PMC:7265102 / 4507-7328 JSON TXT

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LitCovid-PubTator

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T4","span":{"begin":1554,"end":1559},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma7088"}],"text":"COVID-19 and the Elderly\nThe risk posed by COVID-19 is higher for elderly people than for younger people.[2] For this reason, medical and political authorities should offer older adults strict preventive measures to minimise the risk of exposure and infection. In the event that an effective vaccine for SARS-CoV-2 is developed, priority should be given to vaccination of the elderly, with the aim of maximising the number of lives saved. This is also true for other preventive measures, such as possible pre- or post-exposure prophylaxis.[7]\nIn the case of people with COVID-19, the situation is different. When allocating resources in these scenarios, healthcare professionals might prioritise those most likely to survive over those with remote chances of survival. Making a decision based on chronological age is not justified. In addition to age, other aspects that determine theoretical life expectancy must be taken into account. Biological age and the use of frailty scales and comprehensive geriatric assessment are essential for this purpose. The recent statement of the Executive Board of the European Geriatric Medicine Society insists that advanced age alone should not be a criterion for excluding patients from specialised hospital units.[8] If an elderly patient is dismissed from a specialised hospital unit for any reason, access to medical attention, symptomatic treatment and palliative care must be ensured. This last point is essential, as palliative care is frequently suboptimal in elderly patients with other conditions, such as heart failure, and this is probably the case in COVID-19.[2,9,10]\n\nTherapeutic Adaptation after COVID-19 Admission\nIn patients with advanced age who are admitted to hospital due to a severe SARS-CoV-2 infection, it is very important to establish a therapeutic adaptation plan from the time of admission. This plan should be clearly documented in the clinical history, making it clear whether or not the patient is a candidate for mechanical ventilation and, in case of their condition worsening, when to propose the withdrawal of life-sustaining therapies (Table 1). Decisions that maximise survival to hospital discharge, the number of years of life saved and the possibility of living each of the stages of life can be prioritised. In this regard, patients with minimal expected benefit should not be admitted to ICU and the admission of patients with a life expectancy \u003c1–2 years should be carefully evaluated. This applies to patients of all ages. A utilitarian mentality should be applied, which should prevent prejudice against the elderly. For example, a frail elderly patient might have a low chance of surviving the prolonged intubation required to recover from COVID-19 pneumonia, but this is also the case for young patients with severe comorbidities.[11]\n"}

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T5","span":{"begin":975,"end":981},"obj":"Body_part"},{"id":"T6","span":{"begin":1554,"end":1559},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"}],"text":"COVID-19 and the Elderly\nThe risk posed by COVID-19 is higher for elderly people than for younger people.[2] For this reason, medical and political authorities should offer older adults strict preventive measures to minimise the risk of exposure and infection. In the event that an effective vaccine for SARS-CoV-2 is developed, priority should be given to vaccination of the elderly, with the aim of maximising the number of lives saved. This is also true for other preventive measures, such as possible pre- or post-exposure prophylaxis.[7]\nIn the case of people with COVID-19, the situation is different. When allocating resources in these scenarios, healthcare professionals might prioritise those most likely to survive over those with remote chances of survival. Making a decision based on chronological age is not justified. In addition to age, other aspects that determine theoretical life expectancy must be taken into account. Biological age and the use of frailty scales and comprehensive geriatric assessment are essential for this purpose. The recent statement of the Executive Board of the European Geriatric Medicine Society insists that advanced age alone should not be a criterion for excluding patients from specialised hospital units.[8] If an elderly patient is dismissed from a specialised hospital unit for any reason, access to medical attention, symptomatic treatment and palliative care must be ensured. This last point is essential, as palliative care is frequently suboptimal in elderly patients with other conditions, such as heart failure, and this is probably the case in COVID-19.[2,9,10]\n\nTherapeutic Adaptation after COVID-19 Admission\nIn patients with advanced age who are admitted to hospital due to a severe SARS-CoV-2 infection, it is very important to establish a therapeutic adaptation plan from the time of admission. This plan should be clearly documented in the clinical history, making it clear whether or not the patient is a candidate for mechanical ventilation and, in case of their condition worsening, when to propose the withdrawal of life-sustaining therapies (Table 1). Decisions that maximise survival to hospital discharge, the number of years of life saved and the possibility of living each of the stages of life can be prioritised. In this regard, patients with minimal expected benefit should not be admitted to ICU and the admission of patients with a life expectancy \u003c1–2 years should be carefully evaluated. This applies to patients of all ages. A utilitarian mentality should be applied, which should prevent prejudice against the elderly. For example, a frail elderly patient might have a low chance of surviving the prolonged intubation required to recover from COVID-19 pneumonia, but this is also the case for young patients with severe comorbidities.[11]\n"}

