PMC:7253233 / 10609-11656 JSONTXT

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{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T57","span":{"begin":898,"end":901},"obj":"Body_part"}],"attributes":[{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma55675"}],"text":"The SARS-Coronavirus-2 belongs to the β-coronavirus group which includes several human pathogenic viruses including middle east respiratory syndrome (MERS) coronavirus and SARS-CoV-1. These group of coronaviruses are associated with respiratory symptoms. Additional neurological symptoms including delirium, dizziness, and headaches have also been reported with other coronavirus infections prior to the SARS-CoV-2 outbreak [4]. The case series of patients from Wuhan, China, with COVID-19 disease, included both central and peripheral neurological manifestations (i.e., headache, dizziness, impaired consciousness, cerebrovascular disease, and neuralgia) [2]. Seizures were not reported as a direct manifestation of SARS-CoV-2 infection. The patients described in our series developed focal seizures and, in the second case, even progressed to non-convulsive status epilepticus. Seizures may be a CNS manifestation of COVID-19 disease. Further investigations are needed to elucidate the mechanism of neurological symptoms in SARS-CoV-2 infection."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T44","span":{"begin":898,"end":901},"obj":"Body_part"}],"attributes":[{"id":"A44","pred":"uberon_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"}],"text":"The SARS-Coronavirus-2 belongs to the β-coronavirus group which includes several human pathogenic viruses including middle east respiratory syndrome (MERS) coronavirus and SARS-CoV-1. These group of coronaviruses are associated with respiratory symptoms. Additional neurological symptoms including delirium, dizziness, and headaches have also been reported with other coronavirus infections prior to the SARS-CoV-2 outbreak [4]. The case series of patients from Wuhan, China, with COVID-19 disease, included both central and peripheral neurological manifestations (i.e., headache, dizziness, impaired consciousness, cerebrovascular disease, and neuralgia) [2]. Seizures were not reported as a direct manifestation of SARS-CoV-2 infection. The patients described in our series developed focal seizures and, in the second case, even progressed to non-convulsive status epilepticus. Seizures may be a CNS manifestation of COVID-19 disease. Further investigations are needed to elucidate the mechanism of neurological symptoms in SARS-CoV-2 infection."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T87","span":{"begin":4,"end":8},"obj":"Disease"},{"id":"T88","span":{"begin":172,"end":180},"obj":"Disease"},{"id":"T89","span":{"begin":298,"end":306},"obj":"Disease"},{"id":"T90","span":{"begin":380,"end":390},"obj":"Disease"},{"id":"T91","span":{"begin":404,"end":412},"obj":"Disease"},{"id":"T92","span":{"begin":481,"end":489},"obj":"Disease"},{"id":"T93","span":{"begin":616,"end":639},"obj":"Disease"},{"id":"T94","span":{"begin":645,"end":654},"obj":"Disease"},{"id":"T95","span":{"begin":717,"end":725},"obj":"Disease"},{"id":"T96","span":{"begin":728,"end":737},"obj":"Disease"},{"id":"T97","span":{"begin":860,"end":878},"obj":"Disease"},{"id":"T98","span":{"begin":919,"end":927},"obj":"Disease"},{"id":"T99","span":{"begin":1026,"end":1034},"obj":"Disease"},{"id":"T100","span":{"begin":1037,"end":1046},"obj":"Disease"}],"attributes":[{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0045057"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0011057"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0021667"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A96","pred":"mondo_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A97","pred":"mondo_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/MONDO_0002125"},{"id":"A98","pred":"mondo_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A99","pred":"mondo_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A100","pred":"mondo_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"The SARS-Coronavirus-2 belongs to the β-coronavirus group which includes several human pathogenic viruses including middle east respiratory syndrome (MERS) coronavirus and SARS-CoV-1. These group of coronaviruses are associated with respiratory symptoms. Additional neurological symptoms including delirium, dizziness, and headaches have also been reported with other coronavirus infections prior to the SARS-CoV-2 outbreak [4]. The case series of patients from Wuhan, China, with COVID-19 disease, included both central and peripheral neurological manifestations (i.e., headache, dizziness, impaired consciousness, cerebrovascular disease, and neuralgia) [2]. Seizures were not reported as a direct manifestation of SARS-CoV-2 infection. The patients described in our series developed focal seizures and, in the second case, even progressed to non-convulsive status epilepticus. Seizures may be a CNS manifestation of COVID-19 disease. Further investigations are needed to elucidate the mechanism of neurological symptoms in SARS-CoV-2 infection."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T124","span":{"begin":81,"end":86},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T125","span":{"begin":98,"end":105},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T126","span":{"begin":691,"end":692},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T127","span":{"begin":896,"end":897},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T128","span":{"begin":898,"end":901},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T129","span":{"begin":898,"end":901},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T130","span":{"begin":898,"end":901},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"}],"text":"The SARS-Coronavirus-2 belongs to the β-coronavirus group which includes several human pathogenic viruses including middle east respiratory syndrome (MERS) coronavirus and SARS-CoV-1. These group of coronaviruses are associated with respiratory symptoms. Additional neurological symptoms including delirium, dizziness, and headaches have also been reported with other coronavirus infections prior to the SARS-CoV-2 outbreak [4]. The case series of patients from Wuhan, China, with COVID-19 disease, included both central and peripheral neurological manifestations (i.e., headache, dizziness, impaired consciousness, cerebrovascular disease, and neuralgia) [2]. Seizures were not reported as a direct manifestation of SARS-CoV-2 infection. The patients described in our series developed focal seizures and, in the second case, even progressed to non-convulsive status epilepticus. Seizures may be a CNS manifestation of COVID-19 disease. Further investigations are needed to elucidate the mechanism of neurological symptoms in SARS-CoV-2 infection."