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PMC:7264098 / 7141-10365 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T162 36-47 NCBITaxon:11118 denotes Coronavirus
T163 49-60 NCBITaxon:11118 denotes Coronavirus
T164 230-234 SP_10 denotes SARS
T165 271-275 SP_9 denotes MERS
T166 287-295 SP_7 denotes COVID-19
T167 408-414 NCBITaxon:9606 denotes people
T168 521-526 GO:0016265 denotes death
T169 620-628 SP_7 denotes COVID-19
T170 892-900 SP_9 denotes MERS-CoV
T171 1019-1027 SP_10 denotes SARS-CoV
T172 1040-1048 SP_10 denotes SARS-CoV
T173 1237-1245 SP_9 denotes MERS-CoV
T174 1247-1255 SP_10 denotes SARS-CoV
T175 1265-1273 SP_7 denotes COVID-19
T176 1456-1462 UBERON:0002405 denotes immune
T177 1611-1627 CHEBI:26764;CHEBI:26764 denotes steroid hormones
T178 1651-1664 GO:0000805 denotes X-chromosomes
T179 1708-1714 UBERON:0002405;GO:0006955 denotes immune
T180 1715-1723 GO:0006955 denotes response
T181 1724-1725 GO:0000805 denotes X
T182 1733-1738 SO:0000704 denotes genes
T183 1743-1750 SO:0000704 denotes genetic
T184 1769-1774 NCBITaxon:10239 denotes viral
T185 1838-1842 NCBITaxon:10088 denotes mice
T186 1881-1887 NCBITaxon:9606 denotes humans
T187 1963-1967 NCBITaxon:10088 denotes mice
T188 1980-1985 NCBITaxon:10239 denotes viral
T189 2016-2024 UBERON:0003215 denotes alveolar
T190 2063-2067 NCBITaxon:10088 denotes mice
T191 2082-2090 SP_10 denotes SARS-CoV
T192 2158-2164 UBERON:0002405;CL:0000738 denotes immune
T193 2165-2170 CL:0000738 denotes cells
T194 2175-2187 GO:0006954 denotes inflammatory
T195 2208-2229 CL:0000860 denotes inflammatory monocyte
T196 2230-2241 CL:0000235 denotes macrophages
T197 2243-2254 CL:0000775 denotes neutrophils
T198 2256-2257 CL:0000084 denotes T
T199 2263-2270 CL:0000236 denotes B-cells
T200 2356-2364 SP_10 denotes SARS-CoV
T201 2438-2442 NCBITaxon:10088 denotes mice
T202 2453-2464 UBERON:0000992 denotes ovariectomy
T203 2486-2514 CHEBI:50792;CHEBI:50792 denotes estrogen receptor antagonist
T204 2556-2564 SP_10 denotes SARS-CoV
T205 2620-2628 CHEBI:50114;CHEBI:50114 denotes estrogen
T206 2728-2736 SP_7 denotes COVID-19
T207 2851-2859 SP_9 denotes MERS-CoV
T208 2864-2872 SP_10 denotes SARS-CoV
T98870 36-47 NCBITaxon:11118 denotes Coronavirus
T7393 49-60 NCBITaxon:11118 denotes Coronavirus
T34776 230-234 SP_10 denotes SARS
T22826 271-275 SP_9 denotes MERS
T12929 287-295 SP_7 denotes COVID-19
T40898 408-414 NCBITaxon:9606 denotes people
T1820 521-526 GO:0016265 denotes death
T87453 620-628 SP_7 denotes COVID-19
T79078 892-900 SP_9 denotes MERS-CoV
T52660 1019-1027 SP_10 denotes SARS-CoV
T74519 1040-1048 SP_10 denotes SARS-CoV
T37447 1237-1245 SP_9 denotes MERS-CoV
T24835 1247-1255 SP_10 denotes SARS-CoV
T29190 1265-1273 SP_7 denotes COVID-19
T82364 1456-1462 UBERON:0002405 denotes immune
T98271 1611-1627 CHEBI:26764;CHEBI:26764 denotes steroid hormones
T92268 1651-1664 GO:0000805 denotes X-chromosomes
T37017 1708-1714 UBERON:0002405;GO:0006955 denotes immune
T63252 1715-1723 GO:0006955 denotes response
T33352 1724-1725 GO:0000805 denotes X
T13426 1733-1738 SO:0000704 denotes genes
T19263 1743-1750 SO:0000704 denotes genetic
T62193 1769-1774 NCBITaxon:10239 denotes viral
T68998 1838-1842 NCBITaxon:10088 denotes mice
T68552 1881-1887 NCBITaxon:9606 denotes humans
T32050 1963-1967 NCBITaxon:10088 denotes mice
T13564 1980-1985 NCBITaxon:10239 denotes viral
T3911 2016-2024 UBERON:0003215 denotes alveolar
T29622 2063-2067 NCBITaxon:10088 denotes mice
T14074 2082-2090 SP_10 denotes SARS-CoV
T90577 2158-2164 UBERON:0002405;CL:0000738 denotes immune
T47167 2165-2170 CL:0000738 denotes cells
T59777 2175-2187 GO:0006954 denotes inflammatory
T66893 2208-2229 CL:0000860 denotes inflammatory monocyte
T54999 2230-2241 CL:0000235 denotes macrophages
T98092 2243-2254 CL:0000775 denotes neutrophils
T29064 2256-2257 CL:0000084 denotes T
T80806 2263-2270 CL:0000236 denotes B-cells
T4667 2356-2364 SP_10 denotes SARS-CoV
T60852 2438-2442 NCBITaxon:10088 denotes mice
T43570 2453-2464 UBERON:0000992 denotes ovariectomy
T26525 2486-2514 CHEBI:50792;CHEBI:50792 denotes estrogen receptor antagonist
T67365 2556-2564 SP_10 denotes SARS-CoV
T8220 2620-2628 CHEBI:50114;CHEBI:50114 denotes estrogen
T88870 2728-2736 SP_7 denotes COVID-19
