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PMC:7261349 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 39-46 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 39-46 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 163-170 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 163-170 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 556-563 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 556-563 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 1047-1054 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T8 1047-1054 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T9 1087-1094 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T10 1087-1094 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T11 1495-1502 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 1495-1502 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 1676-1683 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 1676-1683 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T15 1765-1772 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T16 1765-1772 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T17 1989-1996 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T18 1989-1996 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T19 2208-2215 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T20 2208-2215 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T21 2274-2281 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T22 2274-2281 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T23 3700-3707 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T24 3700-3707 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T25 3944-3951 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T26 3944-3951 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T27 4060-4067 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T28 4060-4067 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T29 4183-4190 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T30 4183-4190 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T31 4930-4937 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T32 4930-4937 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T33 5495-5502 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T34 5495-5502 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T35 5601-5608 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T36 5601-5608 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T37 5689-5696 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T38 5689-5696 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T39 6903-6910 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T40 6903-6910 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T41 6951-6958 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T42 6951-6958 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T43 7069-7076 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T44 7069-7076 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T45 7494-7501 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T46 7494-7501 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T47 8223-8230 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T48 8223-8230 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T49 8639-8646 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T50 8639-8646 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T51 8878-8885 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T52 8878-8885 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T53 9750-9757 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T54 9750-9757 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T55 9870-9877 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T56 9870-9877 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T57 10275-10282 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T58 10275-10282 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T59 10494-10501 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T60 10494-10501 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T61 10560-10567 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T62 10560-10567 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 63-71 Species denotes patients Tax:9606
4 39-46 Chemical denotes heparin MESH:D006493
5 77-85 Disease denotes Covid-19 MESH:C000657245
32 188-196 Species denotes patients Tax:9606
33 300-308 Species denotes patients Tax:9606
34 839-847 Species denotes patients Tax:9606
35 1077-1085 Species denotes patients Tax:9606
36 163-170 Chemical denotes heparin MESH:D006493
37 520-526 Chemical denotes oxygen MESH:D010100
38 556-563 Chemical denotes heparin MESH:D006493
39 565-583 Chemical denotes hydroxychloroquine MESH:D006886
40 585-597 Chemical denotes azithromycin MESH:D017963
41 599-607 Chemical denotes steroids MESH:D013256
42 609-620 Chemical denotes tocilizumab MESH:C502936
43 639-648 Chemical denotes lopinavir MESH:D061466
44 654-663 Chemical denotes ritonavir MESH:D019438
45 669-680 Chemical denotes oseltamivir MESH:D053139
46 1047-1054 Chemical denotes Heparin MESH:D006493
47 1087-1094 Chemical denotes Heparin MESH:D006493
48 1281-1287 Chemical denotes oxygen MESH:D010100
49 1495-1502 Chemical denotes heparin MESH:D006493
50 1676-1683 Chemical denotes heparin MESH:D006493
51 175-184 Disease denotes mortality MESH:D003643
52 211-219 Disease denotes Covid-19 MESH:C000657245
53 314-322 Disease denotes Covid-19 MESH:C000657245
54 704-713 Disease denotes mortality MESH:D003643
55 852-856 Disease denotes died MESH:D003643
56 1121-1130 Disease denotes mortality MESH:D003643
57 1513-1522 Disease denotes mortality MESH:D003643
62 1812-1820 Species denotes patients Tax:9606
63 1765-1772 Chemical denotes heparin MESH:D006493
64 1799-1808 Disease denotes mortality MESH:D003643
65 1835-1843 Disease denotes Covid-19 MESH:C000657245
69 1956-1964 Species denotes patients Tax:9606
