/fma/fma63194
T30 4502-4512 Body_part denotes arterioles http://purl.org/sig/ont/fma/fma63182
T31 4517-4522 Body_part denotes veins http://purl.org/sig/ont/fma/fma63814
T32 4534-4553 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T33 4548-4553 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T34 4563-4581 Body_part denotes pulmonary arteries http://purl.org/sig/ont/fma/fma66326
T35 4573-4581 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T36 4659-4674 Body_part denotes lung parenchyma http://purl.org/sig/ont/fma/fma27360
T37 4690-4698 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T38 4699-4711 Body_part denotes interstitium http://purl.org/sig/ont/fma/fma86301
T39 4722-4749 Body_part denotes capillary endothelial cells http://purl.org/sig/ont/fma/fma67756
T40 4744-4749 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T41 4850-4854 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T42 4971-4988 Body_part denotes glycosphingolipid http://purl.org/sig/ont/fma/fma82814
T43 5030-5049 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T44 5044-5049 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T45 6127-6131 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T46 6309-6313 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T47 6398-6402 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T48 7057-7061 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T49 7692-7698 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T50 9658-9670 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T51 9682-9687 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T52 9896-9905 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T53 11001-11007 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T54 11054-11065 Body_part denotes renal cells http://purl.org/sig/ont/fma/fma86785
T55 11060-11065 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T56 11244-11249 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 483-487 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 2003-2009 Body_part denotes cornea http://purl.obolibrary.org/obo/UBERON_0000964
T3 2096-2101 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T4 2883-2887 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T5 3056-3073 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T6 3111-3115 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 3624-3634 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T8 3756-3762 Body_part denotes Sputum http://purl.obolibrary.org/obo/UBERON_0007311
T9 3906-3912 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T10 4030-4034 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T11 4213-4222 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T12 4223-4234 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T13 4369-4380 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T14 4502-4512 Body_part denotes arterioles http://purl.obolibrary.org/obo/UBERON_0001980
T15 4563-4581 Body_part denotes pulmonary arteries http://purl.obolibrary.org/obo/UBERON_0002012
T16 4659-4674 Body_part denotes lung parenchyma http://purl.obolibrary.org/obo/UBERON_0008946
T17 4659-4663 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T18 4664-4674 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T19 4722-4731 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T20 4850-4854 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T21 6127-6131 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T22 6309-6313 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T23 6398-6402 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T24 7057-7061 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 9658-9670 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T26 9682-9687 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T27 9764-9770 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T28 11244-11249 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 0-13 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T2 25-33 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 96-109 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T4 116-132 Disease denotes X-linked disease http://purl.obolibrary.org/obo/MONDO_0000425
T5 288-301 Disease denotes angiokeratoma http://purl.obolibrary.org/obo/MONDO_0003143
T6 471-495 Disease denotes obstructive lung disease http://purl.obolibrary.org/obo/MONDO_0002267
T7 483-495 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T8 531-544 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T9 570-578 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 595-603 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 663-676 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T12 758-766 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 784-797 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T14 953-962 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15 1046-1072 Disease denotes lysosomal storage diseases http://purl.obolibrary.org/obo/MONDO_0002561
T16 1483-1496 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T17 1499-1512 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T18 1514-1516 Disease denotes FD http://purl.obolibrary.org/obo/MONDO_0010526
T19 1555-1581 Disease denotes lysosomal storage disorder http://purl.obolibrary.org/obo/MONDO_0002561
T20 1974-1982 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T21 2024-2035 Disease denotes dyshidrosis http://purl.obolibrary.org/obo/MONDO_0006540
T22 2047-2061 Disease denotes angiokeratomas http://purl.obolibrary.org/obo/MONDO_0003143
T23 2279-2285 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057
T25 2749-2751 Disease denotes FD http://purl.obolibrary.org/obo/MONDO_0010526
T26 2871-2895 Disease denotes obstructive lung disease http://purl.obolibrary.org/obo/MONDO_0002267
T27 2883-2895 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T28 2967-2980 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T29 3035-3041 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T30 3056-3084 Disease denotes respiratory tract infections http://purl.obolibrary.org/obo/MONDO_0024355
