PMC:7272971 / 15741-16551 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7272971","sourcedb":"PMC","sourceid":"7272971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7272971","text":"The authors concluded that conjunctival inoculation resulted in a mild lung infection compared to the trachea inoculation. 51 Unfortunately, no histology was performed on the eye during the infection, and given the very transient level of virus found in the conjunctival samples, infection or inflammation probably did not occur. If there was infection of the ocular surface, then conjunctivitis and perhaps keratitis would be expected to be manifestations of the disease. This study does suggest, at least for relatively large inocula (the authors used 1 × 106 50 per cent tissue‐culture infectious doses), that viral particles on the eye can travel to the lung but that they are either reduced in their virulence or the numbers that reach the lung are very low, and so the resulting infection was very mild.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"518","span":{"begin":71,"end":85},"obj":"Disease"},{"id":"519","span":{"begin":191,"end":200},"obj":"Disease"},{"id":"520","span":{"begin":281,"end":290},"obj":"Disease"},{"id":"521","span":{"begin":294,"end":306},"obj":"Disease"},{"id":"522","span":{"begin":344,"end":353},"obj":"Disease"},{"id":"523","span":{"begin":382,"end":396},"obj":"Disease"},{"id":"524","span":{"begin":409,"end":418},"obj":"Disease"},{"id":"525","span":{"begin":786,"end":795},"obj":"Disease"}],"attributes":[{"id":"A518","pred":"tao:has_database_id","subj":"518","obj":"MESH:D012141"},{"id":"A519","pred":"tao:has_database_id","subj":"519","obj":"MESH:D007239"},{"id":"A520","pred":"tao:has_database_id","subj":"520","obj":"MESH:D007239"},{"id":"A521","pred":"tao:has_database_id","subj":"521","obj":"MESH:D007249"},{"id":"A522","pred":"tao:has_database_id","subj":"522","obj":"MESH:D007239"},{"id":"A523","pred":"tao:has_database_id","subj":"523","obj":"MESH:D003231"},{"id":"A524","pred":"tao:has_database_id","subj":"524","obj":"MESH:D007634"},{"id":"A525","pred":"tao:has_database_id","subj":"525","obj":"MESH:D007239"},{"subj":"518","pred":"source","obj":"LitCovid-PubTator"},{"subj":"519","pred":"source","obj":"LitCovid-PubTator"},{"subj":"520","pred":"source","obj":"LitCovid-PubTator"},{"subj":"521","pred":"source","obj":"LitCovid-PubTator"},{"subj":"522","pred":"source","obj":"LitCovid-PubTator"},{"subj":"523","pred":"source","obj":"LitCovid-PubTator"},{"subj":"524","pred":"source","obj":"LitCovid-PubTator"},{"subj":"525","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T196","span":{"begin":71,"end":75},"obj":"Body_part"},{"id":"T197","span":{"begin":102,"end":109},"obj":"Body_part"},{"id":"T198","span":{"begin":176,"end":179},"obj":"Body_part"},{"id":"T199","span":{"begin":575,"end":581},"obj":"Body_part"},{"id":"T200","span":{"begin":637,"end":640},"obj":"Body_part"},{"id":"T201","span":{"begin":659,"end":663},"obj":"Body_part"},{"id":"T202","span":{"begin":746,"end":750},"obj":"Body_part"}],"attributes":[{"id":"A196","pred":"fma_id","subj":"T196","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A197","pred":"fma_id","subj":"T197","obj":"http://purl.org/sig/ont/fma/fma7394"},{"id":"A198","pred":"fma_id","subj":"T198","obj":"http://purl.org/sig/ont/fma/fma54448"},{"id":"A199","pred":"fma_id","subj":"T199","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A200","pred":"fma_id","subj":"T200","obj":"http://purl.org/sig/ont/fma/fma54448"},{"id":"A201","pred":"fma_id","subj":"T201","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A202","pred":"fma_id","subj":"T202","obj":"http://purl.org/sig/ont/fma/fma7195"},{"subj":"T196","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T197","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T198","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T199","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T200","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T201","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T202","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T70","span":{"begin":71,"end":75},"obj":"Body_part"},{"id":"T71","span":{"begin":102,"end":109},"obj":"Body_part"},{"id