PMC:7268883 / 9129-19983
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 151 | 161-168 | Species | denotes | patient | Tax:9606 |
| 152 | 95-103 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 153 | 225-244 | Disease | denotes | pancreatic diseases | MESH:D010182 |
| 169 | 423-426 | Gene | denotes | nte | Gene:6503 |
| 170 | 738-746 | Species | denotes | Patients | Tax:9606 |
| 171 | 957-965 | Species | denotes | patients | Tax:9606 |
| 172 | 526-534 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 173 | 587-604 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 174 | 757-765 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 175 | 770-776 | Disease | denotes | cancer | MESH:D009369 |
| 176 | 924-929 | Disease | denotes | death | MESH:D003643 |
| 177 | 948-956 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 178 | 974-980 | Disease | denotes | cancer | MESH:D009369 |
| 179 | 1111-1117 | Disease | denotes | cancer | MESH:D009369 |
| 180 | 1225-1231 | Disease | denotes | tumors | MESH:D009369 |
| 181 | 1381-1418 | Disease | denotes | hepato-pancreato-biliary malignancies | MESH:D020065 |
| 182 | 1771-1783 | Disease | denotes | malignancies | MESH:D009369 |
| 183 | 1881-1889 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 199 | 2196-2204 | Species | denotes | Patients | Tax:9606 |
| 200 | 2482-2490 | Species | denotes | patients | Tax:9606 |
| 201 | 2573-2581 | Species | denotes | patients | Tax:9606 |
| 202 | 2828-2835 | Species | denotes | patient | Tax:9606 |
| 203 | 2905-2913 | Species | denotes | patients | Tax:9606 |
| 204 | 3108-3116 | Species | denotes | patients | Tax:9606 |
| 205 | 3554-3562 | Species | denotes | patients | Tax:9606 |
| 206 | 2229-2262 | Disease | denotes | postoperative respiratory failure | MESH:D012131 |
| 207 | 2564-2572 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 208 | 2919-2927 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 209 | 2958-2975 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 210 | 3180-3197 | Disease | denotes | Pancreatic cancer | MESH:D010190 |
| 211 | 3461-3469 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 212 | 3659-3678 | Disease | denotes | respiratory failure | MESH:D012131 |
| 213 | 3817-3850 | Disease | denotes | postoperative respiratory failure | MESH:D012131 |
| 215 | 3884-3892 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 226 | 3975-3983 | Species | denotes | patients | Tax:9606 |
| 227 | 4296-4308 | Species | denotes | Corona Virus | Tax:11118 |
| 228 | 4386-4394 | Species | denotes | patients | Tax:9606 |
| 229 | 4558-4566 | Species | denotes | patients | Tax:9606 |
| 230 | 4642-4650 | Species | denotes | patients | Tax:9606 |
| 231 | 4000-4008 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 232 | 4048-4056 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 233 | 4549-4557 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 234 | 4622-4630 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 235 | 4662-4670 | Disease | denotes | infected | MESH:D007239 |
| 244 | 4694-4702 | Species | denotes | patients | Tax:9606 |
| 245 | 4796-4804 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 246 | 4805-4814 | Disease | denotes | infection | MESH:D007239 |
| 247 | 4930-4938 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 248 | 4947-4956 | Disease | denotes | mortality | MESH:D003643 |
| 249 | 4979-4985 | Disease | denotes | cancer | MESH:D009369 |
| 250 | 5191-5199 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 251 | 5200-5209 | Disease | denotes | infection | MESH:D007239 |
| 253 | 5259-5276 | Disease | denotes | Pancreatic Cancer | MESH:D010190 |
| 276 | 5319-5327 | Species | denotes | patients | Tax:9606 |
| 277 | 5357-5364 | Species | denotes | patient | Tax:9606 |
| 278 | 5478-5486 | Species | denotes | patients | Tax:9606 |
| 279 | 5620-5628 | Species | denotes | patients | Tax:9606 |
| 280 | 5743-5750 | Species | denotes | patient | Tax:9606 |
| 281 | 5829-5837 | Species | denotes | patients | Tax:9606 |
| 282 | 6057-6065 | Species | denotes | patients | Tax:9606 |
| 283 | 6381-6388 | Species | denotes | patient | Tax:9606 |
| 284 | 6578-6586 | Species | denotes | patients | Tax:9606 |
| 285 | 6634-6642 | Species | denotes | patients | Tax:9606 |
| 286 | 6788-6796 | Species | denotes | patients | Tax:9606 |
| 287 | 5333-5350 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 288 | 5770-5787 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 289 | 6027-6044 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 290 | 6241-6258 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 291 | 6363-6380 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 292 | 6418-6433 | Disease | denotes | pancreas cancer | MESH:D010190 |