70 1882-1892 Disease denotes thrombotic MESH:D013927
71 1925-1945 Disease denotes respiratory distress MESH:D012128
73 1989-1996 Chemical denotes heparin MESH:D006493
75 2208-2215 Chemical denotes heparin MESH:D006493
78 2327-2335 Species denotes patients Tax:9606
79 2274-2281 Chemical denotes Heparin MESH:D006493
89 2524-2534 Species denotes SARS-CoV-2 Tax:2697049
90 2676-2684 Species denotes patients Tax:9606
91 2887-2895 Species denotes patients Tax:9606
92 2584-2592 Disease denotes Covid-19 MESH:C000657245
93 2762-2771 Disease denotes pneumonia MESH:D011014
94 2776-2811 Disease denotes acute respiratory distress syndrome MESH:D012128
95 2897-2906 Disease denotes Mortality MESH:D003643
96 2989-2997 Disease denotes Covid-19 MESH:C000657245
97 3092-3100 Disease denotes Covid-19 MESH:C000657245
119 3365-3373 Species denotes patients Tax:9606
120 3450-3458 Species denotes patients Tax:9606
121 3618-3626 Species denotes patients Tax:9606
122 3863-3871 Species denotes patients Tax:9606
123 4080-4088 Species denotes patients Tax:9606
124 4227-4235 Species denotes patients Tax:9606
125 3700-3707 Chemical denotes heparin MESH:D006493
126 3944-3951 Chemical denotes Heparin MESH:D006493
127 4060-4067 Chemical denotes heparin MESH:D006493
128 4183-4190 Chemical denotes heparin MESH:D006493
129 3240-3250 Disease denotes Thrombotic MESH:D013927
130 3379-3387 Disease denotes Covid-19 MESH:C000657245
131 3636-3640 Disease denotes died MESH:D003643
132 3644-3652 Disease denotes Covid-19 MESH:C000657245
133 3732-3752 Disease denotes coagulation disorder MESH:D001778
134 3773-3782 Disease denotes infection MESH:D007239
135 3921-3930 Disease denotes mortality MESH:D003643
136 3934-3942 Disease denotes Covid-19 MESH:C000657245
137 4071-4079 Disease denotes Covid-19 MESH:C000657245
138 4196-4205 Disease denotes mortality MESH:D003643
139 4250-4258 Disease denotes Covid-19 MESH:C000657245
154 4334-4342 Species denotes patients Tax:9606
155 4568-4576 Species denotes Patients Tax:9606
156 4659-4669 Species denotes SARS-CoV-2 Tax:2697049
157 4730-4738 Species denotes patients Tax:9606
158 4838-4844 Chemical denotes oxygen MESH:D010100
159 4930-4937 Chemical denotes heparin MESH:D006493
160 4939-4957 Chemical denotes hydroxychloroquine MESH:D006886
161 4959-4971 Chemical denotes azithromycin MESH:D017963
162 4973-4981 Chemical denotes steroids MESH:D013256
163 4983-4994 Chemical denotes tocilizumab MESH:C502936
164 5013-5022 Chemical denotes lopinavir MESH:D061466
165 5043-5054 Chemical denotes oseltamivir MESH:D053139
166 4359-4367 Disease denotes Covid-19 MESH:C000657245
167 5421-5430 Disease denotes mortality MESH:D003643
183 5457-5465 Species denotes patients Tax:9606
184 5548-5551 Species denotes men Tax:9606
185 5556-5561 Species denotes women Tax:9606
186 5495-5502 Chemical denotes heparin MESH:D006493
187 5601-5608 Chemical denotes heparin MESH:D006493
188 5689-5696 Chemical denotes heparin MESH:D006493
189 5872-5878 Chemical denotes oxygen MESH:D010100
190 5964-5982 Chemical denotes hydroxychloroquine MESH:D006886
191 5984-5996 Chemical denotes azithromycin MESH:D017963
192 5998-6006 Chemical denotes steroids MESH:D013256
193 6008-6019 Chemical denotes tocilizumab MESH:C502936
194 6038-6047 Chemical denotes lopinavir MESH:D061466
195 6053-6062 Chemical denotes ritonavir MESH:D019438
196 6067-6078 Chemical denotes oseltamivir MESH:D053139
197 5701-5710 Disease denotes mortality MESH:D003643
211 6521-6529 Species denotes patients Tax:9606
212 6569-6572 Species denotes men Tax:9606
213 6583-6588 Species denotes women Tax:9606
214 6658-6666 Species denotes patients Tax:9606
215 6881-6889 Species denotes patients Tax:9606
216 6929-6937 Species denotes patients Tax:9606
217 7042-7045 Species denotes men Tax:9606
218 7050-7055 Species denotes women Tax:9606
219 6903-6910 Chemical denotes heparin MESH:D006493
220 6951-6958 Chemical denotes heparin MESH:D006493
221 7069-7076 Chemical denotes heparin MESH:D006493
222 6671-6675 Disease denotes died MESH:D003643
223 6919-6923 Disease denotes died MESH:D003643
227 7494-7501 Chemical denotes Heparin MESH:D006493
228 8007-8028 Chemical denotes Lopinavir + Ritonavir MESH:C558899
229 7206-7211 Disease denotes Death MESH:D003643
231 7151-7159 Species denotes patients Tax:9606
235 8223-8230 Chemical denotes Heparin MESH:D006493
236 8415-8421 Chemical denotes oxygen MESH:D010100
237 8257-8266 Disease denotes mortality MESH:D003643
245 8686-8694 Species denotes patients Tax:9606
246 8761-8769 Species denotes Patients Tax:9606
247 9087-9095 Species denotes patients Tax:9606
248 8639-8646 Chemical denotes heparin MESH:D006493
249 8878-8885 Chemical denotes heparin MESH:D006493
250 8673-8682 Disease denotes mortality MESH:D003643
251 8709-8717 Disease denotes Covid-19 MESH:C000657245
266 9558-9566 Species denotes patients Tax:9606
267 9709-9717 Species denotes patients Tax:9606
268 9848-9856 Species denotes patients Tax:9606
269 10078-10086 Species denotes patients Tax:9606
270 9750-9757 Chemical denotes heparin MESH:D006493
271 9870-9877 Chemical denotes heparin MESH:D006493
272 9549-9557 Disease denotes Covid-19 MESH:C000657245
273 9635-9645 Disease denotes thrombotic MESH:D013927
274 9678-9698 Disease denotes respiratory distress MESH:D012128
275 9889-9895 Disease denotes sepsis MESH:D018805
276 9904-9916 Disease denotes coagulopathy MESH:D001778
277 9928-9937 Disease denotes mortality MESH:D003643
278 10045-10054 Disease denotes mortality MESH:D003643
279 10069-10077 Disease denotes Covid-19 MESH:C000657245
286 10613-10621 Species denotes patients Tax:9606
287 10275-10282 Chemical denotes heparin MESH:D006493
288 10494-10501 Chemical denotes heparin MESH:D006493
289 10560-10567 Chemical denotes Heparin MESH:D006493
290 10213-10225 Disease denotes coagulopathy MESH:D001778
291 10242-10250 Disease denotes Covid-19 MESH:C000657245
294 11167-11169 Chemical denotes SA MESH:C012546
295 11174-11176 Chemical denotes CR MESH:D002857

