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PMC:7271924 / 13843-15607 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T221 0-11 CL:0000775 denotes Neutrophils
T222 16-27 PR:000009978 denotes Lactoferrin
T223 58-62 GO:0006968 denotes host
T224 63-70 GO:0006952 denotes defense
T225 98-108 CL:0000775 denotes neutrophil
T226 132-151 CL:0000623 denotes natural killer cell
T227 164-170 UBERON:0002405;GO:0045087 denotes immune
T228 171-178 GO:0006952 denotes defense
T229 206-214 GO:0035376 denotes entry of
T230 219-224 NCBITaxon:10239 denotes virus
T231 304-314 CL:0000738 denotes leucocytes
T232 326-337 CL:0000775 denotes neutrophils
T233 361-369 GO:0009542 denotes granules
T234 410-421 CL:0000775 denotes neutrophils
T235 435-444 GO:0000785 denotes chromatin
T236 462-472 CL:0000775 denotes neutrophil
T237 473-486 GO:0005576 denotes extracellular
T238 538-546 NCBITaxon:2 denotes bacteria
T239 577-585 GO:0065007 denotes modulate
T240 665-675 UBERON:0002405 denotes autoimmune
T241 777-782 SP_6;NCBITaxon:9606 denotes human
T242 783-794 CL:0000775 denotes neutrophils
T243 848-856 CHEBI:15358;CHEBI:15358 denotes histones
T244 877-889 GO:0005634 denotes extranuclear
T245 1001-1010 CHEBI:35222;CHEBI:35222 denotes inhibitor
T246 1081-1092 GO:0065007 denotes controlling
T247 1210-1214 PR:000001153 denotes TLR2
T248 1295-1299 PR:O88807 denotes PAD4
T249 1325-1334 GO:0000785;GO:0006338 denotes chromatin
T250 1335-1349 GO:0006338 denotes decondensation
T251 1374-1382 CHEBI:15358;CHEBI:15358 denotes histones
T252 1398-1405 GO:0005634 denotes nucleus
T253 1411-1427 GO:0031965 denotes nuclear membrane
T254 1475-1485 CL:0000775 denotes Neutrophil
T255 1486-1499 GO:0005576 denotes Extracellular
T256 1590-1600 CL:0000775 denotes neutrophil
T30413 0-11 CL:0000775 denotes Neutrophils
T5074 16-27 PR:000009978 denotes Lactoferrin
T12214 58-62 GO:0006968 denotes host
T10334 63-70 GO:0006952 denotes defense
T1843 98-108 CL:0000775 denotes neutrophil
T73468 132-151 CL:0000623 denotes natural killer cell
T98552 164-170 UBERON:0002405;GO:0045087 denotes immune
T22819 171-178 GO:0006952 denotes defense
T87113 206-214 GO:0035376 denotes entry of
T32312 219-224 NCBITaxon:10239 denotes virus
T76098 304-314 CL:0000738 denotes leucocytes
T77867 326-337 CL:0000775 denotes neutrophils
T14539 361-369 GO:0009542 denotes granules
T25243 410-421 CL:0000775 denotes neutrophils
T93813 435-444 GO:0000785 denotes chromatin
T10111 462-472 CL:0000775 denotes neutrophil
T25368 473-486 GO:0005576 denotes extracellular
T65114 538-546 NCBITaxon:2 denotes bacteria
T36198 577-585 GO:0065007 denotes modulate
T93273 665-675 UBERON:0002405 denotes autoimmune
T37266 777-782 SP_6;NCBITaxon:9606 denotes human
T78039 783-794 CL:0000775 denotes neutrophils
T79769 848-856 CHEBI:15358;CHEBI:15358 denotes histones
T91659 877-889 GO:0005634 denotes extranuclear
T64426 1001-1010 CHEBI:35222;CHEBI:35222 denotes inhibitor
T95147 1081-1092 GO:0065007 denotes controlling
T98033 1210-1214 PR:000001153 denotes TLR2
T2481 1295-1299 PR:O88807 denotes PAD4
T31813 1325-1334 GO:0000785;GO:0006338 denotes chromatin
T18232 1335-1349 GO:0006338 denotes decondensation
T86315 1374-1382 CHEBI:15358;CHEBI:15358 denotes histones
T88880 1398-1405 GO:0005634 denotes nucleus
T7872 1411-1427 GO:0031965 denotes nuclear membrane
T65967 1475-1485 CL:0000775 denotes Neutrophil
T66338 1486-1499 GO:0005576 denotes Extracellular
T6335 1590-1600 CL:0000775 denotes neutrophil

