PMC:7264098 / 13686-16997
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T250 | 4-14 | CL:0000034 | denotes | Stem Cells |
| T251 | 29-37 | SP_7 | denotes | COVID-19 |
| T252 | 46-50 | DG_47 | denotes | MSCs |
| T253 | 110-120 | SP_7 | denotes | SARS-CoV-2 |
| T254 | 178-188 | SP_7 | denotes | SARS-CoV-2 |
| T255 | 251-256 | UBERON:0000170 | denotes | lungs |
| T256 | 258-262 | DG_47 | denotes | MSCs |
| T257 | 447-451 | DG_47 | denotes | MSCs |
| T258 | 600-604 | UBERON:0002048 | denotes | lung |
| T259 | 718-732 | UBERON:0004535 | denotes | cardiovascular |
| T260 | 839-850 | UBERON:0002240 | denotes | spinal cord |
| T261 | 920-930 | CL:0000034 | denotes | stem cells |
| T262 | 952-962 | SP_7 | denotes | SARS-CoV-2 |
| T263 | 2835-2845 | CL:0000034 | denotes | stem cells |
| T264 | 2886-2896 | SP_7 | denotes | SARS-CoV-2 |
| T265 | 2916-2927 | SO:0000704 | denotes | genetically |
| T266 | 2939-2944 | SP_6;NCBITaxon:9606 | denotes | human |
| T267 | 2953-2975 | CL:0002248 | denotes | pluripotent stem cells |
| T268 | 3079-3089 | SP_7 | denotes | SARS-CoV-2 |
| T269 | 3143-3153 | CL:0000057 | denotes | fibroblast |
| T270 | 3230-3239 | CL:0000034 | denotes | stem cell |
| T271 | 3266-3274 | SP_7 | denotes | COVID-19 |
| T24281 | 4-14 | CL:0000034 | denotes | Stem Cells |
| T62649 | 29-37 | SP_7 | denotes | COVID-19 |
| T99960 | 46-50 | DG_47 | denotes | MSCs |
| T89902 | 110-120 | SP_7 | denotes | SARS-CoV-2 |
| T78253 | 178-188 | SP_7 | denotes | SARS-CoV-2 |
| T61080 | 251-256 | UBERON:0000170 | denotes | lungs |
| T66822 | 258-262 | DG_47 | denotes | MSCs |
| T39731 | 447-451 | DG_47 | denotes | MSCs |
| T78045 | 600-604 | UBERON:0002048 | denotes | lung |
| T80335 | 718-732 | UBERON:0004535 | denotes | cardiovascular |
| T48665 | 839-850 | UBERON:0002240 | denotes | spinal cord |
| T4839 | 920-930 | CL:0000034 | denotes | stem cells |
| T89150 | 952-962 | SP_7 | denotes | SARS-CoV-2 |
| T22041 | 2835-2845 | CL:0000034 | denotes | stem cells |
| T60180 | 2886-2896 | SP_7 | denotes | SARS-CoV-2 |
| T16258 | 2916-2927 | SO:0000704 | denotes | genetically |
| T53030 | 2939-2944 | SP_6;NCBITaxon:9606 | denotes | human |
| T92892 | 2953-2975 | CL:0002248 | denotes | pluripotent stem cells |
| T36193 | 3079-3089 | SP_7 | denotes | SARS-CoV-2 |
| T84767 | 3143-3153 | CL:0000057 | denotes | fibroblast |
| T2825 | 3230-3239 | CL:0000034 | denotes | stem cell |
| T37459 | 3266-3274 | SP_7 | denotes | COVID-19 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 303 | 29-37 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 312 | 110-131 | Disease | denotes | SARS-CoV-2 infections | MESH:C000657245 |
| 313 | 178-198 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 314 | 600-613 | Disease | denotes | lung diseases | MESH:D008171 |
| 315 | 622-626 | Disease | denotes | ARDS | MESH:D012128 |
| 316 | 676-702 | Disease | denotes | bronchopulmonary dysplasia | MESH:D001997 |
| 317 | 718-741 | Disease | denotes | cardiovascular diseases | MESH:D002318 |
| 318 | 784-792 | Disease | denotes | diabetes | MESH:D003920 |
| 319 | 839-857 | Disease | denotes | spinal cord injury | MESH:D013119 |
| 338 | 1310-1315 | Gene | denotes | TNF-α | Gene:7124 |
| 339 | 1327-1332 | Gene | denotes | IL-10 | Gene:3586 |
| 340 | 1337-1341 | Gene | denotes | VEGF | Gene:7422 |
| 341 | 1005-1013 | Species | denotes | patients | Tax:9606 |
| 342 | 1089-1100 | Species | denotes | unspecified | Tax:32644 |
| 343 | 1146-1154 | Species | denotes | patients | Tax:9606 |
| 344 | 1464-1472 | Species | denotes | patients | Tax:9606 |
| 345 | 1595-1603 | Species | denotes | patients | Tax:9606 |
| 346 | 1740-1748 | Species | denotes | patients | Tax:9606 |
| 347 | 1903-1911 | Species | denotes | patients | Tax:9606 |
| 348 | 1986-1997 | Species | denotes | unspecified | Tax:32644 |
| 349 | 2051-2059 | Species | denotes | patients | Tax:9606 |
| 350 | 2191-2199 | Species | denotes | patients | Tax:9606 |
| 351 | 2350-2358 | Species | denotes | patients | Tax:9606 |
| 352 | 2470-2478 | Species | denotes | patients | Tax:9606 |
| 353 | 2541-2546 | Species | denotes | Human | Tax:9606 |
| 354 | 2694-2702 | Species | denotes | patients | Tax:9606 |
| 355 | 1167-1185 | Disease | denotes | COVID-19 pneumonia | MESH:C000657245 |
| 357 | 952-972 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 363 | 2939-2944 | Species | denotes | human | Tax:9606 |
| 364 | 3079-3089 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 365 | 2886-2907 | Disease | denotes | SARS-CoV-2 infections | MESH:C000657245 |
| 366 | 3101-3122 | Disease | denotes | pluripotency of iPSCs | |
| 367 | 3266-3274 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T84 | 4-14 | Body_part | denotes | Stem Cells | http://purl.org/sig/ont/fma/fma63368 |
