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PMC:7264098 / 7669-10365 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T169 92-100 SP_7 denotes COVID-19
T170 364-372 SP_9 denotes MERS-CoV
T171 491-499 SP_10 denotes SARS-CoV
T172 512-520 SP_10 denotes SARS-CoV
T173 709-717 SP_9 denotes MERS-CoV
T174 719-727 SP_10 denotes SARS-CoV
T175 737-745 SP_7 denotes COVID-19
T176 928-934 UBERON:0002405 denotes immune
T177 1083-1099 CHEBI:26764;CHEBI:26764 denotes steroid hormones
T178 1123-1136 GO:0000805 denotes X-chromosomes
T179 1180-1186 UBERON:0002405;GO:0006955 denotes immune
T180 1187-1195 GO:0006955 denotes response
T181 1196-1197 GO:0000805 denotes X
T182 1205-1210 SO:0000704 denotes genes
T183 1215-1222 SO:0000704 denotes genetic
T184 1241-1246 NCBITaxon:10239 denotes viral
T185 1310-1314 NCBITaxon:10088 denotes mice
T186 1353-1359 NCBITaxon:9606 denotes humans
T187 1435-1439 NCBITaxon:10088 denotes mice
T188 1452-1457 NCBITaxon:10239 denotes viral
T189 1488-1496 UBERON:0003215 denotes alveolar
T190 1535-1539 NCBITaxon:10088 denotes mice
T191 1554-1562 SP_10 denotes SARS-CoV
T192 1630-1636 UBERON:0002405;CL:0000738 denotes immune
T193 1637-1642 CL:0000738 denotes cells
T194 1647-1659 GO:0006954 denotes inflammatory
T195 1680-1701 CL:0000860 denotes inflammatory monocyte
T196 1702-1713 CL:0000235 denotes macrophages
T197 1715-1726 CL:0000775 denotes neutrophils
T198 1728-1729 CL:0000084 denotes T
T199 1735-1742 CL:0000236 denotes B-cells
T200 1828-1836 SP_10 denotes SARS-CoV
T201 1910-1914 NCBITaxon:10088 denotes mice
T202 1925-1936 UBERON:0000992 denotes ovariectomy
T203 1958-1986 CHEBI:50792;CHEBI:50792 denotes estrogen receptor antagonist
T204 2028-2036 SP_10 denotes SARS-CoV
T205 2092-2100 CHEBI:50114;CHEBI:50114 denotes estrogen
T206 2200-2208 SP_7 denotes COVID-19
T207 2323-2331 SP_9 denotes MERS-CoV
T208 2336-2344 SP_10 denotes SARS-CoV
T87453 92-100 SP_7 denotes COVID-19
T79078 364-372 SP_9 denotes MERS-CoV
T52660 491-499 SP_10 denotes SARS-CoV
T74519 512-520 SP_10 denotes SARS-CoV
T37447 709-717 SP_9 denotes MERS-CoV
T24835 719-727 SP_10 denotes SARS-CoV
T29190 737-745 SP_7 denotes COVID-19
T82364 928-934 UBERON:0002405 denotes immune
T98271 1083-1099 CHEBI:26764;CHEBI:26764 denotes steroid hormones
T92268 1123-1136 GO:0000805 denotes X-chromosomes
T37017 1180-1186 UBERON:0002405;GO:0006955 denotes immune
T63252 1187-1195 GO:0006955 denotes response
T33352 1196-1197 GO:0000805 denotes X
T13426 1205-1210 SO:0000704 denotes genes
T19263 1215-1222 SO:0000704 denotes genetic
T62193 1241-1246 NCBITaxon:10239 denotes viral
T68998 1310-1314 NCBITaxon:10088 denotes mice
T68552 1353-1359 NCBITaxon:9606 denotes humans
T32050 1435-1439 NCBITaxon:10088 denotes mice
T13564 1452-1457 NCBITaxon:10239 denotes viral
T3911 1488-1496 UBERON:0003215 denotes alveolar
T29622 1535-1539 NCBITaxon:10088 denotes mice
T14074 1554-1562 SP_10 denotes SARS-CoV
T90577 1630-1636 UBERON:0002405;CL:0000738 denotes immune
T47167 1637-1642 CL:0000738 denotes cells
T59777 1647-1659 GO:0006954 denotes inflammatory
T66893 1680-1701 CL:0000860 denotes inflammatory monocyte
T54999 1702-1713 CL:0000235 denotes macrophages
T98092 1715-1726 CL:0000775 denotes neutrophils
T29064 1728-1729 CL:0000084 denotes T
T80806 1735-1742 CL:0000236 denotes B-cells
T4667 1828-1836 SP_10 denotes SARS-CoV
T60852 1910-1914 NCBITaxon:10088 denotes mice
T43570 1925-1936 UBERON:0000992 denotes ovariectomy
T26525 1958-1986 CHEBI:50792;CHEBI:50792 denotes estrogen receptor antagonist
T67365 2028-2036 SP_10 denotes SARS-CoV
T8220 2092-2100 CHEBI:50114;CHEBI:50114 denotes estrogen
T88870 2200-2208 SP_7 denotes COVID-19
T18171 2323-2331 SP_9 denotes MERS-CoV
T84892 2336-2344 SP_10 denotes SARS-CoV

