PMC:7253233 / 14622-15257 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"476","span":{"begin":137,"end":145},"obj":"Species"},{"id":"477","span":{"begin":527,"end":537},"obj":"Species"},{"id":"478","span":{"begin":119,"end":127},"obj":"Disease"},{"id":"479","span":{"begin":158,"end":167},"obj":"Disease"},{"id":"480","span":{"begin":209,"end":217},"obj":"Disease"},{"id":"481","span":{"begin":228,"end":242},"obj":"Disease"},{"id":"482","span":{"begin":339,"end":347},"obj":"Disease"},{"id":"483","span":{"begin":361,"end":390},"obj":"Disease"},{"id":"484","span":{"begin":409,"end":417},"obj":"Disease"},{"id":"485","span":{"begin":434,"end":454},"obj":"Disease"}],"attributes":[{"id":"A476","pred":"tao:has_database_id","subj":"476","obj":"Tax:9606"},{"id":"A477","pred":"tao:has_database_id","subj":"477","obj":"Tax:2697049"},{"id":"A478","pred":"tao:has_database_id","subj":"478","obj":"MESH:C000657245"},{"id":"A479","pred":"tao:has_database_id","subj":"479","obj":"MESH:D007239"},{"id":"A480","pred":"tao:has_database_id","subj":"480","obj":"MESH:D012640"},{"id":"A481","pred":"tao:has_database_id","subj":"481","obj":"MESH:D001927"},{"id":"A482","pred":"tao:has_database_id","subj":"482","obj":"MESH:D012640"},{"id":"A483","pred":"tao:has_database_id","subj":"483","obj":"MESH:D013226"},{"id":"A484","pred":"tao:has_database_id","subj":"484","obj":"MESH:D012640"},{"id":"A485","pred":"tao:has_database_id","subj":"485","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Conclusions\nAlthough there are concerns regarding decreasing transmission risk by limiting healthcare interventions in COVID-19 disease, patients with severe infection who demonstrate either clinical signs of seizures or severe encephalopathy may benefit from continuous electroencephalography monitoring to diagnose and treat symptomatic seizures and also non-convulsive status epilepticus. The mechanism of seizures precipitated by SARS-CoV-2 infection appears to be multifactorial and may involve a possible neurotropism of SARS-CoV-2 in addition to blood–brain barrier breakdown precipitated by pro-inflammatory cytokine reactions."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T97","span":{"begin":553,"end":558},"obj":"Body_part"},{"id":"T98","span":{"begin":559,"end":564},"obj":"Body_part"},{"id":"T99","span":{"begin":616,"end":624},"obj":"Body_part"}],"attributes":[{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A98","pred":"fma_id","subj":"T98","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A99","pred":"fma_id","subj":"T99","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Conclusions\nAlthough there are concerns regarding decreasing transmission risk by limiting healthcare interventions in COVID-19 disease, patients with severe infection who demonstrate either clinical signs of seizures or severe encephalopathy may benefit from continuous electroencephalography monitoring to diagnose and treat symptomatic seizures and also non-convulsive status epilepticus. The mechanism of seizures precipitated by SARS-CoV-2 infection appears to be multifactorial and may involve a possible neurotropism of SARS-CoV-2 in addition to blood–brain barrier breakdown precipitated by pro-inflammatory cytokine reactions."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T66","span":{"begin":553,"end":572},"obj":"Body_part"},{"id":"T67","span":{"begin":553,"end":558},"obj":"Body_part"},{"id":"T68","span":{"begin":559,"end":564},"obj":"Body_part"}],"attributes":[{"id":"A66","pred":"uberon_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/UBERON_0000120"},{"id":"A67","pred":"uberon_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A68","pred":"uberon_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"Conclusions\nAlthough there are concerns regarding decreasing transmission risk by limiting healthcare interventions in COVID-19 disease, patients with severe infection who demonstrate either clinical signs of seizures or severe encephalopathy may benefit from continuous electroencephalography monitoring to diagnose and treat symptomatic seizures and also non-convulsive status epilepticus. The mechanism of seizures precipitated by SARS-CoV-2 infection appears to be multifactorial and may involve a possible neurotropism of SARS-CoV-2 in addition to blood–brain barrier breakdown precipitated by pro-inflammatory cytokine reactions."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T124","span":{"begin":119,"end":127},"obj":"Disease"},{"id":"T125","span":{"begin":158,"end":167},"obj":"Disease"},{"id":"T126","span":{"begin":228,"end":242},"obj":"Disease"},{"id":"T127","span":{"begin":372,"end":390},"obj":"Disease"},{"id":"T128","span":{"begin":434,"end":442},"obj":"Disease"},{"id":"T129","span":{"begin":445,"end":454},"obj":"Disease"},{"id":"T130","span":{"begin":527,"end":535},"obj":"Disease"}],"attributes":[{"id":"A124","pred":"mondo_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A125","pred":"mondo_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A126","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0005560"},{"id":"A127","pred":"mondo_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/MONDO_0002125"},{"id":"A128","pred":"mondo_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A129","pred":"mondo_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A130","pred":"mondo_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Conclusions\nAlthough