PMC:7272971 / 8893-9577 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7272971","sourcedb":"PMC","sourceid":"7272971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7272971","text":"For the less pathogenic human coronaviruses, hCoV‐229E uses CD13 to infect cells, 25 OC43 and HKU1 bind to 9‐O‐acetylated sialic acid (Neu5,9Ac2), 26 and NL63 uses ACE2 to bind to host cells. 27 NL63 and SARS‐CoV first anchor to cells via heparan sulfate proteoglycans before interacting with the ACE2 entry receptor,19, 27, 28 but this binding alone is not sufficient for infection. 19 In fact many viruses, not just coronaviruses, utilise heparan sulfate on cell surfaces for initial binding. 29 Feline infectious peritonitis virus uses CD13 (aminopeptidase N) or CD209 to bind to its host cells. 15 Bovine coronavirus binds to 9‐O‐acetylated sialic acid on its host cells. 30","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"288","span":{"begin":136,"end":145},"obj":"Gene"},{"id":"289","span":{"begin":166,"end":170},"obj":"Gene"},{"id":"290","span":{"begin":300,"end":304},"obj":"Gene"},{"id":"291","span":{"begin":550,"end":566},"obj":"Gene"},{"id":"292","span":{"begin":571,"end":576},"obj":"Gene"},{"id":"293","span":{"begin":24,"end":29},"obj":"Species"},{"id":"294","span":{"begin":30,"end":43},"obj":"Species"},{"id":"295","span":{"begin":45,"end":54},"obj":"Species"},{"id":"296","span":{"begin":207,"end":215},"obj":"Species"},{"id":"297","span":{"begin":422,"end":435},"obj":"Species"},{"id":"298","span":{"begin":503,"end":538},"obj":"Species"},{"id":"299","span":{"begin":608,"end":626},"obj":"Species"},{"id":"300","span":{"begin":95,"end":99},"obj":"Species"},{"id":"301","span":{"begin":156,"end":160},"obj":"Species"},{"id":"302","span":{"begin":198,"end":202},"obj":"Species"},{"id":"303","span":{"begin":123,"end":134},"obj":"Chemical"},{"id":"304","span":{"begin":242,"end":257},"obj":"Chemical"},{"id":"305","span":{"begin":445,"end":460},"obj":"Chemical"},{"id":"306","span":{"begin":651,"end":662},"obj":"Chemical"},{"id":"307","span":{"begin":376,"end":385},"obj":"Disease"}],"attributes":[{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"Gene:59272"},{"id":"A290","pred":"tao:has_database_id","subj":"290","obj":"Gene:59272"},{"id":"A291","pred":"tao:has_database_id","subj":"291","obj":"Gene:290"},{"id":"A292","pred":"tao:has_database_id","subj":"292","obj":"Gene:30835"},{"id":"A293","pred":"tao:has_database_id","subj":"293","obj":"Tax:9606"},{"id":"A294","pred":"tao:has_database_id","subj":"294","obj":"Tax:11118"},{"id":"A295","pred":"tao:has_database_id","subj":"295","obj":"Tax:11137"},{"id":"A296","pred":"tao:has_database_id","subj":"296","obj":"Tax:694009"},{"id":"A297","pred":"tao:has_database_id","subj":"297","obj":"Tax:11118"},{"id":"A298","pred":"tao:has_database_id","subj":"298","obj":"Tax:11135"},{"id":"A299","pred":"tao:has_database_id","subj":"299","obj":"Tax:11128"},{"id":"A300","pred":"tao:has_database_id","subj":"300","obj":"Tax:290028"},{"id":"A301","pred":"tao:has_database_id","subj":"301","obj":"Tax:277944"},{"id":"A302","pred":"tao:has_database_id","subj":"302","obj":"Tax:277944"},{"id":"A303","pred":"tao:has_database_id","subj":"303","obj":"MESH:D019158"},{"id":"A304","pred":"tao:has_database_id","subj":"304","obj":"MESH:D006497"},{"id":"A305","pred":"tao:has_database_id","subj":"305","obj":"MESH:D006497"},{"id":"A306","pred":"tao:has_database_id","subj":"306","obj":"MESH:D019158"},{"id":"A307","pred":"tao:has_database_id","subj":"307","obj":"MESH:D007239"},{"subj":"288","pred":"source","obj":"LitCovid-PubTator"},{"subj":"289","pred":"source","obj":"LitCovid-PubTator"},{"subj":"290","pred":"source","obj":"LitCovid-PubTator"},{"subj":"291","pred":"source","obj":"LitCovid-PubTator"},{"subj":"292","pred":"source","obj":"LitCovid-PubTator"},{"subj":"293","pred":"source","obj":"LitCovid-PubTator"},{"subj":"294","pred":"source","obj":"LitCovid-PubTator"},{"subj":"295","pred":"source","obj":"LitCovid-PubTator"},{"subj":"296","pred":"source","obj":"LitCovid-PubTator"},{"subj":"297","pred":"source","obj":"LitCovid-PubTator"},{"subj":"298","pred":"source","obj":"LitCovid-PubTator"},{"subj":"299","pred":"source","obj":"LitCovid-PubTator"},{"subj":"300","pred":"source","obj":"LitCovid-PubTator"},{"subj":"301","pred":"source","obj":"LitCovid-PubTator"},{"subj":"302","pred":"source","obj":"LitCovid-PubTator"},{"subj":"303","pred":"source","obj":"LitCovid-PubTator"},{"subj":"304","pred":"source","obj":"LitCovid-PubTator"},{"subj":"305","pred":"source","obj":"LitCovid-PubTator"},{"subj":"306","pred":"source","obj":"LitCovid-PubTator"},{"subj":"307","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T55","span":{"begin":75,"end":80},"obj":"Body_part"},{"id":"T56","span":{"begin":187,"end":192},"obj":"Body_part"},{"id":"T57","span