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PMC:7271924 / 28544-31050 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T520 12-23 PR:000009978 denotes Lactoferrin
T521 193-206 NCBITaxon:11118 denotes coronaviruses
T522 270-281 NCBITaxon:11118 denotes coronavirus
T523 358-368 SP_7 denotes SARS-CoV-2
T524 440-445 NCBITaxon:10239 denotes virus
T525 546-554 SP_10 denotes SARS-CoV
T526 574-582 SP_10 denotes SARS-CoV
T527 646-656 GO:0035376 denotes cell entry
T528 736-741 NCBITaxon:10239 denotes virus
T529 782-787 NCBITaxon:10239 denotes virus
T530 801-813 GO:0009986 denotes cell surface
T531 815-823 SP_10 denotes SARS-CoV
T532 859-872 GO:0005886 denotes cell membrane
T533 939-949 GO:0035376 denotes cell entry
T534 968-987 CL:0000623 denotes natural killer cell
T535 1012-1022 CL:0000775 denotes neutrophil
T536 1051-1057 UBERON:0002405 denotes immune
T537 1058-1065 GO:0006952 denotes defense
T538 1093-1101 GO:0035376 denotes entry of
T539 1106-1111 NCBITaxon:10239 denotes virus
T540 1197-1205 SP_7 denotes COVID-19
T541 1226-1232 GO:0007601 denotes visual
T542 1362-1366 G_3;PG_10;PR:000003622 denotes ACE2
T543 1558-1566 SP_7 denotes COVID-19
T544 1639-1652 SO:0000409 denotes binding sites
T545 1660-1670 SP_7 denotes SARS-CoV-2
T546 1683-1691 SP_7 denotes COVID-19
T547 1730-1740 SP_7 denotes SARS-CoV-2
T548 1759-1788 CHEBI:24499;CHEBI:24499 denotes Heparan sulfate proteoglycans
T549 1867-1872 NCBITaxon:10239 denotes virus
T550 1892-1897 NCBITaxon:10239 denotes virus
T551 1905-1917 GO:0009986 denotes cell surface
T552 1949-1954 NCBITaxon:10239 denotes virus
T553 1977-1981 G_3;PG_10;PR:000003622 denotes ACE2
T554 2068-2079 GO:0006260 denotes replication
T555 2147-2158 PR:000009978 denotes Lactoferrin
T556 2222-2226 G_3;PG_10;PR:000003622 denotes ACE2
T557 2250-2261 PR:000009978 denotes lactoferrin
T558 2267-2278 PR:000009978 denotes Lactoferrin
T559 2302-2306 PR:000014459;SP_7 denotes SARS
T560 2306-2312 SP_7 denotes -CoV-2
T561 2372-2382 SP_7 denotes SARS-CoV-2
T562 2426-2444 GO:0033644 denotes host cell membrane
T563 2446-2454 SP_7 denotes COVID-19
T66976 12-23 PR:000009978 denotes Lactoferrin
T92245 193-206 NCBITaxon:11118 denotes coronaviruses
T54356 270-281 NCBITaxon:11118 denotes coronavirus
T26051 358-368 SP_7 denotes SARS-CoV-2
T99342 440-445 NCBITaxon:10239 denotes virus
T68308 546-554 SP_10 denotes SARS-CoV
T39819 574-582 SP_10 denotes SARS-CoV
T81448 646-656 GO:0035376 denotes cell entry
T82315 736-741 NCBITaxon:10239 denotes virus
T15886 782-787 NCBITaxon:10239 denotes virus
T76531 801-813 GO:0009986 denotes cell surface
T49656 815-823 SP_10 denotes SARS-CoV
T95560 859-872 GO:0005886 denotes cell membrane
T81157 939-949 GO:0035376 denotes cell entry
T16593 968-987 CL:0000623 denotes natural killer cell
T26835 1012-1022 CL:0000775 denotes neutrophil
T92368 1051-1057 UBERON:0002405 denotes immune
T25486 1058-1065 GO:0006952 denotes defense
T28995 1093-1101 GO:0035376 denotes entry of
T87059 1106-1111 NCBITaxon:10239 denotes virus
T26492 1197-1205 SP_7 denotes COVID-19
T46616 1226-1232 GO:0007601 denotes visual
T7529 1362-1366 G_3;PG_10;PR:000003622 denotes ACE2
T50501 1558-1566 SP_7 denotes COVID-19
T72810 1639-1652 SO:0000409 denotes binding sites
T35553 1660-1670 SP_7 denotes SARS-CoV-2
T97132 1683-1691 SP_7 denotes COVID-19
T67819 1730-1740 SP_7 denotes SARS-CoV-2
T34731 1759-1788 CHEBI:24499;CHEBI:24499 denotes Heparan sulfate proteoglycans
T11160 1867-1872 NCBITaxon:10239 denotes virus
T78505 1892-1897 NCBITaxon:10239 denotes virus
T90756 1905-1917 GO:0009986 denotes cell surface
T54560 1949-1954 NCBITaxon:10239 denotes virus
T72876 1977-1981 G_3;PG_10;PR:000003622 denotes ACE2
T96834 2068-2079 GO:0006260 denotes replication
T36697 2147-2158 PR:000009978 denotes Lactoferrin
T86359 2222-2226 G_3;PG_10;PR:000003622 denotes ACE2
T42997 2250-2261 PR:000009978 denotes lactoferrin
T49171 2267-2278 PR:000009978 denotes Lactoferrin
T95006 2302-2306 PR:000014459;SP_7 denotes SARS
T3005 2306-2312 SP_7 denotes -CoV-2
T14660 2372-2382 SP_7 denotes SARS-CoV-2
T97248 2426-2444 GO:0033644 denotes host cell membrane
T13325 2446-2454 SP_7 denotes COVID-19