T31 3111-3123 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T32 3242-3255 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T33 3409-3421 Disease denotes pneumothorax http://purl.obolibrary.org/obo/MONDO_0002076
T34 3940-3953 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T35 4407-4420 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T36 4820-4833 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T37 4888-4900 Disease denotes bronchospasm http://purl.obolibrary.org/obo/MONDO_0001358
T38 4910-4922 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T39 4993-5004 Disease denotes hyperplasia http://purl.obolibrary.org/obo/MONDO_0005043
T40 5137-5149 Disease denotes bronchospasm http://purl.obolibrary.org/obo/MONDO_0001358
T41 6386-6410 Disease denotes obstructive lung disease http://purl.obolibrary.org/obo/MONDO_0002267
T42 6398-6410 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T43 6461-6474 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T44 6842-6855 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T45 6893-6904 Disease denotes sleep apnea http://purl.obolibrary.org/obo/MONDO_0005296
T46 8229-8237 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T47 8254-8262 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 8378-8405 Disease denotes inborn errors of metabolism http://purl.obolibrary.org/obo/MONDO_0019052
T49 8575-8583 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T50 8685-8703 Disease denotes inherited diseases http://purl.obolibrary.org/obo/MONDO_0003847
T51 8736-8749 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T52 8881-8902 Disease denotes mucopolysaccharidosis http://purl.obolibrary.org/obo/MONDO_0019249
T53 8928-8938 Disease denotes cystinosis http://purl.obolibrary.org/obo/MONDO_0016239
T54 9375-9388 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T55 9896-9922 Disease denotes lysosomal storage diseases http://purl.obolibrary.org/obo/MONDO_0002561
T56 9928-9950 Disease denotes Gaucher disease type I http://purl.obolibrary.org/obo/MONDO_0009265
T57 9928-9943 Disease denotes Gaucher disease http://purl.obolibrary.org/obo/MONDO_0018150
T58 9955-9976 Disease denotes mucopolysaccharidoses http://purl.obolibrary.org/obo/MONDO_0019249
T59 9978-9981 Disease denotes MPS http://purl.obolibrary.org/obo/MONDO_0019249
T60 10556-10559 Disease denotes MPS http://purl.obolibrary.org/obo/MONDO_0019249
T61 10888-10901 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T62 11486-11494 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T63 11662-11670 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T64 11679-11687 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 140-141 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 160-169 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T3 197-198 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T4 242-247 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T5 242-247 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T6 483-487 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T7 483-487 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T8 606-611 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T9 616-623 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T10 627-628 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1046-1055 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T12 1521-1522 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 1555-1564 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T14 1625-1626 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T15 1627-1631 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T16 1700-1701 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T17 1709-1710 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T18 1723-1724 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 2003-2009 http://purl.obolibrary.org/obo/UBERON_0000964 denotes cornea
T20 2003-2009 http://www.ebi.ac.uk/efo/EFO_0000377 denotes cornea
T21 2096-2101 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T22 2167-2172 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T23 2167-2172 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T24 2220-2227 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T25 2717-2721 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T26 2883-2887 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T27 2883-2887 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T28 2923-2930 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T29 3111-3115 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T30 3111-3115 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T31 3264-3266 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T32 3491-3493 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T33 3552-3557 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T34 3617-3623 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T35 3624-3634 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T36 3707-3717 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T37 3718-3723 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T38 3735-3740 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T39 3839-3849 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T40 3850-3855 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T41 4003-4004 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T42 4028-4029 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 4030-4034 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T44 4030-4034 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T45 4077-4078 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 4223-4234 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T47 4384-4385 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 4386-4388 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T49 4468-4485 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T50 4517-4522 http://purl.obolibrary.org/obo/UBERON_0001638 denotes veins