| T85 | 9-14 | Body_part | denotes | Cells | http://purl.org/sig/ont/fma/fma68646 |
| T86 | 229-237 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T87 | 251-256 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T88 | 600-604 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T89 | 839-850 | Body_part | denotes | spinal cord | http://purl.org/sig/ont/fma/fma7647 |
| T90 | 920-930 | Body_part | denotes | stem cells | http://purl.org/sig/ont/fma/fma63368 |
| T91 | 925-930 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T92 | 974-978 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
| T93 | 1075-1081 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T94 | 1126-1131 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T95 | 1234-1240 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T96 | 1252-1259 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T97 | 1269-1277 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T98 | 1295-1300 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T99 | 1372-1386 | Body_part | denotes | Adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
| T100 | 1431-1436 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T101 | 1520-1531 | Body_part | denotes | Dental pulp | http://purl.org/sig/ont/fma/fma55631 |
| T102 | 1532-1542 | Body_part | denotes | stem cells | http://purl.org/sig/ont/fma/fma63368 |
| T103 | 1537-1542 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T104 | 1552-1557 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T105 | 1658-1669 | Body_part | denotes | Dental pulp | http://purl.org/sig/ont/fma/fma55631 |
| T106 | 1670-1680 | Body_part | denotes | stem cells | http://purl.org/sig/ont/fma/fma63368 |
| T107 | 1675-1680 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T108 | 1690-1695 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T109 | 1802-1817 | Body_part | denotes | Wharton's Jelly | http://purl.org/sig/ont/fma/fma323134 |
| T110 | 1843-1848 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T111 | 1972-1978 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T112 | 2008-2013 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T113 | 2114-2128 | Body_part | denotes | Umbilical cord | http://purl.org/sig/ont/fma/fma85541 |
| T114 | 2145-2150 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T115 | 2254-2268 | Body_part | denotes | Umbilical cord | http://purl.org/sig/ont/fma/fma85541 |
| T116 | 2285-2290 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T117 | 2298-2302 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
| T118 | 2397-2408 | Body_part | denotes | Bone Marrow | http://purl.org/sig/ont/fma/fma9608 |
| T119 | 2438-2443 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T120 | 2547-2567 | Body_part | denotes | embryonic stem cells | http://purl.org/sig/ont/fma/fma82841 |
| T121 | 2562-2567 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T122 | 2594-2599 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T123 | 2652-2657 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T124 | 2665-2669 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
| T125 | 2835-2845 | Body_part | denotes | stem cells | http://purl.org/sig/ont/fma/fma63368 |
| T126 | 2840-2845 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T127 | 2953-2975 | Body_part | denotes | pluripotent stem cells | http://purl.org/sig/ont/fma/fma70570 |
| T128 | 2970-2975 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T129 | 3037-3042 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T130 | 3143-3153 | Body_part | denotes | fibroblast | http://purl.org/sig/ont/fma/fma63877 |
| T131 | 3230-3239 | Body_part | denotes | stem cell | http://purl.org/sig/ont/fma/fma63368 |
| T132 | 3235-3239 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T23 | 600-604 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T24 | 839-850 | Body_part | denotes | spinal cord | http://purl.obolibrary.org/obo/UBERON_0002240 |
| T25 | 1075-1081 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T26 | 1372-1386 | Body_part | denotes | Adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T27 | 1380-1386 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T28 | 1520-1531 | Body_part | denotes | Dental pulp | http://purl.obolibrary.org/obo/UBERON_0001754 |
| T29 | 1658-1669 | Body_part | denotes | Dental pulp | http://purl.obolibrary.org/obo/UBERON_0001754 |
| T30 | 1972-1978 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T31 | 2114-2128 | Body_part | denotes | Umbilical cord | http://purl.obolibrary.org/obo/UBERON_0002331 |
