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PMC:7264098 / 16999-21055 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T272 10-20 CL:0000034 denotes Stem Cells
T273 49-57 SP_7 denotes COVID-19
T274 141-145 DG_47 denotes MSCs
T275 149-157 SP_7 denotes COVID-19
T276 371-379 SP_7 denotes COVID-19
T277 420-431 UBERON:0002371 denotes bone-marrow
T278 435-449 UBERON:0002331 denotes umbilical cord
T279 458-462 DG_47 denotes MSCs
T280 823-827 DG_47 denotes MSCs
T281 831-841 SP_7 denotes SARS-CoV-2
T282 856-860 DG_47 denotes MSCs
T283 1026-1030 DG_47 denotes MSCs
T284 1049-1053 UBERON:0002048 denotes lung
T285 1054-1064 UBERON:0000115 denotes epithelial
T286 1204-1212 SP_7 denotes COVID-19
T287 1227-1238 UBERON:0001004 denotes respiratory
T288 1512-1516 DG_47 denotes MSCs
T289 1657-1666 UBERON:0002048 denotes pulmonary
T290 1813-1817 DG_47 denotes MSCs
T291 1832-1840 SP_7 denotes COVID-19
T292 1980-1991 UBERON:0001004 denotes respiratory
T293 2009-2017 SP_7 denotes COVID-19
T294 2133-2141 SP_7 denotes COVID-19
T295 2218-2226 SP_7 denotes COVID-19
T296 2266-2270 DG_47 denotes MSCs
T297 2398-2404 NCBITaxon:9606 denotes humans
T298 2445-2454 CL:0000034 denotes stem cell
T299 2763-2773 CL:0000034 denotes stem cells
T300 2783-2791 SP_7 denotes COVID-19
T301 2931-2940 CL:0000034 denotes stem cell
T302 3106-3116 CL:0000034 denotes stem cells
T303 3155-3160 SP_6;NCBITaxon:9606 denotes human
T304 3209-3214 UBERON:0000062 denotes organ
T305 3280-3290 CL:0000034 denotes stem cells
T306 3312-3334 GO:1903561 denotes Extracellular vesicles
T307 3898-3908 CL:0000034 denotes stem cells
T40615 10-20 CL:0000034 denotes Stem Cells
T22201 49-57 SP_7 denotes COVID-19
T27177 141-145 DG_47 denotes MSCs
T73462 149-157 SP_7 denotes COVID-19
T48642 371-379 SP_7 denotes COVID-19
T95815 420-431 UBERON:0002371 denotes bone-marrow
T87916 435-449 UBERON:0002331 denotes umbilical cord
T58957 458-462 DG_47 denotes MSCs
T85353 823-827 DG_47 denotes MSCs
T54758 831-841 SP_7 denotes SARS-CoV-2
T42509 856-860 DG_47 denotes MSCs
T43075 1026-1030 DG_47 denotes MSCs
T58923 1049-1053 UBERON:0002048 denotes lung
T88625 1054-1064 UBERON:0000115 denotes epithelial
T82425 1204-1212 SP_7 denotes COVID-19
T86543 1227-1238 UBERON:0001004 denotes respiratory
T2347 1512-1516 DG_47 denotes MSCs
T12392 1657-1666 UBERON:0002048 denotes pulmonary
T77015 1813-1817 DG_47 denotes MSCs
T84563 1832-1840 SP_7 denotes COVID-19
T82510 1980-1991 UBERON:0001004 denotes respiratory
T6643 2009-2017 SP_7 denotes COVID-19
T21007 2133-2141 SP_7 denotes COVID-19
T21172 2218-2226 SP_7 denotes COVID-19
T22857 2266-2270 DG_47 denotes MSCs
T94386 2398-2404 NCBITaxon:9606 denotes humans
T33075 2445-2454 CL:0000034 denotes stem cell
T82991 2763-2773 CL:0000034 denotes stem cells
T90311 2783-2791 SP_7 denotes COVID-19
T26981 2931-2940 CL:0000034 denotes stem cell
T90467 3106-3116 CL:0000034 denotes stem cells
T54766 3155-3160 SP_6;NCBITaxon:9606 denotes human
T48295 3209-3214 UBERON:0000062 denotes organ
T65823 3280-3290 CL:0000034 denotes stem cells
T82799 3312-3334 GO:1903561 denotes Extracellular vesicles
T77663 3898-3908 CL:0000034 denotes stem cells

