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PMC:7258756 / 31689-38285 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
471 59-69 Species denotes SARS-CoV-2 Tax:2697049
475 871-872 Gene denotes N Gene:43740575
476 815-823 Species denotes patients Tax:9606
477 1153-1161 Species denotes patients Tax:9606
480 1243-1253 Species denotes SARS-CoV-2 Tax:2697049
481 1841-1851 Species denotes SARS-CoV-2 Tax:2697049
497 1919-1923 Gene denotes nsp1 Gene:10045
498 2607-2611 Gene denotes ACE2 Gene:59272
499 2798-2802 Gene denotes ACE2 Gene:59272
500 2661-2666 Gene denotes spike Gene:43740568
501 2460-2465 Gene denotes spike Gene:43740568
502 2213-2218 Gene denotes spike Gene:43740568
503 2002-2005 Gene denotes Hu1 Gene:6195
504 2050-2055 Species denotes human Tax:9606
505 2056-2073 Species denotes Betacoronaviruses Tax:694002
506 2085-2094 Species denotes HCoV-HKU1 Tax:290028
507 2338-2355 Species denotes Betacoronaviruses Tax:694002
508 2383-2393 Species denotes SARS-CoV-2 Tax:2697049
509 2418-2428 Species denotes SARS-CoV-2 Tax:2697049
510 2688-2698 Species denotes SARS-CoV-2 Tax:2697049
511 2160-2176 Chemical denotes O-linked glycans
519 2908-2911 Gene denotes Hu1 Gene:6195
520 2848-2853 Gene denotes spike Gene:43740568
521 2875-2883 Species denotes SARS CoV Tax:694009
522 2890-2900 Species denotes SARS-CoV-2 Tax:2697049
523 2992-3002 Species denotes SARS-CoV-2 Tax:2697049
524 3062-3070 Species denotes SARS CoV Tax:694009
525 3380-3389 Disease denotes infection MESH:D007239
534 3931-3936 Gene denotes IFN-γ Gene:3458
535 3796-3801 Gene denotes spike Gene:43740568
536 3459-3464 Gene denotes spike Gene:43740568
537 3425-3433 Species denotes SARS-CoV Tax:694009
538 4099-4107 Species denotes SARS-CoV Tax:694009
539 4415-4423 Species denotes SARS-CoV Tax:694009
540 4708-4718 Species denotes SARS-CoV-2 Tax:2697049
541 4723-4731 Species denotes SARS-CoV Tax:694009
547 4890-4895 Gene denotes IFN-γ Gene:3458
548 5044-5049 Gene denotes IFN-γ Gene:3458
549 5227-5232 Gene denotes IFN-γ Gene:3458
550 4807-4812 Gene denotes spike Gene:43740568
551 4824-4832 Species denotes SARS-CoV Tax:694009
554 5987-5997 Species denotes SARS-CoV-2 Tax:2697049
555 6081-6089 Species denotes patients Tax:9606

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T218 318-324 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T219 721-727 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T220 781-787 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T221 789-794 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T222 799-804 Body_part denotes stool http://purl.org/sig/ont/fma/fma64183
T223 873-877 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T224 948-954 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T225 1120-1126 Body_part denotes saliva http://purl.org/sig/ont/fma/fma59862
T226 1174-1180 Body_part denotes saliva http://purl.org/sig/ont/fma/fma59862
T227 1214-1217 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T228 1302-1304 Body_part denotes nt http://purl.org/sig/ont/fma/fma82740
T229 1875-1885 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T230 2219-2226 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T231 2466-2473 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T232 2667-2674 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T233 2854-2861 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T234 2958-2968 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T235 3324-3330 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T236 3445-3453 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T237 3465-3472 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T238 3575-3579 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T239 3720-3724 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T240 3802-3809 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T241 4112-4119 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T242 4479-4483 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T243 4584-4588 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T244 4813-4820 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T245 4907-4911 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T246 5081-5088 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T247 5125-5129 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T248 5148-5155 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T249 5357-5361 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T250 5554-5557 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T251 5603-5606 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T7 781-787 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T8 789-794 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T9 799-804 Body_part denotes stool http://purl.obolibrary.org/obo/UBERON_0001988
T10 948-954 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T11 1120-1126 Body_part denotes saliva http://purl.obolibrary.org/obo/UBERON_0001836
T12 1174-1180 Body_part denotes saliva http://purl.obolibrary.org/obo/UBERON_0001836

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T169 59-67 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T170 59-63 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T171 585-587 Disease denotes TS http://purl.obolibrary.org/obo/MONDO_0010979|http://purl.obolibrary.org/obo/MONDO_0016455
T173 941-943 Disease denotes TS http://purl.obolibrary.org/obo/MONDO_0010979|http://purl.obolibrary.org/obo/MONDO_0016455
T175 1243-1251 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T176 1243-1247 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T177 1841-1849 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T178 1841-1845 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T179 2383-2391 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T180 2383-2387 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T181 2418-2426 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T182 2418-2422 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T183 2688-2696 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T184 2688-2692 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T185 2875-2879 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T186 2890-2898 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T187 2890-2894 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T188 2992-3000 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T189 2992-2996 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T190 3062-3066 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T191 3380-3389 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T192 3425-3433 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T193 3425-3429 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T194 4099-4107 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T195 4099-4103 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T196 4415-4423 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T197 4415-4419 