PMC:7264098 / 10367-13684 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7264098","sourcedb":"PMC","sourceid":"7264098","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7264098","text":"Current Treatments Are Palliative Only\nDespite over 300 active and recruiting clinical trials and a number of trials already completed, there is still no robust evidence that any of the investigated therapeutics are effective as treatments for COVID-19 disease (Channappanavar et al., 2017). Equally, there is no evidence to support prophylactic treatment either (Sanders et al., 2020). However, there are only 29 trials in adult patients with placebo-controlled arm (Channappanavar et al., 2017). Various types of pharmacological treatments are currently under investigation including anti-viral, anti-malarial and anti-inflammatory agents. These therapies generally target the following processes: (1) the entry of the virus into host cells, (2) multiplication of the viral genetic material, and (3) immune response/inflammation. Most of these agents have been previously used as treatments for SARS-CoV and MERS-CoV, however the overall conclusions of the meta-analyses published in 2006 and 2018, respectively, did not support the use of any particular regimen. In relation to the meta-analysis of SARS-CoV treatments, the authors systematically reviewed 54 treatment studies, 15 in vitro studies and three ARDS studies (Stockman et al., 2006). Although the combination of ribavirin and interferon-based (IFN) treatments appears the most effective for MERS (Morra et al., 2018), this needs to be confirmed in randomized placebo-controlled trial settings. In terms of vaccines, there are at least 115 vaccine candidates in development with a number of these already initiated in human trials, however we expect vaccines to be available to people under emergency use only in early 2021 (Callaway, 2020; Thanh Le et al., 2020).\nOverall, there are a number of concerns in relation to the design of various trials and interpretation of the data investigating different pharmacological agents for the treatment of COVID-19. Some of these limitations include small cohort sizes, no placebo control arm, lack of considerations for gender, comorbidities, concurrent treatments, route of drug delivery, primary outcomes lacking effects on the viral load or suppression, and adverse drug effects. Whilst most of these therapies represent supportive and symptomatic care, there are a number of adjunctive therapies such as corticosteroids, immunomodulatory, and immunoglobulin agents that have been investigated with limited results. In particular, corticosteroids are not recommended for the management of COVID-19 because of the associated adverse effects, which potentially include increased viral load, secondary infections and complications, similarly to what was observed previously in influenza, SARS-CoV and MERS-CoV infections (Russell et al., 2020). Potential benefits in severe COVID-19 cases are emerging with IL-6 monoclonal antibody, Tocilizumab, and the use of convalescent plasma or hyperimmune immunoglobulins, however better designs and further trials are needed for this to be established (Chen L. et al., 2020; Fu et al., 2020). Nevertheless, none of these therapies are capable of lung tissue repair and regeneration, particularly in those patients with complications such as ARDS, which is why the use of stem cell-based therapies could be beneficial in COVID-19 patients with respiratory complications.","divisions":[{"label":"title","span":{"begin":0,"end":38}},{"label":"p","span":{"begin":39,"end":1728}}],"tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T209","span":{"begin":244,"end":252},"obj":"SP_7"},{"id":"T210","span":{"begin":424,"end":429},"obj":"UBERON:0007023"},{"id":"T211","span":{"begin":515,"end":530},"obj":"CHEBI:52217;CHEBI:52217"},{"id":"T212","span":{"begin":591,"end":596},"obj":"NCBITaxon:10239"},{"id":"T213","span":{"begin":616,"end":640},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T214","span":{"begin":708,"end":716},"obj":"GO:0035376"},{"id":"T215","span":{"begin":721,"end":726},"obj":"NCBITaxon:10239"},{"id":"T216","span":{"begin":770,"end":775},"obj":"NCBITaxon:10239"},{"id":"T217