| 293 | 6505-6522 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 294 | 6569-6577 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 295 | 6616-6633 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 296 | 6809-6817 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 297 | 6832-6849 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 304 | 7138-7146 | Species | denotes | patients | Tax:9606 |
| 305 | 7170-7178 | Species | denotes | patients | Tax:9606 |
| 306 | 6997-7003 | Disease | denotes | cancer | MESH:D009369 |
| 307 | 7020-7028 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 308 | 7129-7137 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 309 | 7163-7169 | Disease | denotes | cancer | MESH:D009369 |
| 312 | 7257-7269 | Disease | denotes | Malignancies | MESH:D009369 |
| 313 | 7279-7296 | Disease | denotes | Pancreatic Cancer | MESH:D010190 |
| 323 | 7346-7352 | Disease | denotes | cancer | MESH:D009369 |
| 324 | 7370-7387 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 325 | 7498-7515 | Disease | denotes | pancreatic cancer | MESH:D010190 |
| 326 | 7590-7619 | Disease | denotes | extrahepatic bile duct cancer | MESH:D001650 |
| 327 | 7647-7662 | Disease | denotes | adenocarcinomas | MESH:D000230 |
| 328 | 7898-7905 | Disease | denotes | cancers | MESH:D009369 |
| 329 | 7948-7956 | Disease | denotes | bleeding | MESH:D006470 |
| 330 | 7958-7975 | Disease | denotes | bowel obstruction | MESH:D012778 |
| 331 | 8061-8068 | Disease | denotes | cancers | MESH:D009369 |
| 333 | 8202-8234 | Disease | denotes | Premalignant Pancreatic Diseases | MESH:D010182 |
| 341 | 8292-8324 | Disease | denotes | premalignant pancreatic diseases | MESH:D010182 |
| 342 | 8358-8370 | Disease | denotes | pancreatitis | MESH:D010195 |
| 343 | 8376-8404 | Disease | denotes | infected pancreatic necrosis | MESH:D019283 |
| 344 | 8460-8480 | Disease | denotes | chronic pancreatitis | MESH:D050500 |
| 345 | 8484-8492 | Disease | denotes | infected | MESH:D007239 |
| 346 | 8493-8512 | Disease | denotes | pancreatic necrosis | MESH:D019283 |
| 347 | 8618-8628 | Disease | denotes | malignancy | MESH:D009369 |
| 351 | 8849-8857 | Species | denotes | patients | Tax:9606 |
| 352 | 8775-8784 | Disease | denotes | mortality | MESH:D003643 |
| 353 | 8915-8923 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 357 | 10221-10229 | Species | denotes | patients | Tax:9606 |
| 358 | 9716-9724 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 359 | 9953-9966 | Disease | denotes | insufficiency | MESH:D000309 |
| 363 | 10757-10769 | Species | denotes | participants | Tax:9606 |
| 364 | 10805-10817 | Species | denotes | participants | Tax:9606 |
| 365 | 10645-10664 | Disease | denotes | pancreatic diseases | MESH:D010182 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T4 | 4214-4219 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
| T5 | 6418-6426 | Body_part | denotes | pancreas | http://purl.org/sig/ont/fma/fma7198 |
| T6 | 7336-7345 | Body_part | denotes | bile duct | http://purl.org/sig/ont/fma/fma9706 |
| T7 | 7564-7568 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T8 | 7590-7612 | Body_part | denotes | extrahepatic bile duct | http://purl.org/sig/ont/fma/fma14678 |
| T9 | 7958-7963 | Body_part | denotes | bowel | http://purl.org/sig/ont/fma/fma7199 |
| T10 | 9470-9475 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T6 | 4214-4219 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
| T7 | 6418-6426 | Body_part | denotes | pancreas | http://purl.obolibrary.org/obo/UBERON_0001264 |
| T8 | 7336-7345 | Body_part | denotes | bile duct | http://purl.obolibrary.org/obo/UBERON_0002394 |
| T9 | 7336-7340 | Body_part | denotes | bile | http://purl.obolibrary.org/obo/UBERON_0001970 |
| T10 | 7341-7345 | Body_part | denotes | duct | http://purl.obolibrary.org/obo/UBERON_0000058 |
| T11 | 7564-7568 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T12 | 7590-7612 | Body_part | denotes | extrahepatic bile duct | http://purl.obolibrary.org/obo/UBERON_0003703 |
| T13 | 7603-7612 | Body_part | denotes | bile duct | http://purl.obolibrary.org/obo/UBERON_0002394 |
| T14 | 7603-7607 | Body_part | denotes | bile | http://purl.obolibrary.org/obo/UBERON_0001970 |
| T15 | 7608-7612 | Body_part | denotes | duct | http://purl.obolibrary.org/obo/UBERON_0000058 |
| T16 | 9470-9475 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T67 | 95-103 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T68 | 225-244 | Disease | denotes | pancreatic diseases | http://purl.obolibrary.org/obo/MONDO_0002356 |
