PMC:7253233 / 13038-14620
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 444 | 163-176 | Gene | denotes | interleukin-8 | Gene:3576 |
| 445 | 178-181 | Gene | denotes | IL8 | Gene:3576 |
| 446 | 187-221 | Gene | denotes | monocyte chemoattractant protein-1 | Gene:6347 |
| 447 | 223-227 | Gene | denotes | MCP1 | Gene:6347 |
| 448 | 430-434 | Gene | denotes | IL-8 | Gene:20309 |
| 449 | 452-456 | Gene | denotes | MCP1 | Gene:20296 |
| 450 | 571-575 | Gene | denotes | MCP1 | Gene:20296 |
| 451 | 20-38 | Species | denotes | SARS-coronaviruses | Tax:694009 |
| 452 | 284-305 | Species | denotes | Japanese encephalitis | Tax:11072 |
| 453 | 306-311 | Species | denotes | mouse | Tax:10090 |
| 454 | 1123-1133 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 455 | 1324-1331 | Species | denotes | patient | Tax:9606 |
| 456 | 1423-1433 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 457 | 256-278 | Disease | denotes | coronavirus infections | MESH:D018352 |
| 458 | 335-350 | Disease | denotes | viral infection | MESH:D001102 |
| 459 | 863-882 | Disease | denotes | cortical irritation | MESH:D001523 |
| 460 | 901-909 | Disease | denotes | seizures | MESH:D012640 |
| 461 | 921-929 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 462 | 930-939 | Disease | denotes | infection | MESH:D007239 |
| 463 | 993-1005 | Disease | denotes | inflammation | MESH:D007249 |
| 464 | 1029-1038 | Disease | denotes | infection | MESH:D007239 |
| 465 | 1094-1106 | Disease | denotes | coagulopathy | MESH:D001778 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T74 | 92-101 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T75 | 131-136 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T76 | 163-176 | Body_part | denotes | interleukin-8 | http://purl.org/sig/ont/fma/fma264827 |
| T77 | 187-195 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T78 | 212-219 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T79 | 331-334 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
| T80 | 359-368 | Body_part | denotes | astrocyte | http://purl.org/sig/ont/fma/fma54537 |
| T81 | 373-382 | Body_part | denotes | microglia | http://purl.org/sig/ont/fma/fma68923 |
| T82 | 442-445 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T83 | 515-518 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
| T84 | 519-524 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T85 | 535-545 | Body_part | denotes | astrocytes | http://purl.org/sig/ont/fma/fma54537 |
| T86 | 547-554 | Body_part | denotes | neurons | http://purl.org/sig/ont/fma/fma54527 |
| T87 | 560-569 | Body_part | denotes | microglia | http://purl.org/sig/ont/fma/fma68923 |
| T88 | 639-644 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T89 | 645-650 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T90 | 699-704 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T91 | 712-721 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T92 | 741-746 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T93 | 747-752 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T94 | 950-969 | Body_part | denotes | cerebrospinal fluid | http://purl.org/sig/ont/fma/fma20935 |
| T95 | 1271-1290 | Body_part | denotes | cerebrospinal fluid | http://purl.org/sig/ont/fma/fma20935 |
| T96 | 1406-1409 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T55 | 131-136 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T56 | 331-334 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T57 | 515-518 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T58 | 639-658 | Body_part | denotes | blood–brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
| T59 | 639-644 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T60 | 645-650 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T61 | 741-760 | Body_part | denotes | blood–brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
| T62 | 741-746 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T63 | 747-752 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T64 | 950-969 | Body_part | denotes | cerebrospinal fluid | http://purl.obolibrary.org/obo/UBERON_0001359 |
| T65 | 1271-1290 | Body_part | denotes | cerebrospinal fluid | http://purl.obolibrary.org/obo/UBERON_0001359 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T111 | 20-24 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T112 | 268-281 | Disease | denotes | infections in | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T113 | 284-305 | Disease | denotes | Japanese encephalitis | http://purl.obolibrary.org/obo/MONDO_0019209 |
| T114 | 293-305 | Disease | denotes | encephalitis | http://purl.obolibrary.org/obo/MONDO_0019956 |
| T115 | 335-350 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T116 | 341-350 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T117 | 921-929 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T118 | 930-939 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T119 | 993-1005 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T120 | 1029-1038 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T121 | 1094-1106 | Disease | denotes | coagulopathy | http://purl.obolibrary.org/obo/MONDO_0001531 |
| T122 | 1123-1131 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T123 | 1423-1431 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T163 | 111-117 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T164 | 131-136 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T165 | 131-136 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T166 | 178-181 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL8 |