","span":{"begin":776,"end":783},"obj":"SO:0000704"},{"id":"T218","span":{"begin":802,"end":808},"obj":"UBERON:0002405;GO:0006955"},{"id":"T219","span":{"begin":809,"end":817},"obj":"GO:0006955"},{"id":"T220","span":{"begin":897,"end":905},"obj":"SP_10"},{"id":"T221","span":{"begin":910,"end":918},"obj":"SP_9"},{"id":"T222","span":{"begin":1102,"end":1110},"obj":"SP_10"},{"id":"T223","span":{"begin":1277,"end":1286},"obj":"DG_29"},{"id":"T224","span":{"begin":1356,"end":1360},"obj":"SP_9"},{"id":"T225","span":{"begin":1582,"end":1587},"obj":"SP_6;NCBITaxon:9606"},{"id":"T226","span":{"begin":1642,"end":1648},"obj":"NCBITaxon:9606"},{"id":"T227","span":{"begin":1868,"end":1890},"obj":"CHEBI:52217;CHEBI:52217"},{"id":"T228","span":{"begin":1912,"end":1920},"obj":"SP_7"},{"id":"T229","span":{"begin":2082,"end":2086},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T230","span":{"begin":2137,"end":2142},"obj":"NCBITaxon:10239"},{"id":"T231","span":{"begin":2176,"end":2180},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T232","span":{"begin":2315,"end":2330},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T233","span":{"begin":2354,"end":2368},"obj":"GO:0019814"},{"id":"T234","span":{"begin":2441,"end":2456},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T235","span":{"begin":2499,"end":2507},"obj":"SP_7"},{"id":"T236","span":{"begin":2587,"end":2592},"obj":"NCBITaxon:10239"},{"id":"T237","span":{"begin":2695,"end":2703},"obj":"SP_10"},{"id":"T238","span":{"begin":2708,"end":2716},"obj":"SP_9"},{"id":"T239","span":{"begin":2781,"end":2789},"obj":"SP_7"},{"id":"T240","span":{"begin":2814,"end":2818},"obj":"PR:000001393"},{"id":"T241","span":{"begin":2830,"end":2838},"obj":"GO:0042571"},{"id":"T242","span":{"begin":2840,"end":2851},"obj":"DG_35"},{"id":"T243","span":{"begin":2881,"end":2887},"obj":"UBERON:0001969"},{"id":"T244","span":{"begin":3094,"end":3098},"obj":"UBERON:0002048;GO:0030324"},{"id":"T245","span":{"begin":3099,"end":3105},"obj":"UBERON:0000479;GO:0048771"},{"id":"T246","span":{"begin":3106,"end":3112},"obj":"GO:0006281"},{"id":"T247","span":{"begin":3219,"end":3228},"obj":"CL:0000034"},{"id":"T248","span":{"begin":3268,"end":3276},"obj":"SP_7"},{"id":"T249","span":{"begin":3291,"end":3302},"obj":"UBERON:0001004"},{"id":"T19107","span":{"begin":244,"end":252},"obj":"SP_7"},{"id":"T18999","span":{"begin":424,"end":429},"obj":"UBERON:0007023"},{"id":"T82295","span":{"begin":515,"end":530},"obj":"CHEBI:52217;CHEBI:52217"},{"id":"T38095","span":{"begin":591,"end":596},"obj":"NCBITaxon:10239"},{"id":"T83805","span":{"begin":616,"end":640},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T45166","span":{"begin":708,"end":716},"obj":"GO:0035376"},{"id":"T6847","span":{"begin":721,"end":726},"obj":"NCBITaxon:10239"},{"id":"T60882","span":{"begin":770,"end":775},"obj":"NCBITaxon:10239"},{"id":"T38954","span":{"begin":776,"end":783},"obj":"SO:0000704"},{"id":"T73828","span":{"begin":802,"end":808},"obj":"UBERON:0002405;GO:0006955"},{"id":"T2948","span":{"begin":809,"end":817},"obj":"GO:0006955"},{"id":"T72804","span":{"begin":897,"end":905},"obj":"SP_10"},{"id":"T63585","span":{"begin":910,"end":918},"obj":"SP_9"},{"id":"T57772","span":{"begin":1102,"end":1110},"obj":"SP_10"},{"id":"T4874","span":{"begin":1277,"end":1286},"obj":"DG_29"},{"id":"T72833","span":{"begin":1356,"end":1360},"obj":"SP_9"},{"id":"T51389","span":{"begin":1582,"end":1587},"obj":"SP_6;NCBITaxon:9606"},{"id":"T46048","span":{"begin":1642,"end":1648},"obj":"NCBITaxon:9606"},{"id":"T87897","span":{"begin":1868,"end":1890},"obj":"CHEBI:52217;CHEBI:52217"},{"id":"T26480","span":{"begin":1912,"end":1920},"obj":"SP_7"},{"id":"T90542","span":{"begin":2082,"end":2086},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T37163","span":{"begin":2137,"end":2142},"obj":"NCBITaxon:10239"},{"id":"T76008","span":{"begin":2176,"end":2180},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T1743","span":{"begin":2315,"end":2330},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T19878","span":{"begin":2354,"end":2368},"obj":"GO:0019814"},{"id":"T42944","span":{"begin":2441,"end":2456},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T66105","span":{"begin":2499,"end":2507},"obj":