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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
23 111-116 Species denotes human Tax:9606
24 117-130 Species denotes coronaviruses Tax:11118
25 391-399 Species denotes patients Tax:9606
26 516-524 Species denotes patients Tax:9606
27 15-42 Disease denotes coronavirus disease of 2019 MESH:C000657245
28 44-52 Disease denotes COVID-19 MESH:C000657245
29 185-206 Disease denotes neurological symptoms MESH:D009422
30 280-288 Disease denotes COVID-19 MESH:C000657245
31 317-325 Disease denotes Seizures MESH:D012640
32 371-379 Disease denotes COVID-19 MESH:C000657245
33 422-434 Disease denotes brain injury MESH:D001930
34 438-446 Disease denotes epilepsy MESH:D004827
35 489-497 Disease denotes seizures MESH:D012640
36 506-515 Disease denotes epileptic MESH:D004827
37 549-557 Disease denotes COVID-19 MESH:C000657245
47 625-633 Species denotes patients Tax:9606
48 820-830 Species denotes SARS-CoV-2 Tax:2697049
49 984-997 Chemical denotes levetiracetam MESH:D000077287
50 609-618 Disease denotes epileptic MESH:D004827
51 703-712 Disease denotes infection MESH:D007239
52 754-766 Disease denotes lung disease MESH:D008171
53 853-867 Disease denotes encephalopathy MESH:D001927
54 933-941 Disease denotes seizures MESH:D012640
55 957-965 Disease denotes seizures MESH:D012640
72 1011-1019 Species denotes Patients Tax:9606
73 1331-1339 Species denotes patients Tax:9606
74 1559-1567 Species denotes patients Tax:9606
75 1758-1766 Species denotes patients Tax:9606
76 1931-1949 Species denotes SARS-Coronavirus-2 Tax:2697049
77 1025-1033 Disease denotes COVID-19 MESH:C000657245
78 1070-1078 Disease denotes seizures MESH:D012640
79 1107-1115 Disease denotes seizures MESH:D012640
80 1159-1167 Disease denotes seizures MESH:D012640
81 1386-1394 Disease denotes seizures MESH:D012640
82 1445-1465 Disease denotes acute encephalopathy MESH:D001927
83 1524-1545 Disease denotes neurological symptoms MESH:D009422
84 1587-1595 Disease denotes COVID-19 MESH:C000657245
85 1660-1673 Disease denotes organ failure MESH:D009102
86 1694-1741 Disease denotes intravascular coagulopathy-related brain injury MESH:D004211
87 1910-1927 Disease denotes neuroinvasiveness
99 2042-2050 Species denotes patients Tax:9606
100 2266-2274 Species denotes Patients Tax:9606
101 2017-2025 Disease denotes seizures MESH:D012640
102 2056-2064 Disease denotes COVID-19 MESH:C000657245
103 2080-2088 Disease denotes seizures MESH:D012640
104 2136-2155 Disease denotes cortical irritation MESH:D001523
105 2249-2264 Disease denotes viral infection MESH:D001102
106 2298-2306 Disease denotes seizures MESH:D012640
107 2332-2346 Disease denotes encephalopathy MESH:D001927
108 2418-2427 Disease denotes epileptic MESH:D004827
109 2489-2497 Disease denotes seizures MESH:D012640