| T32 | 2254-2268 | Body_part | denotes | Umbilical cord | http://purl.obolibrary.org/obo/UBERON_0002331 |
| T33 | 2397-2408 | Body_part | denotes | Bone Marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T97 | 29-37 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T98 | 110-118 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T99 | 110-114 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T100 | 121-131 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T101 | 178-186 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T102 | 178-182 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T103 | 189-198 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T104 | 600-613 | Disease | denotes | lung diseases | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T105 | 622-626 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T106 | 676-702 | Disease | denotes | bronchopulmonary dysplasia | http://purl.obolibrary.org/obo/MONDO_0019091 |
| T107 | 718-741 | Disease | denotes | cardiovascular diseases | http://purl.obolibrary.org/obo/MONDO_0004995 |
| T108 | 784-792 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T109 | 839-857 | Disease | denotes | spinal cord injury | http://purl.obolibrary.org/obo/MONDO_0043797 |
| T110 | 851-857 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T111 | 952-960 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T112 | 952-956 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T113 | 963-972 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T114 | 1167-1175 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T115 | 1176-1185 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T116 | 2886-2894 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T117 | 2886-2890 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T118 | 2897-2907 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T119 | 3079-3087 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T120 | 3079-3083 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T121 | 3266-3274 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T129 | 4-14 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | Stem Cells |
| T130 | 15-16 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T131 | 251-256 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T132 | 499-500 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T133 | 600-604 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T134 | 600-604 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T135 | 816-819 | http://purl.obolibrary.org/obo/CLO_0002421 | denotes | Cho |
| T136 | 816-819 | http://purl.obolibrary.org/obo/CLO_0052479 | denotes | Cho |
| T137 | 816-819 | http://purl.obolibrary.org/obo/CLO_0052480 | denotes | Cho |
| T138 | 816-819 | http://purl.obolibrary.org/obo/CLO_0052483 | denotes | Cho |
| T139 | 816-819 | http://purl.obolibrary.org/obo/CLO_0052484 | denotes | Cho |
| T140 | 816-819 | http://purl.obolibrary.org/obo/CLO_0052485 | denotes | Cho |
| T141 | 828-832 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T142 | 839-850 | http://purl.obolibrary.org/obo/UBERON_0002240 | denotes | spinal cord |
| T143 | 920-930 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
| T144 | 974-983 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | Cell type |
| T145 | 1126-1131 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T146 | 1234-1240 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T147 | 1295-1300 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T148 | 1372-1386 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | Adipose tissue |
| T149 | 1431-1436 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T150 | 1476-1477 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T151 | 1532-1542 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
| T152 | 1552-1557 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T153 | 1607-1608 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T154 | 1670-1680 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
| T155 | 1690-1695 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T156 | 1752-1753 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T157 | 1843-1848 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T158 | 1856-1861 | http://purl.obolibrary.org/obo/CLO_0006976 | denotes | IV, 3 |
| T159 | 1915-1916 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T160 | 2008-2013 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T161 | 2063-2064 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T162 | 2114-2128 | http://purl.obolibrary.org/obo/UBERON_0002331 | denotes | Umbilical cord |
| T163 | 2114-2128 | http://www.ebi.ac.uk/efo/EFO_0001415 | denotes | Umbilical cord |
