PMC:7264098 / 21094-22152 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T308","span":{"begin":15,"end":26},"obj":"GO:0006412"},{"id":"T309","span":{"begin":83,"end":91},"obj":"SP_7"},{"id":"T310","span":{"begin":100,"end":104},"obj":"UBERON:0002048"},{"id":"T311","span":{"begin":339,"end":349},"obj":"CL:0000034"},{"id":"T312","span":{"begin":590,"end":594},"obj":"UBERON:0002048"},{"id":"T313","span":{"begin":689,"end":699},"obj":"CL:0000034"},{"id":"T314","span":{"begin":743,"end":752},"obj":"CL:0000034"},{"id":"T315","span":{"begin":786,"end":806},"obj":"GO:0031012"},{"id":"T316","span":{"begin":925,"end":929},"obj":"DG_47"},{"id":"T317","span":{"begin":943,"end":958},"obj":"CHEBI:52217;CHEBI:52217"},{"id":"T318","span":{"begin":1013,"end":1019},"obj":"UBERON:0000479;GO:0006281"},{"id":"T319","span":{"begin":1020,"end":1026},"obj":"GO:0006281"},{"id":"T55749","span":{"begin":15,"end":26},"obj":"GO:0006412"},{"id":"T96268","span":{"begin":83,"end":91},"obj":"SP_7"},{"id":"T69032","span":{"begin":100,"end":104},"obj":"UBERON:0002048"},{"id":"T95394","span":{"begin":339,"end":349},"obj":"CL:0000034"},{"id":"T83780","span":{"begin":590,"end":594},"obj":"UBERON:0002048"},{"id":"T98945","span":{"begin":689,"end":699},"obj":"CL:0000034"},{"id":"T52104","span":{"begin":743,"end":752},"obj":"CL:0000034"},{"id":"T53274","span":{"begin":786,"end":806},"obj":"GO:0031012"},{"id":"T54541","span":{"begin":925,"end":929},"obj":"DG_47"},{"id":"T40739","span":{"begin":943,"end":958},"obj":"CHEBI:52217;CHEBI:52217"},{"id":"T46992","span":{"begin":1013,"end":1019},"obj":"UBERON:0000479;GO:0006281"},{"id":"T78120","span":{"begin":1020,"end":1026},"obj":"GO:0006281"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"436","span":{"begin":83,"end":91},"obj":"Disease"},{"id":"437","span":{"begin":100,"end":113},"obj":"Disease"},{"id":"438","span":{"begin":415,"end":422},"obj":"Disease"},{"id":"439","span":{"begin":426,"end":434},"obj":"Disease"}],"attributes":[{"id":"A436","pred":"tao:has_database_id","subj":"436","obj":"MESH:C000657245"},{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"MESH:D055370"},{"id":"A438","pred":"tao:has_database_id","subj":"438","obj":"MESH:D000860"},{"id":"A439","pred":"tao:has_database_id","subj":"439","obj":"MESH:D007511"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T154","span":{"begin":100,"end":104},"obj":"Body_part"},{"id":"T155","span":{"begin":332,"end":337},"obj":"Body_part"},{"id":"T156","span":{"begin":339,"end":349},"obj":"Body_part"},{"id":"T157","span":{"begin":344,"end":349},"obj":"Body_part"},{"id":"T158","span":{"begin":543,"end":548},"obj":"Body_part"},{"id":"T159","span":{"begin":590,"end":594},"obj":"Body_part"},{"id":"T160","span":{"begin":689,"end":699},"obj":"Body_part"},{"id":"T161","span":{"begin":694,"end":699},"obj":"Body_part"},{"id":"T162","span":{"begin":743,"end":752},"obj":"Body_part"},{"id":"T163","span":{"begin":748,"end":752},"obj":"Body_part"},{"id":"T164","span":{"begin":786,"end":806},"obj":"Body_part"},{"id":"T165","span":{"begin":851,"end":855},"obj":"Body_part"},{"id":"T166","span":{"begin":1013,"end":1019},"obj":"Body_part"}],"attributes":[{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma63368"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A159","pred":"fma_id","subj":"T159","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A160","pred":"fma_id","subj":"T160","obj":"http://purl.org/sig/ont/fma/fma63368"},{"id":"A161","pred":"fma_id","subj":"T161","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A162","pred":"fma_id","subj":"T162","obj":"http://purl.org/sig/ont/fma/fma63368"},{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A164","pred":"fma_id","subj":"T164","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A165","pred":"fma_id","subj":"T165","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A166","pred":"fma_id","subj":"T166","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T38","span":{"begin":100,"end":104},"obj":"Body_part"},{"id":"T39","span":{"begin":590,"end":594},"obj":"Body_part"},{"id":"T40","span":{"begin":1013,"end":1019},"obj":"Body_part"}],"attributes":[{