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
369 49-57 Disease denotes COVID-19 MESH:C000657245
381 158-166 Species denotes patients Tax:9606
382 261-269 Species denotes patients Tax:9606
383 357-365 Species denotes patients Tax:9606
384 831-841 Species denotes SARS-CoV-2 Tax:2697049
385 149-157 Disease denotes COVID-19 MESH:C000657245
386 371-379 Disease denotes COVID-19 MESH:C000657245
387 384-393 Disease denotes pneumonia MESH:D011014
388 850-854 Disease denotes ARDS MESH:D012128
389 895-899 Disease denotes ARDS MESH:D012128
390 970-976 Disease denotes Wilson MESH:D006527
391 1119-1139 Disease denotes hypercapnic acidosis MESH:D000138
400 1213-1221 Species denotes patients Tax:9606
401 1380-1388 Species denotes patients Tax:9606
402 1473-1481 Species denotes patients Tax:9606
403 1540-1548 Species denotes patients Tax:9606
404 1613-1621 Species denotes patients Tax:9606
405 1204-1212 Disease denotes COVID-19 MESH:C000657245
406 1227-1252 Disease denotes respiratory complications MESH:D012131
407 1725-1737 Disease denotes inflammation MESH:D007249
410 1841-1849 Species denotes patients Tax:9606
411 1832-1840 Disease denotes COVID-19 MESH:C000657245
421 2142-2150 Species denotes patients Tax:9606
422 2398-2404 Species denotes humans Tax:9606
423 3155-3160 Species denotes human Tax:9606
424 3063-3066 Chemical denotes GMP
425 1980-2005 Disease denotes respiratory complications MESH:D012131
426 2009-2017 Disease denotes COVID-19 MESH:C000657245
427 2133-2141 Disease denotes COVID-19 MESH:C000657245
428 2218-2226 Disease denotes COVID-19 MESH:C000657245
429 2783-2791 Disease denotes COVID-19 MESH:C000657245
431 3548-3573 Disease denotes damage by hostile disease MESH:D004194

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T133 10-20 Body_part denotes Stem Cells http://purl.org/sig/ont/fma/fma63368
T134 15-20 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T135 420-431 Body_part denotes bone-marrow http://purl.org/sig/ont/fma/fma9608
T136 435-449 Body_part denotes umbilical cord http://purl.org/sig/ont/fma/fma85541
T137 1049-1053 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T138 2445-2454 Body_part denotes stem cell http://purl.org/sig/ont/fma/fma63368
T139 2450-2454 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T140 2763-2773 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T141 2768-2773 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T142 2931-2940 Body_part denotes stem cell http://purl.org/sig/ont/fma/fma63368
T143 2936-2940 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T144 3106-3116 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T145 3111-3116 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T146 3209-3214 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T147 3280-3290 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T148 3285-3290 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T149 3396-3400 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T150 3466-3470 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T151 3774-3778 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T152 3898-3908 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T153 3903-3908 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T34 420-431 Body_part denotes bone-marrow http://purl.obolibrary.org/obo/UBERON_0002371
T35 435-449 Body_part denotes umbilical cord http://purl.obolibrary.org/obo/UBERON_0002331
T36 1049-1053 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T37 3209-3214 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T122 49-57 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T123 149-157 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T124 371-379 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T125 384-393 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T126 831-839 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T127 831-835 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T128 850-854 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T129 895-899 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T130 1131-1139 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T131 1204-1212 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T132 1725-1737 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T133 1832-1840 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T134 2009-2017 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T135 2133-2141 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T136 2218-2226 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T137 2783-2791 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T138 3917-3919 Disease denotes EV http://purl.obolibrary.org/obo/MONDO_0009176

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T190 10-20 http://purl.obolibrary.org/obo/CL_0000034 denotes Stem Cells
T191 420-424 http://purl.obolibrary.org/obo/UBERON_0002481 denotes bone
T192 435-449 http://purl.obolibrary.org/obo/UBERON_0002331 denotes umbilical cord
T193 435-449 http://www.ebi.ac.uk/efo/EFO_0001415 denotes umbilical cord
T194 775-778 http://purl.obolibrary.org/obo/PR_000001343 denotes aim
T195 1049-1053 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T196 1049-1053 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T197 1054-1064 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T198 1170-1171 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T199 1440-1441 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 1606-1612 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T201 2019-2020 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 2398-2404 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T203 2445-2454 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T204 2611-2612 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T205 2763-2773 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T206 2853-2854 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T207 2931-2940 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T208 3060-3061 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T209 3106-3116 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T210 3123-3124 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T211 3126-3133 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T212 3155-3160 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T213 3209-3214 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T214 3269-3276 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T215 3280-3290 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T216 3396-3400 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T217 3466-3470 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T218 3774-3778 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T219 3898-3908 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T220 3991-3997 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T58 1575-1580 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T59 1773-1778 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T60 2323-2326 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T62 3063-3066 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T64 3770-3773 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T23 1725-1737 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T24 2347-2358 http://purl.obolibrary.org/obo/GO_0065007 denotes regulations
T25 3621-3628 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T26 3644-3651 http://purl.obolibrary.org/obo/GO_0051235 denotes storage

