PMC:7264932 / 79-4637
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 8 | 155-163 | Species | denotes | patients | Tax:9606 |
| 9 | 42-74 | Disease | denotes | invasive pulmonary aspergillosis | MESH:D055744 |
| 10 | 121-136 | Disease | denotes | viral pneumonia | |
| 11 | 140-154 | Disease | denotes | critically ill | MESH:D016638 |
| 16 | 217-241 | Disease | denotes | coronavirus disease 2019 | MESH:C000657245 |
| 17 | 243-251 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 18 | 265-300 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 19 | 484-504 | Disease | denotes | secondary infections | MESH:D060085 |
| 25 | 545-553 | Species | denotes | patients | Tax:9606 |
| 26 | 670-679 | Species | denotes | influenza | Tax:11309 |
| 27 | 530-544 | Disease | denotes | critically ill | MESH:D016638 |
| 28 | 615-633 | Disease | denotes | COVID-19 pneumonia | MESH:C000657245 |
| 29 | 680-689 | Disease | denotes | pneumonia | MESH:D011014 |
| 35 | 756-763 | Chemical | denotes | steroid | MESH:D013256 |
| 36 | 778-802 | Disease | denotes | other immunospuppression | MESH:D058497 |
| 37 | 858-867 | Disease | denotes | pneumonia | MESH:D011014 |
| 38 | 878-886 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 39 | 948-983 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 50 | 2037-2040 | Gene | denotes | CRP | Gene:1401 |
| 51 | 2057-2061 | Gene | denotes | IL-6 | Gene:3569 |
| 52 | 1672-1679 | Species | denotes | Patient | Tax:9606 |
| 53 | 1728-1735 | Species | denotes | Patient | Tax:9606 |
| 54 | 1903-1924 | Species | denotes | Aspergillus fumigatus | Tax:746128 |
| 55 | 1925-1946 | Species | denotes | Aspergillus fumigatus | Tax:746128 |
| 56 | 1947-1957 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 57 | 1708-1726 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 58 | 2202-2215 | Disease | denotes | Renal failure | MESH:D051437 |
| 59 | 2251-2283 | Disease | denotes | invasive pulmonary aspergillosis | MESH:D055744 |
| 61 | 1602-1615 | Chemical | denotes | galactomannan | MESH:C012990 |
| 66 | 2334-2337 | Gene | denotes | CRP | Gene:1401 |
| 67 | 2339-2357 | Gene | denotes | C-reactive protein | Gene:1401 |
| 68 | 2359-2363 | Gene | denotes | IL-6 | Gene:3569 |
| 69 | 2385-2417 | Disease | denotes | invasive pulmonary aspergillosis | MESH:D055744 |
| 79 | 1031-1039 | Species | denotes | patients | Tax:9606 |
| 80 | 1082-1097 | Species | denotes | influenza virus | Tax:11309 |
| 81 | 1102-1133 | Species | denotes | respiratory syncytial virus); a | Tax:1439707 |
| 82 | 1288-1309 | Species | denotes | Aspergillus fumigatus | Tax:746128 |
| 83 | 1362-1370 | Species | denotes | patients | Tax:9606 |
| 84 | 1260-1273 | Chemical | denotes | galactomannan | MESH:C012990 |
| 85 | 1045-1053 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 86 | 1186-1191 | Disease | denotes | fever | MESH:D005334 |
| 87 | 1458-1476 | Disease | denotes | COVID-19 pneumonia | MESH:C000657245 |
| 93 | 2653-2661 | Species | denotes | patients | Tax:9606 |
| 94 | 2710-2718 | Species | denotes | patients | Tax:9606 |
| 95 | 2674-2683 | Species | denotes | influenza | Tax:11309 |
| 96 | 2684-2693 | Disease | denotes | pneumonia | MESH:D011014 |
| 97 | 2744-2753 | Disease | denotes | mortality | MESH:D003643 |
| 102 | 2790-2798 | Species | denotes | patients | Tax:9606 |
| 103 | 2813-2817 | Disease | denotes | died | MESH:D003643 |
| 104 | 2843-2878 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 105 | 2884-2902 | Disease | denotes | multiorgan failure | MESH:D009102 |
| 113 | 2968-2975 | Species | denotes | patient | Tax:9606 |
| 114 | 3160-3168 | Species | denotes | patients | Tax:9606 |
| 115 | 2914-2925 | Species | denotes | Aspergillus | Tax:746128 |
| 116 | 2936-2947 | Species | denotes | respiratory | Tax:1439707 |
| 117 | 3025-3034 | Disease | denotes | infection | MESH:D007239 |
| 118 | 3136-3150 | Disease | denotes | critically ill | MESH:D016638 |
| 119 | 3151-3159 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 122 | 3260-3273 | Chemical | denotes | galactomannan | MESH:C012990 |
| 123 | 3309-3312 | Chemical | denotes | ODI | |
| 130 | 3458-3466 | Species | denotes | patients | Tax:9606 |
| 131 | 3495-3509 | Chemical | denotes | amphotericin-B | MESH:D000666 |
| 132 | 3586-3598 | Chemical | denotes | voriconazole | MESH:D065819 |
| 133 | 3603-3616 | Chemical | denotes | isavuconazole | MESH:C508735 |
| 134 | 3531-3549 | Disease | denotes | multiorgan failure | MESH:D009102 |
| 135 | 3560-3575 | Disease | denotes | hepatic failure | MESH:D017093 |
| 137 | 3661-3669 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 143 | 3890-3898 | Species | denotes | patients | Tax:9606 |
