PMC:7253233 / 8343-10596
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 293 | 842-860 | Gene | denotes | C-reactive protein | Gene:1401 |
| 294 | 28-35 | Species | denotes | patient | Tax:9606 |
| 295 | 481-488 | Species | denotes | patient | Tax:9606 |
| 296 | 1800-1808 | Species | denotes | patients | Tax:9606 |
| 297 | 1937-1944 | Species | denotes | Patient | Tax:9606 |
| 298 | 775-779 | Chemical | denotes | urea | MESH:D014508 |
| 299 | 780-788 | Chemical | denotes | nitrogen | MESH:D009584 |
| 300 | 805-815 | Chemical | denotes | creatinine | MESH:D003404 |
| 301 | 1468-1481 | Chemical | denotes | levetiracetam | MESH:D000077287 |
| 302 | 41-78 | Disease | denotes | chronic obstructive pulmonary disease | MESH:D029424 |
| 303 | 80-109 | Disease | denotes | venous thromboembolic disease | MESH:D054556 |
| 304 | 120-131 | Disease | denotes | heart block | MESH:D006327 |
| 305 | 137-159 | Disease | denotes | chronic kidney disease | MESH:D051436 |
| 306 | 235-242 | Disease | denotes | dyspnea | MESH:D004417 |
| 307 | 312-319 | Disease | denotes | hypoxic | MESH:D000860 |
| 308 | 384-403 | Disease | denotes | respiratory failure | MESH:D012131 |
| 309 | 464-475 | Disease | denotes | pneumonitis | MESH:D011014 |
| 310 | 531-542 | Disease | denotes | lymphopenia | MESH:D008231 |
| 311 | 592-604 | Disease | denotes | coagulopathy | MESH:D001778 |
| 312 | 719-735 | Disease | denotes | thrombocytopenia | MESH:D013921 |
| 313 | 748-767 | Disease | denotes | acute kidney injury | MESH:D058186 |
| 314 | 972-980 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 315 | 1216-1224 | Disease | denotes | seizures | MESH:D012640 |
| 316 | 1354-1372 | Disease | denotes | status epilepticus | MESH:D013226 |
| 317 | 1390-1398 | Disease | denotes | seizures | MESH:D012640 |
| 318 | 1408-1418 | Disease | denotes | convulsive | MESH:D012640 |
| 319 | 1420-1427 | Disease | denotes | Seizure | MESH:D012640 |
| 320 | 1826-1839 | Disease | denotes | kidney injury | MESH:D058186 |
| 321 | 1903-1915 | Disease | denotes | coagulopathy | MESH:D001778 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T42 | 120-125 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T43 | 145-151 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T44 | 252-258 | Body_part | denotes | mental | http://purl.org/sig/ont/fma/fma264279 |
| T45 | 411-416 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
| T46 | 431-435 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T47 | 568-578 | Body_part | denotes | lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
| T48 | 754-760 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T49 | 769-774 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T50 | 853-860 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T51 | 1143-1149 | Body_part | denotes | eyelid | http://purl.org/sig/ont/fma/fma54437 |
| T52 | 1501-1506 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T53 | 1560-1572 | Body_part | denotes | white matter | http://purl.org/sig/ont/fma/fma83929 |
| T54 | 1685-1690 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T55 | 1724-1741 | Body_part | denotes | cardiac pacemaker | http://purl.org/sig/ont/fma/fma9477 |
| T56 | 1826-1832 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T32 | 120-125 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T33 | 145-151 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T34 | 411-416 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
| T35 | 431-435 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T36 | 754-760 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T37 | 769-774 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T38 | 1143-1149 | Body_part | denotes | eyelid | http://purl.obolibrary.org/obo/UBERON_0001711 |
| T39 | 1501-1506 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T40 | 1560-1572 | Body_part | denotes | white matter | http://purl.obolibrary.org/obo/UBERON_0002316 |
| T41 | 1685-1690 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T42 | 1751-1757 | Body_part | denotes | vessel | http://purl.obolibrary.org/obo/UBERON_0000055 |
| T43 | 1826-1832 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T69 | 41-78 | Disease | denotes | chronic obstructive pulmonary disease | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T70 | 61-78 | Disease | denotes | pulmonary disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T71 | 80-101 | Disease | denotes | venous thromboembolic | http://purl.obolibrary.org/obo/MONDO_0005399 |
| T72 | 111-131 | Disease | denotes | complete heart block | http://purl.obolibrary.org/obo/MONDO_0000468 |
| T73 | 137-159 | Disease | denotes | chronic kidney disease | http://purl.obolibrary.org/obo/MONDO_0005300 |