T51 4517-4522 http://www.ebi.ac.uk/efo/EFO_0000816 denotes veins
T52 4534-4553 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T53 4563-4581 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary arteries
T54 4563-4581 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary arteries
T55 4659-4663 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T56 4659-4663 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T57 4699-4711 http://purl.obolibrary.org/obo/UBERON_0005169 denotes interstitium
T58 4732-4749 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T59 4798-4804 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T60 4850-4854 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T61 4850-4854 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T62 4903-4909 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T63 4927-4933 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T64 5008-5014 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T65 5015-5025 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T66 5030-5049 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T67 5052-5054 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T68 5079-5080 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 5110-5116 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T70 5239-5246 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T71 5257-5258 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 5278-5280 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T73 5357-5361 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T74 5453-5455 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T75 5532-5534 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T76 5904-5906 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T77 6127-6131 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T78 6127-6131 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T79 6196-6202 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T80 6309-6313 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T81 6309-6313 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T82 6343-6344 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 6371-6373 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T84 6398-6402 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T85 6398-6402 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T86 6604-6606 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T87 6608-6613 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T88 6608-6613 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T89 6753-6756 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T90 7052-7054 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T91 7057-7061 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T92 7057-7061 http://www.ebi.ac.uk/efo/EFO_0000934 denotes Lung
T93 7101-7106 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T94 7101-7106 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T95 7332-7333 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 7602-7610 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T97 7692-7698 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T98 7825-7827 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T99 7901-7905 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T100 7901-7905 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T101 7911-7917 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T102 8265-8270 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T103 8292-8293 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 8330-8342 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T105 8470-8479 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T106 8809-8812 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T107 8974-8976 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T108 9428-9432 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T109 9428-9432 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T110 9682-9687 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T111 9682-9687 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T112 9731-9732 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T113 9764-9770 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T114 9896-9905 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T115 10003-10005 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T116 10016-10017 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T117 10220-10222 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T118 10370-10374 http://purl.obolibrary.org/obo/UBERON_0002481 denotes bone
T119 10852-10855 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T120 10856-10857 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T121 11001-11007 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T122 11060-11065 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T123 11072-11073 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T124 11143-11147 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T125 11143-11147 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T126 11244-11249 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T127 11257-11260 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T128 11296-11297 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T129 12007-12010 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 177-182 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T2 1514-1516 Chemical denotes FD http://purl.obolibrary.org/obo/CHEBI_73631
T3 1633-1636 Chemical denotes GLA http://purl.obolibrary.org/obo/CHEBI_28661
T4 1705-1708 Chemical denotes Gal http://purl.obolibrary.org/obo/CHEBI_28260
T5 1753-1759 Chemical denotes lipids http://purl.obolibrary.org/obo/CHEBI_18059
T6 1771-1792 Chemical denotes globotriaosylceramide http://purl.obolibrary.org/obo/CHEBI_18313
