PMC:7253482 / 13799-14443
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
522 | 302-305 | Gene | denotes | Env | Gene:64006 |
523 | 296-301 | Species | denotes | HIV-1 | Tax:11676 |
524 | 324-333 | Species | denotes | influenza | Tax:11320 |
525 | 314-317 | Gene | denotes | GPC | Gene:2995 |
526 | 113-117 | Gene | denotes | DPP4 | Gene:1803 |
527 | 170-177 | Chemical | denotes | glycans | MESH:D011134 |
528 | 501-517 | Chemical | denotes | N-linked glycans | |
529 | 143-147 | Disease | denotes | MERS | MESH:D018352 |
530 | 278-282 | Disease | denotes | SARS | MESH:D045169 |
531 | 440-444 | Disease | denotes | MERS | MESH:D018352 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T85 | 258-266 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T86 | 296-299 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T52 | 278-282 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T53 | 324-333 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T85 | 533-540 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T161 | 170-177 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T162 | 258-266 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T163 | 510-517 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T34 | 135-139 | http://purl.obolibrary.org/obo/BFO_0000029 | denotes | site |
T35 | 228-233 | http://purl.obolibrary.org/obo/BFO_0000029 | denotes | sites |
T36 | 392-405 | http://purl.obolibrary.org/obo/BFO_0000034 | denotes | functionality |
T37 | 533-540 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T38 | 630-643 | http://purl.obolibrary.org/obo/BFO_0000034 | denotes | functionality |
LitCovid-sample-Enju
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T46731 | 0-5 | VBN | denotes | Given |
T24648 | 6-10 | IN | denotes | that |
T45765 | 11-14 | DT | denotes | the |
T56881 | 15-31 | JJ | denotes | receptor-binding |
T98112 | 32-38 | NN | denotes | domain |
T74716 | 39-41 | VBZ | denotes | is |
T2696 | 158-166 | VBN | denotes | occluded |
T85598 | 42-45 | DT | denotes | the |
T16051 | 46-50 | JJ | denotes | main |
T58379 | 51-57 | NN | denotes | target |
T53325 | 58-60 | IN | denotes | of |
T7859 | 61-73 | VBG | denotes | neutralising |
T26958 | 74-85 | NN | denotes | antibodies8 |
T7334 | 85-86 | -COMMA- | denotes | , |
T85070 | 87-89 | PRP | denotes | it |
T1822 | 90-92 | VBZ | denotes | is |
T40337 | 93-103 | JJ | denotes | surprising |
T90378 | 104-108 | IN | denotes | that |
T34257 | 109-112 | DT | denotes | the |
T66548 | 113-117 | NN | denotes | DPP4 |
T75367 | 118-134 | JJ | denotes | receptor-binding |
T76130 | 135-139 | NN | denotes | site |
T72556 | 140-142 | IN | denotes | of |
T49036 | 143-147 | NNS | denotes | MERS |
T45911 | 148-149 | NN | denotes | S |
T21250 | 150-153 | VBD | denotes | was |
T8376 | 154-157 | RB | denotes | not |
T90865 | 167-169 | IN | denotes | by |
T29223 | 170-177 | NNS | denotes | glycans |
T85418 | 178-179 | -LRB- | denotes | ( |
T83410 | 179-186 | NN | denotes | Fig. 3a |
T92859 | 186-187 | -RRB- | denotes | ) |
T98108 | 187-188 | -COMMA- | denotes | , |
T94718 | 189-191 | IN | denotes | as |
T75995 | 192-200 | VBN | denotes | observed |
T33346 | 201-204 | IN | denotes | for |
T37727 | 205-210 | JJ | denotes | other |
T65600 | 211-227 | JJ | denotes | receptor-binding |
T6494 | 228-233 | NNS | denotes | sites |
T57622 | 234-236 | IN | denotes | of |
T15659 | 237-242 | NN | denotes | class |
T77211 | 243-244 | CD | denotes | I |
T77114 | 245-250 | JJ | denotes | viral |
T21676 | 251-257 | NN | denotes | fusion |
T55295 | 258-266 | NNS | denotes | proteins |
T74940 | 266-267 | -COMMA- | denotes | , |
T82828 | 268-277 | VBG | denotes | including |
T94991 | 278-282 | NNP | denotes | SARS |
T30576 | 283-284 | NNP | denotes | S |
T72214 | 285-286 | -LRB- | denotes | ( |
T78031 | 286-293 | NN | denotes | Fig. 3b |
T67457 | 293-294 | -RRB- | denotes | ) |
T6464 | 294-295 | -COMMA- | denotes | , |