LitCovid-PD-MONDO

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T24","span":{"begin":394,"end":397},"obj":"http://purl.obolibrary.org/obo/PR_000001343"},{"id":"T25","span":{"begin":776,"end":777},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T26","span":{"begin":1186,"end":1187},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T27","span":{"begin":1297,"end":1298},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T28","span":{"begin":1554,"end":1559},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T29","span":{"begin":1554,"end":1559},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T30","span":{"begin":1554,"end":1559},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T31","span":{"begin":1554,"end":1559},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T32","span":{"begin":1735,"end":1736},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T33","span":{"begin":1800,"end":1801},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T34","span":{"begin":1968,"end":1969},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T35","span":{"begin":2408,"end":2409},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T36","span":{"begin":2506,"end":2507},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T37","span":{"begin":2614,"end":2615},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T38","span":{"begin":2649,"end":2650},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T39","span":{"begin":2817,"end":2819},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"}],"text":"COVID-19 and the Elderly\nThe risk posed by COVID-19 is higher for elderly people than for younger people.[2] For this reason, medical and political authorities should offer older adults strict preventive measures to minimise the risk of exposure and infection. In the event that an effective vaccine for SARS-CoV-2 is developed, priority should be given to vaccination of the elderly, with the aim of maximising the number of lives saved. This is also true for other preventive measures, such as possible pre- or post-exposure prophylaxis.[7]\nIn the case of people with COVID-19, the situation is different. When allocating resources in these scenarios, healthcare professionals might prioritise those most likely to survive over those with remote chances of survival. Making a decision based on chronological age is not justified. In addition to age, other aspects that determine theoretical life expectancy must be taken into account. Biological age and the use of frailty scales and comprehensive geriatric assessment are essential for this purpose. The recent statement of the Executive Board of the European Geriatric Medicine Society insists that advanced age alone should not be a criterion for excluding patients from specialised hospital units.[8] If an elderly patient is dismissed from a specialised hospital unit for any reason, access to medical attention, symptomatic treatment and palliative care must be ensured. This last point is essential, as palliative care is frequently suboptimal in elderly patients with other conditions, such as heart failure, and this is probably the case in COVID-19.[2,9,10]\n\nTherapeutic Adaptation after COVID-19 Admission\nIn patients with advanced age who are admitted to hospital due to a severe SARS-CoV-2 infection, it is very important to establish a therapeutic adaptation plan from the time of admission. This plan should be clearly documented in the clinical history, making it clear whether or not the patient is a candidate for mechanical ventilation and, in case of their condition worsening, when to propose the withdrawal of life-sustaining therapies (Table 1). Decisions that maximise survival to hospital discharge, the number of years of life saved and the possibility of living each of the stages of life can be prioritised. In this regard, patients with minimal expected benefit should not be admitted to ICU and the admission of patients with a life expectancy \u003c1–2 years should be carefully evaluated. This applies to patients of all ages. A utilitarian mentality should be applied, which should prevent prejudice against the elderly. For example, a frail elderly patient might have a low chance of surviving the prolonged intubation required to recover from COVID-19 pneumonia, but this is also the case for young patients with severe comorbidities.[11]\n"}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T41","span":{"begin":0,"end":24},"obj":"Sentence"},{"id":"T42","span":{"begin":25,"end":260},"obj":"Sentence"},{"id":"T43","span":{"begin":261,"end":438},"obj":"Sentence"},{"id":"T44","span":{"begin":439,"end":542},"obj":"Sentence"},{"id":"T45","span":{"begin":543,"end":607},"obj":"Sentence"},{"id":"T46","span":{"begin":608,"end":768},"obj":"Sentence"},{"id":"T47","span":{"begin":769,"end":831},"obj":"Sentence"},{"id":"T48","span":{"begin":832,"end":936},"obj":"Sentence"},{"id":"T49","span":{"begin":937,"end":1052},"obj":"Sentence"},{"id":"T50","span":{"begin":1053,"end":1428},"obj":"Sentence"},{"id":"T51","span":{"begin":1429,"end":1619},"obj":"Sentence"},{"id":"T52","span":{"begin":1621,"end":1668},"obj":"Sentence"},{"id":"T53","span":{"begin":1669,"end":1857},"obj":"Sentence"},{"id":"T54","span":{"begin":1858,"end":2120},"obj":"Sentence"},{"id":"T55","span":{"begin":2121,"end":2287},"obj":"Sentence"},{"id":"T56","span":{"begin":2288,"end":2467},"obj":"Sentence"},{"id":"T57","span":{"begin":2468,"end":2505},"obj":"Sentence"},{"id":"T58","span":{"begin":2506,"end":2600},"obj":"Sentence"},{"id":"T59","span":{"begin":2601,"end":2820},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"COVID-19 and the Elderly\nThe risk posed by COVID-19 is higher for elderly people than for younger people.