PMC:7253235 / 4749-5837
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7253235","sourcedb":"PMC","sourceid":"7253235","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7253235","text":"Epidemiological data from China confirmed the median age of the patients impacted by the disease to be 59 years, with disease distribution disproportionately impacting males [12]. The data further hypothesized that children might be less likely to become infected, or if infected, demonstrated far milder symptoms. Italy documented nearly 22,512 cases by March of 2020, with the largest proportion of cases and fatalities impacting males greater than 60 years of age [13]. In the Lombardy study, 68% of patients had at least one existing comorbidity, with hypertension being most frequently cited. Other predisposing factors included cardiovascular disease and hypercholesterolemia. A rare subset had pre-existing lung disease, manifesting as chronic obstructive pulmonary disease. Roughly 11% of the Lombardy patients were managed with non-invasive ventilatory support [14]. The need for invasive ventilatory support varied across regions of the world, and some of the Wuhan cohort were directly transitioned to extracorporeal membrane oxygenation (ECMO) for resuscitation purposes 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