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T198 4708-4716 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T199 4708-4712 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T200 4723-4731 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T201 4723-4727 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T202 4824-4832 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T203 4824-4828 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T204 5987-5995 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T205 5987-5991 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T256 120-126 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T257 170-171 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 708-709 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T259 873-877 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T260 1094-1099 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T261 1140-1142 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T262 1181-1188 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T263 1430-1431 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T264 1451-1453 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T265 1673-1675 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T266 2050-2055 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T267 2104-2105 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T268 2113-2114 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T269 2186-2188 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T270 2189-2191 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T271 2189-2191 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T272 2284-2287 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T273 2336-2337 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T274 2363-2364 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T275 2564-2566 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T276 2564-2566 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T277 2741-2743 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T278 2748-2750 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T279 2748-2750 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T280 3473-3476 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T281 3573-3579 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cell
T282 3653-3655 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T283 3678-3680 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T284 3678-3680 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T285 3718-3724 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cell
T286 3918-3919 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T287 4000-4001 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T288 4123-4124 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T289 4206-4209 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T290 4360-4361 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T291 4392-4395 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T292 4477-4483 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cell
T293 4580-4581 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T294 4582-4588 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cell
T295 4744-4747 http://purl.obolibrary.org/obo/CLO_0001178 denotes 243
T296 4744-4747 http://purl.obolibrary.org/obo/CLO_0052433 denotes 243
T297 4833-4836 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T298 4905-4911 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T299 5090-5091 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T300 5123-5129 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T301 5165-5166 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T302 5355-5361 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T303 5442-5444 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T304 5485-5487 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T305 5485-5487 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T306 5546-5547 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T307 5577-5578 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T308 5583-5584 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T309 6046-6049 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T310 6138-6143 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T311 6406-6411 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T312 6562-6565 http://purl.obolibrary.org/obo/CLO_0002941 denotes EPI
T313 6581-6584 http://purl.obolibrary.org/obo/CLO_0002941 denotes EPI

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T135 585-587 Chemical denotes TS http://purl.obolibrary.org/obo/CHEBI_73664
T136 941-943 Chemical denotes TS http://purl.obolibrary.org/obo/CHEBI_73664
T137 1302-1304 Chemical denotes nt http://purl.obolibrary.org/obo/CHEBI_36976
T138 1875-1885 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T139 1875-1880 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T140 1881-1885 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T141 2169-2176 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T142 2189-2191 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T143 2219-2226 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T144 2466-2473 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T145 2564-2566 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T146 2667-2674 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T147 2748-2750 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T148 2854-2861 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 2958-2968 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T150 3445-3453 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T151 3465-3472 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T152 3678-3680 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T153 3802-3809 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T154 4034-4041 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T155 4112-4119 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T156 4155-4162 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T157 4198-4205 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T158 4384-4391 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T159 4499-4506 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T160 4813-4820 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T161 5081-5088 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T162 5148-5155 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T163 5485-5487 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T164 6344-6354 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T26 4223-4245 http://purl.obolibrary.org/obo/GO_0006487 denotes N-linked glycosylation
T27 4232-4245 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T211 0-10 Sentence denotes Discussion
T212 11-145 Sentence denotes Till February 29, 2020, three positive cases of SARS-CoV-2 were reported from India from 881 suspected cases tested at ICMR-NIV, Pune.
