PMC:7253235 / 5838-7040 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7253235","sourcedb":"PMC","sourceid":"7253235","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7253235","text":"Underlying risk factors, such as hypertension, diabetes, cardiovascular disease, and immunosuppression, have been explored as prognosticators regarding clinical outcomes of COVID-19 infections in hospitalized patients [15•]. However, the impact of the pandemic in patients with a history of cancer and pre-existing and/or cancer treatment–associated cardiovascular disease—the cardio-oncology patient—is unknown. Theoretically, this population is likely at higher risk of morbidity and mortality from COVID-19 infection, and has unique healthcare needs that put them at higher risk at exposure from community and healthcare-related transmission. Examples of these risks include needing ongoing cancer treatments in the outpatient and inpatient setting, as well as imaging-related procedures and operations for cancer-related staging and treatments. If these patients also have pre-existing cardiovascular disease and/or acquired cardiotoxicity during and after treatments, they also warrant additional evaluation. Finally, there appears to be a strong correlation with worse outcomes in hospitalized COVID-19 patients in cardiovascular and/or cancer-related comorbidities, which will be reviewed below.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"191","span":{"begin":209,"end":217},"obj":"Species"},{"id":"192","span":{"begin":264,"end":272},"obj":"Species"},{"id":"193","span":{"begin":393,"end":400},"obj":"Species"},{"id":"194","span":{"begin":719,"end":729},"obj":"Species"},{"id":"195","span":{"begin":858,"end":866},"obj":"Species"},{"id":"196","span":{"begin":1109,"end":1117},"obj":"Species"},{"id":"197","span":{"begin":33,"end":45},"obj":"Disease"},{"id":"198","span":{"begin":47,"end":55},"obj":"Disease"},{"id":"199","span":{"begin":57,"end":79},"obj":"Disease"},{"id":"200","span":{"begin":173,"end":181},"obj":"Disease"},{"id":"201","span":{"begin":182,"end":192},"obj":"Disease"},{"id":"202","span":{"begin":291,"end":297},"obj":"Disease"},{"id":"203","span":{"begin":322,"end":328},"obj":"Disease"},{"id":"204","span":{"begin":350,"end":372},"obj":"Disease"},{"id":"205","span":{"begin":486,"end":495},"obj":"Disease"},{"id":"206","span":{"begin":501,"end":509},"obj":"Disease"},{"id":"207","span":{"begin":510,"end":519},"obj":"Disease"},{"id":"208","span":{"begin":694,"end":700},"obj":"Disease"},{"id":"209","span":{"begin":810,"end":816},"obj":"Disease"},{"id":"210","span":{"begin":890,"end":912},"obj":"Disease"},{"id":"211","span":{"begin":929,"end":943},"obj":"Disease"},{"id":"212","span":{"begin":1100,"end":1108},"obj":"Disease"},{"id":"213","span":{"begin":1143,"end":1149},"obj":"Disease"}],"attributes":[{"id":"A191","pred":"tao:has_database_id","subj":"191","obj":"Tax:9606"},{"id":"A192","pred":"tao:has_database_id","subj":"192","obj":"Tax:9606"},{"id":"A193","pred":"tao:has_database_id","subj":"193","obj":"Tax:9606"},{"id":"A194","pred":"tao:has_database_id","subj":"194","obj":"Tax:9606"},{"id":"A195","pred":"tao:has_database_id","subj":"195","obj":"Tax:9606"},{"id":"A196","pred":"tao:has_database_id","subj":"196","obj":"Tax:9606"},{"id":"A197","pred":"tao:has_database_id","subj":"197","obj":"MESH:D006973"},{"id":"A198","pred":"tao:has_database_id","subj":"198","obj":"MESH:D003920"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"MESH:D002318"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"MESH:C000657245"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"MESH:D007239"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"MESH:D009369"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"MESH:D009369"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"MESH:D002318"},{"id":"A205","pred":"tao:has_database_id","subj":"205","obj":"MESH:D003643"},{"id":"A206","pred":"tao:has_database_id","subj":"206","obj":"MESH:C000657245"},{"id":"A207","pred":"tao:has_database_id","subj":"207","obj":"MESH:D007239"},{"id":"A208","pred":"tao:has_database_id","subj":"208","obj":"MESH:D009369"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"MESH:D009369"},{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"MESH:D002318"},{"id":"A211","pred":"tao:has_database_id","subj":"211","obj":"MESH:D066126"},{"id":"A212","pred":"tao:has_database_id","subj":"212","obj":"MESH:C000657245"},{"id":"A213","pred":"tao:has_database_id","subj":"213","obj":"MESH:D009369"},{"subj":"191","pred":"source","obj":"LitCovid-PubTator"},{"subj":"192","pred":"source","obj":"LitCovid-PubTator"},{"subj":"193","pred":"source","obj":"LitCovid-PubTator"},{"subj":"194","pred":"source","obj":"LitCovid-PubTator"},{"subj":"195","pred":"source","obj":"LitCovid-PubTator"},{"subj":"196","pred":"source","obj":"LitCovid-PubTator"},{"subj":"197","pred":"source","obj":"LitCovid-PubTator"},