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PMC:7253233 / 10598-14620 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
351 15-33 Species denotes SARS-Coronavirus-2 Tax:2697049
352 49-62 Species denotes β-coronavirus Tax:694002
353 92-97 Species denotes human Tax:9606
354 127-178 Species denotes middle east respiratory syndrome (MERS) coronavirus Tax:1335626
355 183-191 Species denotes SARS-CoV Tax:694009
356 210-223 Species denotes coronaviruses Tax:11118
357 415-425 Species denotes SARS-CoV-2 Tax:2697049
358 459-467 Species denotes patients Tax:9606
359 754-762 Species denotes patients Tax:9606
360 244-264 Disease denotes respiratory symptoms MESH:D012818
361 277-298 Disease denotes neurological symptoms MESH:D009422
362 309-317 Disease denotes delirium MESH:D003693
363 319-328 Disease denotes dizziness MESH:D004244
364 334-343 Disease denotes headaches MESH:D006261
365 379-401 Disease denotes coronavirus infections MESH:D018352
366 492-500 Disease denotes COVID-19 MESH:C000657245
367 582-590 Disease denotes headache MESH:D006261
368 592-601 Disease denotes dizziness MESH:D004244
369 603-625 Disease denotes impaired consciousness MESH:D003244
370 627-650 Disease denotes cerebrovascular disease MESH:D002561
371 656-665 Disease denotes neuralgia MESH:D009437
372 672-680 Disease denotes Seizures MESH:D012640
373 728-748 Disease denotes SARS-CoV-2 infection MESH:C000657245
374 803-811 Disease denotes seizures MESH:D012640
375 860-889 Disease denotes convulsive status epilepticus MESH:D013226
376 891-899 Disease denotes Seizures MESH:D012640
377 930-938 Disease denotes COVID-19 MESH:C000657245
378 1012-1033 Disease denotes neurological symptoms MESH:D009422
379 1037-1057 Disease denotes SARS-CoV-2 infection MESH:C000657245
401 1059-1064 Species denotes Human Tax:9606
402 1065-1078 Species denotes coronaviruses Tax:11118
403 1118-1123 Species denotes human Tax:9606
404 1221-1226 Species denotes human Tax:9606
405 1505-1515 Species denotes SARS-Cov-2 Tax:2697049
406 1647-1655 Species denotes patients Tax:9606
407 1754-1759 Species denotes human Tax:9606
408 1760-1773 Species denotes coronaviruses Tax:11118
409 1775-1778 Species denotes CoV Tax:11118
410 1785-1790 Species denotes CoV-2 Tax:2697049
411 2022-2030 Species denotes patients Tax:9606
412 2252-2262 Species denotes SARS-CoV-2 Tax:2697049
413 2372-2380 Species denotes patients Tax:9606
414 1329-1349 Disease denotes SARS-CoV-1 infection MESH:C000657245
415 1622-1643 Disease denotes neurological symptoms MESH:D009422
416 1661-1669 Disease denotes COVID-19 MESH:C000657245
417 1851-1859 Disease denotes seizures MESH:D012640
418 1958-1974 Disease denotes systemic disease MESH:D034721
419 2043-2051 Disease denotes COVID-19 MESH:C000657245
420 2384-2392 Disease denotes seizures MESH:D012640
421 2410-2431 Disease denotes neurological diseases MESH:D020271
444 2603-2616 Gene denotes interleukin-8 Gene:3576
445 2618-2621 Gene denotes IL8 Gene:3576
446 2627-2661 Gene denotes monocyte chemoattractant protein-1 Gene:6347
447 2663-2667 Gene denotes MCP1 Gene:6347
448 2870-2874 Gene denotes IL-8 Gene:20309
449 2892-2896 Gene denotes MCP1 Gene:20296
450 3011-3015 Gene denotes MCP1 Gene:20296
451 2460-2478 Species denotes SARS-coronaviruses Tax:694009
452 2724-2745 Species denotes Japanese encephalitis Tax:11072
453 2746-2751 Species denotes mouse Tax:10090
454 3563-3573 Species denotes SARS-CoV-2 Tax:2697049
455 3764-3771 Species denotes patient Tax:9606
456 3863-3873 Species denotes SARS-CoV-2 Tax:2697049
457 2696-2718 Disease denotes coronavirus infections MESH:D018352
458 2775-2790 Disease denotes viral infection MESH:D001102
459 3303-3322 Disease denotes cortical irritation MESH:D001523
460 3341-3349 Disease denotes seizures MESH:D012640
461 3361-3369 Disease denotes COVID-19 MESH:C000657245
462 3370-3379 Disease denotes infection MESH:D007239
463 3433-3445 Disease denotes inflammation MESH:D007249
464 3469-3478 Disease denotes infection MESH:D007239
465 3534-3546 Disease denotes coagulopathy MESH:D001778

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T57 909-912 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T58 1124-1134 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T59 1139-1148 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T60 1152-1163 Body_part denotes neural cell http://purl.org/sig/ont/fma/fma70333
T61 1159-1163 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T62 1203-1206 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T63 1227-1232 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T64 1355-1358 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T65 1426-1431 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T66 1432-1438 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T67 1560-1579 Body_part denotes cerebrospinal fluid http://purl.org/sig/ont/fma/fma20935
T68 1581-1584 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T69 1988-1991 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T70 2086-2091 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T71 2092-2097 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T72 2317-2323 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T73 2352-2356 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T74 2532-2541 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T75 2571-2576 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T76 2603-2616 Body_part denotes interleukin-8 http://purl.org/sig/ont/fma/fma264827
T77 2627-2635 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T78 2652-2659 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T79 2771-2774 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T80 2799-2808 Body_part denotes astrocyte http://purl.org/sig/ont/fma/fma54537
T81 2813-2822 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T82 2882-2885 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T83 2955-2958 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T84 2959-2964 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T85 2975-2985 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T86 2987-2994 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T87 3000-3009 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T88 3079-3084 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T89 3085-3090 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T90 3139-3144 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T91 3152-3161 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T92 3181-3186 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T93 3187-3192 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T94 3390-3409 Body_part denotes cerebrospinal fluid http://purl.org/sig/ont/fma/fma20935