| T69 | 526-534 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T70 | 587-604 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T72 | 598-604 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T73 | 757-765 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T74 | 770-776 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T75 | 948-956 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T76 | 974-980 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T77 | 1111-1117 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T78 | 1225-1231 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T79 | 1881-1889 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T80 | 2243-2262 | Disease | denotes | respiratory failure | http://purl.obolibrary.org/obo/MONDO_0021113 |
| T81 | 2564-2572 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T82 | 2919-2927 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T83 | 2958-2975 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T85 | 2969-2975 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T86 | 3180-3197 | Disease | denotes | Pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T88 | 3191-3197 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T89 | 3461-3469 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T90 | 3659-3678 | Disease | denotes | respiratory failure | http://purl.obolibrary.org/obo/MONDO_0021113 |
| T91 | 3831-3850 | Disease | denotes | respiratory failure | http://purl.obolibrary.org/obo/MONDO_0021113 |
| T92 | 3884-3892 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T93 | 4000-4008 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T94 | 4048-4056 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T95 | 4549-4557 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T96 | 4622-4630 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T97 | 4796-4804 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T98 | 4805-4814 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T99 | 4930-4938 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T100 | 4979-4985 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T101 | 5191-5199 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T102 | 5200-5209 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T103 | 5259-5276 | Disease | denotes | Pancreatic Cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T105 | 5333-5350 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T107 | 5344-5350 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T108 | 5770-5787 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T110 | 5781-5787 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T111 | 6027-6044 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T113 | 6038-6044 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T114 | 6241-6258 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T116 | 6252-6258 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T117 | 6363-6380 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T119 | 6374-6380 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T120 | 6418-6433 | Disease | denotes | pancreas cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T122 | 6418-6426 | Disease | denotes | pancreas | http://purl.obolibrary.org/obo/MONDO_0021040 |
| T123 | 6427-6433 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T124 | 6505-6522 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T126 | 6516-6522 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T127 | 6569-6577 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T128 | 6616-6633 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T130 | 6627-6633 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T131 | 6809-6817 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T132 | 6832-6849 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T134 | 6843-6849 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T135 | 6997-7003 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T136 | 7020-7028 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T137 | 7129-7137 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T138 | 7163-7169 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T139 | 7279-7296 | Disease | denotes | Pancreatic Cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T141 | 7329-7352 | Disease | denotes | distal bile duct cancer | http://purl.obolibrary.org/obo/MONDO_0003707 |
| T142 | 7336-7352 | Disease | denotes | bile duct cancer | http://purl.obolibrary.org/obo/MONDO_0003059|http://purl.obolibrary.org/obo/MONDO_0005496|http://purl.obolibrary.org/obo/MONDO_0019087 |
