PMC:7272971 / 29235-30483 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"916","span":{"begin":35,"end":46},"obj":"Species"},{"id":"917","span":{"begin":344,"end":357},"obj":"Species"},{"id":"918","span":{"begin":520,"end":533},"obj":"Species"},{"id":"919","span":{"begin":224,"end":239},"obj":"Disease"},{"id":"923","span":{"begin":741,"end":746},"obj":"Species"},{"id":"924","span":{"begin":878,"end":888},"obj":"Species"},{"id":"925","span":{"begin":1226,"end":1247},"obj":"Disease"}],"attributes":[{"id":"A916","pred":"tao:has_database_id","subj":"916","obj":"Tax:11118"},{"id":"A917","pred":"tao:has_database_id","subj":"917","obj":"Tax:11118"},{"id":"A918","pred":"tao:has_database_id","subj":"918","obj":"Tax:11118"},{"id":"A919","pred":"tao:has_database_id","subj":"919","obj":"MESH:D015352"},{"id":"A923","pred":"tao:has_database_id","subj":"923","obj":"Tax:9606"},{"id":"A924","pred":"tao:has_database_id","subj":"924","obj":"Tax:2697049"},{"id":"A925","pred":"tao:has_database_id","subj":"925","obj":"MESH:D018352"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Further research\nThe expression of coronavirus receptors on ocular surface cells needs further confirmatory investigation. It would also be of interest to examine whether contact lens wear or ocular surface diseases such as dry eye disease are associated with increased expression of these receptors. The ability of tears to inhibit binding of coronaviruses to ocular surface cells is another area for research. This may identify substances that can be translated into new prophylaxis treatments to reduce the spread of coronaviruses in the environment.\nFurther studies, using animal models, on the role of contamination of the ocular surface on progression of the disease are urgently needed. These studies, as well as further studies with human cases of disease, will also help to definitively identify the virus at the ocular surface. As only one study has been able to grow SARS‐CoV‐2 from ocular swabs and then only reported growth early in the disease and did not attempt to grow viruses from subsequent ocular surface swabs, 53 studies should also then examine whether any ocular surface‐associated viruses are infective. Epidemiological studies and case reports should include analysis of ocular complications during coronavirus infection."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T265","span":{"begin":67,"end":80},"obj":"Body_part"},{"id":"T266","span":{"begin":75,"end":80},"obj":"Body_part"},{"id":"T267","span":{"begin":179,"end":183},"obj":"Body_part"},{"id":"T268","span":{"begin":228,"end":231},"obj":"Body_part"},{"id":"T269","span":{"begin":316,"end":321},"obj":"Body_part"},{"id":"T270","span":{"begin":368,"end":381},"obj":"Body_part"},{"id":"T271","span":{"begin":376,"end":381},"obj":"Body_part"}],"attributes":[{"id":"A265","pred":"fma_id","subj":"T265","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A266","pred":"fma_id","subj":"T266","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A267","pred":"fma_id","subj":"T267","obj":"http://purl.org/sig/ont/fma/fma58241"},{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma54448"},{"id":"A269","pred":"fma_id","subj":"T269","obj":"http://purl.org/sig/ont/fma/fma59756"},{"id":"A270","pred":"fma_id","subj":"T270","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Further research\nThe expression of coronavirus receptors on ocular surface cells needs further confirmatory investigation. It would also be of interest to examine whether contact lens wear or ocular surface diseases such as dry eye disease are associated with increased expression of these receptors. The ability of tears to inhibit binding of coronaviruses to ocular surface cells is another area for research. This may identify substances that can be translated into new prophylaxis treatments to reduce the spread of coronaviruses in the environment.\nFurther studies, using animal models, on the role of contamination of the ocular surface on progression of the disease are urgently needed. These studies, as well as further studies with human cases of disease, will also help to definitively identify the virus at the ocular surface. As only one study has been able to grow SARS‐CoV‐2 from ocular swabs and then only reported growth early in the disease and did not attempt to grow viruses from subsequent ocular surface swabs, 53 studies should also then examine whether any ocular surface‐associated viruses are infective. Epidemiological studies and case reports should include analysis of ocular complications during coronavirus infection."