T4572 | 296-301 | NN | denotes | HIV-1 |
T27072 | 302-307 | NN | denotes | Env49 |
T51710 | 307-308 | -COMMA- | denotes | , |
T37781 | 309-313 | NN | denotes | LASV |
T43889 | 314-319 | NN | denotes | GPC24 |
T95596 | 320-323 | CC | denotes | and |
T81584 | 324-333 | NN | denotes | influenza |
T23338 | 334-338 | NN | denotes | HA50 |
T38368 | 340-342 | PRP | denotes | We |
T7627 | 343-350 | VBP | denotes | suggest |
T64380 | 351-355 | IN | denotes | that |
T64096 | 356-360 | DT | denotes | this |
T56477 | 361-363 | VBZ | denotes | is |
T19767 | 364-370 | RB | denotes | likely |
T70981 | 371-374 | JJ | denotes | due |
T34848 | 375-377 | TO | denotes | to |
T31069 | 378-381 | DT | denotes | the |
T33383 | 382-391 | JJ | denotes | intrinsic |
T53788 | 392-405 | NN | denotes | functionality |
T92413 | 406-408 | IN | denotes | of |
T48963 | 409-412 | DT | denotes | the |
T14314 | 413-429 | JJ | denotes | receptor-binding |
T65172 | 430-436 | NN | denotes | domain |
T24472 | 437-439 | IN | denotes | of |
T66405 | 440-444 | NNP | denotes | MERS |
T3759 | 445-446 | NNP | denotes | S |
T35971 | 446-447 | -COMMA- | denotes | , |
T63119 | 448-452 | WDT | denotes | that |
T19398 | 453-458 | MD | denotes | would |
T5062 | 459-461 | VB | denotes | be |
T26453 | 462-472 | RB | denotes | sterically |
T99830 | 473-481 | VBN | denotes | hindered |
T79196 | 482-484 | IN | denotes | by |
T29715 | 485-488 | DT | denotes | the |
T15993 | 489-497 | NN | denotes | presence |
T46581 | 498-500 | IN | denotes | of |
T41531 | 501-509 | JJ | denotes | N-linked |
T84168 | 510-517 | NNS | denotes | glycans |
T31775 | 517-518 | -COMMA- | denotes | , |
T73121 | 519-526 | IN | denotes | whereas |
T8489 | 527-532 | JJ | denotes | other |
T86129 | 533-540 | NNS | denotes | viruses |
T10448 | 541-544 | VBP | denotes | are |
T85155 | 545-549 | JJ | denotes | able |
T10897 | 550-552 | TO | denotes | to |
T93372 | 553-564 | VB | denotes | accommodate |
T42685 | 565-568 | DT | denotes | the |
T16612 | 569-587 | JJ | denotes | post-translational |
T29096 | 588-601 | NNS | denotes | modifications |
T68645 | 601-602 | -COMMA- | denotes | , |
T93438 | 603-610 | IN | denotes | without |
T18466 | 611-618 | RB | denotes | greatly |
T85948 | 619-629 | VBG | denotes | perturbing |
T35584 | 630-643 | NN | denotes | functionality |
R19912 | T74716 | T46731 | arg2Of | is,Given |
R72618 | T1822 | T46731 | modOf | is,Given |
R28846 | T74716 | T24648 | arg1Of | is,that |
R73554 | T98112 | T45765 | arg1Of | domain,the |
R85720 | T98112 | T56881 | arg1Of | domain,receptor-binding |
R85326 | T98112 | T74716 | arg1Of | domain,is |
R10483 | T58379 | T74716 | arg2Of | target,is |
R59202 | T58379 | T85598 | arg1Of | target,the |
R8717 | T58379 | T16051 | arg1Of | target,main |
R31607 | T58379 | T53325 | arg1Of | target,of |
R13280 | T7859 | T53325 | arg2Of | neutralising,of |
R63181 | T26958 | T7859 | arg2Of | antibodies8,neutralising |
R31883 | T58379 | T7334 | arg1Of | target,"," |
R51342 | T85070 | T7334 | arg2Of | it,"," |
R30657 | T74716 | T1822 | arg1Of | is,is |
R57469 | T40337 | T1822 | arg2Of | surprising,is |
R79271 | T74716 | T40337 | arg1Of | is,surprising |
R43979 | T2696 | T40337 | arg2Of | occluded,surprising |
R57152 | T2696 | T90378 | arg1Of | occluded,that |
R10287 | T76130 | T34257 | arg1Of | site,the |
R91721 | T76130 | T66548 | arg1Of | site,DPP4 |
R46219 | T76130 | T75367 | arg1Of | site,receptor-binding |
R87289 | T76130 | T72556 | arg1Of | site,of |
R72909 | T45911 | T72556 | arg2Of | S,of |
R53198 | T45911 | T49036 | arg1Of | S,MERS |
R53259 | T76130 | T21250 | arg1Of | site,was |
R67385 | T2696 | T21250 | arg2Of | occluded,was |
R98007 | T2696 | T8376 | arg1Of | occluded,not |
R19300 | T29223 | T2696 | arg1Of | glycans,occluded |
R78857 | T76130 | T2696 | arg2Of | site,occluded |
R95353 | T29223 | T90865 | arg2Of | glycans,by |
R40287 | T29223 | T85418 | arg1Of | glycans,( |
R76705 | T83410 | T85418 | arg2Of | Fig. 3a,( |