| 144 | 3792-3800 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 145 | 3812-3844 | Disease | denotes | invasive pulmonary aspergillosis | MESH:D055744 |
| 146 | 3875-3889 | Disease | denotes | critically ill | MESH:D016638 |
| 147 | 3911-3929 | Disease | denotes | COVID-19 pneumonia | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 318-326 | Body_part | denotes | alveolar | http://purl.org/sig/ont/fma/fma264783 |
| T2 | 354-362 | Body_part | denotes | alveolar | http://purl.org/sig/ont/fma/fma264783 |
| T3 | 363-375 | Body_part | denotes | neutrophilic | http://purl.org/sig/ont/fma/fma62860 |
| T4 | 1382-1387 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
| T5 | 1644-1649 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T6 | 1846-1851 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T7 | 2146-2155 | Body_part | denotes | Leucocyte | http://purl.org/sig/ont/fma/fma62852 |
| T8 | 2181-2192 | Body_part | denotes | Lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
| T9 | 2350-2357 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T10 | 2365-2378 | Body_part | denotes | interleukin 6 | http://purl.org/sig/ont/fma/fma264829 |
| T11 | 2365-2376 | Body_part | denotes | interleukin | http://purl.org/sig/ont/fma/fma86578 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1382-1387 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
| T2 | 1644-1649 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T3 | 1846-1851 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T3 | 42-74 | Phenotype | denotes | invasive pulmonary aspergillosis | http://purl.obolibrary.org/obo/HP_0020103 |
| T4 | 76-79 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T5 | 127-136 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T6 | 271-291 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T7 | 310-333 | Phenotype | denotes | diffuse alveolar damage | http://purl.obolibrary.org/obo/HP_0033006 |
| T8 | 568-571 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T9 | 624-633 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T10 | 680-689 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T11 | 746-749 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T12 | 858-867 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T13 | 954-974 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T14 | 1186-1191 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T15 | 1342-1345 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T16 | 1467-1476 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T17 | 1503-1506 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T18 | 1708-1726 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T19 | 2022-2025 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T20 | 2202-2215 | Phenotype | denotes | Renal failure | http://purl.obolibrary.org/obo/HP_0000083 |
| T21 | 2251-2283 | Phenotype | denotes | invasive pulmonary aspergillosis | http://purl.obolibrary.org/obo/HP_0020103 |
| T22 | 2380-2383 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T23 | 2385-2417 | Phenotype | denotes | invasive pulmonary aspergillosis | http://purl.obolibrary.org/obo/HP_0020103 |
| T24 | 2513-2516 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T25 | 2595-2598 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T26 | 2684-2693 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T27 | 2849-2869 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T28 | 3066-3069 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T29 | 3352-3355 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T30 | 3439-3442 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T31 | 3560-3575 | Phenotype | denotes | hepatic failure | http://purl.obolibrary.org/obo/HP_0001399 |
| T32 | 3681-3684 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T33 | 3812-3844 | Phenotype | denotes | invasive pulmonary aspergillosis | http://purl.obolibrary.org/obo/HP_0020103 |
| T34 | 3920-3929 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T4 | 61-74 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
| T5 | 121-136 | Disease | denotes | viral pneumonia | http://purl.obolibrary.org/obo/MONDO_0006012 |