"SP_7"},{"id":"T10959","span":{"begin":2587,"end":2592},"obj":"NCBITaxon:10239"},{"id":"T19275","span":{"begin":2695,"end":2703},"obj":"SP_10"},{"id":"T38092","span":{"begin":2708,"end":2716},"obj":"SP_9"},{"id":"T72801","span":{"begin":2781,"end":2789},"obj":"SP_7"},{"id":"T27059","span":{"begin":2814,"end":2818},"obj":"PR:000001393"},{"id":"T36392","span":{"begin":2830,"end":2838},"obj":"GO:0042571"},{"id":"T43679","span":{"begin":2840,"end":2851},"obj":"DG_35"},{"id":"T33223","span":{"begin":2881,"end":2887},"obj":"UBERON:0001969"},{"id":"T78491","span":{"begin":3094,"end":3098},"obj":"UBERON:0002048;GO:0030324"},{"id":"T78488","span":{"begin":3099,"end":3105},"obj":"UBERON:0000479;GO:0048771"},{"id":"T36301","span":{"begin":3106,"end":3112},"obj":"GO:0006281"},{"id":"T56773","span":{"begin":3219,"end":3228},"obj":"CL:0000034"},{"id":"T4596","span":{"begin":3268,"end":3276},"obj":"SP_7"},{"id":"T56143","span":{"begin":3291,"end":3302},"obj":"UBERON:0001004"}],"attributes":[{"subj":"T209","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T210","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T211","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T212","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T213","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T214","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T215","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T216","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T217","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T218","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T219","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T220","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T221","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T222","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T223","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T224","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T225","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T226","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T227","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T228","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T229","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T230","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T231","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T232","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T233","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T234","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T235","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T236","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T237","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T238","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T239","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T240","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T241","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T242","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T243","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T244","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T245","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T246","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T247","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T248","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T249","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T19107","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T18999","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T82295","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T38095","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T83805","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T45166","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T6847","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T60882","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T38954","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T73828","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T2948","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T72804","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T63585","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