R94953 | T92859 | T85418 | arg3Of | ),( |
R96046 | T1822 | T98108 | arg1Of | is,"," |
R61866 | T1822 | T94718 | arg1Of | is,as |
R35368 | T75995 | T94718 | arg2Of | observed,as |
R73049 | T75995 | T33346 | arg1Of | observed,for |
R14458 | T6494 | T33346 | arg2Of | sites,for |
R78626 | T6494 | T37727 | arg1Of | sites,other |
R30385 | T6494 | T65600 | arg1Of | sites,receptor-binding |
R23066 | T6494 | T57622 | arg1Of | sites,of |
R45373 | T55295 | T57622 | arg2Of | proteins,of |
R94067 | T55295 | T15659 | arg1Of | proteins,class |
R60328 | T55295 | T77211 | arg1Of | proteins,I |
R46477 | T55295 | T77114 | arg1Of | proteins,viral |
R67171 | T55295 | T21676 | arg1Of | proteins,fusion |
R78404 | T55295 | T74940 | arg1Of | proteins,"," |
R41447 | T55295 | T82828 | arg1Of | proteins,including |
R26419 | T95596 | T82828 | arg2Of | and,including |
R76563 | T30576 | T94991 | arg1Of | S,SARS |
R58777 | T30576 | T72214 | arg1Of | S,( |
R98030 | T78031 | T72214 | arg2Of | Fig. 3b,( |
R76229 | T67457 | T72214 | arg3Of | ),( |
R54934 | T30576 | T6464 | arg1Of | S,"," |
R31581 | T27072 | T6464 | arg2Of | Env49,"," |
R73775 | T27072 | T4572 | arg1Of | Env49,HIV-1 |
R75492 | T6464 | T51710 | arg1Of | ",","," |
R20433 | T43889 | T51710 | arg2Of | GPC24,"," |
R18870 | T43889 | T37781 | arg1Of | GPC24,LASV |
R34352 | T51710 | T95596 | arg1Of | ",",and |
R34285 | T23338 | T95596 | arg2Of | HA50,and |
R44564 | T23338 | T81584 | arg1Of | HA50,influenza |
R81334 | T38368 | T7627 | arg1Of | We,suggest |
R26878 | T73121 | T7627 | arg2Of | whereas,suggest |
R65191 | T73121 | T64380 | arg1Of | whereas,that |
R22862 | T64096 | T56477 | arg1Of | this,is |
R38960 | T70981 | T56477 | arg2Of | due,is |
R32000 | T70981 | T19767 | arg1Of | due,likely |
R65480 | T64096 | T70981 | arg1Of | this,due |
R79491 | T70981 | T34848 | arg1Of | due,to |
R55987 | T53788 | T34848 | arg2Of | functionality,to |
R52190 | T53788 | T31069 | arg1Of | functionality,the |
R13680 | T53788 | T33383 | arg1Of | functionality,intrinsic |
R64406 | T53788 | T92413 | arg1Of | functionality,of |
R81081 | T65172 | T92413 | arg2Of | domain,of |
R81896 | T65172 | T48963 | arg1Of | domain,the |
R74108 | T65172 | T14314 | arg1Of | domain,receptor-binding |
R95810 | T65172 | T24472 | arg1Of | domain,of |
R76646 | T3759 | T24472 | arg2Of | S,of |
R26921 | T3759 | T66405 | arg1Of | S,MERS |
R58770 | T53788 | T35971 | arg1Of | functionality,"," |
R77726 | T53788 | T63119 | arg1Of | functionality,that |
R6505 | T53788 | T19398 | arg1Of | functionality,would |
R4568 | T99830 | T19398 | arg2Of | hindered,would |
R61961 | T53788 | T5062 | arg1Of | functionality,be |
R26875 | T99830 | T5062 | arg2Of | hindered,be |
R66003 | T99830 | T26453 | arg1Of | hindered,sterically |
R12914 | T15993 | T99830 | arg1Of | presence,hindered |
R70770 | T53788 | T99830 | arg2Of | functionality,hindered |
R14872 | T15993 | T79196 | arg2Of | presence,by |
R53035 | T15993 | T29715 | arg1Of | presence,the |
R98729 | T15993 | T46581 | arg1Of | presence,of |
R95269 | T84168 | T46581 | arg2Of | glycans,of |
R58211 | T84168 | T41531 | arg1Of | glycans,N-linked |
R37889 | T73121 | T31775 | arg1Of | whereas,"," |
R81691 | T56477 | T73121 | arg1Of | is,whereas |
R99845 | T10448 | T73121 | arg2Of | are,whereas |
R47162 | T86129 | T8489 | arg1Of | viruses,other |
R49164 | T86129 | T10448 | arg1Of | viruses,are |
R94272 | T85155 | T10448 | arg2Of | able,are |
R79979 | T86129 | T85155 | arg1Of | viruses,able |
R97251 | T93372 | T85155 | arg2Of | accommodate,able |
R79103 | T93372 | T10897 | arg1Of | accommodate,to |
R97857 | T86129 | T93372 | arg1Of | viruses,accommodate |
R99255 | T29096 | T93372 | arg2Of | modifications,accommodate |
R1410 | T29096 | T42685 | arg1Of | modifications,the |
R68581 | T29096 | T16612 | arg1Of | modifications,post-translational |
R90371 | T10448 | T68645 | arg1Of | are,"," |
R65530 | T10448 | T93438 | arg1Of | are,without |