| T6 | 127-136 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T7 | 217-241 | Disease | denotes | coronavirus disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T8 | 243-251 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T9 | 265-300 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T10 | 271-300 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T11 | 494-504 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T12 | 615-623 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T13 | 624-633 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T14 | 670-679 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T15 | 680-689 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T16 | 858-867 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T17 | 878-886 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T18 | 948-983 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T19 | 954-983 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T20 | 1045-1053 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T21 | 1082-1091 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T22 | 1458-1466 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T23 | 1467-1476 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T24 | 1708-1726 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T25 | 1947-1955 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T26 | 2078-2081 | Disease | denotes | PCT | http://purl.obolibrary.org/obo/MONDO_0008296|http://purl.obolibrary.org/obo/MONDO_0015104 |
| T28 | 2202-2215 | Disease | denotes | Renal failure | http://purl.obolibrary.org/obo/MONDO_0001106 |
| T29 | 2270-2283 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
| T30 | 2404-2417 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
| T31 | 2475-2478 | Disease | denotes | PCT | http://purl.obolibrary.org/obo/MONDO_0008296|http://purl.obolibrary.org/obo/MONDO_0015104 |
| T33 | 2674-2683 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T34 | 2684-2693 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T35 | 2843-2878 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T36 | 2849-2878 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T37 | 2884-2902 | Disease | denotes | multiorgan failure | http://purl.obolibrary.org/obo/MONDO_0043726 |
| T38 | 3025-3034 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T39 | 3151-3159 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T40 | 3531-3549 | Disease | denotes | multiorgan failure | http://purl.obolibrary.org/obo/MONDO_0043726 |
| T41 | 3661-3669 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T42 | 3792-3800 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T43 | 3831-3844 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
| T44 | 3911-3919 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T45 | 3920-3929 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T46 | 4554-4557 | Disease | denotes | MSD | http://purl.obolibrary.org/obo/MONDO_0010088 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 447-455 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T2 | 581-582 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T3 | 827-828 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T4 | 1092-1097 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T5 | 1124-1129 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T6 | 1132-1133 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T7 | 1192-1193 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T8 | 1380-1381 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T9 | 1382-1387 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
| T10 | 1692-1696 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | male |
| T11 | 1692-1696 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | male |
| T12 | 1748-1752 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | male |
| T13 | 1748-1752 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | male |
| T14 | 2063-2065 | http://purl.obolibrary.org/obo/CLO_0008426 | denotes | pg |
| T15 | 2146-2155 | http://purl.obolibrary.org/obo/CL_0000738 | denotes | Leucocyte |
| T16 | 2365-2378 | http://purl.obolibrary.org/obo/PR_000001393 | denotes | interleukin 6 |
| T17 | 2578-2579 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T18 | 2934-2935 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T19 | 3000-3012 | http://purl.obolibrary.org/obo/UBERON_0001155 | denotes | colonization |
| T20 | 3212-3219 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T21 | 3508-3509 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T22 | 3697-3698 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T23 | 3848-3849 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T24 | 3978-3981 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T25 | 4093-4096 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T26 | 4181-4184 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 76-79 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T3 | 568-571 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T5 | 746-749 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T7 | 756-763 | Chemical | denotes | steroid | http://purl.obolibrary.org/obo/CHEBI_35341 |