T7 1794-1797 Chemical denotes Gb3 http://purl.obolibrary.org/obo/CHEBI_18313
T8 1860-1863 Chemical denotes Gb3 http://purl.obolibrary.org/obo/CHEBI_18313
T9 2410-2414 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T10 2496-2500 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T11 2749-2751 Chemical denotes FD http://purl.obolibrary.org/obo/CHEBI_73631
T12 3517-3525 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T13 4098-4101 Chemical denotes Gb3 http://purl.obolibrary.org/obo/CHEBI_18313
T14 4136-4142 Chemical denotes lipids http://purl.obolibrary.org/obo/CHEBI_18059
T15 4244-4246 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T16 4315-4323 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T17 4971-4988 Chemical denotes glycosphingolipid http://purl.obolibrary.org/obo/CHEBI_24402
T18 5216-5228 Chemical denotes methacholine http://purl.obolibrary.org/obo/CHEBI_6804
T19 6291-6293 Chemical denotes RV http://purl.obolibrary.org/obo/CHEBI_73823
T20 6299-6301 Chemical denotes RV http://purl.obolibrary.org/obo/CHEBI_73823
T21 7678-7681 Chemical denotes Gb3 http://purl.obolibrary.org/obo/CHEBI_18313
T22 7901-7905 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T23 8428-8433 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T24 9428-9432 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T25 9456-9460 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T26 10018-10023 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T27 11013-11016 Chemical denotes Gb3 http://purl.obolibrary.org/obo/CHEBI_18313
T28 11034-11037 Chemical denotes Gb3 http://purl.obolibrary.org/obo/CHEBI_18313
T29 11143-11147 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 256-271 Phenotype denotes acroparesthesia http://purl.obolibrary.org/obo/HP_0031006
T2 273-283 Phenotype denotes anhydrosis http://purl.obolibrary.org/obo/HP_0000970
T3 288-301 Phenotype denotes angiokeratoma http://purl.obolibrary.org/obo/HP_0001014
T4 471-495 Phenotype denotes obstructive lung disease http://purl.obolibrary.org/obo/HP_0006536
T5 1945-1960 Phenotype denotes acroparesthesia http://purl.obolibrary.org/obo/HP_0031006
T6 1974-1982 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T7 1987-2001 Phenotype denotes abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T8 2003-2022 Phenotype denotes cornea verticillata http://purl.obolibrary.org/obo/HP_0500008
T9 2037-2045 Phenotype denotes tinnitus http://purl.obolibrary.org/obo/HP_0000360
T10 2047-2061 Phenotype denotes angiokeratomas http://purl.obolibrary.org/obo/HP_0001014
T11 2067-2083 Phenotype denotes microalbuminuria http://purl.obolibrary.org/obo/HP_0012594
T12 2279-2285 Phenotype denotes stroke http://purl.obolibrary.org/obo/HP_0001297
T13 2871-2895 Phenotype denotes obstructive lung disease http://purl.obolibrary.org/obo/HP_0006536
T14 3035-3041 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T15 3056-3084 Phenotype denotes respiratory tract infections http://purl.obolibrary.org/obo/HP_0011947
T16 3111-3123 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088
T17 3206-3213 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T18 3215-3223 Phenotype denotes wheezing http://purl.obolibrary.org/obo/HP_0030828
T19 3229-3238 Phenotype denotes dry cough http://purl.obolibrary.org/obo/HP_0031246
T20 3396-3407 Phenotype denotes haemoptysis http://purl.obolibrary.org/obo/HP_0002105
T21 3409-3421 Phenotype denotes pneumothorax http://purl.obolibrary.org/obo/HP_0002107
T22 3436-3451 Phenotype denotes thromboembolism http://purl.obolibrary.org/obo/HP_0001907
T23 4422-4434 Phenotype denotes Zebra bodies http://purl.obolibrary.org/obo/HP_0031361
T24 4583-4595 Phenotype denotes Zebra bodies http://purl.obolibrary.org/obo/HP_0031361
T25 4888-4900 Phenotype denotes bronchospasm http://purl.obolibrary.org/obo/HP_0025428
T26 5137-5149 Phenotype denotes bronchospasm http://purl.obolibrary.org/obo/HP_0025428
T27 5388-5407 Phenotype denotes Shortness of breath http://purl.obolibrary.org/obo/HP_0002098
T28 5477-5482 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T29 5487-5495 Phenotype denotes wheezing http://purl.obolibrary.org/obo/HP_0030828
T30 5541-5563 Phenotype denotes reduced FEV1/FVC ratio http://purl.obolibrary.org/obo/HP_0030877
T31 6386-6410 Phenotype denotes obstructive lung disease http://purl.obolibrary.org/obo/HP_0006536
T32 6874-6904 Phenotype denotes obstruction and/or sleep apnea http://purl.obolibrary.org/obo/HP_0002870
T33 9600-9604 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T34 9606-9613 Phenotype denotes fatigue http://purl.obolibrary.org/obo/HP_0012378
T35 10251-10263 Phenotype denotes splenomegaly http://purl.obolibrary.org/obo/HP_0001744
T36 10302-10314 Phenotype denotes hepatomegaly http://purl.obolibrary.org/obo/HP_0002240
T37 10442-10460 Phenotype denotes growth retardation http://purl.obolibrary.org/obo/HP_0001510
T38 10933-10937 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1056-1063 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T2 1565-1572 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T3 4910-4922 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T4 6893-6898 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T5 8395-8405 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T6 9906-9913 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T7 10442-10448 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 1794-1797 GlycoEpitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T2 1860-1863 GlycoEpitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T3 4098-4101 GlycoEpitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T4 7678-7681 GlycoEpitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T5 11013-11016 GlycoEpitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T6 11034-11037 GlycoEpitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-43 Sentence denotes Fabry disease during the COVID-19 pandemic.
