PMC:7253233 / 1104-2089
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 72 | 11-19 | Species | denotes | Patients | Tax:9606 |
| 73 | 331-339 | Species | denotes | patients | Tax:9606 |
| 74 | 559-567 | Species | denotes | patients | Tax:9606 |
| 75 | 758-766 | Species | denotes | patients | Tax:9606 |
| 76 | 931-949 | Species | denotes | SARS-Coronavirus-2 | Tax:2697049 |
| 77 | 25-33 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 78 | 70-78 | Disease | denotes | seizures | MESH:D012640 |
| 79 | 107-115 | Disease | denotes | seizures | MESH:D012640 |
| 80 | 159-167 | Disease | denotes | seizures | MESH:D012640 |
| 81 | 386-394 | Disease | denotes | seizures | MESH:D012640 |
| 82 | 445-465 | Disease | denotes | acute encephalopathy | MESH:D001927 |
| 83 | 524-545 | Disease | denotes | neurological symptoms | MESH:D009422 |
| 84 | 587-595 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 85 | 660-673 | Disease | denotes | organ failure | MESH:D009102 |
| 86 | 694-741 | Disease | denotes | intravascular coagulopathy-related brain injury | MESH:D004211 |
| 87 | 910-927 | Disease | denotes | neuroinvasiveness |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T4 | 660-665 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T5 | 729-734 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T6 | 810-815 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T7 | 816-821 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T8 | 863-871 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T5 | 660-665 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T6 | 729-734 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T7 | 810-829 | Body_part | denotes | blood–brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
| T8 | 810-815 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T9 | 816-821 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T14 | 25-33 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T15 | 451-465 | Disease | denotes | encephalopathy | http://purl.obolibrary.org/obo/MONDO_0005560 |
| T16 | 587-595 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T17 | 647-673 | Disease | denotes | multi-system organ failure | http://purl.obolibrary.org/obo/MONDO_0043726 |
| T18 | 708-720 | Disease | denotes | coagulopathy | http://purl.obolibrary.org/obo/MONDO_0001531 |
| T19 | 729-741 | Disease | denotes | brain injury | http://purl.obolibrary.org/obo/MONDO_0043510 |
| T20 | 735-741 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T21 | 931-935 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T15 | 660-665 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T16 | 729-734 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T17 | 729-734 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T18 | 810-815 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T19 | 810-815 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T20 | 816-821 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T21 | 816-821 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T4 | 251-260 | Chemical | denotes | sedatives | http://purl.obolibrary.org/obo/CHEBI_35717 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 793-802 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | breakdown |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T9 | 70-78 | Phenotype | denotes | seizures | http://purl.obolibrary.org/obo/HP_0001250 |
| T10 | 107-115 | Phenotype | denotes | seizures | http://purl.obolibrary.org/obo/HP_0001250 |
| T11 | 151-167 | Phenotype | denotes | (motor) seizures | http://purl.obolibrary.org/obo/HP_0020219 |
| T12 | 386-394 | Phenotype | denotes | seizures | http://purl.obolibrary.org/obo/HP_0001250 |
| T13 | 445-465 | Phenotype | denotes | acute encephalopathy | http://purl.obolibrary.org/obo/HP_0006846 |
| T14 | 708-720 | Phenotype | denotes | coagulopathy | http://purl.obolibrary.org/obo/HP_0003256 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14 | 0-10 | Sentence | denotes | Discussion |
| T15 | 11-141 | Sentence | denotes | Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial. |
| T16 | 142-316 | Sentence | denotes | Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. |
| T17 | 317-503 | Sentence | denotes | Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination. |
| T18 | 504-742 | Sentence | denotes | Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. |
| T19 | 743-882 | Sentence | denotes | However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions. |
| T20 | 883-985 | Sentence | denotes | The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established. |