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
244 1181-1208 Gene denotes Toll-like receptors 2 and 4 Gene:7097
321 930-945 Gene denotes myeloperoxidase Gene:4353
322 947-950 Gene denotes MPO Gene:4353
323 777-782 Species denotes human Tax:9606
324 248-257 Disease denotes infection MESH:D007239
325 609-621 Disease denotes inflammation MESH:D007249
326 695-715 Disease denotes rheumatoid arthritis MESH:D001172
327 717-745 Disease denotes systemic lupus erythematosus MESH:D008180
338 1295-1299 Gene denotes PAD4 Gene:23569
339 1462-1473 Gene denotes lactoferrin Gene:280846
340 1555-1566 Gene denotes lactoferrin Gene:280846
341 1265-1293 Gene denotes protein arginine deiminase 4 Gene:23569
342 1419-1427 Gene denotes membrane Gene:43740571
343 1351-1370 Disease denotes hypercitrullination

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T174 0-11 Body_part denotes Neutrophils http://purl.org/sig/ont/fma/fma62860
T175 98-108 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T176 132-151 Body_part denotes natural killer cell http://purl.org/sig/ont/fma/fma63147
T177 147-151 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T178 235-240 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T179 304-314 Body_part denotes leucocytes http://purl.org/sig/ont/fma/fma62852
T180 326-337 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T181 410-421 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T182 435-444 Body_part denotes chromatin http://purl.org/sig/ont/fma/fma67526
T183 462-472 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T184 783-794 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T185 840-843 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T186 848-856 Body_part denotes histones http://purl.org/sig/ont/fma/fma74413
T187 890-898 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T188 903-911 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T189 1265-1272 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T190 1273-1281 Body_part denotes arginine http://purl.org/sig/ont/fma/fma82763
T191 1325-1334 Body_part denotes chromatin http://purl.org/sig/ont/fma/fma67526
T192 1374-1382 Body_part denotes histones http://purl.org/sig/ont/fma/fma74413
T193 1411-1427 Body_part denotes nuclear membrane http://purl.org/sig/ont/fma/fma63888
T194 1475-1485 Body_part denotes Neutrophil http://purl.org/sig/ont/fma/fma62860
T195 1523-1530 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T196 1590-1600 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T25 248-257 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T26 609-621 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T27 695-715 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T28 706-715 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T29 717-745 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T30 726-745 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T204 132-151 http://purl.obolibrary.org/obo/CL_0000623 denotes natural killer cell
T205 152-160 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T206 219-224 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T207 235-240 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T208 304-314 http://purl.obolibrary.org/obo/CL_0000738 denotes leucocytes
T209 400-409 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T210 538-546 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T211 777-782 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T212 930-945 http://purl.obolibrary.org/obo/PR_000010543 denotes myeloperoxidase
T213 947-950 http://purl.obolibrary.org/obo/PR_000010543 denotes MPO
T214 1210-1214 http://purl.obolibrary.org/obo/CLO_0050768 denotes TLR2
T215 1301-1311 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T216 1419-1427 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T217 1661-1669 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes Bacteria