T2 44-85 Sentence denotes Why and how treatment should be continued
T3 87-95 Sentence denotes Abstract
T4 96-199 Sentence denotes Fabry disease is an X-linked disease due to a deficiency of the lysosomal enzyme alpha-galactosidase A.
T5 200-392 Sentence denotes Clinical symptoms in classically affected males include acroparesthesia, anhydrosis and angiokeratoma, which may present during childhood followed by cardiac, cerebral and renal complications.
T6 393-545 Sentence denotes Even though pulmonary involvement is not widely appreciated by clinicians, an obstructive lung disease is another recognized component of Fabry disease.
T7 546-743 Sentence denotes Coronavirus Disease-19 (COVID-19), caused by the SARS-CoV-2 virus was labeled as a global pandemic and patients with Fabry disease can be considered at high risk of developing severe complications.
T8 744-852 Sentence denotes The impact of COVID-19 on patients with Fabry disease receiving enzyme replacement therapy is still unknown.
T9 853-963 Sentence denotes Many patients who receive treatment in the hospital experienced infusion disruptions due to fear of infection.
T10 964-1185 Sentence denotes Effects of temporary treatment interruption was described in more detail in other lysosomal storage diseases, but the recommencement of therapy does not fully reverse clinical decline due to the temporary discontinuation.
T11 1186-1311 Sentence denotes When possible, home-therapy seems to be the most efficient way to maintain enzyme replacement therapy access during pandemic.
T12 1312-1339 Sentence denotes Sentence take-home message:
T13 1340-1497 Sentence denotes Home-therapy, when possible, seems to be the most efficient way to maintain enzyme replacement therapy access during pandemic in patients with Fabry disease.
T14 1499-1638 Sentence denotes Fabry disease (FD) is a progressive, X-linked inherited lysosomal storage disorder caused by mutations in the α-Galactosidase A gene (GLA).
T15 1639-1869 Sentence denotes Partial or complete deficiency of the enzyme α-Galactosidase A (α-Gal A) results in a progressive accumulation of lipids, primarily globotriaosylceramide (Gb3) and its deacylated derivative globotriaosylsphingosine (lyso-Gb3) [1].
T16 1870-2088 Sentence denotes Typical signs and symptoms in the early phase of the classic phenotype are acroparesthesia, episodes of diarrhea and abdominal pain, cornea verticillata, dyshidrosis, tinnitus, angiokeratomas, and microalbuminuria [1].
T17 2089-2234 Sentence denotes Severe organ manifestations become evident during the third decade of life in males and approximately the fourth decade of life in females [2,3].
T18 2235-2324 Sentence denotes Cardiac hypertrophy, renal dysfunction, and stroke are the most severe complications [4].