{"subj":"198","pred":"source","obj":"LitCovid-PubTator"},{"subj":"199","pred":"source","obj":"LitCovid-PubTator"},{"subj":"200","pred":"source","obj":"LitCovid-PubTator"},{"subj":"201","pred":"source","obj":"LitCovid-PubTator"},{"subj":"202","pred":"source","obj":"LitCovid-PubTator"},{"subj":"203","pred":"source","obj":"LitCovid-PubTator"},{"subj":"204","pred":"source","obj":"LitCovid-PubTator"},{"subj":"205","pred":"source","obj":"LitCovid-PubTator"},{"subj":"206","pred":"source","obj":"LitCovid-PubTator"},{"subj":"207","pred":"source","obj":"LitCovid-PubTator"},{"subj":"208","pred":"source","obj":"LitCovid-PubTator"},{"subj":"209","pred":"source","obj":"LitCovid-PubTator"},{"subj":"210","pred":"source","obj":"LitCovid-PubTator"},{"subj":"211","pred":"source","obj":"LitCovid-PubTator"},{"subj":"212","pred":"source","obj":"LitCovid-PubTator"},{"subj":"213","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T54","span":{"begin":33,"end":45},"obj":"Disease"},{"id":"T55","span":{"begin":47,"end":55},"obj":"Disease"},{"id":"T56","span":{"begin":57,"end":79},"obj":"Disease"},{"id":"T57","span":{"begin":173,"end":181},"obj":"Disease"},{"id":"T58","span":{"begin":182,"end":195},"obj":"Disease"},{"id":"T59","span":{"begin":291,"end":297},"obj":"Disease"},{"id":"T60","span":{"begin":322,"end":328},"obj":"Disease"},{"id":"T61","span":{"begin":350,"end":372},"obj":"Disease"},{"id":"T62","span":{"begin":501,"end":509},"obj":"Disease"},{"id":"T63","span":{"begin":510,"end":519},"obj":"Disease"},{"id":"T64","span":{"begin":694,"end":700},"obj":"Disease"},{"id":"T65","span":{"begin":810,"end":816},"obj":"Disease"},{"id":"T66","span":{"begin":890,"end":912},"obj":"Disease"},{"id":"T67","span":{"begin":1100,"end":1108},"obj":"Disease"},{"id":"T68","span":{"begin":1121,"end":1149},"obj":"Disease"},{"id":"T69","span":{"begin":1143,"end":1149},"obj":"Disease"}],"attributes":[{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0005015"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0004995"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0004995"},{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0004995"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0002100"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T28","span":{"begin":278,"end":279},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T29","span":{"begin":525,"end":528},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T30","span":{"begin":1043,"end":1044},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T28","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T40","span":{"begin":33,"end":45},"obj":"Phenotype"},{"id":"T41","span":{"begin":57,"end":79},"obj":"Phenotype"},{"id":"T42","span":{"begin":291,"end":297},"obj":"Phenotype"},{"id":"T43","span":{"begin":322,"end":328},"obj":"Phenotype"},{"id":"T44","span":{"begin":350,"end":372},"obj":"Phenotype"},{"id":"T45","span":{"begin":384,"end":392},"obj":"Phenotype"},{"id":"T46","span":{"begin":694,"end":700},"obj":"Phenotype"},{"id":"T47","span":{"begin":810,"end":816},"obj":"Phenotype"},{"id":"T48","span":{"begin":890,"end":912},"obj":"Phenotype"},{"id":"T49","span":{"begin":1143,"end":1149},"obj":"Phenotype"}],"attributes":[{"id":"A40","pred":"hp_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A41","pred":"hp_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/HP_0001626"},{"id":"A42","pred":"hp_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A43","pred":"hp_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A44","pred":"hp_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/HP_0001626"},{"id":"A45","pred":"hp_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A46","pred":"hp_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A47","pred":"hp_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A48","pred":"hp_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/HP_0001626"},{"id":"A49","pred":"hp_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T42","span":{"begin":0,"end":224},"obj":"Sentence"},{"id":"T43","span":{"begin":225,"end":412},"obj":"Sentence"},{"id":"T44","span":{"begin":413,"end":645},"obj":"Sentence"},{"id":"T45","span":{"begin":646,"end":848},"obj":"Sentence"},{"id":"T46","span":{"begin":849,"end":1013},"obj":"Sentence"},{"id":"T47","span":{"begin":1014,"end":1202},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T42","pred":"source","obj":"LitCovid-sentences"},{"subj":"T43","pred":"source","obj":"LitCovid-sentences"},{"subj":"T44","pred":"source","obj":"LitCovid-sentences"},{"subj":"T45","pred":"source","obj":"LitCovid-sentences"},{"subj":"T46","pred":"source","obj":"LitCovid-sentences"},{"subj":"T47","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec9793","default":true},{"id":"LitCovid-PD-MONDO","color":"#93a8ec"},{"id":"LitCovid-PD-CLO","color":"#c2ec93"},{"id":"LitCovid-PD-HP","color":"#ec93dc"},{"id":"LitCovid-sentences","color":"#93ece2"}]}]}}