T95 3711-3730 Body_part denotes cerebrospinal fluid http://purl.org/sig/ont/fma/fma20935
T96 3846-3849 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T44 909-912 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T45 1227-1232 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T46 1355-1358 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T47 1426-1431 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T48 1432-1438 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T49 1560-1579 Body_part denotes cerebrospinal fluid http://purl.obolibrary.org/obo/UBERON_0001359
T50 1988-1991 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T51 2086-2105 Body_part denotes blood–brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T52 2086-2091 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T53 2092-2097 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T54 2317-2323 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T55 2571-2576 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T56 2771-2774 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T57 2955-2958 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T58 3079-3098 Body_part denotes blood–brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T59 3079-3084 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T60 3085-3090 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T61 3181-3200 Body_part denotes blood–brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T62 3181-3186 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T63 3187-3192 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T64 3390-3409 Body_part denotes cerebrospinal fluid http://purl.obolibrary.org/obo/UBERON_0001359
T65 3711-3730 Body_part denotes cerebrospinal fluid http://purl.obolibrary.org/obo/UBERON_0001359

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T87 15-19 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T88 183-191 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T89 309-317 Disease denotes delirium http://purl.obolibrary.org/obo/MONDO_0045057
T90 391-401 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T91 415-423 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 492-500 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T93 627-650 Disease denotes cerebrovascular disease http://purl.obolibrary.org/obo/MONDO_0011057
T94 656-665 Disease denotes neuralgia http://purl.obolibrary.org/obo/MONDO_0021667
T95 728-736 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T96 739-748 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T97 871-889 Disease denotes status epilepticus http://purl.obolibrary.org/obo/MONDO_0002125
T98 930-938 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T99 1037-1045 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 1048-1057 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T101 1329-1337 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 1340-1349 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T103 1379-1383 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T104 1505-1509 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 1661-1669 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T106 1958-1974 Disease denotes systemic disease http://purl.obolibrary.org/obo/MONDO_0015938
T107 2043-2051 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T108 2192-2207 Disease denotes hypercoagulable http://purl.obolibrary.org/obo/MONDO_0002305
T109 2252-2260 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T110 2410-2431 Disease denotes neurological diseases http://purl.obolibrary.org/obo/MONDO_0005071
T111 2460-2464 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T112 2708-2721 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T113 2724-2745 Disease denotes Japanese encephalitis http://purl.obolibrary.org/obo/MONDO_0019209
T114 2733-2745 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T115 2775-2790 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T116 2781-2790 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T117 3361-3369 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T118 3370-3379 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T119 3433-3445 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T120 3469-3478 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T121 3534-3546 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T122 3563-3571 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T123 3863-3871 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T124 92-97 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T125 109-116 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T126 702-703 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T127 907-908 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T128 909-912 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T129 909-912 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T130 909-912 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T131 1059-1064 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T132 1118-1123 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T133 1124-1134 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T134 1139-1148 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T135 1159-1163 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T136 1210-1211 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 1221-1226 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T138 1227-1232 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T139 1227-1232 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T140 1312-1313 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T141 1355-1358 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T142 1355-1358 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T143 1355-1358 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T144 1411-1416 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T145 1424-1425 