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PMC:7265874 / 756-1704
Annnotations
LitCovid-PD-FMA-UBERON
{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":146,"end":155},"obj":"Body_part"},{"id":"T2","span":{"begin":151,"end":155},"obj":"Body_part"},{"id":"T3","span":{"begin":159,"end":170},"obj":"Body_part"},{"id":"T4","span":{"begin":537,"end":547},"obj":"Body_part"},{"id":"T5","span":{"begin":707,"end":715},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma63368"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma55670"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma264783"}],"text":"Invasive pulmonary aspergillosis (IPA) is a well-known complication in immunocompromised patients and is encountered frequently in haematopoietic stem cell or solid organ transplant recipients [2]. Continued improvement in diagnostics has revealed that half of the cases of IPA occur in the ICU, in patients who are often non-neutropenic [3, 4]. Severe influenza infection is a well-known risk factor for developing IPA in non-neutropenic patients; a syndrome termed influenza-associated aspergillosis (IAA) [4–6]. A damaged respiratory epithelium, dysfunctional mucociliary clearance and a local immune paralysis were demonstrated to be key pathophysiological factors [4]. Supported by the hypothesis that alveolar damage facilitates fungal invasion, acute respiratory distress syndrome (ARDS) has frequently been associated with IPA in the ICU [6]. With this in mind, the existence of COVID-19-associated pulmonary aspergillosis is deemed likely."}
LitCovid-PD-UBERON
{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":165,"end":170},"obj":"Body_part"},{"id":"T2","span":{"begin":537,"end":547},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"}],"text":"Invasive pulmonary aspergillosis (IPA) is a well-known complication in immunocompromised patients and is encountered frequently in haematopoietic stem cell or solid organ transplant recipients [2]. Continued improvement in diagnostics has revealed that half of the cases of IPA occur in the ICU, in patients who are often non-neutropenic [3, 4]. Severe influenza infection is a well-known risk factor for developing IPA in non-neutropenic patients; a syndrome termed influenza-associated aspergillosis (IAA) [4–6]. A damaged respiratory epithelium, dysfunctional mucociliary clearance and a local immune paralysis were demonstrated to be key pathophysiological factors [4]. Supported by the hypothesis that alveolar damage facilitates fungal invasion, acute respiratory distress syndrome (ARDS) has frequently been associated with IPA in the ICU [6]. With this in mind, the existence of COVID-19-associated pulmonary aspergillosis is deemed likely."}
LitCovid-PD-MONDO
{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T7","span":{"begin":19,"end":32},"obj":"Disease"},{"id":"T8","span":{"begin":353,"end":372},"obj":"Disease"},{"id":"T9","span":{"begin":363,"end":372},"obj":"Disease"},{"id":"T10","span":{"begin":467,"end":476},"obj":"Disease"},{"id":"T11","span":{"begin":488,"end":501},"obj":"Disease"},{"id":"T12","span":{"begin":752,"end":787},"obj":"Disease"},{"id":"T13","span":{"begin":758,"end":787},"obj":"Disease"},{"id":"T14","span":{"begin":789,"end":793},"obj":"Disease"},{"id":"T15","span":{"begin":887,"end":895},"obj":"Disease"},{"id":"T16","span":{"begin":917,"end":930},"obj":"Disease"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"}],"text":"Invasive pulmonary aspergillosis (IPA) is a well-known complication in immunocompromised patients and is encountered frequently in haematopoietic stem cell or solid organ transplant recipients [2]. Continued improvement in diagnostics has revealed that half of the cases of IPA occur in the ICU, in patients who are often non-neutropenic [3, 4]. Severe influenza infection is a well-known risk factor for developing IPA in non-neutropenic patients; a syndrome termed influenza-associated aspergillosis (IAA) [4–6]. A damaged respiratory epithelium, dysfunctional mucociliary clearance and a local immune paralysis were demonstrated to be key pathophysiological factors [4]. Supported by the hypothesis that alveolar damage facilitates fungal invasion, acute respiratory distress syndrome (ARDS) has frequently been associated with IPA in the ICU [6]. With this in mind, the existence of COVID-19-associated pulmonary aspergillosis is deemed likely."}
LitCovid-PD-CLO