| T74 | 145-159 | Disease | denotes | kidney disease | http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240 |
| T76 | 384-403 | Disease | denotes | respiratory failure | http://purl.obolibrary.org/obo/MONDO_0021113 |
| T77 | 464-475 | Disease | denotes | pneumonitis | http://purl.obolibrary.org/obo/MONDO_0043905 |
| T78 | 531-542 | Disease | denotes | lymphopenia | http://purl.obolibrary.org/obo/MONDO_0003783 |
| T79 | 592-604 | Disease | denotes | coagulopathy | http://purl.obolibrary.org/obo/MONDO_0001531 |
| T80 | 719-735 | Disease | denotes | thrombocytopenia | http://purl.obolibrary.org/obo/MONDO_0002049 |
| T81 | 748-767 | Disease | denotes | acute kidney injury | http://purl.obolibrary.org/obo/MONDO_0002492 |
| T82 | 761-767 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T83 | 972-980 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T84 | 1354-1372 | Disease | denotes | status epilepticus | http://purl.obolibrary.org/obo/MONDO_0002125 |
| T85 | 1833-1839 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T86 | 1903-1915 | Disease | denotes | coagulopathy | http://purl.obolibrary.org/obo/MONDO_0001531 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T89 | 23-27 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | male |
| T90 | 23-27 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | male |
| T91 | 120-125 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T92 | 120-125 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T93 | 120-125 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T94 | 120-125 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T95 | 145-151 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T96 | 145-151 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T97 | 145-151 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T98 | 203-207 | http://purl.obolibrary.org/obo/CLO_0001550 | denotes | a 10 |
| T99 | 409-410 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T100 | 411-416 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
| T101 | 431-435 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T102 | 431-435 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T103 | 737-740 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 132 |
| T104 | 754-760 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T105 | 754-760 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T106 | 754-760 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T107 | 769-774 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T108 | 769-774 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T109 | 909-910 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T110 | 963-967 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
| T111 | 1483-1484 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T112 | 1501-1506 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T113 | 1501-1506 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T114 | 1685-1690 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T115 | 1685-1690 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T116 | 1751-1757 | http://purl.obolibrary.org/obo/UBERON_0000055 | denotes | vessel |
| T117 | 1826-1832 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T118 | 1826-1832 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T119 | 1826-1832 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T120 | 1841-1842 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T121 | 2152-2153 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T122 | 2191-2202 | http://purl.obolibrary.org/obo/UBERON_0001353 | denotes | posteriorly |
| T123 | 2204-2205 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T17 | 23-27 | Chemical | denotes | male | http://purl.obolibrary.org/obo/CHEBI_30780 |
| T18 | 677-680 | Chemical | denotes | PTT | http://purl.obolibrary.org/obo/CHEBI_3088 |
| T19 | 775-779 | Chemical | denotes | urea | http://purl.obolibrary.org/obo/CHEBI_16199 |
| T20 | 780-788 | Chemical | denotes | nitrogen | http://purl.obolibrary.org/obo/CHEBI_25555 |
| T21 | 805-815 | Chemical | denotes | creatinine | http://purl.obolibrary.org/obo/CHEBI_16737 |
| T22 | 853-860 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T23 | 1071-1074 | Chemical | denotes | EEG | http://purl.obolibrary.org/obo/CHEBI_73494 |
| T24 | 1212-1215 | Chemical | denotes | EEG | http://purl.obolibrary.org/obo/CHEBI_73494 |
| T25 | 1468-1481 | Chemical | denotes | levetiracetam | http://purl.obolibrary.org/obo/CHEBI_6437 |
| T26 | 1926-1929 | Chemical | denotes | PTT | http://purl.obolibrary.org/obo/CHEBI_3088 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T49 | 41-78 | Phenotype | denotes | chronic obstructive pulmonary disease | http://purl.obolibrary.org/obo/HP_0006510 |
| T50 | 87-109 | Phenotype | denotes | thromboembolic disease | http://purl.obolibrary.org/obo/HP_0001907 |