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 39-46 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T2 163-170 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T3 556-563 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T4 1047-1054 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T5 1087-1094 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T6 1495-1502 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T7 1676-1683 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T8 1765-1772 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T9 1989-1996 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T10 2208-2215 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T11 2274-2281 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T12 3271-3278 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T13 3422-3427 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T14 3549-3557 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T15 3582-3598 Body_part denotes arterial vessels http://purl.org/sig/ont/fma/fma50720
T16 3602-3606 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T17 3607-3614 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T18 3700-3707 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T19 3944-3951 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T20 4060-4067 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T21 4183-4190 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T22 4930-4937 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T23 5495-5502 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T24 5601-5608 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T25 5689-5696 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T26 6903-6910 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T27 6951-6958 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T28 7069-7076 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T29 7494-7501 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T30 8223-8230 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T31 8639-8646 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T32 8878-8885 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T33 9540-9545 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T34 9750-9757 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T35 9870-9877 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T36 10275-10282 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T37 10494-10501 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T38 10560-10567 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 3591-3598 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T2 3602-3606 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1925-1945 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T2 2762-2771 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T3 2782-2802 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T4 9678-9698 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T5 9889-9895 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T6 9904-9916 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T7 10213-10225 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 2524-2532 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 2762-2771 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T3 2776-2811 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T4 2782-2811 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T5 3732-3752 Disease denotes coagulation disorder http://purl.obolibrary.org/obo/MONDO_0001531
T6 3773-3782 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 4659-4667 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 9904-9916 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T9 10213-10225 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 622-623 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 1880-1881 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 2518-2523 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T4 2940-2944 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3, 4
T5 2998-3001 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T6 3422-3427 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T7 3582-3598 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial vessels
T8 3602-3606 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T9 3602-3606 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T10 4209-4210 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 4555-4561 http://purl.obolibrary.org/obo/CLO_0009382 denotes Toledo
T12 4627-4631 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T13 4996-4997 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 5523-5528 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T15 5639-5644 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T16 5729-5730 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 6021-6022 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 6376-6378 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T19 7194-7200 http://purl.obolibrary.org/obo/UBERON_0003100 denotes Female
T20 7661-7664 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T21 8137-8140 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T22 8199-8202 http://purl.obolibrary.org/obo/CLO_0001471 denotes 731
T23 8730-8733 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T24 9058-9059 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 9158-9162 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T26 9540-9545 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T27 9633-9634 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 9887-9888 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 9968-9969 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T30 10010-10011 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 10021-10024 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T32 11308-11310 http://purl.obolibrary.org/obo/CLO_0009141 denotes St