{"project":"LitCovid-PD-CLO","denotations":[{"id":"T5","span":{"begin":42,"end":43},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":146,"end":155},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T7","span":{"begin":165,"end":170},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T8","span":{"begin":235,"end":238},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T9","span":{"begin":339,"end":343},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T10","span":{"begin":376,"end":377},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T11","span":{"begin":449,"end":450},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T12","span":{"begin":515,"end":516},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T13","span":{"begin":525,"end":547},"obj":"http://purl.obolibrary.org/obo/UBERON_0004802"},{"id":"T14","span":{"begin":589,"end":590},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T15","span":{"begin":795,"end":798},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"Invasive pulmonary aspergillosis (IPA) is a well-known complication in immunocompromised patients and is encountered frequently in haematopoietic stem cell or solid organ transplant recipients [2]. Continued improvement in diagnostics has revealed that half of the cases of IPA occur in the ICU, in patients who are often non-neutropenic [3, 4]. Severe influenza infection is a well-known risk factor for developing IPA in non-neutropenic patients; a syndrome termed influenza-associated aspergillosis (IAA) [4–6]. A damaged respiratory epithelium, dysfunctional mucociliary clearance and a local immune paralysis were demonstrated to be key pathophysiological factors [4]. Supported by the hypothesis that alveolar damage facilitates fungal invasion, acute respiratory distress syndrome (ARDS) has frequently been associated with IPA in the ICU [6]. With this in mind, the existence of COVID-19-associated pulmonary aspergillosis is deemed likely."}
LitCovid-PD-CHEBI
{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":34,"end":37},"obj":"Chemical"},{"id":"T3","span":{"begin":274,"end":277},"obj":"Chemical"},{"id":"T5","span":{"begin":416,"end":419},"obj":"Chemical"},{"id":"T7","span":{"begin":503,"end":506},"obj":"Chemical"},{"id":"T8","span":{"begin":831,"end":834},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A2","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A4","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A6","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_16411"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A9","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"}],"text":"Invasive pulmonary aspergillosis (IPA) is a well-known complication in immunocompromised patients and is encountered frequently in haematopoietic stem cell or solid organ transplant recipients [2]. Continued improvement in diagnostics has revealed that half of the cases of IPA occur in the ICU, in patients who are often non-neutropenic [3, 4]. Severe influenza infection is a well-known risk factor for developing IPA in non-neutropenic patients; a syndrome termed influenza-associated aspergillosis (IAA) [4–6]. A damaged respiratory epithelium, dysfunctional mucociliary clearance and a local immune paralysis were demonstrated to be key pathophysiological factors [4]. Supported by the hypothesis that alveolar damage facilitates fungal invasion, acute respiratory distress syndrome (ARDS) has frequently been associated with IPA in the ICU [6]. With this in mind, the existence of COVID-19-associated pulmonary aspergillosis is deemed likely."}
LitCovid-PD-GO-BP
{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":563,"end":584},"obj":"http://purl.obolibrary.org/obo/GO_0120197"}],"text":"Invasive pulmonary aspergillosis (IPA) is a well-known complication in immunocompromised patients and is encountered frequently in haematopoietic stem cell or solid organ transplant recipients [2]. Continued improvement in diagnostics has revealed that half of the cases of IPA occur in the ICU, in patients who are often non-neutropenic [3, 4]. Severe influenza infection is a well-known risk factor for developing IPA in non-neutropenic patients; a syndrome termed influenza-associated aspergillosis (IAA) [4–6]. A damaged respiratory epithelium, dysfunctional mucociliary clearance and a local immune paralysis were demonstrated to be key pathophysiological factors [4]. Supported by the hypothesis that alveolar damage facilitates fungal invasion, acute respiratory distress syndrome (ARDS) has frequently been associated with IPA in the ICU [6]. With this in mind, the existence of COVID-19-associated pulmonary aspergillosis is deemed likely."}
LitCovid-PD-HP
