PMC:7253235 / 8276-9461 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"267","span":{"begin":68,"end":76},"obj":"Species"},{"id":"268","span":{"begin":265,"end":273},"obj":"Species"},{"id":"269","span":{"begin":635,"end":643},"obj":"Species"},{"id":"270","span":{"begin":943,"end":951},"obj":"Species"},{"id":"271","span":{"begin":1041,"end":1049},"obj":"Species"},{"id":"272","span":{"begin":156,"end":168},"obj":"Disease"},{"id":"273","span":{"begin":193,"end":216},"obj":"Disease"},{"id":"274","span":{"begin":230,"end":238},"obj":"Disease"},{"id":"275","span":{"begin":279,"end":291},"obj":"Disease"},{"id":"276","span":{"begin":311,"end":334},"obj":"Disease"},{"id":"277","span":{"begin":445,"end":457},"obj":"Disease"},{"id":"278","span":{"begin":498,"end":521},"obj":"Disease"},{"id":"279","span":{"begin":860,"end":863},"obj":"Disease"},{"id":"280","span":{"begin":873,"end":881},"obj":"Disease"},{"id":"281","span":{"begin":894,"end":906},"obj":"Disease"},{"id":"282","span":{"begin":994,"end":1006},"obj":"Disease"},{"id":"283","span":{"begin":1065,"end":1100},"obj":"Disease"},{"id":"284","span":{"begin":1102,"end":1106},"obj":"Disease"},{"id":"285","span":{"begin":1146,"end":1151},"obj":"Disease"}],"attributes":[{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"Tax:9606"},{"id":"A268","pred":"tao:has_database_id","subj":"268","obj":"Tax:9606"},{"id":"A269","pred":"tao:has_database_id","subj":"269","obj":"Tax:9606"},{"id":"A270","pred":"tao:has_database_id","subj":"270","obj":"Tax:9606"},{"id":"A271","pred":"tao:has_database_id","subj":"271","obj":"Tax:9606"},{"id":"A272","pred":"tao:has_database_id","subj":"272","obj":"MESH:D006973"},{"id":"A273","pred":"tao:has_database_id","subj":"273","obj":"MESH:D002561"},{"id":"A274","pred":"tao:has_database_id","subj":"274","obj":"MESH:D003920"},{"id":"A275","pred":"tao:has_database_id","subj":"275","obj":"MESH:D006973"},{"id":"A276","pred":"tao:has_database_id","subj":"276","obj":"MESH:D002561"},{"id":"A277","pred":"tao:has_database_id","subj":"277","obj":"MESH:D006973"},{"id":"A278","pred":"tao:has_database_id","subj":"278","obj":"MESH:D002561"},{"id":"A279","pred":"tao:has_database_id","subj":"279","obj":"MESH:D002318"},{"id":"A280","pred":"tao:has_database_id","subj":"280","obj":"MESH:D003920"},{"id":"A281","pred":"tao:has_database_id","subj":"281","obj":"MESH:D006973"},{"id":"A282","pred":"tao:has_database_id","subj":"282","obj":"MESH:D006973"},{"id":"A283","pred":"tao:has_database_id","subj":"283","obj":"MESH:D012128"},{"id":"A284","pred":"tao:has_database_id","subj":"284","obj":"MESH:D012128"},{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"China\nA meta-analysis of 6 Chinese studies evaluating 1527 affected patients showed that the most prevalent cardiovascular metabolic comorbidities included hypertension (17.1%), cardiac and/or cerebrovascular disease (16.4%), and diabetes (9.7%). Most importantly, patients with hypertension and cardiac and/or cerebrovascular disease significantly accounted for more ICU cases compared with non-ICU cases with prevalence of 28.8% (RR 2.03) for hypertension, and 16.7% (RR 3.30) for cardiac and/or cerebrovascular disease [18]. Data from the World Health Organization and Chinese Center for Disease Control and Prevention confirm that patients with comorbidities have a higher case fatality rate (CFR) than those without comorbidities [19, 20]. Of the 55,924 laboratory-confirmed cases in China, there was a 3.8% CFR and higher rates were seen with those with CVD (13.2%), diabetes (9.2%), and hypertension (8.4%) [19•]. A cohort study of 201 patients from Wuhan Jinyintan Hospital showed that hypertension was significantly associated with patients progressing to Acute Respiratory Distress Syndrome (ARDS) (27.4% vs. 13.7%; p = 0.02) and later death (36.4% vs. 17.5%; p = 