T33 11308-11310 http://purl.obolibrary.org/obo/CLO_0050980 denotes St

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 39-46 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T2 163-170 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T3 520-526 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T4 556-563 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T5 565-583 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T6 585-597 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T7 599-607 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T8 609-620 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T9 639-648 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T10 654-663 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T11 669-680 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T12 1047-1054 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T13 1087-1094 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T14 1281-1287 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T15 1406-1411 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T16 1495-1502 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T17 1676-1683 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T18 1765-1772 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T19 1989-1996 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T20 2208-2215 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T21 2274-2281 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T22 3700-3707 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T23 3944-3951 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T24 4060-4067 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T25 4183-4190 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T26 4430-4432 Chemical denotes HM http://purl.obolibrary.org/obo/CHEBI_74053
T27 4838-4844 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T28 4930-4937 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T29 4939-4957 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T30 4959-4971 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T31 4973-4981 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T32 4983-4994 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T33 5013-5022 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T34 5028-5037 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T35 5043-5054 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T36 5194-5199 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T37 5383-5388 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T38 5495-5502 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T39 5601-5608 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T40 5689-5696 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T41 5872-5878 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T42 5964-5982 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T43 5984-5996 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T44 5998-6006 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T45 6008-6019 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T46 6038-6047 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T47 6053-6062 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T48 6067-6078 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T49 6405-6407 Chemical denotes HM http://purl.obolibrary.org/obo/CHEBI_74053
T50 6903-6910 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T51 6951-6958 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T52 7069-7076 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T53 7190-7192 Chemical denotes SD http://purl.obolibrary.org/obo/CHEBI_74807
T54 7275-7281 Chemical denotes Oxygen http://purl.obolibrary.org/obo/CHEBI_15379
T55 7494-7501 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T56 8007-8016 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T57 8121-8132 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T58 8223-8230 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T59 8415-8421 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T60 8540-8545 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T61 8639-8646 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T62 8878-8885 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T63 8964-8969 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T64 9750-9757 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T65 9870-9877 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T66 10275-10282 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T67 10494-10501 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T68 10560-10567 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T69 10951-10953 Chemical denotes HM http://purl.obolibrary.org/obo/CHEBI_74053
T70 11019-11021 Chemical denotes LA http://purl.obolibrary.org/obo/CHEBI_17351|http://purl.obolibrary.org/obo/CHEBI_73527
T72 11023-11025 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801
T76 11053-11055 Chemical denotes LA http://purl.obolibrary.org/obo/CHEBI_17351|http://purl.obolibrary.org/obo/CHEBI_73527
T78 11076-11078 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801
T82 11103-11105 Chemical denotes LA http://purl.obolibrary.org/obo/CHEBI_17351|http://purl.obolibrary.org/obo/CHEBI_73527
T84 11167-11169 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801
T88 11543-11545 Chemical denotes HM http://purl.obolibrary.org/obo/CHEBI_74053
T89 11635-11637 Chemical denotes HM http://purl.obolibrary.org/obo/CHEBI_74053

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 3732-3743 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes The association between treatment with heparin and survival in patients with Covid-19
T2 87-95 Sentence denotes Abstract
T3 96-220 Sentence denotes This study investigates the association between the treatment with heparin and mortality in patients admitted with Covid-19.
