PMC:7253235 / 81-2260
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 10 | 22-39 | Species | denotes | novel Coronavirus | Tax:2697049 |
| 11 | 41-50 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 12 | 360-368 | Species | denotes | Patients | Tax:9606 |
| 13 | 604-612 | Species | denotes | patients | Tax:9606 |
| 14 | 52-60 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 15 | 349-358 | Disease | denotes | mortality | MESH:D003643 |
| 16 | 387-393 | Disease | denotes | cancer | MESH:D009369 |
| 17 | 618-626 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 32 | 749-757 | Species | denotes | patients | Tax:9606 |
| 33 | 872-880 | Species | denotes | patients | Tax:9606 |
| 34 | 742-748 | Disease | denotes | Cancer | MESH:D009369 |
| 35 | 783-797 | Disease | denotes | cardiac injury | MESH:D006331 |
| 36 | 832-841 | Disease | denotes | mortality | MESH:D003643 |
| 37 | 865-871 | Disease | denotes | cancer | MESH:D009369 |
| 38 | 904-910 | Disease | denotes | cancer | MESH:D009369 |
| 39 | 1085-1091 | Disease | denotes | cancer | MESH:D009369 |
| 40 | 1109-1115 | Disease | denotes | cancer | MESH:D009369 |
| 41 | 1158-1180 | Disease | denotes | cardiovascular disease | MESH:D002318 |
| 42 | 1185-1191 | Disease | denotes | cancer | MESH:D009369 |
| 43 | 1278-1284 | Disease | denotes | cancer | MESH:D009369 |
| 44 | 1354-1387 | Disease | denotes | cardiovascular and cancer disease | MESH:D002318 |
| 45 | 1436-1444 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 63 | 1985-1993 | Species | denotes | patients | Tax:9606 |
| 64 | 1591-1599 | Species | denotes | Patients | Tax:9606 |
| 65 | 1455-1467 | Disease | denotes | Hypertension | MESH:D006973 |
| 66 | 1469-1491 | Disease | denotes | cardiovascular disease | MESH:D002318 |
| 67 | 1493-1501 | Disease | denotes | diabetes | MESH:D003920 |
| 68 | 1507-1513 | Disease | denotes | cancer | MESH:D009369 |
| 69 | 1552-1560 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 70 | 1561-1570 | Disease | denotes | infection | MESH:D007239 |
| 71 | 1616-1622 | Disease | denotes | cancer | MESH:D009369 |
| 72 | 1663-1684 | Disease | denotes | coronavirus infection | MESH:D018352 |
| 73 | 1735-1753 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 74 | 1755-1769 | Disease | denotes | hyperlipidemia | MESH:D006949 |
| 75 | 1785-1800 | Disease | denotes | atherosclerosis | MESH:D050197 |
| 76 | 1824-1830 | Disease | denotes | cancer | MESH:D009369 |
| 77 | 1889-1898 | Disease | denotes | infection | MESH:D007239 |
| 78 | 1905-1919 | Disease | denotes | type of cancer | MESH:D009369 |
| 79 | 2021-2027 | Disease | denotes | cancer | MESH:D009369 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 1234-1242 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T2 | 52-60 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T3 | 94-128 | Disease | denotes | severe acute respiratory syndromes | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T4 | 387-393 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T5 | 618-626 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T6 | 742-748 | Disease | denotes | Cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T7 | 791-797 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T8 | 865-871 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T9 | 904-910 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T10 | 1085-1091 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T11 | 1109-1115 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T12 | 1158-1180 | Disease | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/MONDO_0004995 |
| T13 | 1185-1191 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T14 | 1278-1284 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T15 | 1354-1379 | Disease | denotes | cardiovascular and cancer | http://purl.obolibrary.org/obo/MONDO_0002100 |
| T16 | 1373-1379 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T17 | 1436-1444 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T18 | 1455-1491 | Disease | denotes | Hypertension, cardiovascular disease | http://purl.obolibrary.org/obo/MONDO_0001302 |
| T19 | 1455-1467 | Disease | denotes | Hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T20 | 1469-1491 | Disease | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/MONDO_0004995 |
| T21 | 1493-1501 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T22 | 1507-1513 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T23 | 1552-1560 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T24 | 1561-1570 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T25 | 1616-1622 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T26 | 1675-1684 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T27 | 1735-1753 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T28 | 1755-1769 | Disease | denotes | hyperlipidemia | http://purl.obolibrary.org/obo/MONDO_0021187 |
| T29 | 1785-1800 | Disease | denotes | atherosclerosis | http://purl.obolibrary.org/obo/MONDO_0005311 |