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T99","span":{"begin":228,"end":231},"obj":"Body_part"}],"attributes":[{"id":"A99","pred":"uberon_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/UBERON_0000970"}],"text":"Further research\nThe expression of coronavirus receptors on ocular surface cells needs further confirmatory investigation. It would also be of interest to examine whether contact lens wear or ocular surface diseases such as dry eye disease are associated with increased expression of these receptors. The ability of tears to inhibit binding of coronaviruses to ocular surface cells is another area for research. This may identify substances that can be translated into new prophylaxis treatments to reduce the spread of coronaviruses in the environment.\nFurther studies, using animal models, on the role of contamination of the ocular surface on progression of the disease are urgently needed. These studies, as well as further studies with human cases of disease, will also help to definitively identify the virus at the ocular surface. As only one study has been able to grow SARS‐CoV‐2 from ocular swabs and then only reported growth early in the disease and did not attempt to grow viruses from subsequent ocular surface swabs, 53 studies should also then examine whether any ocular surface‐associated viruses are infective. Epidemiological studies and case reports should include analysis of ocular complications during coronavirus infection."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T81","span":{"begin":228,"end":239},"obj":"Phenotype"}],"attributes":[{"id":"A81","pred":"hp_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/HP_0000478"}],"text":"Further research\nThe expression of coronavirus receptors on ocular surface cells needs further confirmatory investigation. It would also be of interest to examine whether contact lens wear or ocular surface diseases such as dry eye disease are associated with increased expression of these receptors. The ability of tears to inhibit binding of coronaviruses to ocular surface cells is another area for research. This may identify substances that can be translated into new prophylaxis treatments to reduce the spread of coronaviruses in the environment.\nFurther studies, using animal models, on the role of contamination of the ocular surface on progression of the disease are urgently needed. These studies, as well as further studies with human cases of disease, will also help to definitively identify the virus at the ocular surface. As only one study has been able to grow SARS‐CoV‐2 from ocular swabs and then only reported growth early in the disease and did not attempt to grow viruses from subsequent ocular surface swabs, 53 studies should also then examine whether any ocular surface‐associated viruses are infective. Epidemiological studies and case reports should include analysis of ocular complications during coronavirus infection."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T213","span":{"begin":224,"end":231},"obj":"Disease"},{"id":"T214","span":{"begin":878,"end":882},"obj":"Disease"},{"id":"T215","span":{"begin":1238,"end":1247},"obj":"Disease"}],"attributes":[{"id":"A213","pred":"mondo_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/MONDO_0006733"},{"id":"A214","pred":"mondo_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A215","pred":"mondo_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Further research\nThe expression of coronavirus receptors on ocular surface cells needs further confirmatory investigation. It would also be of interest to examine whether contact lens wear or ocular surface diseases such as dry eye disease are associated with increased expression of these receptors. The ability of tears to inhibit binding of coronaviruses to ocular surface cells is another area for research. This may identify substances that can be translated into new prophylaxis treatments to reduce the spread of coronaviruses in the environment.\nFurther studies, using animal models, on the role of contamination of the ocular surface on progression of the disease are urgently needed. These studies, as well as further studies with human cases of disease, will also help to definitively identify the virus at the ocular surface. As only one study has been able to grow SARS‐CoV‐2 from ocular swabs and then only reported growth early in the disease and did not attempt to grow viruses from subsequent ocular surface swabs, 53 studies should also then examine whether any ocular surface‐associated viruses are infective. Epidemiological studies and case reports should include analysis of ocular complications during coronavirus infection."