T4 221-420 Sentence denotes Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients with Covid-19, admitted in 17 hospitals in Spain between the 1st of March and the 20th of April 2020 were used.
T5 421-714 Sentence denotes The following variables were extracted for this study: age, gender, temperature, and saturation of oxygen on admission, treatment with heparin, hydroxychloroquine, azithromycin, steroids, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir, together with data on mortality.
T6 715-798 Sentence denotes Multivariable logistic regression models were used to investigate the associations.
T7 799-1001 Sentence denotes At the time of collecting the data, 301 patients had died, 1447 had been discharged home from the hospitals, 201 were still admitted, and 126 had been transferred to hospitals not included in the study.
T8 1002-1046 Sentence denotes Median follow up time was 8 (IQR 5–12) days.
T9 1047-1086 Sentence denotes Heparin had been used in 1734 patients.
T10 1087-1223 Sentence denotes Heparin was associated with lower mortality when the model was adjusted for age and gender, with OR (95% CI) 0.55 (0.37–0.82) p = 0.003.
T11 1224-1470 Sentence denotes This association remained significant when saturation of oxygen < 90%, and temperature > 37 °C were added to de model with OR 0.54 (0.36–0.82) p = 0.003, and also when all the other drugs were included as covariates OR 0.42 (0.26–0.66) p < 0.001.
T12 1471-1614 Sentence denotes The association between heparin and lower mortality observed in this study can be acknowledged by clinicians in hospitals and in the community.
T13 1615-1730 Sentence denotes Randomized controlled trials to assess the causal effects of heparin in different therapeutic regimes are required.
T14 1732-1742 Sentence denotes Highlights
T15 1743-1844 Sentence denotes The administration of heparin was associated with lower mortality in patients admitted with Covid-19.
T16 1845-1965 Sentence denotes Our findings support that there is a thrombotic component in the development of respiratory distress for these patients.
T17 1966-2084 Sentence denotes The positive effect of heparin seems consistent and its use, when indicated, could be considered in clinical settings.
T18 2085-2273 Sentence denotes Randomized controlled trials are necessary to complement observational studies, and assess the causal associations between heparin, in different therapeutic regimes, and clinical outcomes.
T19 2274-2448 Sentence denotes Heparin is easy to administer, its use in ambulatory patients, to prevent admissions, or reduce their duration, could also be considered by clinicians and future researchers.
T20 2450-2462 Sentence denotes Introduction
T21 2463-2557 Sentence denotes In December 2019 an out break of disease caused by the virus SARS-CoV-2 was declared in China.
T22 2558-2661 Sentence denotes This disease, later named Covid-19, spread throughout the world in the first few months of 2020 [1, 2].
T23 2662-2844 Sentence denotes Around 80% of patients have mild symptoms, the rest can develop severe disease, mainly interstitial pneumonia and acute respiratory distress syndrome, and require hospital admission.
T24 2845-2896 Sentence denotes Intensive care may be necessary for 5% of patients.
T25 2897-2946 Sentence denotes Mortality is estimated to be less than 2% [3, 4].
T26 2947-3077 Sentence denotes The large number of simultaneous cases of Covid-19 has overloaded hospitals, making it very difficult to provide an adequate care.
T27 3078-3239 Sentence denotes The spread of Covid-19 is negatively affecting all areas of healthcare, and is also having an adverse impact on the entire society and the international economy.