R3419 | T85948 | T93438 | arg2Of | perturbing,without |
R11432 | T85948 | T18466 | arg1Of | perturbing,greatly |
R44377 | T86129 | T85948 | arg1Of | viruses,perturbing |
R68677 | T35584 | T85948 | arg2Of | functionality,perturbing |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T84 | 258-266 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T85 | 296-299 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T119 | 170-177 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T120 | 258-266 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T121 | 510-517 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T96 | 143-147 | Species | denotes | MERS | NCBItxid:1335626 |
T97 | 278-282 | Species | denotes | SARS | NCBItxid:694009 |
T98 | 296-301 | Species | denotes | HIV-1 | NCBItxid:11676 |
T99 | 309-313 | Species | denotes | LASV | NCBItxid:11620 |
T100 | 440-444 | Species | denotes | MERS | NCBItxid:1335626 |
T101 | 533-540 | Species | denotes | viruses | NCBItxid:10239 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T84 | 0-339 | Sentence | denotes | Given that the receptor-binding domain is the main target of neutralising antibodies8, it is surprising that the DPP4 receptor-binding site of MERS S was not occluded by glycans (Fig. 3a), as observed for other receptor-binding sites of class I viral fusion proteins, including SARS S (Fig. 3b), HIV-1 Env49, LASV GPC24 and influenza HA50. |
T85 | 340-644 | Sentence | denotes | We suggest that this is likely due to the intrinsic functionality of the receptor-binding domain of MERS S, that would be sterically hindered by the presence of N-linked glycans, whereas other viruses are able to accommodate the post-translational modifications, without greatly perturbing functionality. |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T47 | 278-282 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T48 | 324-333 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
526 | 113-117 | Gene | denotes | DPP4 | Gene:1803 |
529 | 143-147 | Disease | denotes | MERS | MESH:D018352 |
527 | 170-177 | Chemical | denotes | glycans | MESH:D011134 |
530 | 278-282 | Disease | denotes | SARS | MESH:D045169 |
523 | 296-301 | Species | denotes | HIV-1 | Tax:11676 |
522 | 302-305 | Gene | denotes | Env | Gene:64006 |
525 | 314-317 | Gene | denotes | GPC | Gene:2995 |
524 | 324-333 | Species | denotes | influenza | Tax:11320 |
531 | 440-444 | Disease | denotes | MERS | MESH:D018352 |
528 | 501-517 | Chemical | denotes | N-linked glycans |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T3669 | 113-117 | Protein | denotes | DPP4 | https://www.uniprot.org/uniprot/Q9N2I7 |
LitCovid-sample-PD-GO-BP-0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T34 | 569-601 | http://purl.obolibrary.org/obo/GO_0043687 | denotes | post-translational modifications |
LitCovid-sample-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T31 | 569-601 | http://purl.obolibrary.org/obo/GO_0043687 | denotes | post-translational modifications |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T35 | 569-601 | http://purl.obolibrary.org/obo/GO_0043687 | denotes | post-translational modifications |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T84 | 0-339 | Sentence | denotes | Given that the receptor-binding domain is the main target of neutralising antibodies8, it is surprising that the DPP4 receptor-binding site of MERS S was not occluded by glycans (Fig. 3a), as observed for other receptor-binding sites of class I viral fusion proteins, including SARS S (Fig. 3b), HIV-1 Env49, LASV GPC24 and influenza HA50. |
T85 | 340-644 | Sentence | denotes | We suggest that this is likely due to the intrinsic functionality of the receptor-binding domain of MERS S, that would be sterically hindered by the presence of N-linked glycans, whereas other viruses are able to accommodate the post-translational modifications, without greatly perturbing functionality. |