[2] For this reason, medical and political authorities should offer older adults strict preventive measures to minimise the risk of exposure and infection. In the event that an effective vaccine for SARS-CoV-2 is developed, priority should be given to vaccination of the elderly, with the aim of maximising the number of lives saved. This is also true for other preventive measures, such as possible pre- or post-exposure prophylaxis.[7]\nIn the case of people with COVID-19, the situation is different. When allocating resources in these scenarios, healthcare professionals might prioritise those most likely to survive over those with remote chances of survival. Making a decision based on chronological age is not justified. In addition to age, other aspects that determine theoretical life expectancy must be taken into account. Biological age and the use of frailty scales and comprehensive geriatric assessment are essential for this purpose. The recent statement of the Executive Board of the European Geriatric Medicine Society insists that advanced age alone should not be a criterion for excluding patients from specialised hospital units.[8] If an elderly patient is dismissed from a specialised hospital unit for any reason, access to medical attention, symptomatic treatment and palliative care must be ensured. This last point is essential, as palliative care is frequently suboptimal in elderly patients with other conditions, such as heart failure, and this is probably the case in COVID-19.[2,9,10]\n\nTherapeutic Adaptation after COVID-19 Admission\nIn patients with advanced age who are admitted to hospital due to a severe SARS-CoV-2 infection, it is very important to establish a therapeutic adaptation plan from the time of admission. This plan should be clearly documented in the clinical history, making it clear whether or not the patient is a candidate for mechanical ventilation and, in case of their condition worsening, when to propose the withdrawal of life-sustaining therapies (Table 1). Decisions that maximise survival to hospital discharge, the number of years of life saved and the possibility of living each of the stages of life can be prioritised. In this regard, patients with minimal expected benefit should not be admitted to ICU and the admission of patients with a life expectancy \u003c1–2 years should be carefully evaluated. This applies to patients of all ages. A utilitarian mentality should be applied, which should prevent prejudice against the elderly. For example, a frail elderly patient might have a low chance of surviving the prolonged intubation required to recover from COVID-19 pneumonia, but this is also the case for young patients with severe comorbidities.[11]\n"}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":1554,"end":1567},"obj":"Phenotype"},{"id":"T2","span":{"begin":1737,"end":1764},"obj":"Phenotype"},{"id":"T3","span":{"begin":2734,"end":2743},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0001635"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0033141"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"COVID-19 and the Elderly\nThe risk posed by COVID-19 is higher for elderly people than for younger people.[2] For this reason, medical and political authorities should offer older adults strict preventive measures to minimise the risk of exposure and infection. In the event that an effective vaccine for SARS-CoV-2 is developed, priority should be given to vaccination of the elderly, with the aim of maximising the number of lives saved. This is also true for other preventive measures, such as possible pre- or post-exposure prophylaxis.[7]\nIn the case of people with COVID-19, the situation is different. When allocating resources in these scenarios, healthcare professionals might prioritise those most likely to survive over those with remote chances of survival. Making a decision based on chronological age is not justified. In addition to age, other aspects that determine theoretical life expectancy must be taken into account. Biological age and the use of frailty scales and comprehensive geriatric assessment are essential for this purpose. The recent statement of the Executive Board of the European Geriatric Medicine Society insists that advanced age alone should not be a criterion for excluding patients from specialised hospital units.[8] If an elderly patient is dismissed from a specialised hospital unit for any reason, access to medical attention, symptomatic treatment and palliative care must be ensured. This last point is essential, as palliative care is frequently suboptimal in elderly patients with other conditions, such as heart failure, and this is probably the case in COVID-19.[2,9,10]\n\nTherapeutic Adaptation after COVID-19 Admission\nIn patients with advanced age who are admitted to hospital due to a severe SARS-CoV-2 infection, it is very important to establish a therapeutic adaptation plan from the time of admission. This plan should be clearly documented in the clinical history, making it clear whether or not the patient is a candidate for mechanical ventilation and, in case of their condition worsening, when to propose the withdrawal of life-sustaining therapies (Table 1). Decisions that maximise survival to hospital discharge, the number of years of life saved and the possibility of living each of the stages of life can be prioritised. In this regard, patients with minimal expected benefit should not be admitted to ICU and the admission of patients with a life expectancy \u003c1–2 years should be carefully evaluated. This applies to patients of all ages. A utilitarian mentality should be applied, which should prevent prejudice against the elderly. For example, a frail elderly patient might have a low chance of surviving the prolonged intubation required to recover from COVID-19 pneumonia, but this is also the case for young patients with severe comorbidities.[11]\n"}

