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PMC:7253235 / 39796-43444 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T7 2145-2148 https://glytoucan.org/Structures/Glycans/G00063MO denotes CAD
T8 3550-3553 https://glytoucan.org/Structures/Glycans/G00063MO denotes CAD

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1371 2416-2420 Gene denotes HER2 Gene:2064
1372 2422-2426 Gene denotes BRAF Gene:673
1373 2427-2430 Gene denotes MEK Gene:5609
1374 423-430 Species denotes patient Tax:9606
1375 536-543 Species denotes patient Tax:9606
1376 818-828 Species denotes outpatient Tax:9606
1377 1371-1379 Species denotes patients Tax:9606
1378 1946-1954 Species denotes patients Tax:9606
1379 2343-2351 Species denotes patients Tax:9606
1380 2535-2543 Species denotes Patients Tax:9606
1381 2740-2748 Species denotes patients Tax:9606
1382 3102-3109 Species denotes patient Tax:9606
1383 3136-3144 Species denotes patients Tax:9606
1384 192-200 Disease denotes COVID-19 MESH:C000657245
1385 229-235 Disease denotes cancer MESH:D009369
1386 396-402 Disease denotes cancer MESH:D009369
1387 451-459 Disease denotes COVID-19 MESH:C000657245
1388 462-468 Disease denotes Cancer MESH:D009369
1389 684-692 Disease denotes COVID-19 MESH:C000657245
1390 797-803 Disease denotes cancer MESH:D009369
1391 941-947 Disease denotes cancer MESH:D009369
1392 1072-1080 Disease denotes COVID-19 MESH:C000657245
1393 1281-1286 Disease denotes tumor MESH:D009369
1394 1501-1515 Disease denotes Cardiotoxicity MESH:D066126
1395 1535-1541 Disease denotes cancer MESH:D009369
1396 1560-1574 Disease denotes cardiomyopathy MESH:D009202
1397 1576-1587 Disease denotes arrhythmias MESH:D001145
1398 1593-1601 Disease denotes ischemic MESH:D007511
1399 1629-1635 Disease denotes cancer MESH:D009369
1400 1689-1697 Disease denotes COVID-19 MESH:C000657245
1401 1711-1729 Disease denotes cardiac and cancer MESH:D006338
1402 1754-1763 Disease denotes mortality MESH:D003643
1403 2005-2008 Disease denotes CVD MESH:D002318
1404 2063-2075 Disease denotes dyslipidemia MESH:D050171
1405 2150-2161 Disease denotes arrhythmias MESH:D001145
1406 2166-2169 Disease denotes CHF
1407 2293-2319 Disease denotes arrhythmias Cardiotoxicity MESH:D066126
1408 2336-2342 Disease denotes cancer MESH:D009369
1409 2386-2392 Disease denotes cancer MESH:D009369
1410 2555-2569 Disease denotes cardiotoxicity MESH:D066126
1411 2621-2635 Disease denotes cardiotoxicity MESH:D066126
1412 2857-2871 Disease denotes cardiotoxicity MESH:D066126
1413 3050-3062 Disease denotes dyslipidemia MESH:D050171
1414 3253-3256 Disease denotes CHF
1415 3289-3295 Disease denotes cancer MESH:D009369
1418 63-70 Species denotes patient Tax:9606
1419 82-90 Disease denotes COVID-19 MESH:C000657245
1423 3522-3548 Disease denotes CVD cardiovascular disease MESH:D002318
1424 3550-3577 Disease denotes CAD coronary artery disease MESH:D003324
1425 3579-3607 Disease denotes CHF congestive heart failure MESH:D006333

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T116 370-384 Body_part denotes immune systems http://purl.org/sig/ont/fma/fma9825
T117 1236-1249 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T118 3164-3168 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T119 3172-3176 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T120 3214-3219 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T121 3229-3234 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T122 3393-3404 Body_part denotes bone marrow http://purl.org/sig/ont/fma/fma9608
T123 3554-3569 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T124 3594-3599 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T53 370-384 Body_part denotes immune systems http://purl.obolibrary.org/obo/UBERON_0002405
T54 1236-1249 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T55 3164-3168 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T56 3172-3176 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T57 3214-3219 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T58 3393-3404 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T59 3554-3569 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T60 3563-3569 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T61 3594-3599 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T398 82-90 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T399 192-200 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T400 229-235 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T401 396-402 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T402 451-459 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T403 462-468 Disease denotes Cancer http://purl.obolibrary.org/obo/MONDO_0004992