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 1426-1431 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T147 1426-1431 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T148 1481-1482 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T149 1516-1519 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T150 1754-1759 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T151 1881-1882 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T152 1918-1923 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T153 1934-1935 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T154 1988-1991 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T155 1988-1991 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T156 1988-1991 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T157 2086-2091 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T158 2086-2091 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T159 2092-2097 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T160 2092-2097 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T161 2111-2116 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T162 2190-2191 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T163 2551-2557 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T164 2571-2576 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T165 2571-2576 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T166 2618-2621 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL8
T167 2627-2635 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T168 2674-2676 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T169 2679-2680 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T170 2722-2723 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T171 2746-2751 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T172 2771-2774 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T173 2771-2774 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T174 2771-2774 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T175 2799-2808 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocyte
T176 2813-2822 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T177 2870-2874 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T178 2955-2958 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T179 2955-2958 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T180 2955-2958 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T181 2959-2964 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T182 2975-2985 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T183 3000-3009 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T184 3079-3084 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T185 3079-3084 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T186 3085-3090 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T187 3085-3090 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T188 3139-3144 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T189 3152-3161 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T190 3181-3186 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T191 3181-3186 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T192 3187-3192 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T193 3187-3192 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T194 3202-3204 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T195 3230-3231 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T196 3572-3576 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2, a
T197 3671-3672 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T198 3790-3791 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T199 3844-3845 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 3854-3858 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T27 63-68 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T28 201-206 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T29 2618-2621 Chemical denotes IL8 http://purl.obolibrary.org/obo/CHEBI_138181
T30 2652-2659 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T31 2870-2872 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T5 2585-2594 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T6 2775-2790 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T7 3433-3445 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T68 309-317 Phenotype denotes delirium http://purl.obolibrary.org/obo/HP_0031258
T69 319-328 Phenotype denotes dizziness http://purl.obolibrary.org/obo/HP_0002321
T70 334-343 Phenotype denotes headaches http://purl.obolibrary.org/obo/HP_0002315
T71 582-590 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T72 592-601 Phenotype denotes dizziness http://purl.obolibrary.org/obo/HP_0002321
T73 656-665 Phenotype denotes neuralgia http://purl.obolibrary.org/obo/HP_0033345
T74 672-680 Phenotype denotes Seizures http://purl.obolibrary.org/obo/HP_0001250
T75 797-811 Phenotype denotes focal seizures http://purl.obolibrary.org/obo/HP_0007359
T76 856-889 Phenotype denotes non-convulsive status epilepticus http://purl.obolibrary.org/obo/HP_0031475
T77 891-899 Phenotype denotes Seizures http://purl.obolibrary.org/obo/HP_0001250
T78 1839-1859 Phenotype denotes symptomatic seizures http://purl.obolibrary.org/obo/HP_0011145
T79 2384-2392 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T80 2733-2745 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T81 3341-3349 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T82 3534-3546 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T82 0-10 Sentence denotes Discussion
T83 11-194 Sentence denotes The SARS-Coronavirus-2 belongs to the β-coronavirus group which includes several human pathogenic viruses including middle east respiratory syndrome (MERS) coronavirus and SARS-CoV-1.
T84 195-265 Sentence denotes These group of coronaviruses are associated with respiratory symptoms.
T85 266-439 Sentence denotes Additional neurological symptoms including delirium, dizziness, and headaches have also been reported with other coronavirus infections prior to the SARS-CoV-2 outbreak [4].
T86 440-671 Sentence denotes The case series of patients from Wuhan, China, with COVID-19 disease, included both central and peripheral neurological manifestations (i.e., headache, dizziness, impaired consciousness, cerebrovascular disease, and neuralgia) [2].