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
223 2092-2109 Gene denotes estrogen receptor Gene:2099
224 285-289 Gene denotes men1 Gene:4221
225 1958-1975 Gene denotes estrogen receptor Gene:13982
226 127-130 Species denotes men Tax:9606
227 143-148 Species denotes women Tax:9606
228 364-372 Species denotes MERS-CoV Tax:1335626
229 403-406 Species denotes men Tax:9606
230 491-499 Species denotes SARS-CoV Tax:694009
231 512-520 Species denotes SARS-CoV Tax:694009
232 548-551 Species denotes men Tax:9606
233 709-717 Species denotes MERS-CoV Tax:1335626
234 719-727 Species denotes SARS-CoV Tax:694009
235 1310-1314 Species denotes mice Tax:10090
236 1353-1359 Species denotes humans Tax:9606
237 1435-1439 Species denotes mice Tax:10090
238 1535-1539 Species denotes mice Tax:10090
239 1554-1562 Species denotes SARS-CoV Tax:694009
240 1910-1914 Species denotes mice Tax:10090
241 2323-2331 Species denotes MERS-CoV Tax:1335626
242 2336-2344 Species denotes SARS-CoV Tax:694009
243 1083-1090 Chemical denotes steroid MESH:D013256
244 92-100 Disease denotes COVID-19 MESH:C000657245
245 155-163 Disease denotes infected MESH:D007239
246 394-402 Disease denotes infected MESH:D007239
247 737-745 Disease denotes COVID-19 MESH:C000657245
248 746-756 Disease denotes infections MESH:D007239
249 1241-1257 Disease denotes viral infections MESH:D001102
250 1488-1502 Disease denotes alveolar edema MESH:D004487
251 1540-1548 Disease denotes infected MESH:D007239
252 1828-1846 Disease denotes SARS-CoV infection MESH:C000657245
253 2002-2011 Disease denotes mortality MESH:D003643
254 2028-2046 Disease denotes SARS-CoV infection MESH:C000657245
255 2200-2208 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T62 1083-1099 Body_part denotes steroid hormones http://purl.org/sig/ont/fma/fma83353
T63 1123-1136 Body_part denotes X-chromosomes http://purl.org/sig/ont/fma/fma84055
T64 1125-1136 Body_part denotes chromosomes http://purl.org/sig/ont/fma/fma67093
T65 1488-1496 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T66 1637-1642 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T67 1693-1701 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T68 1702-1713 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T69 1715-1726 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T70 1737-1742 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 1958-1966 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T72 2092-2100 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T58 92-100 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T59 285-289 Disease denotes men1 http://purl.obolibrary.org/obo/MONDO_0007540
T60 491-499 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 491-495 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T62 512-520 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 512-516 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T64 719-727 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 719-723 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T66 737-745 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T67 746-756 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T68 1241-1257 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T69 1554-1562 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 1554-1558 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T71 1828-1846 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T72 1828-1832 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T73 1837-1846 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T74 2028-2046 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T75 2028-2032 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T76 2037-2046 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77 2200-2208 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T78 2336-2344 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 2336-2340 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T90 197-199 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T91 197-199 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T92 329-330 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 426-433 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T94 604-605 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T95 1026-1030 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T96 1026-1030 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T97 1035-1041 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T98 1140-1147 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T99 1205-1210 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T100 1353-1359 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T101 1430-1434 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T102 1430-1434 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T103 1528-1534 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T104 1637-1642 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T105 1693-1701 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T106 1735-1742 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cells