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T139","span":{"begin":83,"end":91},"obj":"Disease"},{"id":"T140","span":{"begin":426,"end":434},"obj":"Disease"}],"attributes":[{"id":"A139","pred":"mondo_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A140","pred":"mondo_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/MONDO_0005053"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T221","span":{"begin":100,"end":104},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T222","span":{"begin":100,"end":104},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T223","span":{"begin":130,"end":131},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T224","span":{"begin":332,"end":337},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T225","span":{"begin":339,"end":349},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T226","span":{"begin":461,"end":470},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T227","span":{"begin":543,"end":548},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T228","span":{"begin":590,"end":594},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T229","span":{"begin":590,"end":594},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T230","span":{"begin":689,"end":699},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T231","span":{"begin":743,"end":752},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T232","span":{"begin":851,"end":855},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T233","span":{"begin":1048,"end":1050},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T234","span":{"begin":1048,"end":1050},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T235","span":{"begin":1052,"end":1056},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T66","span":{"begin":1048,"end":1050},"obj":"Chemical"}],"attributes":[{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T27","span":{"begin":15,"end":26},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T28","span":{"begin":461,"end":479},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T29","span":{"begin":461,"end":470},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T30","span":{"begin":712,"end":721},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T31","span":{"begin":748,"end":763},"obj":"http://purl.obolibrary.org/obo/GO_0098743"},{"id":"T32","span":{"begin":807,"end":816},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T125","span":{"begin":0,"end":150},"obj":"Sentence"},{"id":"T126","span":{"begin":151,"end":338},"obj":"Sentence"},{"id":"T127","span":{"begin":339,"end":655},"obj":"Sentence"},{"id":"T128","span":{"begin":656,"end":907},"obj":"Sentence"},{"id":"T129","span":{"begin":908,"end":1058},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T17","span":{"begin":415,"end":422},"obj":"Phenotype"}],"attributes":[{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0012418"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"2_test","denotations":[{"id":"32574317-25126478-31466327","span":{"begin":609,"end":613},"obj":"25126478"},{"id":"32574317-25709098-31466328","span":{"begin":627,"end":631},"obj":"25709098"},{"id":"32574317-27822228-31466329","span":{"begin":649,"end":653},"obj":"27822228"},{"id":"32574317-20643923-31466330","span":{"begin":882,"end":886},"obj":"20643923"},{"id":"32574317-25126478-31466331","span":{"begin":901,"end":905},"obj":"25126478"},{"id":"32574317-29392844-31466332","span":{"begin":1052,"end":1056},"obj":"29392844"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}

{"project":"MyTest","denotations":[{"id":"32574317-25126478-31466327","span":{"begin":609,"end":613},"obj":"25126478"},{"id":"32574317-25709098-31466328","span":{"begin":627,"end":631},"obj":"25709098"},{"id":"32574317-27822228-31466329","span":{"begin":649,"end":653},"obj":"27822228"},{"id":"32574317-20643923-31466330","span":{"begin":882,"end":886},"obj":"20643923"},{"id":"32574317-25126478-31466331","span":{"begin":901,"end":905},"obj":"25126478"},{"id":"32574317-29392844-31466332","span":{"begin":1052,"end":1056},"obj":"29392844"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"The successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018)."}