| T30 | 1824-1830 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T31 | 1889-1898 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T32 | 1913-1919 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T33 | 1999-2027 | Disease | denotes | cardiovascular and/or cancer | http://purl.obolibrary.org/obo/MONDO_0002100 |
| T34 | 2021-2027 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 218-223 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T2 | 437-438 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T3 | 814-815 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T4 | 1955-1956 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T2 | 387-393 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T3 | 742-748 | Phenotype | denotes | Cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T4 | 865-871 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T5 | 904-910 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T6 | 1085-1091 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T7 | 1109-1115 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T8 | 1158-1180 | Phenotype | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/HP_0001626 |
| T9 | 1185-1191 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T10 | 1234-1259 | Phenotype | denotes | cytokine release syndrome | http://purl.obolibrary.org/obo/HP_0033041 |
| T11 | 1278-1284 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T12 | 1373-1379 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T13 | 1455-1467 | Phenotype | denotes | Hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
| T14 | 1469-1491 | Phenotype | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/HP_0001626 |
| T15 | 1507-1513 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T16 | 1616-1622 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T17 | 1735-1753 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T18 | 1755-1769 | Phenotype | denotes | hyperlipidemia | http://purl.obolibrary.org/obo/HP_0003077 |
| T19 | 1785-1800 | Phenotype | denotes | atherosclerosis | http://purl.obolibrary.org/obo/HP_0002621 |
| T20 | 1824-1830 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T21 | 1870-1898 | Phenotype | denotes | susceptibility for infection | http://purl.obolibrary.org/obo/HP_0002719 |
| T22 | 1913-1919 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T23 | 2021-2027 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 0-17 | Sentence | denotes | Purpose of Review |
| T4 | 18-191 | Sentence | denotes | The novel Coronavirus (2019-nCoV, COVID-19) is historically one of the most severe acute respiratory syndromes and pandemics to affect the globe in the twenty-first century. |
| T5 | 192-359 | Sentence | denotes | Originating in Wuhan, the virus rapidly spread and impacted subsets of populations with initial unclear risk factors contributing to worsening morbidity and mortality. |
| T6 | 360-497 | Sentence | denotes | Patients with diagnosis of cancer and undergoing treatment further represent a population at risk for worsening cardiopulmonary outcomes. |
| T7 | 498-627 | Sentence | denotes | This review explores specific risk factors, diagnoses, and treatment options that impact cardio-oncologic patients with COVID-19. |
| T8 | 629-644 | Sentence | denotes | Recent Findings |
| T9 | 645-741 | Sentence | denotes | Multiple studies globally, including Italy, China, and the USA, have documented severe outcomes. |
| T10 | 742-842 | Sentence | denotes | Cancer patients are at increased risk of cardiac injury which itself is a risk factor for mortality. |
| T11 | 843-1027 | Sentence | denotes | Additionally, elderly cancer patients undergoing recent anti-cancer treatment may be at greater risk for sustaining worse outcomes, although data remains suboptimal in this population. |
| T12 | 1028-1192 | Sentence | denotes | Major gaps remain regarding risk associated with type of cancer and type of anti-cancer treatment, as well as the layered risk of cardiovascular disease and cancer. |
| T13 | 1193-1445 | Sentence | denotes | Immunomodulatory therapies used to treat cytokine release syndrome secondary to anti-cancer therapies, as well as other agents being traditionally used to treat cardiovascular and cancer disease states, are being investigated for treatment of COVID-19. |
| T14 | 1447-1454 | Sentence | denotes | Summary |
| T15 | 1455-1590 | Sentence | denotes | Hypertension, cardiovascular disease, diabetes, and cancer have been associated with more severe COVID-19 infection and worse outcomes. |
| T16 | 1591-1801 | Sentence | denotes | Patients undergoing anti-cancer therapy or those who have suffered from coronavirus infection may develop long-standing changes, not limited to pulmonary fibrosis, hyperlipidemia, and worsening atherosclerosis. |
| T17 | 1802-1954 | Sentence | denotes | Those undergoing anti-cancer therapy are at theoretically increased susceptibility for infection, with type of cancer not necessarily dictating outcome. |
| T18 | 1955-2179 | Sentence | denotes | A review of the literature of patients with cardiovascular and/or cancer disease is presented, as well as proposed strategies to attenuate risk regarding treatment, management, and surveillance in this vulnerable population. |