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T353","span":{"begin":75,"end":80},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T354","span":{"begin":179,"end":183},"obj":"http://purl.obolibrary.org/obo/UBERON_0005389"},{"id":"T355","span":{"begin":228,"end":231},"obj":"http://www.ebi.ac.uk/efo/EFO_0000827"},{"id":"T356","span":{"begin":376,"end":381},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T357","span":{"begin":577,"end":583},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T358","span":{"begin":741,"end":746},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T359","span":{"begin":809,"end":814},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T360","span":{"begin":856,"end":859},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T361","span":{"begin":986,"end":993},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T362","span":{"begin":1107,"end":1114},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"Further research\nThe expression of coronavirus receptors on ocular surface cells needs further confirmatory investigation. It would also be of interest to examine whether contact lens wear or ocular surface diseases such as dry eye disease are associated with increased expression of these receptors. The ability of tears to inhibit binding of coronaviruses to ocular surface cells is another area for research. This may identify substances that can be translated into new prophylaxis treatments to reduce the spread of coronaviruses in the environment.\nFurther studies, using animal models, on the role of contamination of the ocular surface on progression of the disease are urgently needed. These studies, as well as further studies with human cases of disease, will also help to definitively identify the virus at the ocular surface. As only one study has been able to grow SARS‐CoV‐2 from ocular swabs and then only reported growth early in the disease and did not attempt to grow viruses from subsequent ocular surface swabs, 53 studies should also then examine whether any ocular surface‐associated viruses are infective. Epidemiological studies and case reports should include analysis of ocular complications during coronavirus infection."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T12","span":{"begin":325,"end":340},"obj":"http://purl.obolibrary.org/obo/GO_0051100"},{"id":"T13","span":{"begin":930,"end":936},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"text":"Further research\nThe expression of coronavirus receptors on ocular surface cells needs further confirmatory investigation. It would also be of interest to examine whether contact lens wear or ocular surface diseases such as dry eye disease are associated with increased expression of these receptors. The ability of tears to inhibit binding of coronaviruses to ocular surface cells is another area for research. This may identify substances that can be translated into new prophylaxis treatments to reduce the spread of coronaviruses in the environment.\nFurther studies, using animal models, on the role of contamination of the ocular surface on progression of the disease are urgently needed. These studies, as well as further studies with human cases of disease, will also help to definitively identify the virus at the ocular surface. As only one study has been able to grow SARS‐CoV‐2 from ocular swabs and then only reported growth early in the disease and did not attempt to grow viruses from subsequent ocular surface swabs, 53 studies should also then examine whether any ocular surface‐associated viruses are infective. Epidemiological studies and case reports should include analysis of ocular complications during coronavirus infection."}

{"project":"LitCovid-sentences","denotations":[{"id":"T197","span":{"begin":0,"end":16},"obj":"Sentence"},{"id":"T198","span":{"begin":17,"end":122},"obj":"Sentence"},{"id":"T199","span":{"begin":123,"end":300},"obj":"Sentence"},{"id":"T200","span":{"begin":301,"end":411},"obj":"Sentence"},{"id":"T201","span":{"begin":412,"end":553},"obj":"Sentence"},{"id":"T202","span":{"begin":554,"end":693},"obj":"Sentence"},{"id":"T203","span":{"begin":694,"end":837},"obj":"Sentence"},{"id":"T204","span":{"begin":838,"end":1129},"obj":"Sentence"},{"id":"T205","span":{"begin":1130,"end":1248},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Further research\nThe expression of coronavirus receptors on ocular surface cells needs further confirmatory investigation. It would also be of interest to examine whether contact lens wear or ocular surface diseases such as dry eye disease are associated with increased expression of these receptors. The ability of tears to inhibit binding of coronaviruses to ocular surface cells is another area for research. This may identify substances that can be translated into new prophylaxis treatments to reduce the spread of coronaviruses in the environment.\nFurther studies, using animal models, on the role of contamination of the ocular surface on progression of the disease are urgently needed. These studies, as well as further studies with human cases of disease, will also help to definitively identify the virus at the ocular surface. As only one study has been able to grow SARS‐CoV‐2 from ocular swabs and then only reported growth early in the disease and did not attempt to grow viruses from subsequent ocular surface swabs, 53 studies should also then examine whether any ocular surface‐associated viruses are infective. Epidemiological studies and case reports should include analysis of ocular complications during coronavirus infection."}