PMC:7253235 / 4683-7040
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 144 | 16-24 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 145 | 58-65 | Disease | denotes | Illness | MESH:D002908 |
| 157 | 130-138 | Species | denotes | patients | Tax:9606 |
| 158 | 281-289 | Species | denotes | children | Tax:9606 |
| 159 | 569-577 | Species | denotes | patients | Tax:9606 |
| 160 | 876-884 | Species | denotes | patients | Tax:9606 |
| 161 | 321-329 | Disease | denotes | infected | MESH:D007239 |
| 162 | 337-345 | Disease | denotes | infected | MESH:D007239 |
| 163 | 622-634 | Disease | denotes | hypertension | MESH:D006973 |
| 164 | 700-722 | Disease | denotes | cardiovascular disease | MESH:D002318 |
| 165 | 727-747 | Disease | denotes | hypercholesterolemia | MESH:D006937 |
| 166 | 780-792 | Disease | denotes | lung disease | MESH:D008171 |
| 167 | 809-846 | Disease | denotes | chronic obstructive pulmonary disease | MESH:D029424 |
| 191 | 1364-1372 | Species | denotes | patients | Tax:9606 |
| 192 | 1419-1427 | Species | denotes | patients | Tax:9606 |
| 193 | 1548-1555 | Species | denotes | patient | Tax:9606 |
| 194 | 1874-1884 | Species | denotes | outpatient | Tax:9606 |
| 195 | 2013-2021 | Species | denotes | patients | Tax:9606 |
| 196 | 2264-2272 | Species | denotes | patients | Tax:9606 |
| 197 | 1188-1200 | Disease | denotes | hypertension | MESH:D006973 |
| 198 | 1202-1210 | Disease | denotes | diabetes | MESH:D003920 |
| 199 | 1212-1234 | Disease | denotes | cardiovascular disease | MESH:D002318 |
| 200 | 1328-1336 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 201 | 1337-1347 | Disease | denotes | infections | MESH:D007239 |
| 202 | 1446-1452 | Disease | denotes | cancer | MESH:D009369 |
| 203 | 1477-1483 | Disease | denotes | cancer | MESH:D009369 |
| 204 | 1505-1527 | Disease | denotes | cardiovascular disease | MESH:D002318 |
| 205 | 1641-1650 | Disease | denotes | mortality | MESH:D003643 |
| 206 | 1656-1664 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 207 | 1665-1674 | Disease | denotes | infection | MESH:D007239 |
| 208 | 1849-1855 | Disease | denotes | cancer | MESH:D009369 |
| 209 | 1965-1971 | Disease | denotes | cancer | MESH:D009369 |
| 210 | 2045-2067 | Disease | denotes | cardiovascular disease | MESH:D002318 |
| 211 | 2084-2098 | Disease | denotes | cardiotoxicity | MESH:D066126 |
| 212 | 2255-2263 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 213 | 2298-2304 | Disease | denotes | cancer | MESH:D009369 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T5 | 780-784 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T6 | 780-784 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T48 | 16-24 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T49 | 622-634 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T50 | 700-722 | Disease | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/MONDO_0004995 |
| T51 | 780-792 | Disease | denotes | lung disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T52 | 809-846 | Disease | denotes | chronic obstructive pulmonary disease | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T53 | 829-846 | Disease | denotes | pulmonary disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T54 | 1188-1200 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T55 | 1202-1210 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T56 | 1212-1234 | Disease | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/MONDO_0004995 |
| T57 | 1328-1336 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T58 | 1337-1350 | Disease | denotes | infections in | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T59 | 1446-1452 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T60 | 1477-1483 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T61 | 1505-1527 | Disease | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/MONDO_0004995 |
| T62 | 1656-1664 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T63 | 1665-1674 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T64 | 1849-1855 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T65 | 1965-1971 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T66 | 2045-2067 | Disease | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/MONDO_0004995 |
| T67 | 2255-2263 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T68 | 2276-2304 | Disease | denotes | cardiovascular and/or cancer | http://purl.obolibrary.org/obo/MONDO_0002100 |
| T69 | 2298-2304 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T19 | 234-239 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | males |
| T20 | 234-239 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | males |
| T21 | 498-503 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | males |
| T22 | 498-503 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | males |