| T51 | 111-131 | Phenotype | denotes | complete heart block | http://purl.obolibrary.org/obo/HP_0001709 |
| T52 | 137-159 | Phenotype | denotes | chronic kidney disease | http://purl.obolibrary.org/obo/HP_0012622 |
| T53 | 235-242 | Phenotype | denotes | dyspnea | http://purl.obolibrary.org/obo/HP_0002094 |
| T54 | 271-291 | Phenotype | denotes | generalized weakness | http://purl.obolibrary.org/obo/HP_0003324 |
| T55 | 384-403 | Phenotype | denotes | respiratory failure | http://purl.obolibrary.org/obo/HP_0002878 |
| T56 | 431-447 | Phenotype | denotes | lung infiltrates | http://purl.obolibrary.org/obo/HP_0002113 |
| T57 | 531-542 | Phenotype | denotes | lymphopenia | http://purl.obolibrary.org/obo/HP_0001888 |
| T58 | 592-604 | Phenotype | denotes | coagulopathy | http://purl.obolibrary.org/obo/HP_0003256 |
| T59 | 689-705 | Phenotype | denotes | elevated D-dimer | http://purl.obolibrary.org/obo/HP_0033106 |
| T60 | 719-735 | Phenotype | denotes | thrombocytopenia | http://purl.obolibrary.org/obo/HP_0001873 |
| T61 | 748-767 | Phenotype | denotes | acute kidney injury | http://purl.obolibrary.org/obo/HP_0001919 |
| T62 | 1161-1170 | Phenotype | denotes | twitching | http://purl.obolibrary.org/obo/HP_0010546 |
| T63 | 1216-1224 | Phenotype | denotes | seizures | http://purl.obolibrary.org/obo/HP_0001250 |
| T64 | 1354-1372 | Phenotype | denotes | status epilepticus | http://purl.obolibrary.org/obo/HP_0002133 |
| T65 | 1390-1398 | Phenotype | denotes | seizures | http://purl.obolibrary.org/obo/HP_0001250 |
| T66 | 1420-1427 | Phenotype | denotes | Seizure | http://purl.obolibrary.org/obo/HP_0001250 |
| T67 | 1903-1915 | Phenotype | denotes | coagulopathy | http://purl.obolibrary.org/obo/HP_0003256 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T65 | 0-7 | Sentence | denotes | Case #2 |
| T66 | 8-292 | Sentence | denotes | An 82-year-old male patient with chronic obstructive pulmonary disease, venous thromboembolic disease, complete heart block, and chronic kidney disease presented to the emergency department with a 10-day history of progressive dyspnea, altered mental status, and generalized weakness. |
| T67 | 293-346 | Sentence | denotes | He was found to be hypoxic, febrile, and tachycardic. |
| T68 | 347-476 | Sentence | denotes | He was intubated for acute hypoxemic respiratory failure with a chest X-ray showing lung infiltrates consistent with pneumonitis. |
| T69 | 477-908 | Sentence | denotes | The patient’s laboratory results were significant for lymphopenia (WBC 3.26 k/μl, absolute lymphocyte count 0.70), coagulopathy (international normalised ratio (INR) 2.5, partial thromboplastin time (PTT) 53.9), elevated D-dimer (590 ng/mL), thrombocytopenia (132 k/μl), acute kidney injury (blood urea nitrogen (BUN) 47 mg/dL, creatinine 3.96 mg/dL), and elevated C-reactive protein initially 12.5 mg/L and increased to 26.2 mg/L. |
| T70 | 909-1031 | Sentence | denotes | A nasopharyngeal swab polymerase chain reaction (PCR) test for COVID-19 was sent on admission and was positive 24 h later. |
| T71 | 1032-1202 | Sentence | denotes | Continuous video electroencephalogram (EEG) monitoring was ordered on day 5 of admission after events of right eyelid and facial twitching were observed by the care team. |
| T72 | 1203-1373 | Sentence | denotes | Frequent EEG seizures were captured independently from the left more than right frontal–temporal regions (Fig. 3) which eventually progressed to focal status epilepticus. |
| T73 | 1374-1419 | Sentence | denotes | The majority of seizures were non-convulsive. |
| T74 | 1420-1482 | Sentence | denotes | Seizure frequency improved after treatment with levetiracetam. |
| T75 | 1483-1655 | Sentence | denotes | A non-contrast CT-brain demonstrated hypodensities within the supratentorial white matter, consistent with mild microvascular disease but without acute intracranial lesion. |
| T76 | 1656-1742 | Sentence | denotes | He was unable to have an MRI brain performed due to an incompatible cardiac pacemaker. |
| T77 | 1743-1840 | Sentence | denotes | Further vessel imaging was unable to be performed due to patients acute on chronic kidney injury. |
| T78 | 1841-1936 | Sentence | denotes | A lumbar puncture was unable to be performed due to worsening coagulopathy (INR 3.8, PTT 73.5). |
| T79 | 1937-2063 | Sentence | denotes | Patient remained on the ventilator, and after 20 days of ICU stay, the family opted for withdrawal of life-sustaining support. |
| T80 | 2064-2094 | Sentence | denotes | Fig. 3 Electroencephalography. |
| T81 | 2095-2253 | Sentence | denotes | Rhythmic discharges evolving in the left frontotemporal (a) region and spreading anteriorly and posteriorly (b) corresponding to right facial clonic movements |