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PMC:7264098 / 23180-25845 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T332 66-76 SP_7 denotes SARS-CoV-2
T333 96-100 DG_47 denotes MSCs
T334 195-200 UBERON:0000170 denotes lungs
T335 255-260 UBERON:0000170 denotes lungs
T336 303-320 GO:0006869 denotes delivery of cells
T337 324-329 UBERON:0000170 denotes lungs
T338 496-500 DG_47 denotes MSCs
T339 531-539 GO:0046903 denotes secreted
T340 548-557 GO:0038001 denotes paracrine
T341 571-575 DG_47 denotes MSCs
T342 691-696 UBERON:0000170 denotes lungs
T343 856-864 GO:0070062 denotes exosomes
T344 937-947 SP_7 denotes SARS-CoV-2
T345 1045-1053 GO:0070062 denotes exosomes
T346 1219-1227 GO:0070062 denotes exosomes
T347 1255-1259 DG_47 denotes MSCs
T348 1461-1467 NCBITaxon:33208 denotes animal
T349 1478-1487 UBERON:0002048 denotes pulmonary
T350 1548-1552 UBERON:0002048 denotes lung
T351 1581-1589 GO:0070062 denotes exosomes
T352 1594-1598 UBERON:0002048;GO:0030324 denotes lung
T353 1599-1611 GO:0031099 denotes regeneration
T354 1960-1964 UBERON:0002048 denotes lung
T355 2029-2034 UBERON:0000170 denotes lungs
T356 2257-2265 SP_7 denotes COVID-19
T357 2344-2354 CL:0000034 denotes stem cells
T358 2376-2385 UBERON:0002048 denotes pulmonary
T359 2502-2511 CL:0000034 denotes stem cell
T360 2571-2581 CL:0000034 denotes stem cells
T361 2598-2603 UBERON:0000170 denotes lungs
T66586 66-76 SP_7 denotes SARS-CoV-2
T50773 96-100 DG_47 denotes MSCs
T4691 195-200 UBERON:0000170 denotes lungs
T94411 255-260 UBERON:0000170 denotes lungs
T84218 303-320 GO:0006869 denotes delivery of cells
T2168 324-329 UBERON:0000170 denotes lungs
T75803 496-500 DG_47 denotes MSCs
T35464 531-539 GO:0046903 denotes secreted
T96963 548-557 GO:0038001 denotes paracrine
T91917 571-575 DG_47 denotes MSCs
T29118 691-696 UBERON:0000170 denotes lungs
T84212 856-864 GO:0070062 denotes exosomes
T66922 937-947 SP_7 denotes SARS-CoV-2
T64147 1045-1053 GO:0070062 denotes exosomes
T1520 1219-1227 GO:0070062 denotes exosomes
T75691 1255-1259 DG_47 denotes MSCs
T6180 1461-1467 NCBITaxon:33208 denotes animal
T86648 1478-1487 UBERON:0002048 denotes pulmonary
T88037 1548-1552 UBERON:0002048 denotes lung
T11063 1581-1589 GO:0070062 denotes exosomes
T69796 1594-1598 UBERON:0002048;GO:0030324 denotes lung
T94398 1599-1611 GO:0031099 denotes regeneration
T94609 1960-1964 UBERON:0002048 denotes lung
T87082 2029-2034 UBERON:0000170 denotes lungs
T15321 2257-2265 SP_7 denotes COVID-19
T20785 2344-2354 CL:0000034 denotes stem cells
T12891 2376-2385 UBERON:0002048 denotes pulmonary
T78159 2502-2511 CL:0000034 denotes stem cell
T69272 2571-2581 CL:0000034 denotes stem cells
T20965 2598-2603 UBERON:0000170 denotes lungs

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
453 893-901 Species denotes patients Tax:9606
454 1826-1833 Species denotes patient Tax:9606
455 2266-2274 Species denotes patients Tax:9606
456 66-87 Disease denotes SARS-CoV-2 infections MESH:C000657245
457 914-923 Disease denotes pneumonia MESH:D011014
458 937-957 Disease denotes SARS-CoV-2 infection MESH:C000657245
459 1478-1496 Disease denotes pulmonary fibrosis MESH:D011658
460 1960-1972 Disease denotes lung disease MESH:D008171
461 2257-2265 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T178 195-200 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T179 237-242 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T180 255-260 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T181 315-320 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T182 324-329 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T183 625-630 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T184 691-696 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T185 1548-1552 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T186 1562-1566 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T187 1594-1598 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T188 1752-1756 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T189 1960-1964 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T190 2029-2034 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T191 2344-2354 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T192 2349-2354 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T193 2502-2511 Body_part denotes stem cell http://purl.org/sig/ont/fma/fma63368
T194 2507-2511 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T195 2571-2581 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T196 2576-2581 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T197 2598-2603 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T43 1548-1552 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T44 1594-1598 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T45 1960-1964 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T141 66-74 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T142 66-70 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T143 77-87 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T144 914-923 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T145 937-945 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T146 937-941 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T147 948-957 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T148 1478-1496 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T149 1960-1972 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T150 2257-2265 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T246 195-200 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T247 237-242 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T248 255-260 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T249 315-320 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T250 324-329 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T251 615-624 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T252 625-630 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T253 647-651 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T254 691-696 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T255 749-757 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T256 797-798 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T257 1440-1441 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T258 1461-1467 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T259 1548-1552 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T260 1548-1552 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T261 1562-1566 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T262 1594-1598 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T263 1594-1598 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T264 1752-1756 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T265 1895-1896 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T266 1960-1964 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T267 1960-1964 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T268 2029-2034 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T269 2038-2039 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 2180-2183 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T271 2242-2243 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T272 2276-2277 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T273 2344-2354 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T274 2502-2511 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T275 2571-2581 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T276 2598-2603 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T277 2659-2664 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T33 615-624 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T34 1335-1342 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T35 1599-1611 http://purl.obolibrary.org/obo/GO_0031099 denotes regeneration