| T145 | 7346-7352 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T146 | 7370-7387 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T148 | 7381-7387 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T149 | 7498-7515 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T151 | 7509-7515 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T152 | 7590-7619 | Disease | denotes | extrahepatic bile duct cancer | http://purl.obolibrary.org/obo/MONDO_0003090|http://purl.obolibrary.org/obo/MONDO_0021321 |
| T154 | 7603-7619 | Disease | denotes | bile duct cancer | http://purl.obolibrary.org/obo/MONDO_0003059|http://purl.obolibrary.org/obo/MONDO_0005496|http://purl.obolibrary.org/obo/MONDO_0019087 |
| T157 | 7613-7619 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T158 | 7638-7662 | Disease | denotes | duodenal adenocarcinomas | http://purl.obolibrary.org/obo/MONDO_0006186 |
| T159 | 7647-7662 | Disease | denotes | adenocarcinomas | http://purl.obolibrary.org/obo/MONDO_0004970 |
| T160 | 7888-7905 | Disease | denotes | ampullary cancers | http://purl.obolibrary.org/obo/MONDO_0017590 |
| T161 | 7958-7975 | Disease | denotes | bowel obstruction | http://purl.obolibrary.org/obo/MONDO_0004565 |
| T162 | 8215-8234 | Disease | denotes | Pancreatic Diseases | http://purl.obolibrary.org/obo/MONDO_0002356 |
| T163 | 8305-8324 | Disease | denotes | pancreatic diseases | http://purl.obolibrary.org/obo/MONDO_0002356 |
| T164 | 8336-8341 | Disease | denotes | IPMNs | http://purl.obolibrary.org/obo/MONDO_0004286 |
| T165 | 8343-8348 | Disease | denotes | pNETs | http://purl.obolibrary.org/obo/MONDO_0019954 |
| T166 | 8350-8370 | Disease | denotes | chronic pancreatitis | http://purl.obolibrary.org/obo/MONDO_0005003 |
| T167 | 8358-8370 | Disease | denotes | pancreatitis | http://purl.obolibrary.org/obo/MONDO_0004982 |
| T168 | 8460-8480 | Disease | denotes | chronic pancreatitis | http://purl.obolibrary.org/obo/MONDO_0005003 |
| T169 | 8468-8480 | Disease | denotes | pancreatitis | http://purl.obolibrary.org/obo/MONDO_0004982 |
| T170 | 8526-8531 | Disease | denotes | pNETs | http://purl.obolibrary.org/obo/MONDO_0019954 |
| T171 | 8584-8589 | Disease | denotes | pNETs | http://purl.obolibrary.org/obo/MONDO_0019954 |
| T172 | 8593-8598 | Disease | denotes | IPMNs | http://purl.obolibrary.org/obo/MONDO_0004286 |
| T173 | 8915-8923 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T174 | 9716-9724 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T175 | 10645-10664 | Disease | denotes | pancreatic diseases | http://purl.obolibrary.org/obo/MONDO_0002356 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T27 | 314-315 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T28 | 355-356 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T29 | 413-420 | http://www.ebi.ac.uk/efo/EFO_0000881 | denotes | Digital |
| T30 | 995-996 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T31 | 1504-1506 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T32 | 2694-2695 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T33 | 3283-3284 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T34 | 3380-3383 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T35 | 3501-3502 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T36 | 3516-3525 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | objective |
| T37 | 4070-4077 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T38 | 4115-4116 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T39 | 4214-4219 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
| T40 | 4303-4308 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T41 | 4373-4377 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
| T42 | 4460-4461 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T43 | 4631-4638 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T44 | 5466-5468 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T45 | 5518-5527 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | objective |
| T46 | 6008-6009 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T47 | 6408-6417 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | objective |
| T48 | 6418-6426 | http://purl.obolibrary.org/obo/UBERON_0001264 | denotes | pancreas |
| T49 | 6548-6550 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T50 | 6592-6593 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T51 | 6942-6945 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T52 | 7336-7345 | http://purl.obolibrary.org/obo/UBERON_0002394 | denotes | bile duct |
| T53 | 7421-7423 | http://purl.obolibrary.org/obo/CLO_0054055 | denotes | 71 |
| T54 | 7603-7612 | http://purl.obolibrary.org/obo/UBERON_0002394 | denotes | bile duct |