T57772","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T4874","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T72833","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T51389","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T46048","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T87897","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26480","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T90542","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T37163","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T76008","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1743","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T19878","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T42944","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T66105","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T10959","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T19275","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T38092","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T72801","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T27059","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T36392","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T43679","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T33223","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T78491","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T78488","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T36301","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T56773","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T4596","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T56143","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"266","span":{"begin":430,"end":438},"obj":"Species"},{"id":"267","span":{"begin":897,"end":905},"obj":"Species"},{"id":"268","span":{"begin":910,"end":918},"obj":"Species"},{"id":"269","span":{"begin":1102,"end":1110},"obj":"Species"},{"id":"270","span":{"begin":1582,"end":1587},"obj":"Species"},{"id":"271","span":{"begin":1642,"end":1648},"obj":"Species"},{"id":"272","span":{"begin":1277,"end":1286},"obj":"Chemical"},{"id":"273","span":{"begin":244,"end":252},"obj":"Disease"},{"id":"274","span":{"begin":818,"end":830},"obj":"Disease"},{"id":"275","span":{"begin":1211,"end":1215},"obj":"Disease"},{"id":"289","span":{"begin":2814,"end":2818},"obj":"Gene"},{"id":"290","span":{"begin":2695,"end":2703},"obj":"Species"},{"id":"291","span":{"begin":3153,"end":3161},"obj":"Species"},{"id":"292","span":{"begin":3277,"end":3285},"obj":"Species"},{"id":"293","span":{"begin":2840,"end":2851},"obj":"Chemical"},{"id":"294","span":{"begin":1912,"end":1920},"obj":"Disease"},{"id":"295","span":{"begin":2499,"end":2507},"obj":"Disease"},{"id":"296","span":{"begin":2599,"end":2619},"obj":"Disease"},{"id":"297","span":{"begin":2708,"end":2727},"obj":"Disease"},{"id":"298","span":{"begin":2781,"end":2789},"obj":"Disease"},{"id":"299","span":{"begin":3189,"end":3193},"obj":"Disease"},{"id":"300","span":{"begin":3268,"end":3276},"obj":"Disease"},{"id":"301","span":{"begin":3291,"end":3316},"obj":"Disease"}],"attributes":[{"id":"A266","pred":"tao:has_database_id","subj":"266","obj":"Tax:9606"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"Tax:694009"},{"id":"A268","pred":"tao:has_database_id","subj":"268","obj":"Tax:1335626"},{"id":"A269","pred":"tao:has_database_id","subj":"269","obj":"Tax:694009"},{"id":"A270","pred":"tao:has_database_id","subj":"270","obj":"Tax:9606"},{"id":"A271","pred":"tao:has_database_id","subj":"271","obj":"Tax:9606"},{"id":"A272","pred":"tao:has_database_id","subj":"272","obj":"MESH:D012254"},{"id":"A273","pred":"tao:has_database_id","subj":"273","obj":"MESH:C000657245"},{"id":"A274","pred":"tao:has_database_id","subj":"274","obj":"MESH:D007249"},{"id":"A275","pred":"tao:has_database_id","subj":"275","obj":"MESH:D012128"},{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"Gene:3569"},{"id":"A290","pred":"tao:has_database_id","subj":"290","obj":"Tax:694009"},{"id":"A291","pred":"tao:has_database_id","subj":"291","obj":"Tax:9606"},{"id":"A292","pred":"tao:has_database_id","subj":"292","obj":"Tax:9606"},{"id":"A293","pred":"tao:has_database