T87 672-749 Sentence denotes Seizures were not reported as a direct manifestation of SARS-CoV-2 infection.
T88 750-890 Sentence denotes The patients described in our series developed focal seizures and, in the second case, even progressed to non-convulsive status epilepticus.
T89 891-947 Sentence denotes Seizures may be a CNS manifestation of COVID-19 disease.
T90 948-1058 Sentence denotes Further investigations are needed to elucidate the mechanism of neurological symptoms in SARS-CoV-2 infection.
T91 1059-1311 Sentence denotes Human coronaviruses (HCoV) have been established to infect human astrocytes and microglia in neural cell cultures as well as detection of viral RNA in a study of human brain autopsy samples supporting their neurotropic and neuroinvasive properties [5].
T92 1312-1452 Sentence denotes A case report of SARS-CoV-1 infection with CNS symptoms during the SARS epidemic also isolated the virus within a brain tissue specimen [6].
T93 1453-1832 Sentence denotes Although direct evidence of a neurotropic effect of SARS-Cov-2 has not been reported as yet through either cerebrospinal fluid (CSF) or autopsy studies, the presence of neurological symptoms in patients with COVID-19 disease during this current pandemic, and the similarity between the two strains of human coronaviruses (CoV-1 and CoV-2), makes this mechanism highly suggestive.
T94 1833-2060 Sentence denotes Acute symptomatic seizures may be the result of a possible neurotropic effect of the virus or can be a marker of severity of systemic disease itself since CNS symptoms were found mainly in patients with severe COVID-19 disease.
T95 2061-2214 Sentence denotes After penetration of the blood–brain barrier, the virus can slow the cerebral microcirculation, possibly through the creation of a hypercoagulable state.
T96 2215-2328 Sentence denotes This allows increased interaction of SARS-CoV-2 with the endothelial receptors and receptors on glial tissue [7].
T97 2329-2439 Sentence denotes The interaction at the glia may predispose patients to seizures as seen in other neurological diseases [8, 9].
T98 2440-2678 Sentence denotes Previous studies of SARS-coronaviruses have described the proliferation of pro-inflammatory cytokines that are active in promoting blood–barrier breakdown, namely interleukin-8 (IL8) and monocyte chemoattractant protein-1 (MCP1) [10, 11].
T99 2679-2891 Sentence denotes A description of coronavirus infections in a Japanese encephalitis mouse model demonstrated CNS viral infection induced astrocyte and microglia proliferation, leading to increased release of IL-8 in the CSF [10].
T100 2892-3010 Sentence denotes MCP1 is another pro-inflammatory mediator that is expressed in CNS cells including astrocytes, neurons, and microglia.
T101 3011-3206 Sentence denotes MCP1 may be up-regulated in conditions which target and degrade the blood–brain barrier and can recruit additional inflammatory cells as the monocytes migrate across the blood–brain barrier [11].
T102 3207-3380 Sentence denotes We hypothesize that as a result of the accumulation of inflammatory markers, there may be local cortical irritation that precipitates seizures related to COVID-19 infection.
T103 3381-3670 Sentence denotes Although cerebrospinal fluid may contain markers of inflammation, the treatment of this infection is largely supportive, and with the additional risk of coagulopathy precipitated by SARS-CoV-2, a lumbar puncture may not be justifiable unless there is an alternative diagnosis to be sought.
T104 3671-3909 Sentence denotes A limitation of our case series is that cerebrospinal fluid was unable to be obtained due to patient factors that made a lumbar puncture relatively contraindicated and that a CSF-PCR test for SARS-CoV-2 was not yet commercially available.
T105 3910-4022 Sentence denotes As this disease continues to spread, we will continue to learn about its direct and/or indirect epileptogenesis.

2_test

Id Subject Object Predicate Lexical cue
32462412-10982334-75539779 1308-1309 10982334 denotes 5
32462412-16163626-75539780 1449-1450 16163626 denotes 6
32462412-32167747-75539781 2325-2326 32167747 denotes 7
32462412-18336559-75539782 2436-2437 18336559 denotes 9
32462412-28103598-75539783 2670-2672 28103598 denotes 10
32462412-24051980-75539784 2674-2676 24051980 denotes 11
32462412-28103598-75539785 2887-2889 28103598 denotes 10
32462412-24051980-75539786 3202-3204 24051980 denotes 11