| T164 | 2145-2150 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T165 | 2164-2168 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 3, 5 |
| T166 | 2203-2204 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T167 | 2254-2268 | http://purl.obolibrary.org/obo/UBERON_0002331 | denotes | Umbilical cord |
| T168 | 2254-2268 | http://www.ebi.ac.uk/efo/EFO_0001415 | denotes | Umbilical cord |
| T169 | 2285-2290 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T170 | 2323-2327 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 3, 5 |
| T171 | 2347-2349 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T172 | 2362-2363 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T173 | 2397-2401 | http://purl.obolibrary.org/obo/UBERON_0002481 | denotes | Bone |
| T174 | 2438-2443 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T175 | 2482-2483 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T176 | 2541-2546 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T177 | 2557-2567 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
| T178 | 2594-2599 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T179 | 2632-2636 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 3, 5 |
| T180 | 2652-2657 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T181 | 2706-2707 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T182 | 2835-2845 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
| T183 | 2939-2944 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T184 | 2965-2975 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
| T185 | 2984-2985 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T186 | 3009-3010 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T187 | 3037-3051 | http://purl.obolibrary.org/obo/CL_0001034 | denotes | cells in vitro |
| T188 | 3143-3153 | http://purl.obolibrary.org/obo/CL_0000057 | denotes | fibroblast |
| T189 | 3230-3239 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T45 | 1140-1142 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T46 | 1252-1259 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T47 | 1327-1329 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T49 | 1445-1447 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T50 | 1558-1560 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T51 | 1703-1705 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T52 | 1856-1858 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T53 | 2014-2016 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T54 | 2151-2153 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T55 | 2310-2312 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T56 | 2452-2454 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T57 | 2677-2679 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T20 | 1187-1222 | http://purl.obolibrary.org/obo/GO_0050727 | denotes | Regulation of inflammatory response |
| T21 | 1201-1222 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T22 | 1269-1287 | http://purl.obolibrary.org/obo/GO_0001816 | denotes | cytokine-secreting |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T75 | 0-45 | Sentence | denotes | Are Stem Cells a Solution to COVID-19 Crisis? |
| T76 | 46-142 | Sentence | denotes | MSCs could be the most promising candidate for the treatment of SARS-CoV-2 infections (Table 1). |
| T77 | 143-411 | Sentence | denotes | Since the key for the treatment of SARS-CoV-2 infection lies in the management of the cytokine storm in the lungs, MSCs are well-suited considering their main mechanism of action is through their immunomodulatory and anti-inflammatory properties (Fatima et al., 2017). |
| T78 | 412-878 | Sentence | denotes | The safety profile and efficacy of MSCs are well-established based on the results from a number of completed clinical studies investigating the therapeutic potential of these therapies in lung diseases such as ARDS (Matthay et al., 2019; Chen J. et al., 2020) and bronchopulmonary dysplasia (Namba, 2019), cardiovascular diseases (Kim et al., 2015; Suvakov et al., 2020), diabetes (Thakkar et al., 2015; Cho et al., 2018), and spinal cord injury (Xu and Yang, 2019). |
| T79 | 879-973 | Sentence | denotes | Table 1 Selected clinical studies using stem cells for the treatment of SARS-CoV-2 infection. |
| T80 | 974-1068 | Sentence | denotes | Cell type Dosage Number of patients Outcome Stage of study Reference or NCT numbers# |
| T81 | 1069-1371 | Sentence | denotes | MSCs (tissue source unspecified) Single dose of 1 × 106 cells per kg, IV 7 patients with severe COVID-19 pneumonia Regulation of inflammatory response (Decreased plasma C-reaction protein, reduced cytokine-secreting immune cells, reduced TNF-α, increased IL-10 and VEGF) Complete Leng et al., 2020 |