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T177 28-30 Chemical denotes LF http://purl.obolibrary.org/obo/CHEBI_73585
T178 115-117 Chemical denotes LF http://purl.obolibrary.org/obo/CHEBI_73585
T179 347-349 Chemical denotes LF http://purl.obolibrary.org/obo/CHEBI_73585
T180 816-818 Chemical denotes LF http://purl.obolibrary.org/obo/CHEBI_73585
T181 840-843 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T182 890-898 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T183 903-911 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T184 957-959 Chemical denotes LF http://purl.obolibrary.org/obo/CHEBI_73585
T185 967-969 Chemical denotes LF http://purl.obolibrary.org/obo/CHEBI_73585
T186 1001-1010 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T187 1265-1272 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T188 1273-1281 Chemical denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696
T191 1398-1405 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T192 1523-1530 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T34 132-160 http://purl.obolibrary.org/obo/GO_0030101 denotes natural killer cell activity
T35 281-302 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T36 609-621 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T109 0-27 Sentence denotes Neutrophils and Lactoferrin
T110 28-114 Sentence denotes LF plays an important role in host defense, upon its release from the neutrophil (26).
T111 115-258 Sentence denotes LF also enhances natural killer cell activity in immune defense (135) and can restrict the entry of the virus into host cells during infection.
T112 259-399 Sentence denotes As part of the host's inflammatory response, leucocytes, including neutrophils, release LF from their granules, where it is normally stored.
T113 400-556 Sentence denotes Activated neutrophils also release chromatin fibers, known as neutrophil extracellular traps (NETs), which trap and kill, amongst others, bacteria (1, 136).
T114 557-633 Sentence denotes These NETs likewise modulate both acute and chronic inflammation (137, 138).
T115 634-757 Sentence denotes NETs are also found in various autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus (139, 140).
T116 758-824 Sentence denotes Interestingly, 106 human neutrophils can release 15 μg of LF (26).
T117 825-966 Sentence denotes In addition to DNA and histones, NET fibers contain extranuclear proteins and proteins such as elastase, myeloperoxidase (MPO), and LF (141).
T118 967-1110 Sentence denotes LF may also serve as an intrinsic inhibitor of NETs release into the circulation, and may therefore be central in controlling NETs release (1).
T119 1111-1124 Sentence denotes See Figure 3.
T120 1125-1439 Sentence denotes Figure 3 Bacterial binding to various receptors, e.g., Toll-like receptors 2 and 4 (TLR2 and 4), as well as complement receptors, leads to protein arginine deiminase 4 (PAD4) activation, followed by chromatin decondensation, hypercitrullination of histones 3 and 4 in the nucleus, and nuclear membrane disruption.
T121 1440-1474 Sentence denotes Granules also release lactoferrin.
T122 1475-1601 Sentence denotes Neutrophil Extracellular Traps (NETs) and their protein constituents (including lactoferrin) are released from the neutrophil.
T123 1602-1660 Sentence denotes Adapted from Jorch and Kubes (142) and Law and Gray (143).
T124 1661-1707 Sentence denotes Bacteria are expelled and trapped in the NETs.
T125 1708-1764 Sentence denotes Diagram created with BioRender (https://biorender.com/).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 665-686 Phenotype denotes autoimmune conditions http://purl.obolibrary.org/obo/HP_0002960
T4 695-715 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T5 717-745 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725

MyTest

Id Subject Object Predicate Lexical cue
32574271-30987256-34514663 110-112 30987256 denotes 26
32574271-15655079-34514664 180-183 15655079 denotes 135
32574271-27453322-34514665 548-549 27453322 denotes 1
32574271-15001782-34514666 551-554 15001782 denotes 136
32574271-30898862-34514667 623-626 30898862 denotes 137
32574271-27586795-34514668 628-631 27586795 denotes 138
32574271-28899799-34514669 747-750 28899799 denotes 139
32574271-28990587-34514670 752-755 28990587 denotes 140
32574271-30987256-34514671 820-822 30987256 denotes 26
32574271-19876394-34514672 961-964 19876394 denotes 141
32574271-27453322-34514673 1107-1108 27453322 denotes 1
32574271-28267716-34514674 1632-1635 28267716 denotes 142
32574271-29299029-34514675 1655-1658 29299029 denotes 143

TEST0

Id Subject Object Predicate Lexical cue
32574271-82-88-2882255 110-112 ["30987256"] denotes 26
32574271-65-72-2882256 180-183 ["15655079"] denotes 135
32574271-148-153-2882257 548-549 ["27453322"] denotes 1
32574271-151-158-2882258 551-554 ["15001782"] denotes 136
32574271-66-73-2882259 623-626 ["30898862"] denotes 137
32574271-71-78-2882260 628-631 ["27586795"] denotes 138
32574271-113-120-2882261 747-750 ["28899799"] denotes 139
32574271-118-125-2882262 752-755 ["28990587"] denotes 140
32574271-62-68-2882263 820-822 ["30987256"] denotes 26
32574271-136-143-2882264 961-964 ["19876394"] denotes 141
32574271-140-145-2882265 1107-1108 ["27453322"] denotes 1
32574271-30-37-2882266 1632-1635 ["28267716"] denotes 142
32574271-53-60-2882267 1655-1658 ["29299029"] denotes 143

2_test

Id Subject Object Predicate Lexical cue
32574271-30987256-34514663 110-112 30987256 denotes 26
32574271-15655079-34514664 180-183 15655079 denotes 135
32574271-27453322-34514665 548-549 27453322 denotes 1
32574271-15001782-34514666 551-554 15001782 denotes 136
32574271-30898862-34514667 623-626 30898862 denotes 137
32574271-27586795-34514668 628-631 27586795 denotes 138
32574271-28899799-34514669 747-750 28899799 denotes 139
32574271-28990587-34514670 752-755 28990587 denotes 140
32574271-30987256-34514671 820-822 30987256 denotes 26
32574271-19876394-34514672 961-964 19876394 denotes 141
32574271-27453322-34514673 1107-1108 27453322 denotes 1
32574271-28267716-34514674 1632-1635 28267716 denotes 142
32574271-29299029-34514675 1655-1658 29299029 denotes 143