| T167 | 187-195 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T168 | 234-236 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T169 | 239-240 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T170 | 282-283 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T171 | 306-311 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T172 | 331-334 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
| T173 | 331-334 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
| T174 | 331-334 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
| T175 | 359-368 | http://purl.obolibrary.org/obo/CL_0000127 | denotes | astrocyte |
| T176 | 373-382 | http://purl.obolibrary.org/obo/CL_0000129 | denotes | microglia |
| T177 | 430-434 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T178 | 515-518 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
| T179 | 515-518 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
| T180 | 515-518 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
| T181 | 519-524 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T182 | 535-545 | http://purl.obolibrary.org/obo/CL_0000127 | denotes | astrocytes |
| T183 | 560-569 | http://purl.obolibrary.org/obo/CL_0000129 | denotes | microglia |
| T184 | 639-644 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T185 | 639-644 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T186 | 645-650 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T187 | 645-650 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T188 | 699-704 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T189 | 712-721 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T190 | 741-746 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T191 | 741-746 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T192 | 747-752 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T193 | 747-752 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T194 | 762-764 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T195 | 790-791 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T196 | 1132-1136 | http://purl.obolibrary.org/obo/CLO_0001236 | denotes | 2, a |
| T197 | 1231-1232 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T198 | 1350-1351 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T199 | 1404-1405 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T200 | 1414-1418 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T29 | 178-181 | Chemical | denotes | IL8 | http://purl.obolibrary.org/obo/CHEBI_138181 |
| T30 | 212-219 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T31 | 430-432 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T5 | 145-154 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | breakdown |
| T6 | 335-350 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
| T7 | 993-1005 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T80 | 293-305 | Phenotype | denotes | encephalitis | http://purl.obolibrary.org/obo/HP_0002383 |
| T81 | 901-909 | Phenotype | denotes | seizures | http://purl.obolibrary.org/obo/HP_0001250 |
| T82 | 1094-1106 | Phenotype | denotes | coagulopathy | http://purl.obolibrary.org/obo/HP_0003256 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T98 | 0-238 | Sentence | denotes | Previous studies of SARS-coronaviruses have described the proliferation of pro-inflammatory cytokines that are active in promoting blood–barrier breakdown, namely interleukin-8 (IL8) and monocyte chemoattractant protein-1 (MCP1) [10, 11]. |
| T99 | 239-451 | Sentence | denotes | A description of coronavirus infections in a Japanese encephalitis mouse model demonstrated CNS viral infection induced astrocyte and microglia proliferation, leading to increased release of IL-8 in the CSF [10]. |
| T100 | 452-570 | Sentence | denotes | MCP1 is another pro-inflammatory mediator that is expressed in CNS cells including astrocytes, neurons, and microglia. |
| T101 | 571-766 | Sentence | denotes | MCP1 may be up-regulated in conditions which target and degrade the blood–brain barrier and can recruit additional inflammatory cells as the monocytes migrate across the blood–brain barrier [11]. |
| T102 | 767-940 | Sentence | denotes | We hypothesize that as a result of the accumulation of inflammatory markers, there may be local cortical irritation that precipitates seizures related to COVID-19 infection. |
| T103 | 941-1230 | Sentence | denotes | Although cerebrospinal fluid may contain markers of inflammation, the treatment of this infection is largely supportive, and with the additional risk of coagulopathy precipitated by SARS-CoV-2, a lumbar puncture may not be justifiable unless there is an alternative diagnosis to be sought. |
| T104 | 1231-1469 | Sentence | denotes | A limitation of our case series is that cerebrospinal fluid was unable to be obtained due to patient factors that made a lumbar puncture relatively contraindicated and that a CSF-PCR test for SARS-CoV-2 was not yet commercially available. |
| T105 | 1470-1582 | Sentence | denotes | As this disease continues to spread, we will continue to learn about its direct and/or indirect epileptogenesis. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32462412-28103598-75539783 | 230-232 | 28103598 | denotes | 10 |
| 32462412-24051980-75539784 | 234-236 | 24051980 | denotes | 11 |
| 32462412-28103598-75539785 | 447-449 | 28103598 | denotes | 10 |
| 32462412-24051980-75539786 | 762-764 | 24051980 | denotes | 11 |