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T27","span":{"begin":52,"end":57},"obj":"Chemical"},{"id":"T28","span":{"begin":190,"end":195},"obj":"Chemical"}],"attributes":[{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"}],"text":"The SARS-Coronavirus-2 belongs to the β-coronavirus group which includes several human pathogenic viruses including middle east respiratory syndrome (MERS) coronavirus and SARS-CoV-1. These group of coronaviruses are associated with respiratory symptoms. Additional neurological symptoms including delirium, dizziness, and headaches have also been reported with other coronavirus infections prior to the SARS-CoV-2 outbreak [4]. The case series of patients from Wuhan, China, with COVID-19 disease, included both central and peripheral neurological manifestations (i.e., headache, dizziness, impaired consciousness, cerebrovascular disease, and neuralgia) [2]. Seizures were not reported as a direct manifestation of SARS-CoV-2 infection. The patients described in our series developed focal seizures and, in the second case, even progressed to non-convulsive status epilepticus. Seizures may be a CNS manifestation of COVID-19 disease. Further investigations are needed to elucidate the mechanism of neurological symptoms in SARS-CoV-2 infection."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T68","span":{"begin":298,"end":306},"obj":"Phenotype"},{"id":"T69","span":{"begin":308,"end":317},"obj":"Phenotype"},{"id":"T70","span":{"begin":323,"end":332},"obj":"Phenotype"},{"id":"T71","span":{"begin":571,"end":579},"obj":"Phenotype"},{"id":"T72","span":{"begin":581,"end":590},"obj":"Phenotype"},{"id":"T73","span":{"begin":645,"end":654},"obj":"Phenotype"},{"id":"T74","span":{"begin":661,"end":669},"obj":"Phenotype"},{"id":"T75","span":{"begin":786,"end":800},"obj":"Phenotype"},{"id":"T76","span":{"begin":845,"end":878},"obj":"Phenotype"},{"id":"T77","span":{"begin":880,"end":888},"obj":"Phenotype"}],"attributes":[{"id":"A68","pred":"hp_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/HP_0031258"},{"id":"A69","pred":"hp_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/HP_0002321"},{"id":"A70","pred":"hp_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/HP_0002315"},{"id":"A71","pred":"hp_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/HP_0002315"},{"id":"A72","pred":"hp_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/HP_0002321"},{"id":"A73","pred":"hp_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/HP_0033345"},{"id":"A74","pred":"hp_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A75","pred":"hp_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/HP_0007359"},{"id":"A76","pred":"hp_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/HP_0031475"},{"id":"A77","pred":"hp_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/HP_0001250"}],"text":"The SARS-Coronavirus-2 belongs to the β-coronavirus group which includes several human pathogenic viruses including middle east respiratory syndrome (MERS) coronavirus and SARS-CoV-1. These group of coronaviruses are associated with respiratory symptoms. Additional neurological symptoms including delirium, dizziness, and headaches have also been reported with other coronavirus infections prior to the SARS-CoV-2 outbreak [4]. The case series of patients from Wuhan, China, with COVID-19 disease, included both central and peripheral neurological manifestations (i.e., headache, dizziness, impaired consciousness, cerebrovascular disease, and neuralgia) [2]. Seizures were not reported as a direct manifestation of SARS-CoV-2 infection. The patients described in our series developed focal seizures and, in the second case, even progressed to non-convulsive status epilepticus. Seizures may be a CNS manifestation of COVID-19 disease. Further investigations are needed to elucidate the mechanism of neurological symptoms in SARS-CoV-2 infection."}

{"project":"LitCovid-sentences","denotations":[{"id":"T83","span":{"begin":0,"end":183},"obj":"Sentence"},{"id":"T84","span":{"begin":184,"end":254},"obj":"Sentence"},{"id":"T85","span":{"begin":255,"end":428},"obj":"Sentence"},{"id":"T86","span":{"begin":429,"end":660},"obj":"Sentence"},{"id":"T87","span":{"begin":661,"end":738},"obj":"Sentence"},{"id":"T88","span":{"begin":739,"end":879},"obj":"Sentence"},{"id":"T89","span":{"begin":880,"end":936},"obj":"Sentence"},{"id":"T90","span":{"begin":937,"end":1047},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The SARS-Coronavirus-2 belongs to the β-coronavirus group which includes several human pathogenic viruses including middle east respiratory syndrome (MERS) coronavirus and SARS-CoV-1. These group of coronaviruses are associated with respiratory symptoms. Additional neurological symptoms including delirium, dizziness, and headaches have also been reported with other coronavirus infections prior to the SARS-CoV-2 outbreak [4]. The case series of patients from Wuhan, China, with COVID-19 disease, included both central and peripheral neurological manifestations (i.e., headache, dizziness, impaired consciousness, cerebrovascular disease, and neuralgia) [2]. Seizures were not reported as a direct manifestation of SARS-CoV-2 infection. The patients described in our series developed focal seizures and, in the second case, even progressed to non-convulsive status epilepticus. Seizures may be a CNS manifestation of COVID-19 disease. Further investigations are needed to elucidate the mechanism of neurological symptoms in SARS-CoV-2 infection."}