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PMC:7261349 / 96-1730 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T3 67-74 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 67-74 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 460-467 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 460-467 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 951-958 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T8 951-958 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T9 991-998 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T10 991-998 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T11 1399-1406 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 1399-1406 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 1580-1587 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 1580-1587 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
32 92-100 Species denotes patients Tax:9606
33 204-212 Species denotes patients Tax:9606
34 743-751 Species denotes patients Tax:9606
35 981-989 Species denotes patients Tax:9606
36 67-74 Chemical denotes heparin MESH:D006493
37 424-430 Chemical denotes oxygen MESH:D010100
38 460-467 Chemical denotes heparin MESH:D006493
39 469-487 Chemical denotes hydroxychloroquine MESH:D006886
40 489-501 Chemical denotes azithromycin MESH:D017963
41 503-511 Chemical denotes steroids MESH:D013256
42 513-524 Chemical denotes tocilizumab MESH:C502936
43 543-552 Chemical denotes lopinavir MESH:D061466
44 558-567 Chemical denotes ritonavir MESH:D019438
45 573-584 Chemical denotes oseltamivir MESH:D053139
46 951-958 Chemical denotes Heparin MESH:D006493
47 991-998 Chemical denotes Heparin MESH:D006493
48 1185-1191 Chemical denotes oxygen MESH:D010100
49 1399-1406 Chemical denotes heparin MESH:D006493
50 1580-1587 Chemical denotes heparin MESH:D006493
51 79-88 Disease denotes mortality MESH:D003643
52 115-123 Disease denotes Covid-19 MESH:C000657245
53 218-226 Disease denotes Covid-19 MESH:C000657245
54 608-617 Disease denotes mortality MESH:D003643
55 756-760 Disease denotes died MESH:D003643
56 1025-1034 Disease denotes mortality MESH:D003643
57 1417-1426 Disease denotes mortality MESH:D003643

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T2 67-74 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T3 460-467 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T4 951-958 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T5 991-998 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T6 1399-1406 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T7 1580-1587 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 526-527 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T2 67-74 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T3 424-430 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T4 460-467 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T5 469-487 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T6 489-501 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T7 503-511 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T8 513-524 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T9 543-552 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T10 558-567 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T11 573-584 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T12 951-958 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T13 991-998 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T14 1185-1191 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T15 1310-1315 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T16 1399-1406 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T17 1580-1587 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-124 Sentence denotes This study investigates the association between the treatment with heparin and mortality in patients admitted with Covid-19.
T4 125-324 Sentence denotes Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients with Covid-19, admitted in 17 hospitals in Spain between the 1st of March and the 20th of April 2020 were used.
T5 325-618 Sentence denotes The following variables were extracted for this study: age, gender, temperature, and saturation of oxygen on admission, treatment with heparin, hydroxychloroquine, azithromycin, steroids, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir, together with data on mortality.
T6 619-702 Sentence denotes Multivariable logistic regression models were used to investigate the associations.
T7 703-905 Sentence denotes At the time of collecting the data, 301 patients had died, 1447 had been discharged home from the hospitals, 201 were still admitted, and 126 had been transferred to hospitals not included in the study.
T8 906-950 Sentence denotes Median follow up time was 8 (IQR 5–12) days.
T9 951-990 Sentence denotes Heparin had been used in 1734 patients.
T10 991-1127 Sentence denotes Heparin was associated with lower mortality when the model was adjusted for age and gender, with OR (95% CI) 0.55 (0.37–0.82) p = 0.003.
T11 1128-1374 Sentence denotes This association remained significant when saturation of oxygen < 90%, and temperature > 37 °C were added to de model with OR 0.54 (0.36–0.82) p = 0.003, and also when all the other drugs were included as covariates OR 0.42 (0.26–0.66) p < 0.001.
T12 1375-1518 Sentence denotes The association between heparin and lower mortality observed in this study can be acknowledged by clinicians in hospitals and in the community.
T13 1519-1634 Sentence denotes Randomized controlled trials to assess the causal effects of heparin in different therapeutic regimes are required.