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PMC:7253235 / 33554-34905 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1176 96-100 Gene denotes CCR5 Gene:1234
1177 163-167 Gene denotes CCR5 Gene:1234
1178 662-666 Gene denotes CCR5 Gene:1234
1179 725-729 Gene denotes CCR5 Gene:1234
1180 1062-1066 Gene denotes IL-6 Gene:3569
1181 1083-1086 Gene denotes CD4 Gene:920
1182 1087-1090 Gene denotes CD8 Gene:925
1183 955-963 Species denotes patients Tax:9606
1184 1248-1256 Species denotes patients Tax:9606
1185 1313-1321 Species denotes patients Tax:9606
1186 116-131 Gene denotes tyrosine kinase Gene:7294
1187 522-531 Chemical denotes maraviroc MESH:D000077592
1188 536-546 Chemical denotes vicriviroc MESH:C486781
1189 587-597 Chemical denotes leronlimab MESH:C420063
1190 20-26 Disease denotes cancer MESH:D009369
1191 78-86 Disease denotes COVID-19 MESH:C000657245
1192 614-630 Disease denotes multiple cancers MESH:D009369
1193 694-700 Disease denotes cancer MESH:D009369
1194 782-811 Disease denotes colorectal and breast cancers MESH:D001943
1195 946-954 Disease denotes COVID-19 MESH:C000657245
1196 1124-1132 Disease denotes COVID-19 MESH:C000657245
1197 1133-1140 Disease denotes viremia MESH:D014766
1198 1266-1280 Disease denotes critically ill MESH:D016638
1199 1334-1340 Disease denotes cancer MESH:D009369

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T83 116-124 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T84 182-191 Body_part denotes G protein http://purl.org/sig/ont/fma/fma61788
T85 234-245 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T86 249-254 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T87 256-267 Body_part denotes eosinophils http://purl.org/sig/ont/fma/fma62861
T88 269-284 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T89 279-284 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T90 290-299 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T91 321-330 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T92 405-408 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T93 563-571 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T94 797-803 Body_part denotes breast http://purl.org/sig/ont/fma/fma9601
T95 833-846 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T44 797-803 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T45 833-846 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T346 20-26 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T347 78-86 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T348 797-811 Disease denotes breast cancers http://purl.obolibrary.org/obo/MONDO_0007254
T349 946-954 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T350 1124-1132 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T351 1334-1340 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T260 180-181 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T261 182-208 http://purl.obolibrary.org/obo/PR_000030035 denotes G protein–coupled receptor
T262 247-254 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T263 269-284 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T264 290-299 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T265 340-349 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T266 351-353 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T267 370-373 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T268 673-676 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T269 692-693 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 797-803 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T271 817-819 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T272 833-846 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T273 1083-1086 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T274 1087-1090 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T95 116-142 Chemical denotes tyrosine kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_38637
T96 116-124 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T97 132-142 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T98 184-191 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T99 409-418 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T100 497-505 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T101 522-531 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T102 1062-1064 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T16 62-74 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T17 125-142 http://purl.obolibrary.org/obo/GO_0033673 denotes kinase inhibitors
T18 340-349 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T182 20-26 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T183 797-811 Phenotype denotes breast cancers http://purl.obolibrary.org/obo/HP_0003002
T184 1133-1140 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T185 1334-1340 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T213 0-158 Sentence denotes There are potential cancer treatments that may counteract the pathogenesis of COVID-19, such as CCR5 treatments and tyrosine kinase inhibitors (TKIs) [91–93].
T214 159-355 Sentence denotes The CCR5 receptor is a G protein–coupled receptor selectively expressed on macrophages, T cells, eosinophils, dendritic cells, and microglia and is implicated in chemokine-mediated signaling [94].
T215 356-603 Sentence denotes This receptor has historically been targeted for HIV antiviral therapy, in the setting of disrupting viral entry, specifically through small molecule inhibition with maraviroc and vicriviroc, and monoclonal antibody treatment with leronlimab [95].
T216 604-724 Sentence denotes Moreover, multiple cancers have been shown to overexpress CCR5 which has been linked to a cancer’s metastatic potential.
T217 725-821 Sentence denotes CCR5 therapies are currently being studied in metastatic colorectal and breast cancers [91, 94].
T218 822-973 Sentence denotes Due to its immune system restorative properties, leronlimab is being investigated for compassionate use in the treatment of COVID-19 patients [96, 97].
T219 974-1146 Sentence denotes Studies examining receptor blockade in leronlimab preliminarily have shown decreases in IL-6, restoration of CD4/CD8 ratios, and reduction in overall COVID-19 viremia [98].
T220 1147-1351 Sentence denotes These collective findings suggest possible therapeutic role in establishing immune reconstitution in patients that are critically ill and may provide dual benefit in patients with shared cancer diagnoses.

2_test

Id Subject Object Predicate Lexical cue
32462289-31292161-24380986 151-153 31292161 denotes 91
32462289-32032529-24380986 151-153 32032529 denotes 91
32462289-32113509-24380986 151-153 32113509 denotes 91
32462289-22637726-24380987 351-353 22637726 denotes 94
32462289-16905787-24380988 599-601 16905787 denotes 95
32462289-31292161-24380989 813-815 31292161 denotes 91
32462289-22637726-24380990 817-819 22637726 denotes 94