":{"begin":232,"end":237},"obj":"Body_part"},{"id":"T58","span":{"begin":242,"end":271},"obj":"Body_part"},{"id":"T59","span":{"begin":242,"end":257},"obj":"Body_part"},{"id":"T60","span":{"begin":445,"end":460},"obj":"Body_part"},{"id":"T61","span":{"begin":464,"end":477},"obj":"Body_part"},{"id":"T62","span":{"begin":464,"end":468},"obj":"Body_part"},{"id":"T63","span":{"begin":597,"end":602},"obj":"Body_part"},{"id":"T64","span":{"begin":675,"end":680},"obj":"Body_part"}],"attributes":[{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma82834"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T7","span":{"begin":521,"end":532},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002586"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T51","span":{"begin":207,"end":211},"obj":"Disease"},{"id":"T52","span":{"begin":376,"end":385},"obj":"Disease"},{"id":"T53","span":{"begin":503,"end":532},"obj":"Disease"},{"id":"T54","span":{"begin":510,"end":520},"obj":"Disease"},{"id":"T55","span":{"begin":521,"end":532},"obj":"Disease"}],"attributes":[{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0025491"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0004522"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T81","span":{"begin":24,"end":29},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T82","span":{"begin":75,"end":80},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T83","span":{"begin":187,"end":192},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T84","span":{"begin":194,"end":196},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T85","span":{"begin":232,"end":237},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T86","span":{"begin":242,"end":271},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T87","span":{"begin":324,"end":326},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T88","span":{"begin":404,"end":411},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T89","span":{"begin":464,"end":468},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T90","span":{"begin":533,"end":538},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T91","span":{"begin":597,"end":602},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T92","span":{"begin":675,"end":680},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T81","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T31","span":{"begin":123,"end":134},"obj":"Chemical"},{"id":"T32","span":{"begin":130,"end":134},"obj":"Chemical"},{"id":"T33","span":{"begin":242,"end":257},"obj":"Chemical"},{"id":"T34","span":{"begin":242,"end":249},"obj":"Chemical"},{"id":"T35","span":{"begin":250,"end":257},"obj":"Chemical"},{"id":"T36","span":{"begin":258,"end":271},"obj":"Chemical"},{"id":"T37","span":{"begin":445,"end":460},"obj":"Chemical"},{"id":"T38","span":{"begin":445,"end":452},"obj":"Chemical"},{"id":"T39","span":{"begin":453,"end":460},"obj":"Chemical"},{"id":"T40","span":{"begin":651,"end":662},"obj":"Chemical"},{"id":"T41","span":{"begin":658,"end":662},"obj":"Chemical"}],"attributes":[{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A33","pred":"chebi_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A34","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A35","pred":"chebi_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A36","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_37396"},{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":242,"end":257},"obj":"GlycoEpitope"},{"id":"T2","span":{"begin":445,"end":460},"obj":"GlycoEpitope"}],"attributes":[{"id":"A1","pred":"glyco_epitope_db_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"A2","pred":"glyco_epitope_db_id","subj":"T2","obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T60","span":{"begin":0,"end":193},"obj":"Sentence"},{"id":"T61","span":{"begin":194,"end":386},"obj":"Sentence"},{"id":"T62","span":{"begin":387,"end":498},"obj":"Sentence"},{"id":"T63","span":{"begin":499,"end":603},"obj":"Sentence"},{"id":"T64","span":{"begin":604,"end":681},"obj":"Sentence"},{"id":"T65","span":{"begin":682,"end":684},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T60","pred":"source","obj":"LitCovid-sentences"},{"subj":"T61","pred":"source","obj":"LitCovid-sentences"},{"subj":"T62","pred":"source","obj":"LitCovid-sentences"},{"subj":"T63","pred":"source","obj":"LitCovid-sentences"},{"subj":"T64","pred":"source","obj":"LitCovid-sentences"},{"subj":"T65","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93b4ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ceec93"},{"id":"LitCovid-PD-HP","color":"#ec93e8"},{"id":"LitCovid-PD-MONDO","color":"#93ecd6"},{"id":"LitCovid-PD-CLO","color":"#ecbc93"},{"id":"LitCovid-PD-CHEBI","color":"#a293ec"},{"id":"LitCovid-PD-GlycoEpitope","color":"#9eec93"},{"id":"LitCovid-sentences","color":"#ec93b8"}]}]}}