2_test

{"project":"2_test","denotations":[{"id":"32514316-32202722-28782519","span":{"begin":540,"end":541},"obj":"32202722"},{"id":"32514316-31761573-28782520","span":{"begin":1614,"end":1615},"obj":"31761573"},{"id":"32514316-31386104-28782521","span":{"begin":1616,"end":1618},"obj":"31386104"},{"id":"32514316-32187459-28782522","span":{"begin":2817,"end":2819},"obj":"32187459"}],"text":"COVID-19 and the Elderly\nThe risk posed by COVID-19 is higher for elderly people than for younger people.[2] For this reason, medical and political authorities should offer older adults strict preventive measures to minimise the risk of exposure and infection. In the event that an effective vaccine for SARS-CoV-2 is developed, priority should be given to vaccination of the elderly, with the aim of maximising the number of lives saved. This is also true for other preventive measures, such as possible pre- or post-exposure prophylaxis.[7]\nIn the case of people with COVID-19, the situation is different. When allocating resources in these scenarios, healthcare professionals might prioritise those most likely to survive over those with remote chances of survival. Making a decision based on chronological age is not justified. In addition to age, other aspects that determine theoretical life expectancy must be taken into account. Biological age and the use of frailty scales and comprehensive geriatric assessment are essential for this purpose. The recent statement of the Executive Board of the European Geriatric Medicine Society insists that advanced age alone should not be a criterion for excluding patients from specialised hospital units.[8] If an elderly patient is dismissed from a specialised hospital unit for any reason, access to medical attention, symptomatic treatment and palliative care must be ensured. This last point is essential, as palliative care is frequently suboptimal in elderly patients with other conditions, such as heart failure, and this is probably the case in COVID-19.[2,9,10]\n\nTherapeutic Adaptation after COVID-19 Admission\nIn patients with advanced age who are admitted to hospital due to a severe SARS-CoV-2 infection, it is very important to establish a therapeutic adaptation plan from the time of admission. This plan should be clearly documented in the clinical history, making it clear whether or not the patient is a candidate for mechanical ventilation and, in case of their condition worsening, when to propose the withdrawal of life-sustaining therapies (Table 1). Decisions that maximise survival to hospital discharge, the number of years of life saved and the possibility of living each of the stages of life can be prioritised. In this regard, patients with minimal expected benefit should not be admitted to ICU and the admission of patients with a life expectancy \u003c1–2 years should be carefully evaluated. This applies to patients of all ages. A utilitarian mentality should be applied, which should prevent prejudice against the elderly. For example, a frail elderly patient might have a low chance of surviving the prolonged intubation required to recover from COVID-19 pneumonia, but this is also the case for young patients with severe comorbidities.[11]\n"}