{"project":"LitCovid-PD-HP","denotations":[{"id":"T3","span":{"begin":0,"end":32},"obj":"Phenotype"},{"id":"T4","span":{"begin":34,"end":37},"obj":"Phenotype"},{"id":"T5","span":{"begin":274,"end":277},"obj":"Phenotype"},{"id":"T6","span":{"begin":416,"end":419},"obj":"Phenotype"},{"id":"T7","span":{"begin":604,"end":613},"obj":"Phenotype"},{"id":"T8","span":{"begin":758,"end":778},"obj":"Phenotype"},{"id":"T9","span":{"begin":831,"end":834},"obj":"Phenotype"}],"attributes":[{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0003470"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0020103"}],"text":"Invasive pulmonary aspergillosis (IPA) is a well-known complication in immunocompromised patients and is encountered frequently in haematopoietic stem cell or solid organ transplant recipients [2]. Continued improvement in diagnostics has revealed that half of the cases of IPA occur in the ICU, in patients who are often non-neutropenic [3, 4]. Severe influenza infection is a well-known risk factor for developing IPA in non-neutropenic patients; a syndrome termed influenza-associated aspergillosis (IAA) [4–6]. A damaged respiratory epithelium, dysfunctional mucociliary clearance and a local immune paralysis were demonstrated to be key pathophysiological factors [4]. Supported by the hypothesis that alveolar damage facilitates fungal invasion, acute respiratory distress syndrome (ARDS) has frequently been associated with IPA in the ICU [6]. With this in mind, the existence of COVID-19-associated pulmonary aspergillosis is deemed likely."}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":0,"end":197},"obj":"Sentence"},{"id":"T8","span":{"begin":198,"end":345},"obj":"Sentence"},{"id":"T9","span":{"begin":346,"end":514},"obj":"Sentence"},{"id":"T10","span":{"begin":515,"end":673},"obj":"Sentence"},{"id":"T11","span":{"begin":674,"end":850},"obj":"Sentence"},{"id":"T12","span":{"begin":851,"end":948},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Invasive pulmonary aspergillosis (IPA) is a well-known complication in immunocompromised patients and is encountered frequently in haematopoietic stem cell or solid organ transplant recipients [2]. Continued improvement in diagnostics has revealed that half of the cases of IPA occur in the ICU, in patients who are often non-neutropenic [3, 4]. Severe influenza infection is a well-known risk factor for developing IPA in non-neutropenic patients; a syndrome termed influenza-associated aspergillosis (IAA) [4–6]. A damaged respiratory epithelium, dysfunctional mucociliary clearance and a local immune paralysis were demonstrated to be key pathophysiological factors [4]. Supported by the hypothesis that alveolar damage facilitates fungal invasion, acute respiratory distress syndrome (ARDS) has frequently been associated with IPA in the ICU [6]. With this in mind, the existence of COVID-19-associated pulmonary aspergillosis is deemed likely."}
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"27","span":{"begin":89,"end":97},"obj":"Species"},{"id":"28","span":{"begin":299,"end":307},"obj":"Species"},{"id":"29","span":{"begin":439,"end":447},"obj":"Species"},{"id":"30","span":{"begin":0,"end":32},"obj":"Disease"},{"id":"31","span":{"begin":363,"end":372},"obj":"Disease"},{"id":"32","span":{"begin":488,"end":501},"obj":"Disease"},{"id":"33","span":{"begin":604,"end":613},"obj":"Disease"},{"id":"34","span":{"begin":752,"end":787},"obj":"Disease"},{"id":"35","span":{"begin":789,"end":793},"obj":"Disease"},{"id":"36","span":{"begin":887,"end":895},"obj":"Disease"},{"id":"37","span":{"begin":907,"end":930},"obj":"Disease"}],"attributes":[{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:9606"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Tax:9606"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Tax:9606"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D055744"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:D007239"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D001228"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D010243"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D012128"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:D012128"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:C000657245"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D055732"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Invasive pulmonary aspergillosis (IPA) is a well-known complication in immunocompromised patients and is encountered frequently in haematopoietic stem cell or solid organ transplant recipients [2]. Continued improvement in diagnostics has revealed that half of the cases of IPA occur in the ICU, in patients who are often non-neutropenic [3, 4]. Severe influenza infection is a well-known risk factor for developing IPA in non-neutropenic patients; a syndrome termed influenza-associated aspergillosis (IAA) [4–6]. A damaged respiratory epithelium, dysfunctional mucociliary clearance and a local immune paralysis were demonstrated to be key pathophysiological factors [4]. Supported by the hypothesis that alveolar damage facilitates fungal invasion, acute respiratory distress syndrome (ARDS) has frequently been associated with IPA in the ICU [6]. With this in mind, the existence of COVID-19-associated pulmonary aspergillosis is deemed likely."}