T18171 2851-2859 SP_9 denotes MERS-CoV
T84892 2864-2872 SP_10 denotes SARS-CoV

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
169 36-47 Species denotes Coronavirus Tax:11118
180 49-60 Species denotes Coronavirus Tax:11118
181 408-414 Species denotes people Tax:9606
182 69-79 Disease denotes infections MESH:D007239
183 169-173 Disease denotes cold MESH:D000067390
184 195-228 Disease denotes Severe Acute Respiratory Syndrome MESH:D045169
185 237-269 Disease denotes Middle East Respiratory Syndrome MESH:D018352
186 287-295 Disease denotes COVID-19 MESH:C000657245
187 319-329 Disease denotes infections MESH:D007239
188 454-463 Disease denotes infection MESH:D007239
189 521-526 Disease denotes death MESH:D003643
223 2620-2637 Gene denotes estrogen receptor Gene:2099
224 813-817 Gene denotes men1 Gene:4221
225 2486-2503 Gene denotes estrogen receptor Gene:13982
226 655-658 Species denotes men Tax:9606
227 671-676 Species denotes women Tax:9606
228 892-900 Species denotes MERS-CoV Tax:1335626
229 931-934 Species denotes men Tax:9606
230 1019-1027 Species denotes SARS-CoV Tax:694009
231 1040-1048 Species denotes SARS-CoV Tax:694009
232 1076-1079 Species denotes men Tax:9606
233 1237-1245 Species denotes MERS-CoV Tax:1335626
234 1247-1255 Species denotes SARS-CoV Tax:694009
235 1838-1842 Species denotes mice Tax:10090
236 1881-1887 Species denotes humans Tax:9606
237 1963-1967 Species denotes mice Tax:10090
238 2063-2067 Species denotes mice Tax:10090
239 2082-2090 Species denotes SARS-CoV Tax:694009
240 2438-2442 Species denotes mice Tax:10090
241 2851-2859 Species denotes MERS-CoV Tax:1335626
242 2864-2872 Species denotes SARS-CoV Tax:694009
243 1611-1618 Chemical denotes steroid MESH:D013256
244 620-628 Disease denotes COVID-19 MESH:C000657245
245 683-691 Disease denotes infected MESH:D007239
246 922-930 Disease denotes infected MESH:D007239
247 1265-1273 Disease denotes COVID-19 MESH:C000657245
248 1274-1284 Disease denotes infections MESH:D007239
249 1769-1785 Disease denotes viral infections MESH:D001102
250 2016-2030 Disease denotes alveolar edema MESH:D004487
251 2068-2076 Disease denotes infected MESH:D007239
252 2356-2374 Disease denotes SARS-CoV infection MESH:C000657245
253 2530-2539 Disease denotes mortality MESH:D003643
254 2556-2574 Disease denotes SARS-CoV infection MESH:C000657245
255 2728-2736 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T62 1611-1627 Body_part denotes steroid hormones http://purl.org/sig/ont/fma/fma83353
T63 1651-1664 Body_part denotes X-chromosomes http://purl.org/sig/ont/fma/fma84055
T64 1653-1664 Body_part denotes chromosomes http://purl.org/sig/ont/fma/fma67093
T65 2016-2024 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T66 2165-2170 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T67 2221-2229 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T68 2230-2241 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T69 2243-2254 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T70 2265-2270 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 2486-2494 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T72 2620-2628 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T51 69-79 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T52 162-173 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T53 195-228 Disease denotes Severe Acute Respiratory Syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T54 230-234 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T55 287-295 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T56 319-329 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T57 454-463 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58 620-628 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T59 813-817 Disease denotes men1 http://purl.obolibrary.org/obo/MONDO_0007540
