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PMC:7253235 / 11404-14946 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
364 0-17 Disease denotes Myocardial Injury MESH:D009202
365 22-30 Disease denotes COVID-19 MESH:C000657245
399 676-686 Gene denotes troponin T Gene:7138
400 688-691 Gene denotes TnT Gene:7138
401 763-766 Gene denotes TnT Gene:7138
402 955-958 Gene denotes TnT Gene:7138
403 107-115 Species denotes patients Tax:9606
404 587-595 Species denotes patients Tax:9606
405 653-661 Species denotes patients Tax:9606
406 803-811 Species denotes Patients Tax:9606
407 1057-1065 Species denotes patients Tax:9606
408 1268-1276 Species denotes patients Tax:9606
409 1282-1290 Species denotes SARS-CoV Tax:694009
410 1353-1361 Species denotes patients Tax:9606
411 1001-1006 Chemical denotes Lipid MESH:D008055
412 1120-1131 Chemical denotes fatty acids MESH:D005227
413 1133-1156 Chemical denotes lysophosphatidylcholine MESH:D008244
414 1162-1182 Chemical denotes phosphatidylglycerol MESH:D010715
415 57-60 Disease denotes CVD MESH:D002318
416 97-105 Disease denotes COVID-19 MESH:C000657245
417 135-152 Disease denotes myocardial injury MESH:D009202
418 205-231 Disease denotes cardiovascular dysfunction MESH:D002318
419 247-264 Disease denotes myocardial injury MESH:D009202
420 410-423 Disease denotes heart failure MESH:D006333
421 429-440 Disease denotes myocarditis MESH:D009205
422 547-556 Disease denotes mortality MESH:D003643
423 727-736 Disease denotes mortality MESH:D003643
424 828-831 Disease denotes CVD MESH:D002318
425 864-876 Disease denotes hypertension MESH:D006973
426 878-900 Disease denotes coronary heart disease MESH:D003324
427 906-920 Disease denotes cardiomyopathy MESH:D009202
428 1071-1089 Disease denotes SARS-CoV infection MESH:C000657245
429 1228-1264 Disease denotes cardiovascular damage post infection MESH:D002318
430 1326-1341 Disease denotes atherosclerotic MESH:D050197
431 1378-1386 Disease denotes COVID-19 MESH:C000657245
448 1502-1510 Species denotes patients Tax:9606
449 1559-1567 Species denotes patients Tax:9606
450 1734-1742 Species denotes patients Tax:9606
451 1478-1492 Disease denotes critically ill MESH:D016638
452 1493-1501 Disease denotes COVID-19 MESH:C000657245
453 1582-1596 Disease denotes cardiomyopathy MESH:D009202
454 1602-1619 Disease denotes cardiogenic shock MESH:D012770
455 1644-1664 Disease denotes systolic dysfunction MESH:D006331
456 1758-1772 Disease denotes cardiomyopathy MESH:D009202
457 1783-1794 Disease denotes myocarditis MESH:D009205
458 1813-1816 Disease denotes CVD MESH:D002318
459 1873-1881 Disease denotes COVID-19 MESH:C000657245
460 1915-1926 Disease denotes myocarditis MESH:D009205
461 2000-2008 Disease denotes COVID-19 MESH:C000657245
462 2042-2059 Disease denotes myocardial injury MESH:D009202
463 2073-2082 Disease denotes mortality MESH:D003643
485 2335-2338 Gene denotes BNP Gene:4879
486 2583-2587 Gene denotes HER2 Gene:2064
487 2537-2545 Species denotes patients Tax:9606
488 2611-2619 Species denotes patients Tax:9606
489 2669-2677 Species denotes patients Tax:9606
490 3357-3364 Species denotes patient Tax:9606
491 2717-2732 Gene denotes tyrosine kinase Gene:7294
492 2556-2570 Chemical denotes anthracyclines MESH:D018943
493 2775-2784 Chemical denotes ponatinib MESH:C545373
494 2789-2804 Chemical denotes fluoropyridines
495 2812-2826 Chemical denotes 5-fluorouracil MESH:D005472
496 3211-3222 Chemical denotes carfilzomib MESH:C524865
497 2371-2385 Disease denotes cardiotoxicity MESH:D066126
498 2391-2397 Disease denotes cancer MESH:D009369
499 2519-2533 Disease denotes cardiotoxicity MESH:D066126
500 2839-2853 Disease denotes cardiotoxicity MESH:D066126
501 2869-2896 Disease denotes coronary ischemia/vasospasm MESH:D003329
502 3160-3173 Disease denotes heart failure MESH:D006333
503 3228-3239 Disease denotes myocarditis MESH:D009205
504 3350-3356 Disease denotes cancer MESH:D009369
505 3385-3393 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T12 313-321 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T13 410-415 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T14 489-497 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T15 676-686 Body_part denotes troponin T http://purl.org/sig/ont/fma/fma67900
T16 676-684 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T17 887-892 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T18 1001-1006 Body_part denotes Lipid http://purl.org/sig/ont/fma/fma67264
T19 1091-1096 Body_part denotes Serum http://purl.org/sig/ont/fma/fma63083
T20 1120-1131 Body_part denotes fatty acids http://purl.org/sig/ont/fma/fma82738
T21 2119-2127 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T22 2322-2330 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T23 2717-2725 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T24 3095-3103 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T25 3160-3165 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T15 410-415 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T16 887-892 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T17 1091-1096 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T18 3160-3165 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T123 11-17 Disease denotes Injury http://purl.obolibrary.org/obo/MONDO_0021178
T124 22-30 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T125 97-105 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T126 146-152 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T127 258-264 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T128 410-423 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T129 429-440 Disease denotes myocarditis http://purl.obolibrary.org/obo/MONDO_0004496
T130 864-876 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T131 878-900 Disease denotes coronary heart disease http://purl.obolibrary.org/obo/MONDO_0005010