":"T72","span":{"begin":176,"end":179},"obj":"Body_part"},{"id":"T73","span":{"begin":575,"end":581},"obj":"Body_part"},{"id":"T74","span":{"begin":637,"end":640},"obj":"Body_part"},{"id":"T75","span":{"begin":659,"end":663},"obj":"Body_part"},{"id":"T76","span":{"begin":746,"end":750},"obj":"Body_part"}],"attributes":[{"id":"A70","pred":"uberon_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A71","pred":"uberon_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/UBERON_0003126"},{"id":"A72","pred":"uberon_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/UBERON_0000970"},{"id":"A73","pred":"uberon_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A74","pred":"uberon_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/UBERON_0000970"},{"id":"A75","pred":"uberon_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A76","pred":"uberon_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T12","span":{"begin":382,"end":396},"obj":"Phenotype"},{"id":"T13","span":{"begin":409,"end":418},"obj":"Phenotype"}],"attributes":[{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0000509"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0000491"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T80","span":{"begin":76,"end":85},"obj":"Disease"},{"id":"T81","span":{"begin":191,"end":200},"obj":"Disease"},{"id":"T82","span":{"begin":281,"end":290},"obj":"Disease"},{"id":"T83","span":{"begin":294,"end":306},"obj":"Disease"},{"id":"T84","span":{"begin":344,"end":367},"obj":"Disease"},{"id":"T85","span":{"begin":344,"end":353},"obj":"Disease"},{"id":"T86","span":{"begin":382,"end":396},"obj":"Disease"},{"id":"T87","span":{"begin":409,"end":418},"obj":"Disease"},{"id":"T88","span":{"begin":590,"end":600},"obj":"Disease"},{"id":"T89","span":{"begin":786,"end":795},"obj":"Disease"}],"attributes":[{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0043885"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0003799"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0003085"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T248","span":{"begin":64,"end":65},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T249","span":{"begin":71,"end":75},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T250","span":{"begin":71,"end":75},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T251","span":{"begin":176,"end":179},"obj":"http://www.ebi.ac.uk/efo/EFO_0000827"},{"id":"T252","span":{"begin":240,"end":245},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T253","span":{"begin":637,"end":640},"obj":"http://www.ebi.ac.uk/efo/EFO_0000827"},{"id":"T254","span":{"begin":659,"end":663},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T255","span":{"begin":659,"end":663},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T256","span":{"begin":746,"end":750},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T257","span":{"begin":746,"end":750},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"attributes":[{"subj":"T248","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T4","span":{"begin":294,"end":306},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T5","span":{"begin":706,"end":715},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T6","span":{"begin":706,"end":715},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"attributes":[{"subj":"T4","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T108","span":{"begin":0,"end":122},"obj":"Sentence"},{"id":"T109","span":{"begin":123,"end":330},"obj":"Sentence"},{"id":"T110","span":{"begin":331,"end":473},"obj":"Sentence"},{"id":"T111","span":{"begin":474,"end":810},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T108","pred":"source","obj":"LitCovid-sentences"},{"subj":"T109","pred":"source","obj":"LitCovid-sentences"},{"subj":"T110","pred":"source","obj":"LitCovid-sentences"},{"subj":"T111","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#d0ec93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93ea"},{"id":"LitCovid-PD-UBERON","color":"#93ecd3"},{"id":"LitCovid-PD-HP","color":"#ecb993"},{"id":"LitCovid-PD-MONDO","color":"#9f93ec"},{"id":"LitCovid-PD-CLO","color":"#a0ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93ba"},{"id":"LitCovid-sentences","color":"#93d4ec"}]}]}}