| T55 | 7742-7744 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T56 | 7754-7755 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T57 | 8119-8121 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T58 | 9413-9416 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T59 | 9470-9475 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T60 | 9470-9475 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T61 | 9482-9489 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T62 | 10335-10336 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T63 | 10674-10675 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T64 | 10791-10792 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T3 | 720-728 | Chemical | denotes | adjuvant | http://purl.obolibrary.org/obo/CHEBI_60809 |
| T4 | 1058-1066 | Chemical | denotes | adjuvant | http://purl.obolibrary.org/obo/CHEBI_60809 |
| T5 | 1177-1185 | Chemical | denotes | adjuvant | http://purl.obolibrary.org/obo/CHEBI_60809 |
| T6 | 10693-10698 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 8396-8404 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T2 | 8396-8404 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T3 | 8396-8404 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T4 | 8396-8404 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T5 | 8504-8512 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T6 | 8504-8512 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T7 | 8504-8512 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T8 | 8504-8512 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T76 | 0-10 | Sentence | denotes | DISCUSSION |
| T77 | 11-135 | Sentence | denotes | This global survey study aimed to clarify the role of pancreatic surgery during the COVID-19 pandemic through 21 statements. |
| T78 | 136-354 | Sentence | denotes | The statements regarding patient selection for the oncological and surgical treatment of pancreatic diseases could assist clinicians in their clinical decision-making and create a starting point for further discussion. |
| T79 | 355-544 | Sentence | denotes | A literature review was performed (see Table—Supplemental Digital Content 5, for the search strategy) to evaluate the current evidence about pancreatic surgery during the COVID-19 pandemic. |
| T80 | 545-737 | Sentence | denotes | Kutikov et al6 concluded that (suspected) pancreatic cancer does not allow any treatment delay and, therefore, requires immediate surgical treatment, but did not address (neo)adjuvant therapy. |
| T81 | 738-1135 | Sentence | denotes | Patients with both COVID-19 and cancer or treated with chemotherapy/surgery in the last months seem to be at risk for severe events (ie, ICU admission requiring invasive ventilation, or death) in comparison to COVID-19 patients without cancer, according to a Chinese series.4 Therefore, Liang et al4 advised to postpone adjuvant chemotherapy or elective surgery for stable cancer in endemic areas. |
| T82 | 1136-1289 | Sentence | denotes | In contrast, Ueda et al7 emphasized that adjuvant therapy with curative intent for solid tumors should proceed, and surgery needs prioritization as well. |
| T83 | 1290-2031 | Sentence | denotes | This latter statement is supported by the Society of Surgical Oncology (SSO), stating that hepato-pancreato-biliary malignancies are typically aggressive and, therefore, should not be considered as “elective” care.11 In addition, the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) and the European Association of Endoscopic Surgery recommended to postpone all elective surgery with exception of surgical care for life threatening diseases such as progressive malignancies.12 Nevertheless, the limited evidence regarding the role of pancreatic surgery in the era of the COVID-19 pandemic underlines the need for an international survey with clear statements, aiming to guide clinicians in their clinical decision-making. |
| T84 | 2032-2187 | Sentence | denotes | The statement outcomes of the present international expert survey revealed several consensus statements as well as statements that need further discussion. |
| T85 | 2189-2195 | Sentence | denotes | Triage |
| T86 | 2196-2374 | Sentence | denotes | Patients with increased risk for postoperative respiratory failure should not be prioritized for surgery in absence of full hospital capacity, according to consensus statement 6. |
| T87 | 2375-2582 | Sentence | denotes | In contrast, only 61% agreement was reached on statement 5 comprising the proposition for surgery only for patients with limited/without comorbidity to minimize the use of ICU capacity for COVID-19 patients. |