_id","subj":"293","obj":"MESH:C502936"},{"id":"A294","pred":"tao:has_database_id","subj":"294","obj":"MESH:C000657245"},{"id":"A295","pred":"tao:has_database_id","subj":"295","obj":"MESH:C000657245"},{"id":"A296","pred":"tao:has_database_id","subj":"296","obj":"MESH:D060085"},{"id":"A297","pred":"tao:has_database_id","subj":"297","obj":"MESH:D018352"},{"id":"A298","pred":"tao:has_database_id","subj":"298","obj":"MESH:C000657245"},{"id":"A299","pred":"tao:has_database_id","subj":"299","obj":"MESH:D012128"},{"id":"A300","pred":"tao:has_database_id","subj":"300","obj":"MESH:C000657245"},{"id":"A301","pred":"tao:has_database_id","subj":"301","obj":"MESH:D012131"},{"subj":"266","pred":"source","obj":"LitCovid-PubTator"},{"subj":"267","pred":"source","obj":"LitCovid-PubTator"},{"subj":"268","pred":"source","obj":"LitCovid-PubTator"},{"subj":"269","pred":"source","obj":"LitCovid-PubTator"},{"subj":"270","pred":"source","obj":"LitCovid-PubTator"},{"subj":"271","pred":"source","obj":"LitCovid-PubTator"},{"subj":"272","pred":"source","obj":"LitCovid-PubTator"},{"subj":"273","pred":"source","obj":"LitCovid-PubTator"},{"subj":"274","pred":"source","obj":"LitCovid-PubTator"},{"subj":"275","pred":"source","obj":"LitCovid-PubTator"},{"subj":"289","pred":"source","obj":"LitCovid-PubTator"},{"subj":"290","pred":"source","obj":"LitCovid-PubTator"},{"subj":"291","pred":"source","obj":"LitCovid-PubTator"},{"subj":"292","pred":"source","obj":"LitCovid-PubTator"},{"subj":"293","pred":"source","obj":"LitCovid-PubTator"},{"subj":"294","pred":"source","obj":"LitCovid-PubTator"},{"subj":"295","pred":"source","obj":"LitCovid-PubTator"},{"subj":"296","pred":"source","obj":"LitCovid-PubTator"},{"subj":"297","pred":"source","obj":"LitCovid-PubTator"},{"subj":"298","pred":"source","obj":"LitCovid-PubTator"},{"subj":"299","pred":"source","obj":"LitCovid-PubTator"},{"subj":"300","pred":"source","obj":"LitCovid-PubTator"},{"subj":"301","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T73","span":{"begin":463,"end":466},"obj":"Body_part"},{"id":"T74","span":{"begin":737,"end":742},"obj":"Body_part"},{"id":"T75","span":{"begin":1995,"end":1998},"obj":"Body_part"},{"id":"T76","span":{"begin":2354,"end":2368},"obj":"Body_part"},{"id":"T77","span":{"begin":2830,"end":2838},"obj":"Body_part"},{"id":"T78","span":{"begin":2881,"end":2887},"obj":"Body_part"},{"id":"T79","span":{"begin":2903,"end":2918},"obj":"Body_part"},{"id":"T80","span":{"begin":3094,"end":3098},"obj":"Body_part"},{"id":"T81","span":{"begin":3099,"end":3105},"obj":"Body_part"},{"id":"T82","span":{"begin":3219,"end":3228},"obj":"Body_part"},{"id":"T83","span":{"begin":3224,"end":3228},"obj":"Body_part"}],"attributes":[{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma24890"},{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma24890"},{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma63368"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T19","span":{"begin":463,"end":466},"obj":"Body_part"},{"id":"T20","span":{"begin":1995,"end":1998},"obj":"Body_part"},{"id":"T21","span":{"begin":3094,"end":3098},"obj":"Body_part"},{"id":"T22","span":{"begin":3099,"end":3105},"obj":"Body_part"}],"attributes":[{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T80","span":{"begin":244,"end":252},"obj":"Disease"},{"id":"T81","span":{"begin":818,"end":830},"obj":"Disease"},{"id":"T82","span":{"begin":897,"end":905},"obj":"Disease"},{"id":"T83","span":{"begin":897,"end":901},"obj":"Disease"},{"id":"T84","span":{"begin":1102,"end":1110},"obj":"Disease"},{"id":"T85","span":{"begin":1102,"end":1106},"obj":"Disease"},{"id":"T86","span":{"begin":1211,"end":1215},"obj":"Disease"},{"id":"T87","span":{"begin":1912,"end":1920},"obj":"Disease"},{"id":"T88","span":{"begin":2499,"end":2507},"obj":"Disease"},{"id":"T89","span":{"begin":2609,"end":2619},"obj":"Disease"},{"id":"T90","span":{"begin":2684,"end":2693},"obj":"Disease"},{"id":"T91","span":{"begin":2695,"end":2703},"obj":"Disease"},{"id":"T92","span":{"begin":2695,"end":2699},"obj":"Disease"},{"id":"T93","span":{"begin":2717,"end":2727},"obj":"Disease"},{"id":"T94","span":{"begin":2781,"end":2789},"obj":"Disease"},{"id":"T95","span":{"begin":3189,"end":3193},"obj":"Disease"},{"id":"T96","