T213 146-226 Sentence denotes All the three cases had a travel history from Wuhan, China, during January 2020.
T214 227-381 Sentence denotes Although NGS was performed on the specimens for all the three positive cases, the complete genome sequence could be retrieved only from case 1 and case 3.
T215 382-551 Sentence denotes The three cases were recovered after hospitalization and were home quarantined as per the guidelines of the Ministry of Health and Family Welfare, Government of India14.
T216 552-728 Sentence denotes The low viral copy number of the TS specimen from case 2 could be the possible reason for lesser viral reads being retrieved during the NGS run, leading to a fragmented genome.
T217 729-870 Sentence denotes The recent study from China on serial samples (TSs, sputum, urine and stool) from two patients followed days 3-12 and days 4-15 post onset20.
T218 871-1071 Sentence denotes N gene-specific real-time RT-PCR assay showed that the viral loads in TS and sputum samples peaked at around 5-6 days after symptom onset, ranging from around 104-107 copies per ml during this time20.
T219 1072-1227 Sentence denotes In another study, the virus was detected in the saliva specimens of 11 of the 12 patients, and serial saliva testing showed declines of viral RNA levels21.
T220 1228-1429 Sentence denotes The two Indian SARS-CoV-2 sequences were found to be non-identical (0.04% nt divergence), and the result of phylogenetic analysis indicated that there were two different introductions into the country.
T221 1430-1641 Sentence denotes A recent study using 52 published GenBank sequences showed evidence of substantial genetic heterogeneity and estimated the time to the most recent common ancestor to be December 5, 2019 (95% confidence interval:
T222 1642-1676 Sentence denotes November 6 - December 13, 2019)22.
T223 1677-1852 Sentence denotes Continuous monitoring and analysis of the sequences from the affected countries would be vital to understand the genetic evolution and rates of substitution of the SARS-CoV-2.
T224 1853-2044 Sentence denotes The comparison of the amino acid sequences of the non-structural (nsp1-nsp16) and structural polyproteins was undertaken with reference to the Wuhan-Hu1 strain for molecular characterization.
T225 2045-2227 Sentence denotes Some human Betacoronaviruses, including HCoV-HKU1 (lineage A), have a polybasic cleavage site as well as predicted O-linked glycans near the S1/S2 cleavage site of the spike protein.
T226 2228-2429 Sentence denotes As published recently, the polybasic cleavage site that has not been previously observed in related lineage B Betacoronaviruses and is a unique feature of SARS-CoV-2 was noted in the Indian SARS-CoV-2.
T227 2430-2574 Sentence denotes The mutation Arg408Ile in the spike protein of one of the Indian sequences is noted to be in the RBD and Ala930Val, is located in the S2 domain.
T228 2575-2643 Sentence denotes However, both are away from the ACE2 receptor-binding interface1923.
T229 2644-2821 Sentence denotes Mutations in the spike protein sequences of SARS-CoV-2 observed currently are localized over the S1 and S2 domains and, so far have not been found in the ACE2-binding interface.
T230 2822-3208 Sentence denotes From the alignment of the spike protein sequences of SARS CoV-1 and SARS-CoV-2 (Wuhan-Hu1 and India), it can be observed that the three nucleotide-deletion in the case 1 SARS-CoV-2 from India, is located close to the insert 1 region of the SARS CoV-1 (Supplementary Fig. 3 (available from http://www.ijmr.org.in/articles/2020/151/2/images/IndianJMedRes_2020_151_2_200_281471_sm11.pdf)).
T231 3209-3414 Sentence denotes Notably, case 1 and case 2 were in close contact while travelling to India, but due to the absence of the complete genome of case 2, the genetic relatedness and source of infection could not be pinpointed.
T232 3415-3524 Sentence denotes Among the SARS-CoV structural proteins, the spike protein has been found to elicit neutralizing antibodies24.
T233 3525-3688 Sentence denotes In this study, it was observed that of the five B-cell linear epitopes, which were predicted, four epitopes were present in the S1 domain and one in the S2 domain.