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T136 0-141 Sentence denotes In the majority of clinical trials investigating the treatment of SARS-CoV-2 infections so far, MSCs are delivered via the intravenous route.
T137 142-285 Sentence denotes Since intravenous route does not specifically target lungs, the inhalation route that delivers cells directly to lungs could be more effective.
T138 286-422 Sentence denotes However, uniform delivery of cells to lungs through inhalation is technically challenging (Kim et al., 2016; Kim and Chrzanowski, 2019).
T139 423-671 Sentence denotes Strong evidence is emerging to suggest that the therapeutic potential of MSCs is attributed mostly to their secreted EVs via paracrine effects, and MSCs could also be referred to as medicinal signaling cells (Bjørge et al., 2018; Kim et al., 2019).
T140 672-787 Sentence denotes Delivery of EVs to lungs is feasible and exogenous EVs can facilitate prompt activity directly at the injured site.
T141 788-972 Sentence denotes There is a pilot clinical study that intends to deliver MSC-derived exosomes via the inhalation route to patients with severe pneumonia arising from SARS-CoV-2 infection (NCT04276987).
T142 973-1193 Sentence denotes In this clinical trial, the main advantage of administering MSC-derived exosomes via inhalation route compared to the intravenous administration is the prevention of their aggregation within the injured microcirculation.
T143 1194-1439 Sentence denotes In addition, MSC-derived exosomes have other advantages over MSCs including lower or no risk of mutagenicity and oncogenicity as well as the storage stability of several weeks or months facilitating less urgent transportation and administration.
T144 1440-1632 Sentence denotes A recent study using animal models of pulmonary fibrosis also demonstrated therapeutic potential of inhaled lung spheroid cell-secretome and exosomes for lung regeneration (Dinh et al., 2020).
T145 1633-1878 Sentence denotes While the intravenous route is the most widely used often for the ease of administration albeit invasive, the route of cell delivery should be tailored according to the disease in question and patient's circumstances (Kim and Chrzanowski, 2019).
T146 1879-2133 Sentence denotes As evident from a number of clinically available inhaled medications for chronic lung disease, the inhalation route of delivering therapeutics to the lungs is a more direct route with lower incidence of adverse effects, compared to the intravenous route.
T147 2134-2275 Sentence denotes Nevertheless, the environment in the hospital has to be appropriately managed for inhaled administration of a treatment in COVID-19 patients.
T148 2276-2481 Sentence denotes A number of studies have demonstrated the feasibility of delivering stem cells via spray for direct pulmonary delivery with high viability (Kardia et al., 2016; Kim et al., 2016; Skolasinski et al., 2020).
T149 2482-2665 Sentence denotes Inhalation route of stem cell administration is an opportunity for efficient delivery of stem cells directly to the lungs, yet it remains an under-explored research area in the field.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T18 914-923 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T19 1478-1496 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T20 1952-1972 Phenotype denotes chronic lung disease http://purl.obolibrary.org/obo/HP_0006528

2_test

Id Subject Object Predicate Lexical cue
32574317-27186789-31466338 389-393 27186789 denotes 2016
32574317-29184934-31466339 647-651 29184934 denotes 2018
32574317-31318160-31466340 665-669 31318160 denotes 2019
32574317-32111836-31466341 1626-1630 32111836 denotes 2020
32574317-27186789-31466342 2449-2453 27186789 denotes 2016

MyTest

Id Subject Object Predicate Lexical cue
32574317-27186789-31466338 389-393 27186789 denotes 2016
32574317-29184934-31466339 647-651 29184934 denotes 2018
32574317-31318160-31466340 665-669 31318160 denotes 2019
32574317-32111836-31466341 1626-1630 32111836 denotes 2020
32574317-27186789-31466342 2449-2453 27186789 denotes 2016