T28 3240-3394 Sentence denotes Thrombotic events in different tissues, with consistent clinical laboratory and radiological findings, have been reported in patients with Covid-19 [5–7].
T29 3395-3493 Sentence denotes Perfusion abnormalities in lungs have been observed in patients who underwent dual-energy CTs [8].
T30 3494-3657 Sentence denotes There is also pathological evidence of the presence of platelet-fibrin thrombi in small arterial vessels in lung tissues of patients who have died of Covid-19 [9].
T31 3658-3792 Sentence denotes Based on these finding, doctors have used heparin to treat or prevent the coagulation disorder associated with the infection [5–7, 9].
T32 3793-3943 Sentence denotes This treatment can be associated with the clinical improvement of the patients, and decrease the duration of admissions and the mortality of Covid-19.
T33 3944-4039 Sentence denotes Heparin is safe, economical, and easy to use, it can be given both to admitted and outpatients.
T34 4040-4128 Sentence denotes However, the use of heparin in Covid-19 patients is still supported by limited evidence.
T35 4129-4259 Sentence denotes This study investigates the association of the use of heparin with mortality in a large number of patients admitted with Covid-19.
T36 4261-4268 Sentence denotes Methods
T37 4269-4459 Sentence denotes Anonymized clinical records up to the 24th of April 2020, of all patients (n = 2075) with Covid-19, admitted in 17 Spanish hospitals, of the healthcare provider HM Hospitales, were reviewed.
T38 4460-4567 Sentence denotes These hospitals are based in the provinces of Barcelona, Coruña, León, Madrid, Pontevedra, and Toledo [10].
T39 4568-4723 Sentence denotes Patients had been diagnosed with polymerase chain reaction test of respiratory samples for SARS-CoV-2, between the 1st of March and the 20th of April 2020.
T40 4724-4786 Sentence denotes Seven patients had been admitted before the 1st of March 2020.
T41 4787-5071 Sentence denotes Data on age, gender, temperature and saturation of oxygen at the time of admission, together with treatments at any time during admission with heparin, hydroxychloroquine, azithromycin, steroids, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir, were collected.
T42 5072-5274 Sentence denotes The limited evidence on which these treatments were based, and the rapidly evolving clinical protocols, resulted in these drugs being given in many different specific preparations, doses, and frequency.
T43 5275-5403 Sentence denotes No information on dosage, duration of treatment, route of administration, or specific preparations of these drugs was collected.
T44 5404-5445 Sentence denotes Finally, data on mortality were recorded.
T45 5446-5529 Sentence denotes The age of patients treated and not treated with heparin was compared with t tests.
T46 5530-5645 Sentence denotes The proportion of men and women for those treated and not treated with heparin was compared with chi squared tests.
T47 5646-5800 Sentence denotes The association between the treatment with heparin and mortality was examined with a logistic regression model that was first adjusted for age and gender.
T48 5801-5938 Sentence denotes Second, two markers of severity, temperature > 37 °C and saturation of oxygen < 90% on admission, were introduced into the model as well.
T49 5939-6104 Sentence denotes Finally, treatments with hydroxychloroquine, azithromycin, steroids, tocilizumab, a combination of lopinavir with ritonavir, or oseltamivir, were added to the model.
T50 6105-6339 Sentence denotes Sensitivity analyses were made to compare estimates based on using missing data of severity markers as categories with, (1) estimates based on complete data dropping variables with missing observations, and (2) complete case analysis.
T51 6340-6380 Sentence denotes Stata 14 was used for the analysis [11].
T52 6381-6439 Sentence denotes The ethics committee of HM Hospitales approved this study.
T53 6440-6496 Sentence denotes Data were anonymized before the authors could access it.
T54 6498-6505 Sentence denotes Results
T55 6506-6617 Sentence denotes Among the 2075 patients whose records were reviewed, 1256 were men, 819 were women, and the mean age was 67.57.