| T88 | 2583-3250 | Sentence | denotes | The American College of Surgeons (ACS) underlined consensus statement 6, stating that “For elective cases with a high likelihood of postoperative ICU or respirator utilization, it will be more imperative that the risk of delay to the individual patient is balanced against the imminent availability of these resources for patients with COVID-19.”13 The aggressive biology of pancreatic cancer justifies elective pancreatic surgery as indispensable care12 and, therefore, should not be exclusively performed for very low risk patients as prevention to overload hospital resources (see the section “Pancreatic cancer” below for further explanation and recommendations). |
| T89 | 3251-3314 | Sentence | denotes | This could be the rationale for a low agreement on statement 5. |
| T90 | 3315-3853 | Sentence | denotes | The ACS emphasized that continuation of “elective” surgical care has to be frequently evaluated and adapted if needed, based on the impact of the COVID-19 pandemic on local resources.13 A reliable and objective model is needed to stratify patients and guide prioritization in accordance to hospital capabilities, such as the recently developed respiratory failure risk score for elective abdominal and vascular surgery, that identified pancreatic surgery among others as an independent risk factor for postoperative respiratory failure.14 |
| T91 | 3855-3892 | Sentence | denotes | Screening and Protection for COVID-19 |
| T92 | 3893-4009 | Sentence | denotes | Before pancreatic surgery, most centers represented in this survey screened their patients for symptoms of COVID-19. |
| T93 | 4010-4103 | Sentence | denotes | No consensus was reached to recommend COVID-19 preoperative testing/screening (statement 19). |
| T94 | 4104-4252 | Sentence | denotes | This seems a plea to obligate some type of screening, but not necessarily with PCR and/or computed tomography chest, particularly considering SAGES. |
| T95 | 4253-4673 | Sentence | denotes | SAGES underlines the recommendation of the Corona Virus Global Surgical Collaborative to perform some type of screening test for all patients (even if asymptomatic and without risk factors) who will undergo a surgical or interventional endoscopic procedure in institutions seeing high volumes of COVID-19 patients.12 In addition, ACS advised to wait for the results of COVID-19 testing in patients who may be infected.13 |
| T96 | 4674-5011 | Sentence | denotes | Based on consensus, patients who will undergo pancreatic surgery should be informed about the following additional risks: COVID-19 infection during hospitalization, possible nonoptimal postoperative management (ie, shortage of ICU beds), increased risk of COVID-19 related mortality due to surgery or the cancer condition (statement 17). |
| T97 | 5012-5257 | Sentence | denotes | Furthermore, this survey convincingly recommends that operating room (OR) personnel have to wear adequate protective features during surgery, considering their increased risk for COVID-19 infection during surgical procedures (statement 20).15,16 |
| T98 | 5259-5276 | Sentence | denotes | Pancreatic Cancer |
| T99 | 5277-5594 | Sentence | denotes | According to the consensus statements for patients with pancreatic cancer, each patient should be operated after completing neoadjuvant therapy (statement 1), as is also advised by the SSO.11 However, patients should be prioritized based on objective prognostic factors and comorbidities in case of limited resources. |
| T100 | 5595-5814 | Sentence | denotes | If surgery is postponed, patients should continue with neoadjuvant therapy (statement 3), but neoadjuvant therapy should not be used to select each patient with nonmetastatic pancreatic cancer for surgery (statement 2). |
| T101 | 5815-5963 | Sentence | denotes | Subsequently, patients with postponed surgery need to be evaluated as soon as possible for surgery when resources are available again (statement 7). |
| T102 | 5964-6179 | Sentence | denotes | Oba et al17 recently described the value of a new nomogram for pancreatic cancer, estimating patients’ predicted survival based on preoperative factors and confirmed the prognostic power of known predictive factors. |
| T103 | 6180-6288 | Sentence | denotes | These models could be used for prioritization of surgery for pancreatic cancer in case of limited resources. |
| T104 | 6289-6523 | Sentence | denotes | However, no consensus was reached on statement 4 and 5 to prioritize each pancreatic cancer patient on comorbidity and objective pancreas cancer-related prognostic factors, considering the life threatening nature of pancreatic cancer. |