| T8 | 1260-1273 | Chemical | denotes | galactomannan | http://purl.obolibrary.org/obo/CHEBI_27680 |
| T9 | 1342-1345 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T11 | 1503-1506 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T13 | 1602-1615 | Chemical | denotes | galactomannan | http://purl.obolibrary.org/obo/CHEBI_27680 |
| T14 | 1692-1696 | Chemical | denotes | male | http://purl.obolibrary.org/obo/CHEBI_30780 |
| T15 | 1748-1752 | Chemical | denotes | male | http://purl.obolibrary.org/obo/CHEBI_30780 |
| T16 | 1790-1793 | Chemical | denotes | BAL | http://purl.obolibrary.org/obo/CHEBI_64198 |
| T17 | 2022-2025 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T19 | 2057-2059 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T21 | 2305-2308 | Chemical | denotes | BAL | http://purl.obolibrary.org/obo/CHEBI_64198 |
| T22 | 2350-2357 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T23 | 2359-2361 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T25 | 2380-2383 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T27 | 2424-2431 | Chemical | denotes | lactate | http://purl.obolibrary.org/obo/CHEBI_24996 |
| T28 | 2513-2516 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T30 | 2595-2598 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T32 | 3066-3069 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T34 | 3260-3273 | Chemical | denotes | galactomannan | http://purl.obolibrary.org/obo/CHEBI_27680 |
| T35 | 3352-3355 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T37 | 3384-3405 | Chemical | denotes | antifungal medication | http://purl.obolibrary.org/obo/CHEBI_86327 |
| T38 | 3384-3394 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T39 | 3439-3442 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T41 | 3586-3598 | Chemical | denotes | voriconazole | http://purl.obolibrary.org/obo/CHEBI_10023 |
| T42 | 3603-3616 | Chemical | denotes | isavuconazole | http://purl.obolibrary.org/obo/CHEBI_85979 |
| T43 | 3681-3684 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1278-1284 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T2 | 2904-2910 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | Growth |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 1260-1273 | GlycoEpitope | denotes | galactomannan | http://www.glycoepitope.jp/epitopes/EP0510 |
| T2 | 1602-1615 | GlycoEpitope | denotes | galactomannan | http://www.glycoepitope.jp/epitopes/EP0510 |
| T3 | 1771-1784 | GlycoEpitope | denotes | Galactomannan | http://www.glycoepitope.jp/epitopes/EP0510 |
| T4 | 1827-1840 | GlycoEpitope | denotes | Galactomannan | http://www.glycoepitope.jp/epitopes/EP0510 |
| T5 | 3260-3273 | GlycoEpitope | denotes | galactomannan | http://www.glycoepitope.jp/epitopes/EP0510 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 0-14 | Sentence | denotes | To the editor, |
| T3 | 15-168 | Sentence | denotes | Superinfections, including invasive pulmonary aspergillosis (IPA), are well-known complications of severe viral pneumonia in critically ill patients [1]. |
| T4 | 169-511 | Sentence | denotes | Pathological studies of individuals with severe coronavirus disease 2019 (COVID-19) -associated acute respiratory distress syndrome reported diffuse alveolar damage combined with intra-alveolar neutrophilic infiltration and vascular congestion, assuming an impaired mucociliary activity that might pave the way for secondary infections [2,3]. |
| T5 | 512-690 | Sentence | denotes | Our report of two critically ill patients suggests that IPA might be a relevant complication of severe COVID-19 pneumonia in analogy to experiences in severe influenza pneumonia. |
| T6 | 691-984 | Sentence | denotes | Both individuals were without typical risk factors for IPA, e.g. steroid medication or other immunospuppression, and were admitted from a secondary-care hospital with pneumonia caused by COVID-19 to our intensive care unit (ICU) after progression to severe acute respiratory distress syndrome. |
| T7 | 985-1357 | Sentence | denotes | In the initial bronchoalveolar lavage of both patients only COVID-19 was found (PCR negative for influenza virus and respiratory syncytial virus); a follow-up bronchoalveolar lavage because of ongoing fever a few days later (days 5 and 6 after ICU admission) showed elevated galactomannan and growth of Aspergillus fumigatus in standard culture, suggesting IPA (Table 1 ). |
| T8 | 1358-1507 | Sentence | denotes | All patients received a chest computed tomography scan before ICU admittance with typical signs for COVID-19 pneumonia but no specific signs for IPA. |