MyTest

{"project":"MyTest","denotations":[{"id":"32514316-32202722-28782519","span":{"begin":540,"end":541},"obj":"32202722"},{"id":"32514316-31761573-28782520","span":{"begin":1614,"end":1615},"obj":"31761573"},{"id":"32514316-31386104-28782521","span":{"begin":1616,"end":1618},"obj":"31386104"},{"id":"32514316-32187459-28782522","span":{"begin":2817,"end":2819},"obj":"32187459"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"COVID-19 and the Elderly\nThe risk posed by COVID-19 is higher for elderly people than for younger people.[2] For this reason, medical and political authorities should offer older adults strict preventive measures to minimise the risk of exposure and infection. In the event that an effective vaccine for SARS-CoV-2 is developed, priority should be given to vaccination of the elderly, with the aim of maximising the number of lives saved. This is also true for other preventive measures, such as possible pre- or post-exposure prophylaxis.[7]\nIn the case of people with COVID-19, the situation is different. When allocating resources in these scenarios, healthcare professionals might prioritise those most likely to survive over those with remote chances of survival. Making a decision based on chronological age is not justified. In addition to age, other aspects that determine theoretical life expectancy must be taken into account. Biological age and the use of frailty scales and comprehensive geriatric assessment are essential for this purpose. The recent statement of the Executive Board of the European Geriatric Medicine Society insists that advanced age alone should not be a criterion for excluding patients from specialised hospital units.[8] If an elderly patient is dismissed from a specialised hospital unit for any reason, access to medical attention, symptomatic treatment and palliative care must be ensured. This last point is essential, as palliative care is frequently suboptimal in elderly patients with other conditions, such as heart failure, and this is probably the case in COVID-19.[2,9,10]\n\nTherapeutic Adaptation after COVID-19 Admission\nIn patients with advanced age who are admitted to hospital due to a severe SARS-CoV-2 infection, it is very important to establish a therapeutic adaptation plan from the time of admission. This plan should be clearly documented in the clinical history, making it clear whether or not the patient is a candidate for mechanical ventilation and, in case of their condition worsening, when to propose the withdrawal of life-sustaining therapies (Table 1). Decisions that maximise survival to hospital discharge, the number of years of life saved and the possibility of living each of the stages of life can be prioritised. In this regard, patients with minimal expected benefit should not be admitted to ICU and the admission of patients with a life expectancy \u003c1–2 years should be carefully evaluated. This applies to patients of all ages. A utilitarian mentality should be applied, which should prevent prejudice against the elderly. For example, a frail elderly patient might have a low chance of surviving the prolonged intubation required to recover from COVID-19 pneumonia, but this is also the case for young patients with severe comorbidities.[11]\n"}

PMC:7265102 / 4507-7328 JSONTXT

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PMC:7265102 / 4507-7328 JSON TXT