| T82 | 1372-1459 | Sentence | denotes | Adipose tissue-derived MSCs Two serial doses of 1.5 × 106 cells per kg, IV Estimated: |
| T83 | 1460-1519 | Sentence | denotes | 100 patients N/A Phase 2; Not yet recruiting NCT04348461 |
| T84 | 1520-1591 | Sentence | denotes | Dental pulp stem cells 3 × 107 cells IV on day 1, 4, and 7 Estimated: |
| T85 | 1592-1657 | Sentence | denotes | 20 patients N/A Phase 1 clinical trial; recruiting NCT04336254 |
| T86 | 1658-1736 | Sentence | denotes | Dental pulp stem cells 1 × 106 cells per kg IV on day 1, 3, and 7 Estimated: |
| T87 | 1737-1801 | Sentence | denotes | 24 patients N/A Early Phase 1; Not yet recruiting NCT04302519 |
| T88 | 1802-1900 | Sentence | denotes | Wharton's Jelly MSCs 3 doses of 1 × 106 cells per kg IV, 3 days apart from each other Estimated: |
| T89 | 1901-1965 | Sentence | denotes | 5 patients N/A Phase 1 clinical trial; recruiting NCT04313322 |
| T90 | 1966-2047 | Sentence | denotes | MSCs (tissue source unspecified) 3 × 107 cells IV on day 0, 3, and 6 Estimated: |
| T91 | 2048-2113 | Sentence | denotes | 20 patients N/A Phase 1 clinical trial; recruiting NCT04252118 |
| T92 | 2114-2187 | Sentence | denotes | Umbilical cord MSCs 9.9 × 107 cells IV on day 1, 3, 5, and 7 Estimated: |
| T93 | 2188-2253 | Sentence | denotes | 10 patients N/A Phase 2 clinical trial; recruiting NCT04269525 |
| T94 | 2254-2346 | Sentence | denotes | Umbilical cord MSCs 0.5 × 106 cells per kg body weight IV on day 1, 3, 5, and 7 Estimated: |
| T95 | 2347-2396 | Sentence | denotes | 48 patients N/A Not yet recruiting NCT04273646 |
| T96 | 2397-2466 | Sentence | denotes | Bone Marrow MSCs Single dose of 1 × 106 cells per kg, IV Estimated: |
| T97 | 2467-2540 | Sentence | denotes | 20 patients N/A Phase 1 clinical trial; Not yet recruiting NCT04346368 |
| T98 | 2541-2691 | Sentence | denotes | Human embryonic stem cells derived matrix-regulatory cells 3 cohorts who receive doses of 3, 5, or 10 million cells per kg body weight IV Estimated: |
| T99 | 2692-2756 | Sentence | denotes | 9 patients N/A Phase 1 clinical trial; recruiting NCT04331613 |
| T100 | 2757-2819 | Sentence | denotes | # NCT numbers refer to ClinicalTrials.gov Identifier numbers. |
| T101 | 2820-2983 | Sentence | denotes | Other types of stem cells investigated for potential treatment of SARS-CoV-2 infections include genetically engineered human induced pluripotent stem cells (iPSC). |
| T102 | 2984-3190 | Sentence | denotes | A recent study presented a deleterious effect on the cells in vitro when iPSCs were exposed to SARS-CoV-2, where the pluripotency of iPSCs was lost leading to fibroblast-like phenotype (Zebin et al., 2020). |
| T103 | 3191-3311 | Sentence | denotes | Therefore, evidence-based selection of stem cell type for the treatment of COVID-19 is critical for safety and efficacy. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T11 | 229-243 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T12 | 600-613 | Phenotype | denotes | lung diseases | http://purl.obolibrary.org/obo/HP_0002088 |
| T13 | 718-741 | Phenotype | denotes | cardiovascular diseases | http://purl.obolibrary.org/obo/HP_0001626 |
| T14 | 1176-1185 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32574317-29123544-31466314 | 405-409 | 29123544 | denotes | 2017 |
| 32574317-30455077-31466315 | 644-648 | 30455077 | denotes | 2019 |
| 32574317-32292627-31466316 | 666-670 | 32292627 | denotes | 2020 |
| 32574317-31487104-31466317 | 711-715 | 31487104 | denotes | 2019 |
| 32574317-25709098-31466318 | 755-759 | 25709098 | denotes | 2015 |
| 32574317-32291521-31466319 | 777-781 | 32291521 | denotes | 2020 |
| 32574317-25869301-31466320 | 810-814 | 25869301 | denotes | 2015 |
| 32574317-30510843-31466321 | 828-832 | 30510843 | denotes | 2018 |
| 32574317-30362373-31466322 | 872-876 | 30362373 | denotes | 2019 |
| 32574317-32257537-31466323 | 1367-1371 | 32257537 | denotes | 2020 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32574317-29123544-31466314 | 405-409 | 29123544 | denotes | 2017 |
| 32574317-30455077-31466315 | 644-648 | 30455077 | denotes | 2019 |
| 32574317-32292627-31466316 | 666-670 | 32292627 | denotes | 2020 |
| 32574317-31487104-31466317 | 711-715 | 31487104 | denotes | 2019 |
| 32574317-25709098-31466318 | 755-759 | 25709098 | denotes | 2015 |
| 32574317-32291521-31466319 | 777-781 | 32291521 | denotes | 2020 |
| 32574317-25869301-31466320 | 810-814 | 25869301 | denotes | 2015 |
| 32574317-30510843-31466321 | 828-832 | 30510843 | denotes | 2018 |
| 32574317-30362373-31466322 | 872-876 | 30362373 | denotes | 2019 |
| 32574317-32257537-31466323 | 1367-1372 | 32257537 | denotes | 2020 |