T107 1903-1909 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T108 1958-1975 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T109 2069-2070 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 2092-2109 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T111 2110-2119 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T112 2524-2525 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T25 197-199 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T26 1026-1030 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T27 1083-1099 Chemical denotes steroid hormones http://purl.obolibrary.org/obo/CHEBI_26764
T28 1083-1090 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T29 1091-1099 Chemical denotes hormones http://purl.obolibrary.org/obo/CHEBI_24621
T30 1430-1434 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T31 1958-1986 Chemical denotes estrogen receptor antagonist http://purl.obolibrary.org/obo/CHEBI_50792
T32 1958-1966 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T33 1976-1986 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T34 2092-2100 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T35 2542-2547 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T12 919-944 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune responses
T13 1180-1195 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T14 1241-1257 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T15 1647-1669 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T16 2110-2119 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T47 0-290 Sentence denotes Interestingly, there appears to also be gender disparity in the number of acquired cases of COVID-19 with higher percentage of men (~60%) than women being infected, as was first reported in China (Li et al., 2020); other countries have also reported higher case fatality rate (CFR) in men1.
T48 291-458 Sentence denotes Similar observations were reported in a meta-analysis in relation to the MERS-CoV, where the number of infected men was double that of females (Badawi and Ryoo, 2016).
T49 459-603 Sentence denotes Epidemiological studies tracing SARS-CoV showed that SARS-CoV was also more prevalent in men and associated with increased CFR (Karlberg, 2004).
T50 604-988 Sentence denotes A number of proposed explanations for these gender differences in terms of both the incidence and CFR of MERS-CoV, SARS-CoV, and now COVID-19 infections, include past smoking history, work-environmental factors, different treatment regimens, and underlying biological differences such as gender-specific innate and adaptive immune responses (Karlberg, 2004; Klein and Flanagan, 2016).
T51 989-1285 Sentence denotes Clear biological differences between male and female gender include the presence of different steroid hormones and two instead of one X-chromosomes in females, which influences the number of immune response X-linked genes and genetic susceptibility to viral infections (Klein and Flanagan, 2016).
T52 1286-1593 Sentence denotes Notably, experiments in mice, which seem to represent responses in humans well in this particular study, demonstrated greater susceptibility of male mice to enhanced viral titres, vascular leakage, and alveolar edema, compared to age-matched female mice infected with SARS-CoV (Channappanavar et al., 2017).
T53 1594-1743 Sentence denotes This was attributed to differential immune cells and inflammatory responses including inflammatory monocyte macrophages, neutrophils, T- and B-cells.
T54 1744-1888 Sentence denotes Notably, in this pre-clinical study, sex-dependent differences in susceptibility to SARS-CoV infection became more prominent with advancing age.
T55 1889-2120 Sentence denotes In fact, once female mice underwent ovariectomy or were administered estrogen receptor antagonist treatment, the mortality associated with SARS-CoV infection increased, suggesting a protective effect of estrogen receptor signaling.
T56 2121-2345 Sentence denotes Although experimental and mechanistic data is lacking in relation to the novel COVID-19 sex-specific differences, it is likely that similar factors and biological differences will be applicable as with MERS-CoV and SARS-CoV.
T57 2346-2548 Sentence denotes It is important for these differences to be clearly elucidated particularly in the context of the treatment response, with certain treatments potentially being more effective in a specific gender group.
T58 2549-2696 Sentence denotes Nevertheless, other confounding factors need to be taken into the account such as age, smoking, comorbidities and work-environmental circumstances.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T10 1497-1502 Phenotype denotes edema http://purl.obolibrary.org/obo/HP_0000969

2_test

Id Subject Object Predicate Lexical cue
32574317-27352628-31466298 452-456 27352628 denotes 2016
32574317-14742282-31466299 597-601 14742282 denotes 2004
32574317-14742282-31466300 956-960 14742282 denotes 2004
32574317-27546235-31466301 982-986 27546235 denotes 2016
32574317-27546235-31466302 1279-1283 27546235 denotes 2016
32574317-28373583-31466303 1587-1591 28373583 denotes 2017

MyTest

Id Subject Object Predicate Lexical cue
32574317-27352628-31466298 452-456 27352628 denotes 2016
32574317-14742282-31466299 597-601 14742282 denotes 2004
32574317-14742282-31466300 956-960 14742282 denotes 2004
32574317-27546235-31466301 982-986 27546235 denotes 2016
32574317-27546235-31466302 1279-1283 27546235 denotes 2016
32574317-28373583-31466303 1587-1591 28373583 denotes 2017