T56 6618-6820 Sentence denotes At the time of collecting the data, 301 patients had died, 1447 had been discharged home from the hospitals, 201 were still admitted, and 126 had been transferred to hospitals not included in the study.
T57 6821-6865 Sentence denotes Median follow up time was 8 (IQR 5–12) days.
T58 6866-6924 Sentence denotes Among the 1734 patients who received heparin 242 had died.
T59 6925-7123 Sentence denotes The patients treated with heparin were older than the ones who did not received it (p < 0.001) and the proportion of men and women who received heparin did not have significant difference (Table 1).
T60 7124-7181 Sentence denotes Table 1 Description of the patients included in the study
T61 7182-7216 Sentence denotes N Age M(SD) Female n(%) Death n(%)
T62 7217-7274 Sentence denotes Total cohort 2075 67.57 (15.52) 819 (39.47%) 301 (14.51%)
T63 7275-7340 Sentence denotes Oxygen saturation < 90% Yes 70 73.18 (13.7) 20 (28.57) 28 (53.85)
T64 7341-7383 Sentence denotes No 221 67.00 (16.14) 95 (42.99) 24 (46.15)
T65 7384-7447 Sentence denotes Temperature > 37° C Yes 159 61.20 (17.27) 47 (29.56) 24 (10.86)
T66 7448-7493 Sentence denotes No 1422 68.53 (15.65) 577 (40.58) 197 (89.14)
T67 7494-7548 Sentence denotes Heparin Yes 1734 68.77 (15.09) 686 (39.56) 242 (13.96)
T68 7549-7591 Sentence denotes No 285 61.76 (17.67) 96 (33.68) 44 (15.44)
T69 7592-7657 Sentence denotes Hydroxychloroquine Yes 1857 67.11 (15.51) 705 (37.96) 237 (12.76)
T70 7658-7700 Sentence denotes No 162 73.47 (16.22) 77 (47.53) 49 (30.25)
T71 7701-7760 Sentence denotes Azithromycin Yes 1223 68.33 (15.03) 456 (37.29) 146 (11.94)
T72 7761-7805 Sentence denotes No 796 66.54 (16.51) 326 (40.95) 140 (17.59)
T73 7806-7860 Sentence denotes Steroids Yes 960 69.88 (16.76) 330 (34.38) 200 (20.83)
T74 7861-7904 Sentence denotes No 1059 65.58 (16.76) 452 (42.68) 86 (8.12)
T75 7905-7960 Sentence denotes Tocilizumab Yes 421 66.1 (13.11) 117 (27.79) 89 (21.14)
T76 7961-8006 Sentence denotes No 1598 68.00 (16.24) 665 (41.61) 197 (12.33)
T77 8007-8075 Sentence denotes Lopinavir + Ritonavir Yes 1230 63.94 (14.28) 421 (34.23) 160 (13.01)
T78 8076-8120 Sentence denotes No 789 73.37 (15.99) 361 (45.75) 126 (15.97)
T79 8121-8176 Sentence denotes Oseltamivir Yes 132 67.78 (13.79) 51 (38.64) 26 (19.70)
T80 8177-8222 Sentence denotes No 1887 67.61 (15.78) 731 (38.74) 260 (13.78)
T81 8223-8359 Sentence denotes Heparin was associated with lower mortality when the model was adjusted for age and gender, with OR (95% CI) 0.55 (0.37–0.82) p = 0.003.
T82 8360-8604 Sentence denotes This association remain significant when saturation of oxygen < 90%, and temperature > 37 °C were added to de model with OR 0.54 (0.36–0.82) p = 0.003, and also when all the other drugs were included as covariates OR 0.42 (0.26–0.66) p < 0.001.
T83 8606-8616 Sentence denotes Discussion
T84 8617-8718 Sentence denotes The administration of heparin was associated with lower mortality in patients admitted with Covid-19.
T85 8719-8760 Sentence denotes This study has strengths and limitations.
T86 8761-8886 Sentence denotes Patients were not randomized and the difference in outcome may be explained by factors other than the treatment with heparin.
T87 8887-9038 Sentence denotes In an effort to control for the severity of disease, or the effects of other drugs, the models were adjusted for clinical markers and other treatments.