T19 2325-2484 Sentence denotes Two preparations of enzyme replacement therapy (ERT) -agalsidase alfa and agalsidase beta- with recombinant α-galactosidase was approved in Europe in 2001 [5].
T20 2485-2580 Sentence denotes Agalsidase beta is the only ERT approved by the US Food and Drug Administration since 2003 [6].
T21 2581-2792 Sentence denotes Migalastat (Galafold®) was approved in Europe in May 2016, in Canada in September 2017, in Japan in March 2017 and in the USA in August 2018 for long-term treatment of FD in adults with an amenable mutation [7].
T22 2793-2981 Sentence denotes Even though pulmonary involvement is not widely appreciated by clinicians, an obstructive lung disease (specifically of the small airways) is another recognized component of Fabry disease.
T23 2982-3128 Sentence denotes The original patient described by Fabry in 1898 had “asthma” and frequent respiratory tract infections [8] and died at age 43 of lung disease [9].
T24 3129-3281 Sentence denotes Several reports describe signs and symptoms of pulmonary involvement such as dyspnea, wheezing, and dry cough in Fabry disease [[10], [11], [12], [13]].
T25 3282-3370 Sentence denotes Many of these signs and symptoms were described without simultaneous cardiac compromise.
T26 3371-3472 Sentence denotes Less frequent signs like haemoptysis, pneumothorax and pulmonary thromboembolism have been described.
T27 3473-3649 Sentence denotes Rosenberg et al. [11] reported on light and electron microscopic evaluation of cells recovered from alveolar lavage fluid and from brushing the airway epithelium in 3 patients.
T28 3650-3755 Sentence denotes In all of them, cytoplasmic inclusion bodies in ciliated epithelial cells and goblet cells were revealed.
T29 3756-3880 Sentence denotes Sputum induced exam showed lamellar inclusion bodies within all ciliated bronchial epithelial cells examined in one patient.
T30 3881-4002 Sentence denotes The same report examined sputum from five subjects without Fabry disease and were unable to find similar inclusions [14].
T31 4003-4264 Sentence denotes A histochemical study of a lung biopsy specimen from one patient revealed a marked increase of Gb3 that accounted for 10.7% of total lipids, and histopathologic examination revealed laminated inclusions in the capillary endothelium and type II pneumocytes [15].
T32 4265-4421 Sentence denotes Smith et al. [16] reported the histopathology and electron microscopy autopsy findings of the pulmonary vasculature in a 52 year-old man with Fabry disease.
T33 4422-4582 Sentence denotes Zebra bodies inclusions were found within the endothelial cells of capillaries, arterioles and veins and in the smooth muscle cells of small pulmonary arteries.
T34 4583-4750 Sentence denotes Zebra bodies with much thinner, delicate dense bands were also found in the lung parenchyma, either in the alveolar interstitium or within capillary endothelial cells.
T35 4751-5069 Sentence denotes The proposed mechanisms for the development of airway obstruction in Fabry disease include loss of lung elastic recoil, hyperreactivity (bronchospasm), airway inflammation and airway narrowing related to accumulation of glycosphingolipid and hyperplasia in airway epithelial and smooth muscle cells [[11], [12], [13]].
T36 5070-5181 Sentence denotes However, a putative mechanism involving airway hyperreactivity and bronchospasm was not supported in one study.
T37 5182-5282 Sentence denotes None of the patients subjected to methacholine challenge testing exhibited a positive response [11].
T38 5283-5387 Sentence denotes Brown et al. [10] studied pulmonary manifestations and pulmonary function test in 25 affected Fabry men.
T39 5388-5516 Sentence denotes Shortness of breath on mild to moderate exertion was reported by 36% of the subjects and cough and wheezing were present in 24%.
T40 5517-5649 Sentence denotes Nine patients (36%) had reduced FEV1/FVC ratio consistent with obstructive ventilatory impairment; four of the nine were nonsmokers.