there are concerns regarding decreasing transmission risk by limiting healthcare interventions in COVID-19 disease, patients with severe infection who demonstrate either clinical signs of seizures or severe encephalopathy may benefit from continuous electroencephalography monitoring to diagnose and treat symptomatic seizures and also non-convulsive status epilepticus. The mechanism of seizures precipitated by SARS-CoV-2 infection appears to be multifactorial and may involve a possible neurotropism of SARS-CoV-2 in addition to blood–brain barrier breakdown precipitated by pro-inflammatory cytokine reactions."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T201","span":{"begin":500,"end":501},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T202","span":{"begin":553,"end":558},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T203","span":{"begin":553,"end":558},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T204","span":{"begin":559,"end":564},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T205","span":{"begin":559,"end":564},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"}],"text":"Conclusions\nAlthough there are concerns regarding decreasing transmission risk by limiting healthcare interventions in COVID-19 disease, patients with severe infection who demonstrate either clinical signs of seizures or severe encephalopathy may benefit from continuous electroencephalography monitoring to diagnose and treat symptomatic seizures and also non-convulsive status epilepticus. The mechanism of seizures precipitated by SARS-CoV-2 infection appears to be multifactorial and may involve a possible neurotropism of SARS-CoV-2 in addition to blood–brain barrier breakdown precipitated by pro-inflammatory cytokine reactions."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T8","span":{"begin":573,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"text":"Conclusions\nAlthough there are concerns regarding decreasing transmission risk by limiting healthcare interventions in COVID-19 disease, patients with severe infection who demonstrate either clinical signs of seizures or severe encephalopathy may benefit from continuous electroencephalography monitoring to diagnose and treat symptomatic seizures and also non-convulsive status epilepticus. The mechanism of seizures precipitated by SARS-CoV-2 infection appears to be multifactorial and may involve a possible neurotropism of SARS-CoV-2 in addition to blood–brain barrier breakdown precipitated by pro-inflammatory cytokine reactions."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T83","span":{"begin":151,"end":167},"obj":"Phenotype"},{"id":"T84","span":{"begin":209,"end":217},"obj":"Phenotype"},{"id":"T85","span":{"begin":228,"end":242},"obj":"Phenotype"},{"id":"T86","span":{"begin":327,"end":347},"obj":"Phenotype"},{"id":"T87","span":{"begin":357,"end":390},"obj":"Phenotype"},{"id":"T88","span":{"begin":409,"end":417},"obj":"Phenotype"}],"attributes":[{"id":"A83","pred":"hp_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/HP_0032169"},{"id":"A84","pred":"hp_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A85","pred":"hp_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/HP_0001298"},{"id":"A86","pred":"hp_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/HP_0011145"},{"id":"A87","pred":"hp_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/HP_0031475"},{"id":"A88","pred":"hp_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/HP_0001250"}],"text":"Conclusions\nAlthough there are concerns regarding decreasing transmission risk by limiting healthcare interventions in COVID-19 disease, patients with severe infection who demonstrate either clinical signs of seizures or severe encephalopathy may benefit from continuous electroencephalography monitoring to diagnose and treat symptomatic seizures and also non-convulsive status epilepticus. The mechanism of seizures precipitated by SARS-CoV-2 infection appears to be multifactorial and may involve a possible neurotropism of SARS-CoV-2 in addition to blood–brain barrier breakdown precipitated by pro-inflammatory cytokine reactions."}

{"project":"LitCovid-sentences","denotations":[{"id":"T106","span":{"begin":0,"end":11},"obj":"Sentence"},{"id":"T107","span":{"begin":12,"end":391},"obj":"Sentence"},{"id":"T108","span":{"begin":392,"end":635},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Conclusions\nAlthough there are concerns regarding decreasing transmission risk by limiting healthcare interventions in COVID-19 disease, patients with severe infection who demonstrate either clinical signs of seizures or severe encephalopathy may benefit from continuous electroencephalography monitoring to diagnose and treat symptomatic seizures and also non-convulsive status epilepticus. The mechanism of seizures precipitated by SARS-CoV-2 infection appears to be multifactorial and may involve a possible neurotropism of SARS-CoV-2 in addition to blood–brain barrier breakdown precipitated by pro-inflammatory cytokine reactions."}