T132 887-900 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T133 906-920 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T134 1071-1089 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T135 1080-1089 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T136 1255-1264 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T137 1282-1290 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T138 1378-1386 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T139 1493-1501 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T140 1582-1596 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T141 1758-1772 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T142 1783-1794 Disease denotes myocarditis http://purl.obolibrary.org/obo/MONDO_0004496
T143 1873-1881 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T144 1915-1926 Disease denotes myocarditis http://purl.obolibrary.org/obo/MONDO_0004496
T145 2000-2008 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T146 2053-2059 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T147 2391-2397 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T148 2878-2886 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053
T149 3160-3173 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T150 3228-3239 Disease denotes myocarditis http://purl.obolibrary.org/obo/MONDO_0004496
T151 3350-3356 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T152 3385-3393 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T71 67-68 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 410-415 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T73 410-415 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T74 410-415 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T75 410-415 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T76 566-567 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T77 704-705 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 887-892 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T79 887-892 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T80 887-892 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T81 887-892 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T82 1458-1459 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T83 1882-1885 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T84 2650-2652 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T85 2963-2965 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T86 3152-3155 http://purl.obolibrary.org/obo/CLO_0002199 denotes CAR
T87 3160-3165 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T88 3160-3165 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T89 3160-3165 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T90 3160-3165 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T91 3285-3287 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T92 3348-3349 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 3451-3452 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T5 1001-1006 Chemical denotes Lipid http://purl.obolibrary.org/obo/CHEBI_18059
T6 1120-1131 Chemical denotes fatty acids http://purl.obolibrary.org/obo/CHEBI_35366
T7 1126-1131 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T8 1133-1156 Chemical denotes lysophosphatidylcholine http://purl.obolibrary.org/obo/CHEBI_60479
T9 1162-1182 Chemical denotes phosphatidylglycerol http://purl.obolibrary.org/obo/CHEBI_17517|http://purl.obolibrary.org/obo/CHEBI_64961
T11 2335-2338 Chemical denotes BNP http://purl.obolibrary.org/obo/CHEBI_80234
T12 2556-2570 Chemical denotes anthracyclines http://purl.obolibrary.org/obo/CHEBI_48120|http://purl.obolibrary.org/obo/CHEBI_49322
T14 2717-2743 Chemical denotes tyrosine kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_38637
T15 2717-2725 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T16 2733-2743 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T17 2775-2784 Chemical denotes ponatinib http://purl.obolibrary.org/obo/CHEBI_78543
T18 2812-2826 Chemical denotes 5-fluorouracil http://purl.obolibrary.org/obo/CHEBI_46345
T19 3135-3142 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T20 3179-3199 Chemical denotes proteasome inhibitor http://purl.obolibrary.org/obo/CHEBI_52726
T21 3190-3199 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T22 3211-3222 Chemical denotes carfilzomib http://purl.obolibrary.org/obo/CHEBI_65347
T23 3263-3272 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T4 1001-1017 http://purl.obolibrary.org/obo/GO_0006629 denotes Lipid metabolism
T5 1007-1017 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T6 2726-2743 http://purl.obolibrary.org/obo/GO_0033673 denotes kinase inhibitors

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T74 410-423 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T75 429-440 Phenotype denotes myocarditis http://purl.obolibrary.org/obo/HP_0012819
T76 864-876 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T77 906-920 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T78 1582-1596 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T79 1602-1619 Phenotype denotes cardiogenic shock http://purl.obolibrary.org/obo/HP_0030149
T80 1758-1772 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T81 1783-1794 Phenotype denotes myocarditis http://purl.obolibrary.org/obo/HP_0012819
T82 1915-1926 Phenotype denotes myocarditis http://purl.obolibrary.org/obo/HP_0012819
T83 2163-2171 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T84 2391-2397 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T85 2887-2896 Phenotype denotes vasospasm http://purl.obolibrary.org/obo/HP_0025637
T86 3095-3120 Phenotype denotes cytokine release syndrome http://purl.obolibrary.org/obo/HP_0033041
T87 3160-3173 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T88 3228-3239 Phenotype denotes myocarditis http://purl.obolibrary.org/obo/HP_0012819
T89 3350-3356 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T71 0-30 Sentence denotes Myocardial Injury and COVID-19
T72 31-240 Sentence denotes In addition to underlying CVD being a risk factor for contracting COVID-19, patients that develop acute myocardial injury have worse outcomes, even in those without baseline cardiovascular dysfunction [25–28].