| T9 | 1508-1582 | Sentence | denotes | Follow-up computed tomography scans were not performed for safety reasons. |
| T10 | 1583-1671 | Sentence | denotes | Table 1 Results of galactomannan (bronchoalveolar lavage and serum) and standard culture |
| T11 | 1672-1770 | Sentence | denotes | Patient 1(80 years, male, suspected pulmonary fibrosis) Patient 2(70 years, male, no risk factors) |
| T12 | 1771-1826 | Sentence | denotes | Galactomannan from BAL (ODI; normal range <1.0) 6.3 6.1 |
| T13 | 1827-1885 | Sentence | denotes | Galactomannan from serum (ODI; normal range <0.5) 1.5 <0.5 |
| T14 | 1886-1946 | Sentence | denotes | Standard culture Aspergillus fumigatus Aspergillus fumigatus |
| T15 | 1947-1990 | Sentence | denotes | SARS-CoV-2 (at follow up) positive positive |
| T16 | 1991-2035 | Sentence | denotes | Laboratory parameters, mean at IPA diagnosis |
| T17 | 2036-2055 | Sentence | denotes | CRP (mg/dL) 26 5.1 |
| T18 | 2056-2076 | Sentence | denotes | IL-6 (pg/mL) 460 82 |
| T19 | 2077-2097 | Sentence | denotes | PCT (ng/mL) 3.7 0.4 |
| T20 | 2098-2125 | Sentence | denotes | D-Dimer (μg/L) 4820 14 151 |
| T21 | 2126-2144 | Sentence | denotes | LDH (U/L) 481 530 |
| T22 | 2145-2179 | Sentence | denotes | Leucocyte count (G/L) 10.38 14.55 |
| T23 | 2180-2201 | Sentence | denotes | Lymphocytes (%) 15 7 |
| T24 | 2202-2223 | Sentence | denotes | Renal failure Yes Yes |
| T25 | 2224-2289 | Sentence | denotes | Classical risk factors for invasive pulmonary aspergillosis No No |
| T26 | 2290-2494 | Sentence | denotes | Abbreviations: BAL, bronchoalveolar lavage; CRP, C-reactive protein; IL-6, interleukin 6; IPA, invasive pulmonary aspergillosis; LDH, lactate dehydrogenase; ODI, optical density index; PCT, procalcitonin. |
| T27 | 2495-2700 | Sentence | denotes | The time-point of IPA diagnosis is in line with previous studies that demonstrated a median time to IPA diagnosis between 3 and 9 days after ICU admission of patients with severe influenza pneumonia [1,3]. |
| T28 | 2701-2784 | Sentence | denotes | In these patients also, high incidence and mortality rates could be observed [1,3]. |
| T29 | 2785-2903 | Sentence | denotes | Both patients in our report died as the result of ongoing acute respiratory distress syndrome with multiorgan failure. |
| T30 | 2904-3035 | Sentence | denotes | Growth of Aspergillus spp. in a respiratory culture from an ICU patient is often interpreted as colonization rather than infection. |
| T31 | 3036-3189 | Sentence | denotes | Other typical diagnostics for IPA, such as biopsy or imaging techniques, may be more challenging in critically ill COVID-19 patients for several reasons. |
| T32 | 3190-3362 | Sentence | denotes | Therefore, additional testing of bronchoalveolar lavage specimens for galactomannan is easy, and the specificity of an ODI cut-off of >1·0 is about 90% to detect IPA [4,5]. |
| T33 | 3363-3453 | Sentence | denotes | Early and sufficient antifungal medication is the cornerstone for effective IPA treatment. |
| T34 | 3454-3645 | Sentence | denotes | Our patients were treated with liposomal amphotericin-B (3 mg/kg) because of multiorgan failure including hepatic failure; however, voriconazole and isavuconazole are sufficient alternatives. |
| T35 | 3646-3749 | Sentence | denotes | In conclusion, COVID-19-associated IPA may lead to a poor outcome even in immune competent individuals. |
| T36 | 3750-3930 | Sentence | denotes | Further studies are needed to indicate if COVID-19-associated invasive pulmonary aspergillosis is a relevant complication in critically ill patients with severe COVID-19 pneumonia. |
| T37 | 3932-3957 | Sentence | denotes | Transparency declarations |
| T38 | 3958-4072 | Sentence | denotes | None of the authors has any potential financial or non-financial conflicts of interest related to this manuscript. |
| T39 | 4073-4165 | Sentence | denotes | None of the authors has received any funding or financial support regarding this manuscript. |
| T40 | 4166-4226 | Sentence | denotes | The manuscript has not been submitted or accepted elsewhere. |
| T41 | 4227-4293 | Sentence | denotes | All authors fulfil the criteria given in the authorship paragraph. |
| T42 | 4294-4390 | Sentence | denotes | No writing assistance other than copy editing was provided in the preparation of the manuscript. |
| T43 | 4392-4408 | Sentence | denotes | Research funding |
| T44 | 4409-4428 | Sentence | denotes | Nothing to declare. |
| T45 | 4430-4454 | Sentence | denotes | Employment or leadership |
| T46 | 4455-4474 | Sentence | denotes | Nothing to declare. |
| T47 | 4475-4558 | Sentence | denotes | Tobias Lahmer received travel grants from 10.13039/100004319Pfizer, Gilead and MSD. |