T41 5650-5764 Sentence denotes Forced expiratory time to deliver the middle half of the FVC (FEF25 – 75) was elevated in eight of these patients.
T42 5765-5908 Sentence denotes The prevalence of obstructive impairment was strongly age-dependent, in parallel with the relationship found for extra-pulmonary symptoms [11].
T43 5909-6012 Sentence denotes Odler et al. [17] published the evaluation of 7 Fabry patients (40.2 ± 5.6 years) before and after ERT.
T44 6013-6107 Sentence denotes At baseline, all patients had respiratory symptoms; however, these symptoms were usually mild.
T45 6108-6329 Sentence denotes The most prominent lung function changes were registered in parameters reflecting small airway involvement, including significant decrease in FEF25 – 75, increase in residual volume (RV) and RV/ total lung capacity ratio.
T46 6330-6510 Sentence denotes Furthermore, a review by Franzen et al. [18] found that obstructive lung disease was up to 10 times more frequent in patients with Fabry disease compared to the general population.
T47 6511-6615 Sentence denotes The same author later reported the long-term follow-up of pulmonary function in 95 patients (41% males).
T48 6616-6712 Sentence denotes The overall prevalence of bronchial obstruction was 46%, and FEV1 decreased 29 ml per year [19].
T49 6713-6913 Sentence denotes In two small retrospective studies, ERT has been reported to stabilize or even ameliorate the burden of pulmonary involvement in Fabry disease, mainly bronchial obstruction and/or sleep apnea [20,21].
T50 6914-7056 Sentence denotes An interventional study of six patients receiving either ERT or placebo showed an increased exercise tolerance in patients receiving ERT [22].
T51 7057-7178 Sentence denotes Lung function parameter in five patients (2 males) on ERT were followed longitudinally for an average of five years [17].
T52 7179-7383 Sentence denotes In three patients, FVC and FEV1 increased during the treatment period, in one patient slight decrease of FVC and FEV1 were registered and in one patient a slight decrease in FVC, with an increase in FEV1.
T53 7384-7492 Sentence denotes Recently, Franzen et al. [23] reported the change in z-scores of FEV1 and FEV1/FVC over time in 53 patients.
T54 7493-7748 Sentence denotes In the same study, they investigated whether factors related to age, sex, tobacco, phenotype, residual α-gal activity, age at ERT initiation, Mainz Severity Score Index (MSSI) and lyso-Gb3 levels in plasma may affect change in FEV1 and FEV1/FVC over time.
T55 7749-7797 Sentence denotes Median spirometric follow-up time was 7.7 years.
T56 7798-7882 Sentence denotes When considering z-scores, 27 patients (51%) developed airflow limitation over time.
T57 7883-8086 Sentence denotes Factors including male sex, active tobacco or past history of smoking, cardiac involvement and increased patient age at ERT initiation were associated with faster FEV1 decline in the univariate analysis.
T58 8087-8204 Sentence denotes These results suggest that earlier ERT initiation may help to stabilize FEV1 decline and preserve pulmonary function.
T59 8205-8357 Sentence denotes Coronavirus Disease-19 (COVID-19), caused by the SARS-CoV-2 virus was characterized as a global pandemic by the World Health Organization in March 2020.
T60 8358-8513 Sentence denotes Rare diseases, like inborn errors of metabolism, were included in the group of conditions considered to have an extremely high risk of severe illness [24].
T61 8514-8647 Sentence denotes There are no reports describing Fabry patients affected with COVID-19 or practical recommendations related to ERT during this period.
T62 8648-8750 Sentence denotes Due to lack of data analogy to other inherited diseases is used for recommendations for Fabry disease.
T63 8751-8857 Sentence denotes Sechi et al. [25] recently reported their experience with 102 patients affected by the following diseases:
T64 8858-8939 Sentence denotes Gaucher, Pompe, Fabry, mucopolysaccharidosis, Niemann Pick type C and cystinosis.