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
750 12-23 Gene denotes Lactoferrin Gene:280846
751 1362-1366 Gene denotes ACE2 Gene:59272
752 1371-1375 Gene denotes HSPG Gene:6383
753 864-872 Gene denotes membrane Gene:43740571
754 193-206 Species denotes coronaviruses Tax:11118
755 358-368 Species denotes SARS-CoV-2 Tax:2697049
756 546-554 Species denotes SARS-CoV Tax:694009
757 815-823 Species denotes SARS-CoV Tax:694009
758 270-292 Disease denotes coronavirus infections MESH:D018352
759 490-499 Disease denotes infection MESH:D007239
760 574-593 Disease denotes SARS-CoV infections MESH:C000657245
761 1135-1144 Disease denotes infection MESH:D007239
762 1197-1205 Disease denotes COVID-19 MESH:C000657245
763 1558-1566 Disease denotes COVID-19 MESH:C000657245
779 1614-1625 Gene denotes lactoferrin Gene:280846
780 1977-1981 Gene denotes ACE2 Gene:59272
781 2147-2158 Gene denotes Lactoferrin Gene:280846
782 2222-2226 Gene denotes ACE2 Gene:59272
783 2250-2261 Gene denotes lactoferrin Gene:280846
784 2267-2278 Gene denotes Lactoferrin Gene:280846
785 2436-2444 Gene denotes membrane Gene:43740571
786 1660-1670 Species denotes SARS-CoV-2 Tax:2697049
787 1730-1740 Species denotes SARS-CoV-2 Tax:2697049
788 2302-2312 Species denotes SARS-CoV-2 Tax:2697049
789 2372-2382 Species denotes SARS-CoV-2 Tax:2697049
791 1683-1691 Disease denotes COVID-19 MESH:C000657245
792 2446-2454 Disease denotes COVID-19 MESH:C000657245
793 2455-2464 Disease denotes infection MESH:D007239

