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PMC:7253235 / 36166-38031 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1036-1043 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 1036-1043 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 1427-1434 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 1427-1434 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 1460-1467 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 1460-1467 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1284 423-436 Gene denotes Tissue factor Gene:2152
1285 438-440 Gene denotes TF Gene:2152
1286 680-682 Gene denotes TF Gene:2152
1287 0-8 Species denotes Patients Tax:9606
1288 652-660 Species denotes patients Tax:9606
1289 857-865 Species denotes patients Tax:9606
1290 1221-1229 Species denotes patients Tax:9606
1291 1376-1384 Species denotes Patients Tax:9606
1292 1729-1737 Species denotes patients Tax:9606
1293 1036-1043 Chemical denotes heparin MESH:D006493
1294 1427-1434 Chemical denotes heparin MESH:D006493
1295 1460-1467 Chemical denotes heparin MESH:D006493
1296 25-37 Disease denotes hypertension MESH:D006973
1297 39-47 Disease denotes diabetes MESH:D003920
1298 53-59 Disease denotes cancer MESH:D009369
1299 94-104 Disease denotes thrombotic MESH:D013927
1300 113-150 Disease denotes Coagulopathy in coronavirus infection MESH:D018352
1301 179-188 Disease denotes mortality MESH:D003643
1302 239-256 Disease denotes Lung inflammation MESH:D011014
1303 456-461 Disease denotes tumor MESH:D009369
1304 484-494 Disease denotes thrombosis MESH:D013927
1305 508-520 Disease denotes tumor growth MESH:D006130
1306 526-531 Disease denotes tumor MESH:D009369
1307 633-648 Disease denotes thromboembolism MESH:D013923
1308 666-672 Disease denotes cancer MESH:D009369
1309 698-703 Disease denotes tumor MESH:D009369
1310 884-890 Disease denotes cancer MESH:D009369
1311 909-924 Disease denotes COVID infection MESH:C000657245
1312 936-943 Disease denotes hypoxia MESH:D000860
1313 1005-1015 Disease denotes thrombotic MESH:D013927
1314 1258-1266 Disease denotes COVID-19 MESH:C000657245
1315 1267-1276 Disease denotes infection MESH:D007239
1316 1344-1356 Disease denotes hypertension MESH:D006973
1317 1361-1374 Disease denotes heart disease MESH:D006331
1318 1483-1492 Disease denotes mortality MESH:D003643
1319 1738-1746 Disease denotes infected MESH:D007239
1320 1752-1760 Disease denotes COVID-19 MESH:C000657245
1321 1843-1857 Disease denotes thromboembolic MESH:D013923

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T103 239-243 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T104 308-316 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T105 423-429 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T106 462-467 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T107 704-709 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T108 730-735 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T109 1036-1043 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T110 1361-1366 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T111 1427-1434 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T112 1460-1467 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T47 239-243 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T48 423-429 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T49 1361-1366 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T367 25-37 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T368 39-47 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T369 53-59 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T370 113-125 Disease denotes Coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T371 141-150 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T372 244-256 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T373 456-461 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T374 484-494 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T375 508-513 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T376 526-531 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T377 666-672 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T378 698-703 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T379 884-890 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T380 915-924 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T381 1258-1266 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T382 1267-1276 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T383 1344-1374 Disease denotes hypertension and heart disease http://purl.obolibrary.org/obo/MONDO_0001302
T384 1344-1356 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T385 1361-1374 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T386 1752-1760 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T283 233-236 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T284 239-243 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T285 239-243 http://www.ebi.ac.uk/efo/EFO_0000934 denotes Lung
T286 462-467 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T287 704-709 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T288 730-735 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T289 1175-1176 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T290 1361-1366 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T291 1361-1366 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T292 1361-1366 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T293 1361-1366 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T294 1475-1476 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T295 1780-1781 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T108 438-440 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T109 680-682 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T110 1036-1043 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T111 1427-1434 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T112 1460-1467 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T23 244-256 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T24 284-292 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T25 364-385 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T26 514-520 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T27 532-544 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T192 25-37 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T193 53-59 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T194 113-125 Phenotype denotes Coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T195 308-322 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T196 456-461 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T197 508-513 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T198 526-531 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T199 633-648 Phenotype denotes thromboembolism http://purl.obolibrary.org/obo/HP_0001907
T200 666-672 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T201 698-703 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T202 823-846 Phenotype denotes endothelial dysfunction http://purl.obolibrary.org/obo/HP_0032654
T203 884-890 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T204 936-943 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T205 1344-1356 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T206 1720-1728 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T207 1843-1864 Phenotype denotes thromboembolic events http://purl.obolibrary.org/obo/HP_0001907

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T230 0-112 Sentence denotes Patients with underlying hypertension, diabetes, and cancer are at higher risk for developing thrombotic events.
T231 113-238 Sentence denotes Coagulopathy in coronavirus infection is now associated with high mortality and manifests with high d-dimer elevations [102].
T232 239-422 Sentence denotes Lung inflammation and impaired pulmonary gas exchange contributes to cytokine storm, which leads to spike in d-dimer and pro-inflammatory response, with impaired endothelial function.
T233 423-679 Sentence denotes Tissue factor (TF), expressed by tumor cells, contributes to thrombosis, metastasis, tumor growth, and tumor angiogenesis, leading to release of pro-coagulant microparticles into the circulation and triggering thromboembolism in patients with cancer [103].
T234 680-853 Sentence denotes TF on circulating tumor cells leads to coating of cells with fibrin that traps them within microvasculature, thereby contributing to worsening endothelial dysfunction [104].
T235 854-1029 Sentence denotes In patients with pre-existing cancer diagnoses, shared COVID infection as well as hypoxia places them at even greater risk of developing and incurring thrombotic events [105].
T236 1030-1174 Sentence denotes Early heparin initiation is posited to delay the spike in inflammatory biomarkers and may reduce contributions to pro-coagulopathic state [106].
T237 1175-1375 Sentence denotes A retrospective study from China examined 449 patients classified as having severe COVID-19 infection, of which 272 had one or more chronic underlying diseases, such as hypertension and heart disease.
T238 1376-1531 Sentence denotes Patients were assigned to receive various forms of heparin, with those treated with heparin having a lower mortality rate (40% vs. 64.2%, p = 0.029) [107].
T239 1532-1865 Sentence denotes Data regarding initiation and choice of anticoagulation remains limited, and further randomized clinical trials are necessary to determine prophylactic and treatment strategies for cardio-oncology patients infected with COVID-19, as they represent a population with elevated theoretical risk for suffering from thromboembolic events.

2_test

Id Subject Object Predicate Lexical cue
32462289-32073213-24380995 233-236 32073213 denotes 102
32462289-15117736-24380996 674-677 15117736 denotes 103
32462289-19738116-24380997 848-851 19738116 denotes 104
32462289-31376606-24380998 1024-1027 31376606 denotes 105
32462289-26064103-24380999 1169-1172 26064103 denotes 106
32462289-32220112-24381000 1526-1529 32220112 denotes 107