T404 684-692 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T405 797-803 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T406 941-947 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T407 1072-1080 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T408 1281-1286 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T409 1535-1541 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T410 1560-1574 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T411 1576-1587 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T412 1629-1635 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T413 1689-1697 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T414 1723-1729 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T415 2052-2055 Disease denotes HTN http://purl.obolibrary.org/obo/MONDO_0005044
T416 2063-2075 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T417 2145-2148 Disease denotes CAD http://purl.obolibrary.org/obo/MONDO_0005010|http://purl.obolibrary.org/obo/MONDO_0018922
T419 2150-2161 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T420 2166-2169 Disease denotes CHF http://purl.obolibrary.org/obo/MONDO_0005009
T421 2293-2304 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T422 2336-2342 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T423 2386-2392 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T424 3050-3062 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T425 3253-3256 Disease denotes CHF http://purl.obolibrary.org/obo/MONDO_0005009
T426 3289-3295 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T427 3526-3548 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T428 3550-3553 Disease denotes CAD http://purl.obolibrary.org/obo/MONDO_0005010|http://purl.obolibrary.org/obo/MONDO_0018922
T430 3554-3577 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010
T431 3563-3577 Disease denotes artery disease http://purl.obolibrary.org/obo/MONDO_0000473
T432 3579-3582 Disease denotes CHF http://purl.obolibrary.org/obo/MONDO_0005009
T433 3583-3607 Disease denotes congestive heart failure http://purl.obolibrary.org/obo/MONDO_0005009
T434 3594-3607 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T304 308-311 http://purl.obolibrary.org/obo/CLO_0002199 denotes CAR
T305 370-384 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune systems
T306 693-700 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T307 1060-1067 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T308 1236-1249 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T309 1786-1793 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T310 2910-2917 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T311 3164-3168 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T312 3172-3176 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T313 3214-3219 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T314 3214-3219 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T315 3393-3397 http://purl.obolibrary.org/obo/UBERON_0002481 denotes bone
T316 3422-3425 http://purl.obolibrary.org/obo/CLO_0002199 denotes CAR
T317 3563-3569 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T318 3563-3569 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T319 3594-3599 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T320 3594-3599 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T321 3594-3599 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T322 3594-3599 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T115 560-568 Chemical denotes carriers http://purl.obolibrary.org/obo/CHEBI_78059
T116 1837-1845 Chemical denotes carriers http://purl.obolibrary.org/obo/CHEBI_78059
T117 2427-2430 Chemical denotes MEK http://purl.obolibrary.org/obo/CHEBI_28398
T118 2643-2657 Chemical denotes anthracyclines http://purl.obolibrary.org/obo/CHEBI_48120|http://purl.obolibrary.org/obo/CHEBI_49322
T120 3229-3234 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T121 3437-3444 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T28 2241-2247 http://purl.obolibrary.org/obo/GO_0048511 denotes rhythm

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T215 54-62 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T216 107-115 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T217 229-235 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T218 396-402 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T219 462-468 Phenotype denotes Cancer http://purl.obolibrary.org/obo/HP_0002664
T220 797-803 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T221 941-947 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T222 1125-1133 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T223 1134-1142 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T224 1281-1286 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T225 1535-1541 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T226 1560-1574 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T227 1576-1587 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T228 1629-1635 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T229 1658-1666 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T230 1723-1729 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T231 2063-2075 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T232 2150-2161 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T233 2166-2169 Phenotype denotes CHF http://purl.obolibrary.org/obo/HP_0001635