T65 8940-9047 Sentence denotes At the beginning of the pandemic, 71 pt. (69.6%) were receiving ERT and 26 (25.5%) were on oral treatments.
T66 9048-9130 Sentence denotes No interruption or modification occurred for patients receiving only oral therapy.
T67 9131-9302 Sentence denotes All patients who were already on home-therapy continued their ERT infusions regularly, but 49% of patients receiving ERT in the hospital experienced treatment disruptions.
T68 9303-9389 Sentence denotes There is limited evidence regarding temporary discontinuation of ERT in Fabry disease.
T69 9390-9461 Sentence denotes Cabrera and Politei [26] reported one male who started agalsidase beta.
T70 9462-9549 Sentence denotes After two years of favorable response to ERT, the patient decided to suspend treatment.
T71 9550-9692 Sentence denotes Patient presented two years later with increasing pain, fatigue, progression of cardiac involvement and new white matter lesions in brain MRI.
T72 9693-9818 Sentence denotes Treatment discontinuation resulted in a fast deterioration of impaired organs and the appearance of new Fabry manifestations.
T73 9819-9983 Sentence denotes Effects of temporary ERT interruption were described in more detail in other lysosomal storage diseases like Gaucher disease type I and mucopolysaccharidoses (MPS).
T74 9984-10198 Sentence denotes Drelichman et al. [27] reported a group of Gaucher type I patients, that after 1 to 7 years of ERT, none had skeletal manifestations, organomegaly had decreased or disappeared and hematologic features had improved.
T75 10199-10461 Sentence denotes However, after 15 to 36 months of ERT interruption, splenomegaly recurred or worsened in all children, hepatomegaly and hematologic features recurred or worsened, serious bone manifestations developed in 4 children, and 3 children experienced growth retardation.
T76 10462-10552 Sentence denotes They concluded that skeletal manifestations did not resolve after treatment reinstatement.
T77 10553-10831 Sentence denotes In MPS, ERT interruption can lead to the loss of the beneficial effects and, in some circumstances, the abrupt withdrawal of ERT significantly worsened the clinical evolution of the patient, especially if the interruptions were for more than two months [[28], [29], [30], [31]].
T78 10833-10847 Sentence denotes 1 Conclusions
T79 10848-11112 Sentence denotes ERT has a beneficial clinical impact in Fabry disease, as it can relieve neuropathic pain and gastrointestinal symptoms, improve quality of life, reduce plasma lyso-Gb3 levels and clear Gb3 inclusions from renal cells, with a dose-dependent mechanism in podocytes.
T80 11113-11271 Sentence denotes Evidence, mainly derived from male studies, shows that patients may benefit from early treatment initiation, before major clinical organ damage has developed.
T81 11272-11399 Sentence denotes After ERT interruption, a recommencement of therapy does not fully reverse clinical decline resulting from the discontinuation.
T82 11400-11588 Sentence denotes Home-therapy seems to be the most efficient way to maintain therapy access during the COVID-19 pandemic when possible and correct use of personal protective equipment should be guaranteed.
T83 11589-11760 Sentence denotes If home-therapy is not available, safe locations and plans that separate COVID-19 and non-COVID-19 patients should be carefully prepared in hospitals and infusion centers.
T84 11762-11793 Sentence denotes Individual author contributions
T85 11794-11958 Sentence denotes Juan Politei is the only contributor to the concept/design of the manuscript, data acquisition, data analysis/interpretation and critically revising the manuscript.
T86 11960-11993 Sentence denotes Declaration of Competing Interest
T87 11994-12073 Sentence denotes Juan Politei has no conflicts of interest to declare related to this manuscript
T88 12074-12104 Sentence denotes No funding for this manuscript
T89 12106-12122 Sentence denotes Acknowledgements
T90 12123-12197 Sentence denotes To Dr. Hernan Trimarchi for his comments during the manuscript progression