0.05) [21]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T83","span":{"begin":156,"end":168},"obj":"Disease"},{"id":"T84","span":{"begin":193,"end":216},"obj":"Disease"},{"id":"T85","span":{"begin":230,"end":238},"obj":"Disease"},{"id":"T86","span":{"begin":279,"end":291},"obj":"Disease"},{"id":"T87","span":{"begin":311,"end":334},"obj":"Disease"},{"id":"T88","span":{"begin":445,"end":457},"obj":"Disease"},{"id":"T89","span":{"begin":498,"end":521},"obj":"Disease"},{"id":"T90","span":{"begin":873,"end":881},"obj":"Disease"},{"id":"T91","span":{"begin":894,"end":906},"obj":"Disease"},{"id":"T92","span":{"begin":994,"end":1006},"obj":"Disease"},{"id":"T93","span":{"begin":1065,"end":1100},"obj":"Disease"},{"id":"T94","span":{"begin":1071,"end":1100},"obj":"Disease"},{"id":"T95","span":{"begin":1102,"end":1106},"obj":"Disease"}],"attributes":[{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0011057"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0005015"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0011057"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0011057"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0005015"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"}],"text":"China\nA meta-analysis of 6 Chinese studies evaluating 1527 affected patients showed that the most prevalent cardiovascular metabolic comorbidities included hypertension (17.1%), cardiac and/or cerebrovascular disease (16.4%), and diabetes (9.7%). Most importantly, patients with hypertension and cardiac and/or cerebrovascular disease significantly accounted for more ICU cases compared with non-ICU cases with prevalence of 28.8% (RR 2.03) for hypertension, and 16.7% (RR 3.30) for cardiac and/or cerebrovascular disease [18]. Data from the World Health Organization and Chinese Center for Disease Control and Prevention confirm that patients with comorbidities have a higher case fatality rate (CFR) than those without comorbidities [19, 20]. Of the 55,924 laboratory-confirmed cases in China, there was a 3.8% CFR and higher rates were seen with those with CVD (13.2%), diabetes (9.2%), and hypertension (8.4%) [19•]. A cohort study of 201 patients from Wuhan Jinyintan Hospital showed that hypertension was significantly associated with patients progressing to Acute Respiratory Distress Syndrome (ARDS) (27.4% vs. 13.7%; p = 0.02) and later death (36.4% vs. 17.5%; p = 0.05) [21]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T39","span":{"begin":6,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T40","span":{"begin":523,"end":525},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T41","span":{"begin":555,"end":567},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T42","span":{"begin":668,"end":669},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T43","span":{"begin":806,"end":807},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T44","span":{"begin":921,"end":922},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"China\nA meta-analysis of 6 Chinese studies evaluating 1527 affected patients showed that the most prevalent cardiovascular metabolic comorbidities included hypertension (17.1%), cardiac and/or cerebrovascular disease (16.4%), and diabetes (9.7%). Most importantly, patients with hypertension and cardiac and/or cerebrovascular disease significantly accounted for more ICU cases compared with non-ICU cases with prevalence of 28.8% (RR 2.03) for hypertension, and 16.7% (RR 3.30) for cardiac and/or cerebrovascular disease [18]. Data from the World Health Organization and Chinese Center for Disease Control and Prevention confirm that patients with comorbidities have a higher case fatality rate (CFR) than those without comorbidities [19, 20]. Of the 55,924 laboratory-confirmed cases in China, there was a 3.8% CFR and higher rates were seen with those with CVD (13.2%), diabetes (9.2%), and hypertension (8.4%) [19•]. A cohort study of 201 patients from Wuhan Jinyintan Hospital showed that hypertension was significantly associated with patients progressing to Acute Respiratory Distress Syndrome (ARDS) (27.4% vs. 13.7%; p = 0.02) and later death (36.4% vs. 17.5%; p = 0.05) [21]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3","span":{"begin":432,"end":434},"obj":"Chemical"},{"id":"T4","span":{"begin":470,"end":472},"obj":"Chemical"}],"attributes":[{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_73811"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_73811"}],"text":"China\nA meta-analysis of 6 Chinese studies evaluating 1527 affected patients showed that the most prevalent cardiovascular metabolic comorbidities included hypertension (17.1%), cardiac and/or cerebrovascular disease (16.4%), and diabetes (9.7%). Most importantly, patients with hypertension and cardiac and/or cerebrovascular disease significantly accounted for more ICU cases compared with non-ICU cases with prevalence of 28.8% (RR 2.03) for hypertension, and 16.7% (RR 3.30) for