T60 1019-1027 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 1019-1023 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T62 1040-1048 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 1040-1044 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T64 1247-1255 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 1247-1251 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T66 1265-1273 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T67 1274-1284 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T68 1769-1785 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T69 2082-2090 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 2082-2086 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T71 2356-2374 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T72 2356-2360 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T73 2365-2374 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T74 2556-2574 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T75 2556-2560 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T76 2565-2574 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77 2728-2736 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T78 2864-2872 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 2864-2868 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T88 90-91 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89 160-161 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 725-727 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T91 725-727 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T92 857-858 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 954-961 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T94 1132-1133 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T95 1554-1558 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T96 1554-1558 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T97 1563-1569 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T98 1668-1675 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T99 1733-1738 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T100 1881-1887 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T101 1958-1962 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T102 1958-1962 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T103 2056-2062 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T104 2165-2170 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T105 2221-2229 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T106 2263-2270 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cells
T107 2431-2437 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T108 2486-2503 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T109 2597-2598 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 2620-2637 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T111 2638-2647 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T112 3052-3053 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T25 725-727 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T26 1554-1558 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T27 1611-1627 Chemical denotes steroid hormones http://purl.obolibrary.org/obo/CHEBI_26764
T28 1611-1618 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T29 1619-1627 Chemical denotes hormones http://purl.obolibrary.org/obo/CHEBI_24621
T30 1958-1962 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T31 2486-2514 Chemical denotes estrogen receptor antagonist http://purl.obolibrary.org/obo/CHEBI_50792
T32 2486-2494 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T33 2504-2514 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T34 2620-2628 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T35 3070-3075 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T12 1447-1472 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune responses
T13 1708-1723 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T14 1769-1785 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T15 2175-2197 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T16 2638-2647 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T43 0-48 Sentence denotes Are We All Affected the Same Way by Coronavirus?
T44 49-296 Sentence denotes Coronavirus-related infections can cause a variety of illnesses, which range from asymptomatic or mild such as a common cold, to severe including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and now, COVID-19.
T45 297-401 Sentence denotes The severity of these infections also varies widely between age-groups and different ethnic populations.