T88 9039-9228 Sentence denotes The observation of a large number of unselected patients in 17 hospitals, and the analyses run with some variations to test the consistency of the results, are also strengths of this study.
T89 9229-9307 Sentence denotes However, residual confounding is always present in all observational research.
T90 9308-9498 Sentence denotes For all models the sensitivity analyses described in the methods were used to assess the impact of missing data on the two severity markers, and results were consistent with those presented.
T91 9499-9725 Sentence denotes While the nature of the hypoperfusion of lungs in Covid-19 patients is still not fully understood, our findings support that there is a thrombotic component in the development of respiratory distress for these patients [6, 8].
T92 9726-9967 Sentence denotes The association between heparin and survival is consistent with the findings of an observational study where among the 99 patients who received heparin, and had a sepsis-induced coagulopathy index > 4, mortality was significantly lower [12].
T93 9968-10121 Sentence denotes A recent observational study conducted in a hospital has also reported lower mortality among the 786 Covid-19 patients who received anticoagulation [13].
T94 10122-10251 Sentence denotes To the best of our knowledge, there is no interventional evidence on the management of the coagulopathy associated with Covid-19.
T95 10252-10370 Sentence denotes The positive effect of heparin seems consistent and its use, when indicated, could be considered in clinical settings.
T96 10371-10559 Sentence denotes Randomized controlled trials are necessary to complement observational studies, and assess the causal associations between heparin, in different therapeutic regimes, and clinical outcomes.
T97 10560-10734 Sentence denotes Heparin is easy to administer, its use in ambulatory patients, to prevent admissions, or reduce their duration, could also be considered by clinicians and future researchers.
T98 10736-10752 Sentence denotes Publisher's Note
T99 10753-10871 Sentence denotes Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
T100 10873-10889 Sentence denotes Acknowledgements
T101 10890-10996 Sentence denotes Thank you to all clinicians and administrators of Hospitales HM (Spain) on which data this study is based.
T102 10998-11018 Sentence denotes Author contributions
T103 11019-11052 Sentence denotes LA, SA and CR conceived the idea.
T104 11053-11075 Sentence denotes LA extracted the data.
T105 11076-11102 Sentence denotes SA conducted the analyses.
T106 11103-11177 Sentence denotes LA wrote the first draft, that received later contribution from SA and CR.
T107 11179-11186 Sentence denotes Funding
T108 11187-11366 Sentence denotes Salma Ayis was funded by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London.
T109 11367-11487 Sentence denotes The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
T110 11489-11506 Sentence denotes Data availability
T111 11507-11557 Sentence denotes Data queries should be addressed to HM Hospitales.
T112 11559-11592 Sentence denotes Compliance with ethical standards
T113 11594-11610 Sentence denotes Ethical approval
T114 11611-11669 Sentence denotes The Ethics committee of HM Hospitales approved this study.
T115 11671-11693 Sentence denotes Consent to participate
T116 11694-11754 Sentence denotes All data were anonymized before researchers could access it.
T117 11756-11779 Sentence denotes Consent for publication
T118 11780-11868 Sentence denotes Authors have agreed for the final version of this paper to be submitted for publication.

2_test

Id Subject Object Predicate Lexical cue
32476080-32284616-64991614 2940-2941 32284616 denotes 3
32476080-32222181-64991615 2943-2944 32222181 denotes 4
32476080-32268022-64991616 3389-3390 32268022 denotes 5
32476080-32717754-64991616 3389-3390 32717754 denotes 5
32476080-32073213-64991616 3389-3390 32073213 denotes 5
32476080-32268022-64991617 3784-3785 32268022 denotes 5
32476080-32717754-64991617 3784-3785 32717754 denotes 5
32476080-32073213-64991617 3784-3785 32073213 denotes 5
32476080-32717754-64991618 9719-9720 32717754 denotes 6
32476080-32220112-64991619 9963-9965 32220112 denotes 12
32476080-32517963-64991620 10117-10119 32517963 denotes 13