cardiac and/or cerebrovascular disease [18]. Data from the World Health Organization and Chinese Center for Disease Control and Prevention confirm that patients with comorbidities have a higher case fatality rate (CFR) than those without comorbidities [19, 20]. Of the 55,924 laboratory-confirmed cases in China, there was a 3.8% CFR and higher rates were seen with those with CVD (13.2%), diabetes (9.2%), and hypertension (8.4%) [19•]. A cohort study of 201 patients from Wuhan Jinyintan Hospital showed that hypertension was significantly associated with patients progressing to Acute Respiratory Distress Syndrome (ARDS) (27.4% vs. 13.7%; p = 0.02) and later death (36.4% vs. 17.5%; p = 0.05) [21]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T55","span":{"begin":156,"end":168},"obj":"Phenotype"},{"id":"T56","span":{"begin":279,"end":291},"obj":"Phenotype"},{"id":"T57","span":{"begin":445,"end":457},"obj":"Phenotype"},{"id":"T58","span":{"begin":894,"end":906},"obj":"Phenotype"},{"id":"T59","span":{"begin":994,"end":1006},"obj":"Phenotype"},{"id":"T60","span":{"begin":1071,"end":1091},"obj":"Phenotype"}],"attributes":[{"id":"A55","pred":"hp_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A56","pred":"hp_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A57","pred":"hp_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A58","pred":"hp_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A59","pred":"hp_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A60","pred":"hp_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/HP_0002098"}],"text":"China\nA meta-analysis of 6 Chinese studies evaluating 1527 affected patients showed that the most prevalent cardiovascular metabolic comorbidities included hypertension (17.1%), cardiac and/or cerebrovascular disease (16.4%), and diabetes (9.7%). Most importantly, patients with hypertension and cardiac and/or cerebrovascular disease significantly accounted for more ICU cases compared with non-ICU cases with prevalence of 28.8% (RR 2.03) for hypertension, and 16.7% (RR 3.30) for cardiac and/or cerebrovascular disease [18]. Data from the World Health Organization and Chinese Center for Disease Control and Prevention confirm that patients with comorbidities have a higher case fatality rate (CFR) than those without comorbidities [19, 20]. Of the 55,924 laboratory-confirmed cases in China, there was a 3.8% CFR and higher rates were seen with those with CVD (13.2%), diabetes (9.2%), and hypertension (8.4%) [19•]. A cohort study of 201 patients from Wuhan Jinyintan Hospital showed that hypertension was significantly associated with patients progressing to Acute Respiratory Distress Syndrome (ARDS) (27.4% vs. 13.7%; p = 0.02) and later death (36.4% vs. 17.5%; p = 0.05) [21]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T53","span":{"begin":0,"end":5},"obj":"Sentence"},{"id":"T54","span":{"begin":6,"end":246},"obj":"Sentence"},{"id":"T55","span":{"begin":247,"end":527},"obj":"Sentence"},{"id":"T56","span":{"begin":528,"end":744},"obj":"Sentence"},{"id":"T57","span":{"begin":745,"end":920},"obj":"Sentence"},{"id":"T58","span":{"begin":921,"end":1185},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"China\nA meta-analysis of 6 Chinese studies evaluating 1527 affected patients showed that the most prevalent cardiovascular metabolic comorbidities included hypertension (17.1%), cardiac and/or cerebrovascular disease (16.4%), and diabetes (9.7%). Most importantly, patients with hypertension and cardiac and/or cerebrovascular disease significantly accounted for more ICU cases compared with non-ICU cases with prevalence of 28.8% (RR 2.03) for hypertension, and 16.7% (RR 3.30) for cardiac and/or cerebrovascular disease [18]. Data from the World Health Organization and Chinese Center for Disease Control and Prevention confirm that patients with comorbidities have a higher case fatality rate (CFR) than those without comorbidities [19, 20]. Of the 55,924 laboratory-confirmed cases in China, there was a 3.8% CFR and higher rates were seen with those with CVD (13.2%), diabetes (9.2%), and hypertension (8.4%) [19•]. A cohort study of 201 patients from Wuhan Jinyintan Hospital showed that hypertension was significantly associated with patients progressing to Acute Respiratory Distress Syndrome (ARDS) (27.4% vs. 13.7%; p = 0.02) and later death (36.4% vs. 17.5%; p = 0.05) [21]."}