T46 402-527 Sentence denotes Older people are at increased risk of acquiring the infection and are likely to develop severe symptoms culminating in death.
T47 528-818 Sentence denotes Interestingly, there appears to also be gender disparity in the number of acquired cases of COVID-19 with higher percentage of men (~60%) than women being infected, as was first reported in China (Li et al., 2020); other countries have also reported higher case fatality rate (CFR) in men1.
T48 819-986 Sentence denotes Similar observations were reported in a meta-analysis in relation to the MERS-CoV, where the number of infected men was double that of females (Badawi and Ryoo, 2016).
T49 987-1131 Sentence denotes Epidemiological studies tracing SARS-CoV showed that SARS-CoV was also more prevalent in men and associated with increased CFR (Karlberg, 2004).
T50 1132-1516 Sentence denotes A number of proposed explanations for these gender differences in terms of both the incidence and CFR of MERS-CoV, SARS-CoV, and now COVID-19 infections, include past smoking history, work-environmental factors, different treatment regimens, and underlying biological differences such as gender-specific innate and adaptive immune responses (Karlberg, 2004; Klein and Flanagan, 2016).
T51 1517-1813 Sentence denotes Clear biological differences between male and female gender include the presence of different steroid hormones and two instead of one X-chromosomes in females, which influences the number of immune response X-linked genes and genetic susceptibility to viral infections (Klein and Flanagan, 2016).
T52 1814-2121 Sentence denotes Notably, experiments in mice, which seem to represent responses in humans well in this particular study, demonstrated greater susceptibility of male mice to enhanced viral titres, vascular leakage, and alveolar edema, compared to age-matched female mice infected with SARS-CoV (Channappanavar et al., 2017).
T53 2122-2271 Sentence denotes This was attributed to differential immune cells and inflammatory responses including inflammatory monocyte macrophages, neutrophils, T- and B-cells.
T54 2272-2416 Sentence denotes Notably, in this pre-clinical study, sex-dependent differences in susceptibility to SARS-CoV infection became more prominent with advancing age.
T55 2417-2648 Sentence denotes In fact, once female mice underwent ovariectomy or were administered estrogen receptor antagonist treatment, the mortality associated with SARS-CoV infection increased, suggesting a protective effect of estrogen receptor signaling.
T56 2649-2873 Sentence denotes Although experimental and mechanistic data is lacking in relation to the novel COVID-19 sex-specific differences, it is likely that similar factors and biological differences will be applicable as with MERS-CoV and SARS-CoV.
T57 2874-3076 Sentence denotes It is important for these differences to be clearly elucidated particularly in the context of the treatment response, with certain treatments potentially being more effective in a specific gender group.
T58 3077-3224 Sentence denotes Nevertheless, other confounding factors need to be taken into the account such as age, smoking, comorbidities and work-environmental circumstances.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T10 2025-2030 Phenotype denotes edema http://purl.obolibrary.org/obo/HP_0000969

2_test

Id Subject Object Predicate Lexical cue
32574317-27352628-31466298 980-984 27352628 denotes 2016
32574317-14742282-31466299 1125-1129 14742282 denotes 2004
32574317-14742282-31466300 1484-1488 14742282 denotes 2004
32574317-27546235-31466301 1510-1514 27546235 denotes 2016
32574317-27546235-31466302 1807-1811 27546235 denotes 2016
32574317-28373583-31466303 2115-2119 28373583 denotes 2017

MyTest

Id Subject Object Predicate Lexical cue
32574317-27352628-31466298 980-984 27352628 denotes 2016
32574317-14742282-31466299 1125-1129 14742282 denotes 2004
32574317-14742282-31466300 1484-1488 14742282 denotes 2004
32574317-27546235-31466301 1510-1514 27546235 denotes 2016
32574317-27546235-31466302 1807-1811 27546235 denotes 2016
32574317-28373583-31466303 2115-2119 28373583 denotes 2017