| T105 | 6524-6741 | Sentence | denotes | Nevertheless, statement 18—prioritization of COVID-19 patients with a better prognosis over pancreatic cancer patients adhering to the process of triage for hospital resources and ICU beds—did not reach 60% agreement. |
| T106 | 6742-6865 | Sentence | denotes | However, the difficulty to prioritize between patients with severe COVID-19 or resectable pancreatic cancer is conceivable. |
| T107 | 6866-6935 | Sentence | denotes | See the section “Triage” for further explanation and recommendations. |
| T108 | 6936-7241 | Sentence | denotes | Italy has demonstrated the feasibility of continuing crucial cancer care during the COVID-19 pandemic, among others by appropriate resource allocation and separate health care pathways between COVID-19 patients and noninfected cancer patients, structured by performance criteria (eg, hospital volume).3,18 |
| T109 | 7243-7297 | Sentence | denotes | Periampullary Malignancies (Without Pancreatic Cancer) |
| T110 | 7298-7388 | Sentence | denotes | Statement 8 proposed to manage distal bile duct cancer as equivalent to pancreatic cancer. |
| T111 | 7389-7569 | Sentence | denotes | However, the lack of consensus (71%) implies that surgery might have slightly less priority in comparison to pancreatic cancer since 23% of respondents disagreed on the other hand. |
| T112 | 7570-7977 | Sentence | denotes | The SSO stated that extrahepatic bile duct cancer and ampullary and duodenal adenocarcinomas should be operated as soon as feasible, regardless of the presence of symptoms.11 However, a high disagreement rate (40%) was reached on statement 15 for postponing surgery or giving neoadjuvant chemotherapy for duodenal and ampullary cancers in absence of life threatening risks (ie, bleeding, bowel obstruction). |
| T113 | 7978-8190 | Sentence | denotes | Since evidence is limited about the efficacy of neoadjuvant chemotherapy for these cancers so far and could not be deemed to stable diseases,11 many physicians might thought these should be resected as indicated. |
| T114 | 8192-8234 | Sentence | denotes | Benign or Premalignant Pancreatic Diseases |
| T115 | 8235-8405 | Sentence | denotes | Consensus was reached to postpone surgery for benign and premalignant pancreatic diseases, including IPMNs, pNETs, chronic pancreatitis, and infected pancreatic necrosis. |
| T116 | 8406-8647 | Sentence | denotes | Exceptions comprise life threatening complications of chronic pancreatitis or infected pancreatic necrosis, symptomatic pNETs without effective alternative treatment options, or pNETs or IPMNs with suspicion for malignancy (statements 9–14). |
| T117 | 8649-8665 | Sentence | denotes | High-Volume Care |
| T118 | 8666-9040 | Sentence | denotes | Volume–outcome relationships in pancreatic surgery are well established with shorter hospital stay and lower mortality in high-volume centers.10,19,20 Pancreatic surgery in high-risk patients should not be performed in low-volume centers during the COVID-19 pandemic, aiming to reduce the risk of long hospital stay and major complications requiring ICU care (statement 16). |
| T119 | 9041-9159 | Sentence | denotes | Remarkably, the sensitivity analysis revealed that only Europe reached consensus in contrast to Asia and the Americas. |
| T120 | 9161-9187 | Sentence | denotes | Minimally Invasive Surgery |
| T121 | 9188-9385 | Sentence | denotes | Statement 21 demonstrated the limited evidence regarding the safety of minimally invasive surgery, illustrated by the substantial percentage of respondents who agreed (65%) or were uncertain (24%). |
| T122 | 9386-9618 | Sentence | denotes | Although previous research has shown that laparoscopy can lead to aerosolization of blood borne viruses,21,16,15 SAGES advised to continue to perform minimally invasive surgery in accordance to their risk reducing procedural advice. |
| T123 | 9619-10230 | Sentence | denotes | SAGES will monitor emerging evidence considering the limited evidence about the relative risk of COVID-19 spreading in the OR by minimally invasive surgery in comparison to conventional open surgery.12 The ACS mentioned that aerosol-generating procedures increase the risk for OR personnel and may not be avoidable, but confirmed the insufficiency of evidence to recommend or discommend minimally invasive surgery.13 Meanwhile, SAGES underlined the proven benefits of minimally invasive surgery to reduce postoperative morbidity and hospital stay and, therefore, should be strongly considered in these patients. |
| T124 | 10232-10257 | Sentence | denotes | Strengths and Limitations |
| T125 | 10258-10376 | Sentence | denotes | The strength of this survey is the global range of respondents, representing a wide range of countries and continents. |