| T23 | 749-750 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T24 | 780-784 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T25 | 780-784 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T26 | 856-858 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T27 | 1094-1102 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T28 | 1433-1434 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T29 | 1680-1683 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T30 | 2198-2199 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T35 | 622-634 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
| T36 | 700-722 | Phenotype | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/HP_0001626 |
| T37 | 727-747 | Phenotype | denotes | hypercholesterolemia | http://purl.obolibrary.org/obo/HP_0003124 |
| T38 | 780-792 | Phenotype | denotes | lung disease | http://purl.obolibrary.org/obo/HP_0002088 |
| T39 | 809-846 | Phenotype | denotes | chronic obstructive pulmonary disease | http://purl.obolibrary.org/obo/HP_0006510 |
| T40 | 1188-1200 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
| T41 | 1212-1234 | Phenotype | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/HP_0001626 |
| T42 | 1446-1452 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T43 | 1477-1483 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T44 | 1505-1527 | Phenotype | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/HP_0001626 |
| T45 | 1539-1547 | Phenotype | denotes | oncology | http://purl.obolibrary.org/obo/HP_0002664 |
| T46 | 1849-1855 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T47 | 1965-1971 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T48 | 2045-2067 | Phenotype | denotes | cardiovascular disease | http://purl.obolibrary.org/obo/HP_0001626 |
| T49 | 2298-2304 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T33 | 0-65 | Sentence | denotes | Epidemiology of COVID-19 and Risk Factors for Severity of Illness |
| T34 | 66-245 | Sentence | denotes | Epidemiological data from China confirmed the median age of the patients impacted by the disease to be 59 years, with disease distribution disproportionately impacting males [12]. |
| T35 | 246-380 | Sentence | denotes | The data further hypothesized that children might be less likely to become infected, or if infected, demonstrated far milder symptoms. |
| T36 | 381-538 | Sentence | denotes | Italy documented nearly 22,512 cases by March of 2020, with the largest proportion of cases and fatalities impacting males greater than 60 years of age [13]. |
| T37 | 539-663 | Sentence | denotes | In the Lombardy study, 68% of patients had at least one existing comorbidity, with hypertension being most frequently cited. |
| T38 | 664-748 | Sentence | denotes | Other predisposing factors included cardiovascular disease and hypercholesterolemia. |
| T39 | 749-847 | Sentence | denotes | A rare subset had pre-existing lung disease, manifesting as chronic obstructive pulmonary disease. |
| T40 | 848-941 | Sentence | denotes | Roughly 11% of the Lombardy patients were managed with non-invasive ventilatory support [14]. |
| T41 | 942-1154 | Sentence | denotes | The need for invasive ventilatory support varied across regions of the world, and some of the Wuhan cohort were directly transitioned to extracorporeal membrane oxygenation (ECMO) for resuscitation purposes [10]. |
| T42 | 1155-1379 | Sentence | denotes | Underlying risk factors, such as hypertension, diabetes, cardiovascular disease, and immunosuppression, have been explored as prognosticators regarding clinical outcomes of COVID-19 infections in hospitalized patients [15•]. |
| T43 | 1380-1567 | Sentence | denotes | However, the impact of the pandemic in patients with a history of cancer and pre-existing and/or cancer treatment–associated cardiovascular disease—the cardio-oncology patient—is unknown. |
| T44 | 1568-1800 | Sentence | denotes | Theoretically, this population is likely at higher risk of morbidity and mortality from COVID-19 infection, and has unique healthcare needs that put them at higher risk at exposure from community and healthcare-related transmission. |
| T45 | 1801-2003 | Sentence | denotes | Examples of these risks include needing ongoing cancer treatments in the outpatient and inpatient setting, as well as imaging-related procedures and operations for cancer-related staging and treatments. |
| T46 | 2004-2168 | Sentence | denotes | If these patients also have pre-existing cardiovascular disease and/or acquired cardiotoxicity during and after treatments, they also warrant additional evaluation. |
| T47 | 2169-2357 | Sentence | denotes | Finally, there appears to be a strong correlation with worse outcomes in hospitalized COVID-19 patients in cardiovascular and/or cancer-related comorbidities, which will be reviewed below. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32462289-31995857-24380935 | 241-243 | 31995857 | denotes | 12 |
| 32462289-31986264-24380936 | 1150-1152 | 31986264 | denotes | 10 |