span":{"begin":3268,"end":3276},"obj":"Disease"}],"attributes":[{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A96","pred":"mondo_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T113","span":{"begin":56,"end":62},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T114","span":{"begin":98,"end":99},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T115","span":{"begin":463,"end":466},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T116","span":{"begin":721,"end":726},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T117","span":{"begin":737,"end":742},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T118","span":{"begin":995,"end":999},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T119","span":{"begin":1376,"end":1380},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T120","span":{"begin":1543,"end":1544},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T121","span":{"begin":1582,"end":1587},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T122","span":{"begin":1748,"end":1749},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T123","span":{"begin":1995,"end":1998},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T124","span":{"begin":2274,"end":2275},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T125","span":{"begin":2881,"end":2887},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T126","span":{"begin":3094,"end":3098},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T127","span":{"begin":3094,"end":3098},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T128","span":{"begin":3219,"end":3228},"obj":"http://purl.obolibrary.org/obo/CL_0000034"}],"attributes":[{"subj":"T113","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T121","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T36","span":{"begin":616,"end":640},"obj":"Chemical"},{"id":"T37","span":{"begin":1277,"end":1286},"obj":"Chemical"},{"id":"T38","span":{"begin":1291,"end":1301},"obj":"Chemical"},{"id":"T39","span":{"begin":2082,"end":2086},"obj":"Chemical"},{"id":"T40","span":{"begin":2176,"end":2180},"obj":"Chemical"},{"id":"T41","span":{"begin":2315,"end":2330},"obj":"Chemical"},{"id":"T42","span":{"begin":2441,"end":2456},"obj":"Chemical"},{"id":"T43","span":{"begin":2814,"end":2816},"obj":"Chemical"}],"attributes":[{"id":"A36","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_67079"},{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_63580"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A44","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T17","span":{"begin":802,"end":817},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T18","span":{"begin":818,"end":830},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T19","span":{"begin":3117,"end":3129},"obj":"http://purl.obolibrary.org/obo/GO_0031099"}],"attributes":[{"subj":"T17","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T59","span":{"begin":0,"end":38},"obj":"Sentence"},{"id":"T60","span":{"begin":39,"end":291},"obj":"Sentence"},{"id":"T61","span":{"begin":292,"end":386},"obj":"Sentence"},{"id":"T62","span":{"begin":387,"end":497},"obj":"Sentence"},{"id":"T63","span":{"begin":498,"end":641},"obj":"Sentence"},{"id":"T64","span":{"begin":642,"end":831},"obj":"Sentence"},{"id":"T65","span":{"begin":832,"end":1065},"obj":"Sentence"},{"id":"T66","span":{"begin":1066,"end":1248},"obj":"Sentence"},{"id":"T67","span":{"begin":1249,"end":1458},"obj":"Sentence"},{"id":"T68","span":{"begin":1459,"end":1728},"obj":"Sentence"},{"id":"T69","span":{"begin":1729,"end":1921},"obj":"Sentence"},{"id":"T70","span":{"begin":1922,"end":2189},"obj":"Sentence"},{"id":"T71","span":{"begin":2190,"end":2425},"obj":"Sentence"},{"id":"T72","span":{"begin":2426,"end":2751},"obj":"Sentence"},{"id":"T73","span":{"begin":2752,"end":3040},"obj":"Sentence"},{"id":"T74","span":{"begin":3041,"end":3317},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T59","pred":"source","obj":"LitCovid-sentences"},{"subj":"T60","pred":"source","obj":"LitCovid-sentences"},{"subj":"T61","pred":"source","obj":"LitCovid-sentences"},{"subj":"T62","pred":"source","obj":"LitCovid-sentences"},{"subj":"T63","pred":"source","obj":"LitCovid-sentences"},{"subj":"T64","pred":"source","obj":"LitCovid-sentences"},{"subj":"T65","pred":"source","obj":"LitCovid-sentences"},{"subj":"T66","pred":"source","obj":"LitCovid-sentences"},{"subj":"T67","pred":"source","obj":"LitCovid-sentences"},{"subj":"T68","pred":"source","obj":"LitCovid-sentences"},{"subj":"T69","pred":"source","obj":"LitCovid-sentences"},{"subj":"T70","pred":"source","obj":"LitCovid-sentences"},{"subj":"T71","pred":"source","obj":"LitCovid-sentences"},{"subj":"T72","pred":"source","obj":"LitCovid-sentences"},{"subj":"T73","pred":"source","obj":"LitCovid-sentences"},{"subj":"T74","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32574317-28373583-31466304","span":{"begin":285,"end":289},"obj":"28373583"},{"id":"32574317-32282022-31466305","span":{"begin":380,"end":384},"obj":"32282022"},{"id":"32574317-28373583-31466306","span":{"begin":491,"end":495},"obj":"28373583"},{"id":"32574317-16968120-31466307","span":{"begin":1242,"end":1246},"obj":"16968120"},{"id":"32574317-29664167-31466308","span":{"begin":1376,"end":1380},"obj":"29664167"},{"id":"32574317-32346146-31466309","span":{"begin":1699,"end":1703},"obj":"32346146"},{"id":"32574317-32273591-31466310","span":{"begin":1722,"end":1726},"obj":"32273591"},{"id":"32574317-32043983-31466311","span":{"begin":2745,"end":2749},"obj":"32043983"},{"id":"32574317-32113510-31466312","span":{"begin":3017,"end":3021},"obj":"32113510"},{"id":"32574317-32290839-31466313","span":{"begin":3034,"end":3038},"obj":"32290839"}],"attributes":[{"subj":"32574317-28373583-31466304","pred":"source","obj":"2_test"},{"subj":"32574317-32282022-31466305","pred":"source","obj":"2_test"},{"subj":"32574317-28373583-31466306","pred":"source","obj":"2_test"},{"subj":"32574317-16968120-31466307","pred":"source","obj":"2_test"},{"subj":"32574317-29664167-31466308","pred":"source","obj":"2_test"},{"subj":"32574317-32346146-31466309","pred":"source","obj":"2_test"},{"subj":"32574317-32273591-31466310","pred":"source","obj":"2_test"},{"subj":"32574317-32043983-31466311","pred":"source","obj":"2_test"},{"subj":"32574317-32113510-31466312","pred":"source","obj":"2_test"},{"subj":"32574317-32290839-31466313","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"32574317-28373583-31466304","span":{"begin":285,"end":289},"obj":"28373583"},{"id":"32574317-32282022-31466305","span":{"begin":380,"end":384},"obj":"32282022"},{"id":"32574317-28373583-31466306","span":{"begin":491,"end":495},"obj":"28373583"},{"id":"32574317-16968120-31466307","span":{"begin":1242,"end":1246},"obj":"16968120"},{"id":"32574317-29664167-31466308","span":{"begin":1376,"end":1380},"obj":"29664167"},{"id":"32574317-32346146-31466309","span":{"begin":1699,"end":1703},"obj":"32346146"},{"id":"32574317-32273591-31466310","span":{"begin":1722,"end":1726},"obj":"32273591"},{"id":"32574317-32043983-31466311","span":{"begin":2745,"end":2749},"obj":"32043983"},{"id":"32574317-32113510-31466312","span":{"begin":3017,"end":3021},"obj":"32113510"},{"id":"32574317-32290839-31466313","span":{"begin":3034,"end":3038},"obj":"32290839"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32574317-28373583-31466304","pred":"source","obj":"MyTest"},{"subj":"32574317-32282022-31466305","pred":"source","obj":"MyTest"},{"subj":"32574317-28373583-31466306","pred":"source","obj":"MyTest"},{"subj":"32574317-16968120-31466307","pred":"source","obj":"MyTest"},{"subj":"32574317-29664167-31466308","pred":"source","obj":"MyTest"},{"subj":"32574317-32346146-31466309","pred":"source","obj":"MyTest"},{"subj":"32574317-32273591-31466310","pred":"source","obj":"MyTest"},{"subj":"32574317-32043983-31466311","pred":"source","obj":"MyTest"},{"subj":"32574317-32113510-31466312","pred":"source","obj":"MyTest"},{"subj":"32574317-32290839-31466313","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#93caec","default":true},{"id":"LitCovid-PubTator","color":"#e4ec93"},{"id":"LitCovid-PD-FMA-UBERON","color":"#da93ec"},{"id":"LitCovid-PD-UBERON","color":"#93ecc0"},{"id":"LitCovid-PD-MONDO","color":"#eca693"},{"id":"LitCovid-PD-CLO","color":"#9399ec"},{"id":"LitCovid-PD-CHEBI","color":"#b3ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93cd"},{"id":"LitCovid-sentences","color":"#93e7ec"},{"id":"2_test","color":"#ecd693"},{"id":"MyTest","color":"#bc93ec"}]}]}}