T234 3689-4010 Sentence denotes Prediction of conformational B-cell epitopes revealed that one of these (residue positions 341-505) in the spike protein incorporates two of the predicted linear epitopes (327-342 and 404-419) having good antigenicity along with a favourable IFN-γ response that enables differentiation and proliferation of the B-cells25.
T235 4011-4134 Sentence denotes Notably, an equivalent epitope (347-499) is predicted for the model generated using the SARS-CoV-1 S protein as a template.
T236 4135-4184 Sentence denotes In both cases, this epitope lies within the RBD6.
T237 4185-4359 Sentence denotes Although the epitope has two putative N-linked glycosylation sites within it at positions 330 and 332, the probability of these sites being actually glycosylated is very low.
T238 4360-4455 Sentence denotes A major immuno-dominant epitope has been reported from SARS-CoV between residues 441 and 70026.
T239 4456-4598 Sentence denotes Hence, the predicted B-cell conformational epitope identified in the present study may play an important role in initiating a B-cell response.
T240 4599-4734 Sentence denotes Among the five linear epitopes predicted in this study, epitopes 327-342 and 1204-1219 are conserved between SARS-CoV-2 and SARS-CoV-1.
T241 4735-4802 Sentence denotes Epitopes 243-258, 404-419 and 413-428 are found to have variations.
T242 4803-4923 Sentence denotes The spike protein of SARS-CoV has also been reported to be immunogenic and elicit high IFN-γ-specific T-cell response26.
T243 4924-5089 Sentence denotes The prediction results in this study revealed that nine possible CTL epitopes possessing good antigenicity and inducing IFN-γ response were present in the S protein.
T244 5090-5213 Sentence denotes A recent report27 also predicted T-cell epitopes in the S protein based on a similar ANN/SVM method and antigenicity score.
T245 5214-5344 Sentence denotes Although the IFN-γ response was not considered by these authors, it was noted that two of the predictions were found to be common.
T246 5345-5596 Sentence denotes Among the T-cell epitopes predicted in the present study, four epitopes 89-97 and 256-264 in the S1 domain and 825-833 and 1058-1066 in the S2 domain were found to have good CTL prediction scores with a broad HLA allele coverage of A and B supertypes.
T247 5597-5758 Sentence denotes These HLA supertypes being predominant in the Indian population, the predicted epitopes may be considered suitable for future experiments towards vaccine design.
T248 5759-5948 Sentence denotes To conclude, the prompt intervention by the Government of India and the health authorities of the State of Kerala, ensured that the said cases did not become secondary foci of transmission.
T249 5949-6172 Sentence denotes Further, the timely identification of SARS-CoV-2 in these suspected cases by the ICMR-NIV, Pune, has helped in the isolation of the patients, containment and enhanced surveillances for the virus and its restricted movement.
T250 6173-6355 Sentence denotes The availability of the genomic sequences of the identified cases will contribute to the public repositories and help towards the development of diagnostics, vaccines and antivirals.
T251 6356-6472 Sentence denotes The sequence data would also help in tracking the virus from its origin and evolution with its transmission in time.
T252 6473-6494 Sentence denotes Availability of data:
T253 6495-6596 Sentence denotes Sequences are deposited in GISAID database, with accession numbers EPI ISL 413522 and EPI ISL 413523.

2_test

Id Subject Object Predicate Lexical cue
32242873-31950516-47036570 1030-1033 31950516 denotes 104
32242873-31138817-47036571 2638-2642 31138817 denotes 1923
32242873-15210961-47036572 3521-3523 15210961 denotes 24
32242873-9916700-47036573 4007-4009 9916700 denotes 25
32242873-32007145-47036574 4182-4183 32007145 denotes 6
32242873-26038429-47036575 4449-4454 26038429 denotes 70026
32242873-26038429-47036576 4920-4922 26038429 denotes 26
32242873-32022276-47036577 5105-5107 32022276 denotes 27
T37244 1030-1033 31950516 denotes 104
T1135 2638-2642 31138817 denotes 1923
T80103 3521-3523 15210961 denotes 24
T68904 4007-4009 9916700 denotes 25
T89340 4182-4183 32007145 denotes 6
T29055 4449-4454 26038429 denotes 70026
T63478 4920-4922 26038429 denotes 26
T36379 5105-5107 32022276 denotes 27