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T322 399-404 Body_part denotes HSPGs http://purl.org/sig/ont/fma/fma82834
T323 455-460 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T324 506-511 Body_part denotes HSPGs http://purl.org/sig/ont/fma/fma82834
T325 599-604 Body_part denotes HSPGs http://purl.org/sig/ont/fma/fma82834
T326 646-650 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T327 695-700 Body_part denotes HSPGs http://purl.org/sig/ont/fma/fma82834
T328 751-756 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T329 801-813 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T330 801-805 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T331 833-838 Body_part denotes HSPGs http://purl.org/sig/ont/fma/fma82834
T332 859-872 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T333 859-863 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T334 939-943 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T335 968-987 Body_part denotes natural killer cell http://purl.org/sig/ont/fma/fma63147
T336 983-987 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T337 1012-1022 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T338 1122-1127 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T339 1371-1375 Body_part denotes HSPG http://purl.org/sig/ont/fma/fma82834
T340 1713-1718 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T341 1759-1788 Body_part denotes Heparan sulfate proteoglycans http://purl.org/sig/ont/fma/fma82834
T342 1759-1774 Body_part denotes Heparan sulfate http://purl.org/sig/ont/fma/fma63023
T343 1759-1766 Body_part denotes Heparan http://purl.org/sig/ont/fma/fma67110
T344 1790-1795 Body_part denotes HSPGs http://purl.org/sig/ont/fma/fma82834
T345 1854-1858 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T346 1905-1917 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T347 1905-1909 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T348 2037-2045 Body_part denotes clathrin http://purl.org/sig/ont/fma/fma62262
T349 2107-2111 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T350 2183-2188 Body_part denotes HSPGs http://purl.org/sig/ont/fma/fma82834
T351 2327-2331 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T352 2431-2444 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T353 2431-2435 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T104 282-292 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T105 358-366 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T106 490-499 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T107 546-554 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T108 574-582 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T109 583-593 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T110 815-823 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 1135-1144 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T112 1197-1205 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 1558-1566 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T114 1660-1668 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T115 1683-1691 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T116 1730-1738 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T117 2302-2310 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T118 2372-2380 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T119 2446-2454 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 2455-2464 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T379 32-35 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T380 309-310 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T381 399-404 http://purl.obolibrary.org/obo/PR_000001307 denotes HSPGs
T382 440-445 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T383 455-460 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T384 506-511 http://purl.obolibrary.org/obo/PR_000001307 denotes HSPGs
T385 599-604 http://purl.obolibrary.org/obo/PR_000001307 denotes HSPGs
T386 646-650 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T387 695-700 http://purl.obolibrary.org/obo/PR_000001307 denotes HSPGs
T388 736-741 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T389 751-756 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T390 782-787 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T391 801-805 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T392 833-838 http://purl.obolibrary.org/obo/PR_000001307 denotes HSPGs
T393 859-863 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T394 864-872 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T395 939-943 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T396 968-987 http://purl.obolibrary.org/obo/CL_0000623 denotes natural killer cell
T397 988-996 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T398 1106-1111 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T399 1122-1127 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T400 1224-1225 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T401 1340-1341 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T402 1491-1492 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T403 1535-1536 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T404 1713-1718 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T405 1759-1788 http://purl.obolibrary.org/obo/PR_000001307 denotes Heparan sulfate proteoglycans
T406 1790-1795 http://purl.obolibrary.org/obo/PR_000001307 denotes HSPGs
T407 1854-1858 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T408 1867-1872 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T409 1892-1897 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T410 1905-1909 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T411 1949-1954 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T412 2062-2067 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T413 2107-2111 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T414 2183-2188 http://purl.obolibrary.org/obo/PR_000001307 denotes HSPGs
T415 2235-2236 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T416 2327-2331 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T417 2431-2435 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T418 2436-2444 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T354 109-118 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T355 334-336 Chemical denotes LF http://purl.obolibrary.org/obo/CHEBI_73585
T356 393-395 Chemical denotes LF http://purl.obolibrary.org/obo/CHEBI_73585
T357 956-958 Chemical denotes LF http://purl.obolibrary.org/obo/CHEBI_73585
T358 1426-1428 Chemical denotes LF http://purl.obolibrary.org/obo/CHEBI_73585
T359 1759-1774 Chemical denotes Heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T360 1767-1774 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T361 1775-1788 Chemical denotes proteoglycans http://purl.obolibrary.org/obo/CHEBI_37396

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T64 968-996 http://purl.obolibrary.org/obo/GO_0030101 denotes natural killer cell activity
T65 1012-1034 http://purl.obolibrary.org/obo/GO_0070488 denotes neutrophil aggregation
T66 1697-1712 http://purl.obolibrary.org/obo/GO_0044409 denotes Entry into host