T73 241-441 Sentence denotes Acute myocardial injury can be categorized in three varieties: elevated troponin levels above the 99th percentile upper reference limit, development of new or worsening heart failure, and myocarditis.
T74 442-565 Sentence denotes Several studies from China found that elevated troponin levels were significantly associated with higher mortality [26–28].
T75 566-802 Sentence denotes A case series of 187 patients at the Seventh Hospital of Wuhan City, China, found that patients with elevated troponin T (TnT) levels had a significantly higher mortality rate to those with normal TnT levels (59.6% vs. 8.9%; p < 0.001).
T76 803-1000 Sentence denotes Patients with underlying CVD including those with underlying hypertension, coronary heart disease, and cardiomyopathy were more likely to have elevated TnT levels during their hospital course [26].
T77 1001-1090 Sentence denotes Lipid metabolism is also observed to be dysregulated in patients with SARS-CoV infection.
T78 1091-1296 Sentence denotes Serum concentrations of free fatty acids, lysophosphatidylcholine, and phosphatidylglycerol remained elevated and contributed to chronic cardiovascular damage post infection in patients with SARS-CoV [29].
T79 1297-1457 Sentence denotes Long-term cardiovascular and atherosclerotic changes in patients who suffer from COVID-19 have not been documented yet given the recent nature of this pandemic.
T80 1458-1710 Sentence denotes A case series of 21 critically ill COVID-19 patients from Seattle also found that one-third of their patients developed new cardiomyopathy with cardiogenic shock in the absence of prior systolic dysfunction during the progression of their illness [25].
T81 1711-1863 Sentence denotes It is unclear if these patients that developed cardiomyopathy truly had myocarditis or had underlying CVD that predisposed them to this clinical course.
T82 1864-1993 Sentence denotes However, COVID-19 has been shown to directly cause myocarditis in otherwise healthy individuals in several case reports [30, 31].
T83 1994-2135 Sentence denotes Thus, COVID-19 demonstrates various patterns of myocardial injury, with higher mortality risk being associated with elevated troponin levels.
T84 2136-2298 Sentence denotes In addition, in the cardio-oncology population, elevated cardiac biomarkers can pose an additional layer of complexity and challenge when dealing with management.
T85 2299-2448 Sentence denotes Abnormal elevations of troponin and BNP biomarkers can be indicative of cardiotoxicity from cancer physiology or from the treatments themselves [32].
T86 2449-2654 Sentence denotes Some elevations may be non-specific and are reflective of subclinical cardiotoxicity in patients receiving anthracyclines and/or anti-HER2 agents in which stable patients can be medically managed [33, 34].
T87 2655-2970 Sentence denotes However, some patients receiving other agents such as certain tyrosine kinase inhibitors with prothrombotic risk (i.e., ponatinib) or fluoropyridines (i.e., 5-fluorouracil) may suffer cardiotoxicity in the form of coronary ischemia/vasospasm, which may warrant more invasive diagnostic/treatment strategies [35–37].
T88 2971-3289 Sentence denotes Elevated cardiac biomarkers have also been associated with worse outcomes and or cardiac hemodynamic instability, including cytokine release syndrome from chimeric antigen therapy (CAR-T), heart failure from proteasome inhibitor use (i.e., carfilzomib), or myocarditis from immune checkpoint inhibitor therapy [38–41].
T89 3290-3542 Sentence denotes Some of these disease processes may confound treatment of a cancer patient also afflicted with COVID-19, and thus, multidisciplinary assessment, particularly by a cardio-oncologist, may be essential to provide optimal care in this high-risk population.

2_test

Id Subject Object Predicate Lexical cue
32462289-28831119-24380939 1292-1294 28831119 denotes 29
32462289-28421484-24380940 2444-2446 28421484 denotes 32
32462289-31959034-24380941 2650-2652 31959034 denotes 34
32462289-27022039-24380942 2963-2965 27022039 denotes 35
32462289-29977352-24380942 2963-2965 29977352 denotes 35
32462289-31875699-24380942 2963-2965 31875699 denotes 35
32462289-29567210-24380943 3282-3284 29567210 denotes 38
32462289-29285538-24380943 3282-3284 29285538 denotes 38
32462289-29536852-24380943 3282-3284 29536852 denotes 38