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T104 0-57 Sentence denotes Advancing Stem Cells to Mainstream Medicines for COVID-19
T105 58-310 Sentence denotes Currently, there are 17 clinical trials investigating the therapeutic potential of MSCs in COVID-19 patients that are registered on clinicaltrials.gov website; most of these trials are either recruiting patients or have not yet started the recruitment.
T106 311-529 Sentence denotes The vast majority of the trials are selecting patients with COVID-19 and pneumonia, and utilizing allogeneic bone-marrow or umbilical cord-derived MSCs transplanted intravenously on three different occasions (Table 1).
T107 530-593 Sentence denotes Approximately 50% of the trials are being carried out in China.
T108 594-855 Sentence denotes Three trials (NCT03042143 already recruiting in Northern Ireland, United Kingdom; NCT04333368 planned in France and NCT04345601 in the United States of America, not yet recruiting) aim to investigate the therapeutic potential of MSCs in SARS-CoV-2-induced ARDS.
T109 856-1162 Sentence denotes MSCs have already been investigated in ARDS both in the pre-clinical (Curley et al., 2013) and clinical settings (Wilson et al., 2015), which demonstrated the ability of MSCs to promote distal lung epithelial repair, albeit potentially limited in the presence of hypercapnic acidosis (Fergie et al., 2019).
T110 1163-1389 Sentence denotes Whilst a number of MSC-related trials in COVID-19 patients with respiratory complications are underway, limited reports are available that these treatments have the potential to improve recovery and survival of these patients.
T111 1390-1790 Sentence denotes Some encouraging data is emerging, for example in a recent study, which assessed 7 patients transplanted with intravenous MSCs (1 × 106 per kg) and 3 patients in the placebo controlled group albeit consisting of all female patients, showed significant improvement in pulmonary function and symptoms as well as substantial reduction in inflammation compared to the placebo controlled group (Figure 2).
T112 1791-1883 Sentence denotes Figure 2 Outcomes of MSCs treatment for COVID-19 patients reported in pilot clinical trial:
T113 1884-1901 Sentence denotes ChiCTR2000029990.
T114 1902-2151 Sentence denotes Despite the lack of convincing evidence in support of MSC-based therapies for respiratory complications of COVID-19, a number of promising trials are currently underway, which could revolutionize the treatment prospects for severe COVID-19 patients.
T115 2152-2405 Sentence denotes Regardless of the urgency of the need for MSC-based therapies for COVID-19, it is critical that the production of MSCs is in compliance with good manufacturing practices (GMP) and follows strict regulations prior to being approved for the use in humans.
T116 2406-2556 Sentence denotes The use of unauthorized and unapproved stem cell therapies not validated through stringent multicenter clinical trials should be strongly discouraged.
T117 2557-2821 Sentence denotes At the same time current findings imply that there is a need for globally coordinated approach and support to conduct multicenter clinical trials to demonstrate safety and effectiveness of various types of stem cells to treat COVID-19-induced health complications.
T118 2822-3021 Sentence denotes It also suggests that there is a need in biomedical research and development to establish the most effective stem cell types that are ideally suited for the treatment of aforementioned complications.
T119 3022-3311 Sentence denotes These developments will also require (a) GMP compliant technologies to mass produce stem cells, and (b) testing platforms that mimic human pathophysiology (e.g., 3D bioprinted organoids, organ-on-chip) to allow high-throughput screening and rapid testing of stem cells safety and efficacy.
T120 3312-3415 Sentence denotes Extracellular vesicles (EVs) are emerging as an attractive alternative to the whole cell–based therapy.
T121 3416-3629 Sentence denotes EVs have several advantages compared to the whole cell therapy including lower risk of tumorigenic effects, lower susceptibility to damage by hostile disease microenvironment and possibility for long-term storage.
T122 3630-3812 Sentence denotes The long-term storage is fundamental to make the treatment accessible in developing countries and it circumvents the need to have expensive GMP cell manufacturing facilities on-site.
T123 3813-4056 Sentence denotes Nevertheless, production of EVs must follow the same strict guidelines that apply to stem cells and any EV-based therapy needs to be approved by the governing bodies after being tested in clinical trials to demonstrate the safety and efficacy.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T15 384-393 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T16 1131-1139 Phenotype denotes acidosis http://purl.obolibrary.org/obo/HP_0001941

2_test

Id Subject Object Predicate Lexical cue
32574317-23377221-31466324 941-945 23377221 denotes 2013
32574317-25529339-31466325 985-989 25529339 denotes 2015
32574317-30649987-31466326 1156-1160 30649987 denotes 2019

MyTest

Id Subject Object Predicate Lexical cue
32574317-23377221-31466324 941-945 23377221 denotes 2013
32574317-25529339-31466325 985-989 25529339 denotes 2015
32574317-30649987-31466326 1156-1160 30649987 denotes 2019