| T126 | 10377-10449 | Sentence | denotes | However, the results should be interpreted in light of some limitations. |
| T127 | 10450-10665 | Sentence | denotes | First, only 10.4% nonsurgeons (eg, medical oncologists and gastroenterologists) participated in this survey, which could possibly outbalance the discussion regarding the oncological treatment of pancreatic diseases. |
| T128 | 10666-10778 | Sentence | denotes | Second, a relatively small group of 8 countries was responsible for the majority of survey participants (76.6%). |
| T129 | 10779-10854 | Sentence | denotes | Third, only a minority of participants represented the nonacademic centers. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T12 | 225-244 | Phenotype | denotes | pancreatic diseases | http://purl.obolibrary.org/obo/HP_0001732 |
| T13 | 587-604 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T14 | 770-776 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T15 | 974-980 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T16 | 1111-1117 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T17 | 1352-1360 | Phenotype | denotes | Oncology | http://purl.obolibrary.org/obo/HP_0002664 |
| T18 | 2243-2262 | Phenotype | denotes | respiratory failure | http://purl.obolibrary.org/obo/HP_0002878 |
| T19 | 2958-2975 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T20 | 3180-3197 | Phenotype | denotes | Pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T21 | 3659-3678 | Phenotype | denotes | respiratory failure | http://purl.obolibrary.org/obo/HP_0002878 |
| T22 | 3831-3850 | Phenotype | denotes | respiratory failure | http://purl.obolibrary.org/obo/HP_0002878 |
| T23 | 4979-4985 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T24 | 5259-5276 | Phenotype | denotes | Pancreatic Cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T25 | 5333-5350 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T26 | 5770-5787 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T27 | 6027-6044 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T28 | 6241-6258 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T29 | 6363-6380 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T30 | 6427-6433 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T31 | 6505-6522 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T32 | 6616-6633 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T33 | 6832-6849 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T34 | 6997-7003 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T35 | 7163-7169 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T36 | 7279-7296 | Phenotype | denotes | Pancreatic Cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T37 | 7336-7352 | Phenotype | denotes | bile duct cancer | http://purl.obolibrary.org/obo/HP_0030153 |
| T38 | 7370-7387 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T39 | 7498-7515 | Phenotype | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/HP_0002894 |
| T40 | 7603-7619 | Phenotype | denotes | bile duct cancer | http://purl.obolibrary.org/obo/HP_0030153 |
| T41 | 7638-7662 | Phenotype | denotes | duodenal adenocarcinomas | http://purl.obolibrary.org/obo/HP_0006771 |
| T42 | 7958-7975 | Phenotype | denotes | bowel obstruction | http://purl.obolibrary.org/obo/HP_0005214 |
| T43 | 8215-8234 | Phenotype | denotes | Pancreatic Diseases | http://purl.obolibrary.org/obo/HP_0001732 |
| T44 | 8305-8324 | Phenotype | denotes | pancreatic diseases | http://purl.obolibrary.org/obo/HP_0001732 |
| T45 | 8350-8370 | Phenotype | denotes | chronic pancreatitis | http://purl.obolibrary.org/obo/HP_0006280 |
| T46 | 8460-8480 | Phenotype | denotes | chronic pancreatitis | http://purl.obolibrary.org/obo/HP_0006280 |
| T47 | 10645-10664 | Phenotype | denotes | pancreatic diseases | http://purl.obolibrary.org/obo/HP_0001732 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32675507-32066541-3180347 | 1012-1013 | 32066541 | denotes | 4 |
| 32675507-32066541-3180348 | 1036-1037 | 32066541 | denotes | 4 |
| 32675507-27607099-3180349 | 3851-3853 | 27607099 | denotes | 14 |
| 32675507-24570016-3180350 | 5252-5254 | 24570016 | denotes | 15 |
| 32675507-27484956-3180351 | 5255-5257 | 27484956 | denotes | 16 |
| 32675507-26636243-3180352 | 8808-8810 | 26636243 | denotes | 10 |
| 32675507-27037200-3180353 | 8811-8813 | 27037200 | denotes | 19 |
| 32675507-29571615-3180354 | 8814-8816 | 29571615 | denotes | 20 |
| 32675507-16002179-3180355 | 9490-9492 | 16002179 | denotes | 21 |
| 32675507-27484956-3180356 | 9493-9495 | 27484956 | denotes | 16 |
| 32675507-24570016-3180357 | 9496-9498 | 24570016 | denotes | 15 |