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PMC:7261349 / 8606-10734 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T49 33-40 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T50 33-40 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T51 272-279 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T52 272-279 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T53 1144-1151 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T54 1144-1151 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T55 1264-1271 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T56 1264-1271 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T57 1669-1676 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T58 1669-1676 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T59 1888-1895 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T60 1888-1895 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T61 1954-1961 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T62 1954-1961 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
245 80-88 Species denotes patients Tax:9606
246 155-163 Species denotes Patients Tax:9606
247 481-489 Species denotes patients Tax:9606
248 33-40 Chemical denotes heparin MESH:D006493
249 272-279 Chemical denotes heparin MESH:D006493
250 67-76 Disease denotes mortality MESH:D003643
251 103-111 Disease denotes Covid-19 MESH:C000657245
266 952-960 Species denotes patients Tax:9606
267 1103-1111 Species denotes patients Tax:9606
268 1242-1250 Species denotes patients Tax:9606
269 1472-1480 Species denotes patients Tax:9606
270 1144-1151 Chemical denotes heparin MESH:D006493
271 1264-1271 Chemical denotes heparin MESH:D006493
272 943-951 Disease denotes Covid-19 MESH:C000657245
273 1029-1039 Disease denotes thrombotic MESH:D013927
274 1072-1092 Disease denotes respiratory distress MESH:D012128
275 1283-1289 Disease denotes sepsis MESH:D018805
276 1298-1310 Disease denotes coagulopathy MESH:D001778
277 1322-1331 Disease denotes mortality MESH:D003643
278 1439-1448 Disease denotes mortality MESH:D003643
279 1463-1471 Disease denotes Covid-19 MESH:C000657245
286 2007-2015 Species denotes patients Tax:9606
287 1669-1676 Chemical denotes heparin MESH:D006493
288 1888-1895 Chemical denotes heparin MESH:D006493
289 1954-1961 Chemical denotes Heparin MESH:D006493
290 1607-1619 Disease denotes coagulopathy MESH:D001778
291 1636-1644 Disease denotes Covid-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T31 33-40 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T32 272-279 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T33 934-939 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T34 1144-1151 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T35 1264-1271 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T36 1669-1676 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T37 1888-1895 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T38 1954-1961 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T4 1072-1092 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T5 1283-1289 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T6 1298-1310 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T7 1607-1619 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T8 1298-1310 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T9 1607-1619 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T23 124-127 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T24 452-453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 552-556 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T26 934-939 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T27 1027-1028 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 1281-1282 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 1362-1363 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T30 1404-1405 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 1415-1418 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T61 33-40 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T62 272-279 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T63 358-363 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T64 1144-1151 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T65 1264-1271 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T66 1669-1676 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T67 1888-1895 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T68 1954-1961 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T83 0-10 Sentence denotes Discussion
T84 11-112 Sentence denotes The administration of heparin was associated with lower mortality in patients admitted with Covid-19.
T85 113-154 Sentence denotes This study has strengths and limitations.
T86 155-280 Sentence denotes Patients were not randomized and the difference in outcome may be explained by factors other than the treatment with heparin.
T87 281-432 Sentence denotes In an effort to control for the severity of disease, or the effects of other drugs, the models were adjusted for clinical markers and other treatments.
T88 433-622 Sentence denotes The observation of a large number of unselected patients in 17 hospitals, and the analyses run with some variations to test the consistency of the results, are also strengths of this study.
T89 623-701 Sentence denotes However, residual confounding is always present in all observational research.
T90 702-892 Sentence denotes For all models the sensitivity analyses described in the methods were used to assess the impact of missing data on the two severity markers, and results were consistent with those presented.
T91 893-1119 Sentence denotes While the nature of the hypoperfusion of lungs in Covid-19 patients is still not fully understood, our findings support that there is a thrombotic component in the development of respiratory distress for these patients [6, 8].
T92 1120-1361 Sentence denotes The association between heparin and survival is consistent with the findings of an observational study where among the 99 patients who received heparin, and had a sepsis-induced coagulopathy index > 4, mortality was significantly lower [12].
T93 1362-1515 Sentence denotes A recent observational study conducted in a hospital has also reported lower mortality among the 786 Covid-19 patients who received anticoagulation [13].
T94 1516-1645 Sentence denotes To the best of our knowledge, there is no interventional evidence on the management of the coagulopathy associated with Covid-19.
T95 1646-1764 Sentence denotes The positive effect of heparin seems consistent and its use, when indicated, could be considered in clinical settings.
T96 1765-1953 Sentence denotes Randomized controlled trials are necessary to complement observational studies, and assess the causal associations between heparin, in different therapeutic regimes, and clinical outcomes.
T97 1954-2128 Sentence denotes Heparin is easy to administer, its use in ambulatory patients, to prevent admissions, or reduce their duration, could also be considered by clinicians and future researchers.

2_test

Id Subject Object Predicate Lexical cue
32476080-32717754-64991618 1113-1114 32717754 denotes 6
32476080-32220112-64991619 1357-1359 32220112 denotes 12
32476080-32517963-64991620 1511-1513 32517963 denotes 13