PMC:7264098 / 18901-20310
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T292 | 78-89 | UBERON:0001004 | denotes | respiratory |
| T293 | 107-115 | SP_7 | denotes | COVID-19 |
| T294 | 231-239 | SP_7 | denotes | COVID-19 |
| T295 | 316-324 | SP_7 | denotes | COVID-19 |
| T296 | 364-368 | DG_47 | denotes | MSCs |
| T297 | 496-502 | NCBITaxon:9606 | denotes | humans |
| T298 | 543-552 | CL:0000034 | denotes | stem cell |
| T299 | 861-871 | CL:0000034 | denotes | stem cells |
| T300 | 881-889 | SP_7 | denotes | COVID-19 |
| T301 | 1029-1038 | CL:0000034 | denotes | stem cell |
| T302 | 1204-1214 | CL:0000034 | denotes | stem cells |
| T303 | 1253-1258 | SP_6;NCBITaxon:9606 | denotes | human |
| T304 | 1307-1312 | UBERON:0000062 | denotes | organ |
| T305 | 1378-1388 | CL:0000034 | denotes | stem cells |
| T82510 | 78-89 | UBERON:0001004 | denotes | respiratory |
| T6643 | 107-115 | SP_7 | denotes | COVID-19 |
| T21007 | 231-239 | SP_7 | denotes | COVID-19 |
| T21172 | 316-324 | SP_7 | denotes | COVID-19 |
| T22857 | 364-368 | DG_47 | denotes | MSCs |
| T94386 | 496-502 | NCBITaxon:9606 | denotes | humans |
| T33075 | 543-552 | CL:0000034 | denotes | stem cell |
| T82991 | 861-871 | CL:0000034 | denotes | stem cells |
| T90311 | 881-889 | SP_7 | denotes | COVID-19 |
| T26981 | 1029-1038 | CL:0000034 | denotes | stem cell |
| T90467 | 1204-1214 | CL:0000034 | denotes | stem cells |
| T54766 | 1253-1258 | SP_6;NCBITaxon:9606 | denotes | human |
| T48295 | 1307-1312 | UBERON:0000062 | denotes | organ |
| T65823 | 1378-1388 | CL:0000034 | denotes | stem cells |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 421 | 240-248 | Species | denotes | patients | Tax:9606 |
| 422 | 496-502 | Species | denotes | humans | Tax:9606 |
| 423 | 1253-1258 | Species | denotes | human | Tax:9606 |
| 424 | 1161-1164 | Chemical | denotes | GMP | |
| 425 | 78-103 | Disease | denotes | respiratory complications | MESH:D012131 |
| 426 | 107-115 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 427 | 231-239 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 428 | 316-324 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 429 | 881-889 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T138 | 543-552 | Body_part | denotes | stem cell | http://purl.org/sig/ont/fma/fma63368 |
| T139 | 548-552 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T140 | 861-871 | Body_part | denotes | stem cells | http://purl.org/sig/ont/fma/fma63368 |
| T141 | 866-871 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T142 | 1029-1038 | Body_part | denotes | stem cell | http://purl.org/sig/ont/fma/fma63368 |
| T143 | 1034-1038 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T144 | 1204-1214 | Body_part | denotes | stem cells | http://purl.org/sig/ont/fma/fma63368 |
| T145 | 1209-1214 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T146 | 1307-1312 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T147 | 1378-1388 | Body_part | denotes | stem cells | http://purl.org/sig/ont/fma/fma63368 |
| T148 | 1383-1388 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T37 | 1307-1312 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T134 | 107-115 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T135 | 231-239 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T136 | 316-324 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T137 | 881-889 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T201 | 117-118 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T202 | 496-502 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T203 | 543-552 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cell |
| T204 | 709-710 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T205 | 861-871 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
| T206 | 951-952 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T207 | 1029-1038 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cell |
| T208 | 1158-1159 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T209 | 1204-1214 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
| T210 | 1221-1222 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T211 | 1224-1231 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T212 | 1253-1258 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T213 | 1307-1312 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T214 | 1367-1374 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T215 | 1378-1388 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T60 | 421-424 | Chemical | denotes | GMP | http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115 |
| T62 | 1161-1164 | Chemical | denotes | GMP | http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T24 | 445-456 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulations |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T114 | 0-249 | Sentence | denotes | Despite the lack of convincing evidence in support of MSC-based therapies for respiratory complications of COVID-19, a number of promising trials are currently underway, which could revolutionize the treatment prospects for severe COVID-19 patients. |
| T115 | 250-503 | Sentence | denotes | Regardless of the urgency of the need for MSC-based therapies for COVID-19, it is critical that the production of MSCs is in compliance with good manufacturing practices (GMP) and follows strict regulations prior to being approved for the use in humans. |
| T116 | 504-654 | Sentence | denotes | The use of unauthorized and unapproved stem cell therapies not validated through stringent multicenter clinical trials should be strongly discouraged. |
| T117 | 655-919 | Sentence | denotes | At the same time current findings imply that there is a need for globally coordinated approach and support to conduct multicenter clinical trials to demonstrate safety and effectiveness of various types of stem cells to treat COVID-19-induced health complications. |
| T118 | 920-1119 | Sentence | denotes | It also suggests that there is a need in biomedical research and development to establish the most effective stem cell types that are ideally suited for the treatment of aforementioned complications. |
| T119 | 1120-1409 | Sentence | denotes | These developments will also require (a) GMP compliant technologies to mass produce stem cells, and (b) testing platforms that mimic human pathophysiology (e.g., 3D bioprinted organoids, organ-on-chip) to allow high-throughput screening and rapid testing of stem cells safety and efficacy. |