T234 2293-2304 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T235 2336-2342 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T236 2386-2392 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T237 3050-3062 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T238 3253-3256 Phenotype denotes CHF http://purl.obolibrary.org/obo/HP_0001635
T239 3289-3295 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T240 3526-3548 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T241 3579-3582 Phenotype denotes CHF http://purl.obolibrary.org/obo/HP_0001635
T242 3583-3607 Phenotype denotes congestive heart failure http://purl.obolibrary.org/obo/HP_0001635

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T250 0-99 Sentence denotes Table 2 Proposed special considerations of the cardio-oncology patient during the COVID-19 pandemic
T251 100-209 Sentence denotes Cardio-oncology aspect of care Theoretical areas of concern Proposed Strategies to Mitigate COVID-19 Exposure
T252 210-459 Sentence denotes Initiating/ongoing cancer treatments (i.e., chemotherapy, targeted therapies, immunotherapy, BMT, CAR-T), and timing of oncologic-related surgery • Compromised immune systems induced by cancer treatments may make patient more susceptible to COVID-19
T253 460-580 Sentence denotes • Cancer treatments may require healthcare facility/inpatient stay exposing patient to asymptomatic carriers (i.e., HCW)
T254 581-672 Sentence denotes • Delaying of potential critical, life-prolonging surgery as it may be deemed as “elective”
T255 673-883 Sentence denotes • Ensuring COVID-19 testing adequacy by healthcare providers • Implementation of universal PPE and social distancing during cancer treatments in outpatient/inpatient settings, and with family members/caretakers
T256 884-1019 Sentence denotes • Weighing risk-benefit of postponing/delaying timing of cancer treatments/surgery to minimize exposure to inpatient healthcare setting
T257 1020-1080 Sentence denotes • Preoperative/procedural screening and testing for COVID-19
T258 1081-1179 Sentence denotes • Telemedicine for routine follow-up cardio-oncology/oncology visits unless clinically symptomatic
T259 1180-1294 Sentence denotes • Research efforts investigating earlier utilization of immune system restorative measures post anti-tumor therapy
T260 1295-1413 Sentence denotes • Consideration of delaying myeloablative therapies and immunotherapies for patients in clinical remission if possible
T261 1414-1500 Sentence denotes • Consideration of minimizing surveillance/staging imaging during and after treatments
T262 1501-1763 Sentence denotes Cardiotoxicity experienced during cancer treatments (i.e., cardiomyopathy, arrhythmias, and ischemic events) • Further delay of cancer treatments and cardio-oncology evaluation because of COVID-19 may increase cardiac and cancer-related comorbidity and mortality
T263 1764-1926 Sentence denotes • Cardiac imaging and testing may cause further exposure to asymptomatic carriers • Inpatient admission and evaluation as clinically indicated for severe symptoms
T264 1927-2076 Sentence denotes • Telemedicine for patients who are asymptomatic or minimally symptomatic, or CVD risk factor modification (i.e., visits for HTN and/or dyslipidemia)
T265 2077-2222 Sentence denotes • Preemptive aggressive treatment for suspected symptoms related to CAD, arrhythmias, or CHF and deferring of imaging unless clinically necessary
T266 2223-2304 Sentence denotes • Mail ambulatory rhythm monitors to home to evaluate suspected/known arrhythmias
T267 2305-2532 Sentence denotes Cardiotoxicity surveillance in cancer patients during and after treatment • Some cancer treatments (i.e., anti-HER2, BRAF-MEK treatments, clinical trials) require frequent surveillance of cardiac function (i.e., every 3 months)
T268 2533-2768 Sentence denotes • Patients with known cardiotoxicity, or with known treatments that can cause long-term cardiotoxicity (i.e., anthracyclines, radiation) may not get timely surveillance imaging • Minimize cardiac imaging to patients who are symptomatic
T269 2769-2930 Sentence denotes • Multidisciplinary discussion with hematologist/oncologist about reducing frequency of cardiotoxicity screening, especially if prior serial testing unremarkable
T270 2931-3004 Sentence denotes • Limited imaging protocols to evaluate LVEF to minimize acquisition time
T271 3005-3109 Sentence denotes • Defer primary prevention assessment (i.e., dyslipidemia management) unless critical to care of patient
T272 3110-3257 Sentence denotes • Telemedicine visits for patients who do not require face-to-face assessment for medical issues (i.e., blood pressure/lipid management/stable CHF)
T273 3258-3388 Sentence denotes • Defer asymptomatic long-term cancer survivor surveillance (i.e., assessment of ventricular and valvular function) if no symptoms
T274 3389-3648 Sentence denotes BMT bone marrow transplantation, CAR-T chimeric antigen receptor therapy, HCW healthcare workers, PPE personal protective equipment, CVD cardiovascular disease, CAD coronary artery disease, CHF congestive heart failure, LVEF left ventricular ejection fraction