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T223 0-11 Sentence denotes Conclusions
T224 12-124 Sentence denotes Lactoferrin clearly has immunological benefits, as well as having an important antibacterial and antiviral role.
T225 125-293 Sentence denotes Because it is known to interfere with some of the receptors used by coronaviruses, it may contribute usefully to the prevention and treatment of coronavirus infections.
T226 294-377 Sentence denotes Figure 6 shows a possible scheme on how LF might interfere with SARS-CoV-2 binding.
T227 378-505 Sentence denotes The binding of LF to HSPGs prevents the first contact between virus and host cells and thus prevents subsequent infection (99).
T228 506-561 Sentence denotes HSPGs themselves are not sufficient for SARS-CoV entry.
T229 562-662 Sentence denotes However, in SARS-CoV infections, the HSPGs play an important role in the process of cell entry (99).
T230 663-814 Sentence denotes The anchoring sites provided by HSPGs permit initial contact between the virus and host cells and the concentration of virus particles on cell surface.
T231 815-955 Sentence denotes SARS-CoV bound to HSPGs then rolls onto the cell membrane and scans for specific entry receptors, which leads to subsequent cell entry (99).
T232 956-1145 Sentence denotes LF enhances natural killer cell activity and stimulates neutrophil aggregation and adhesion in immune defense (135) and can restrict the entry of the virus into host cells during infection.
T233 1146-1314 Sentence denotes We suggest that this process might be the same for COVID-19 (see Figure 6 for a visual representation), thereby offering useful strategies for prevention and treatment.
T234 1315-1425 Sentence denotes Currently, there is also a renewed interest in ACE2 and HSPG blocking, as discussed in the introduction (5–8).
T235 1426-1580 Sentence denotes LF may therefore be an excellent supplement to take, not only as a contribution to prevention but perhaps as a therapy in the event COVID-19 is diagnosed.
T236 1581-1797 Sentence denotes Figure 6 Possible action of (1) lactoferrin by occupying binding sites of (2) SARS-CoV-2 that causes COVID-19. (3) Entry into host cells occur when SARS-CoV-2 first attaches to Heparan sulfate proteoglycans (HSPGs).
T237 1798-2445 Sentence denotes This attachment initiates the first contact between the cell and the virus, concentrating the virus on the cell surface, (4) followed attaching of the virus to the host receptor (ACE2) and association and entering are then facilitated via clathrin-coated pits (5) Virus replication can then happen inside the cell. (6) One of the characteristics of Lactoferrin, is that it attaches to HSPGs. (7) Currently we do not know if ACE2 is also a receptor for lactoferrin. (8) Lactoferrin may block the entry of SARS-CoV-2 into the host cell, by occupying HPSGs, thereby preventing SARS-CoV-2 initial attachment and accumulation on the host cell membrane.
T238 2446-2506 Sentence denotes COVID-19 infection template adjusted from www.biorender.com.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T6 1759-1774 GlycoEpitope denotes Heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

MyTest

Id Subject Object Predicate Lexical cue
32574271-21887302-34514761 501-503 21887302 denotes 99
32574271-21887302-34514762 658-660 21887302 denotes 99
32574271-21887302-34514763 951-953 21887302 denotes 99
32574271-15655079-34514764 1067-1070 15655079 denotes 135
32574271-32228252-34514765 1420-1421 32228252 denotes 5
32574271-32334062-34514765 1420-1421 32334062 denotes 5
32574271-32333836-34514765 1420-1421 32333836 denotes 5
32574271-32395702-34514765 1420-1421 32395702 denotes 5

TEST0

Id Subject Object Predicate Lexical cue
32574271-123-129-2882353 501-503 ["21887302"] denotes 99
32574271-96-102-2882354 658-660 ["21887302"] denotes 99
32574271-136-142-2882355 951-953 ["21887302"] denotes 99
32574271-111-118-2882356 1067-1070 ["15655079"] denotes 135
32574271-105-110-2882357 1420-1421 ["32228252", "32334062", "32333836", "32395702"] denotes 5

2_test

Id Subject Object Predicate Lexical cue
32574271-21887302-34514761 501-503 21887302 denotes 99
32574271-21887302-34514762 658-660 21887302 denotes 99
32574271-21887302-34514763 951-953 21887302 denotes 99
32574271-15655079-34514764 1067-1070 15655079 denotes 135
32574271-32228252-34514765 1420-1421 32228252 denotes 5
32574271-32334062-34514765 1420-1421 32334062 denotes 5
32574271-32333836-34514765 1420-1421 32333836 denotes 5
32574271-32395702-34514765 1420-1421 32395702 denotes 5