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 151-173 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T2 422-427 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T3 754-758 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T4 1660-1665 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T5 1729-1734 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T6 1810-1815 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T7 1816-1821 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T8 1863-1871 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T9 2163-2168 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T10 2169-2174 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T11 2214-2222 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 151-173 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T2 159-173 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T3 422-427 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T4 754-758 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T5 1660-1665 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T6 1729-1734 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T7 1810-1829 Body_part denotes blood–brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T8 1810-1815 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T9 1816-1821 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T10 2163-2182 Body_part denotes blood–brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T11 2163-2168 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T12 2169-2174 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 15-42 Disease denotes coronavirus disease of 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T3 44-52 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 280-288 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 371-379 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 422-434 Disease denotes brain injury http://purl.obolibrary.org/obo/MONDO_0043510
T7 428-434 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T8 438-446 Disease denotes epilepsy http://purl.obolibrary.org/obo/MONDO_0005027
T9 549-557 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 703-712 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T11 754-766 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T12 820-828 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 853-867 Disease denotes encephalopathy http://purl.obolibrary.org/obo/MONDO_0005560
T14 1025-1033 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 1451-1465 Disease denotes encephalopathy http://purl.obolibrary.org/obo/MONDO_0005560
T16 1587-1595 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 1647-1673 Disease denotes multi-system organ failure http://purl.obolibrary.org/obo/MONDO_0043726
T18 1708-1720 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T19 1729-1741 Disease denotes brain injury http://purl.obolibrary.org/obo/MONDO_0043510
T20 1735-1741 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T21 1931-1935 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T22 2056-2064 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T23 2249-2264 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T24 2255-2264 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T25 2332-2346 Disease denotes encephalopathy http://purl.obolibrary.org/obo/MONDO_0005560

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 65-66 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 111-116 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T3 151-173 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T4 151-173 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T5 151-173 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T6 361-362 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 422-427 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T8 422-427 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T9 620-624 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T10 620-624 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T11 741-742 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 754-758 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T13 754-758 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T14 800-806 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T15 1660-1665 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T16 1729-1734 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T17 1729-1734 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T18 1810-1815 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T19 1810-1815 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T20 1816-1821 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T21 1816-1821 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T22 2163-2168 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T23 2163-2168 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T24 2169-2174 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T25 2169-2174 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T26 2235-2236 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 102-107 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T2 620-624 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T3 984-997 Chemical denotes levetiracetam http://purl.obolibrary.org/obo/CHEBI_6437
T4 1251-1260 Chemical denotes sedatives http://purl.obolibrary.org/obo/CHEBI_35717

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1793-1802 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T2 2183-2192 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T3 2249-2264 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 317-325 Phenotype denotes Seizures http://purl.obolibrary.org/obo/HP_0001250
T3 438-446 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T4 477-497 Phenotype denotes symptomatic seizures http://purl.obolibrary.org/obo/HP_0011145
T5 754-766 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088
T6 847-867 Phenotype denotes acute encephalopathy http://purl.obolibrary.org/obo/HP_0006846
T7 933-941 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T8 957-965 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T9 1070-1078 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T10 1107-1115 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T11 1151-1167 Phenotype denotes (motor) seizures http://purl.obolibrary.org/obo/HP_0020219
T12 1386-1394 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T13 1445-1465 Phenotype denotes acute encephalopathy http://purl.obolibrary.org/obo/HP_0006846
T14 1708-1720 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T15 2005-2025 Phenotype denotes symptomatic seizures http://purl.obolibrary.org/obo/HP_0011145
T16 2080-2088 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T17 2298-2306 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T18 2332-2346 Phenotype denotes encephalopathy http://purl.obolibrary.org/obo/HP_0001298
T19 2489-2497 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T4 0-10 Sentence denotes Background
T5 11-83 Sentence denotes The coronavirus disease of 2019 (COVID-19) emerged as a global pandemic.
T6 84-316 Sentence denotes Historically, the group of human coronaviruses can also affect the central nervous system leading to neurological symptoms; however, the causative mechanisms of the neurological manifestations of COVID-19 disease are not well known.
T7 317-447 Sentence denotes Seizures have not been directly reported as a part of COVID-19 outside of patients with previously known brain injury or epilepsy.
T8 448-566 Sentence denotes We report two cases of acute symptomatic seizures, in non-epileptic patients, associated with severe COVID-19 disease.
T9 568-586 Sentence denotes Case Presentations
T10 587-731 Sentence denotes Two advanced-age, non-epileptic, male patients presented to our northeast Ohio-based health system with concern for infection in Mid-March 2020.
T11 732-831 Sentence denotes Both had a history of lung disease and during their hospitalization tested positive for SARS-CoV-2.
T12 832-942 Sentence denotes They developed acute encephalopathy days into their hospitalization with clinical and electrographic seizures.
T13 943-998 Sentence denotes Resolution of seizures was achieved with levetiracetam.
T14 1000-1010 Sentence denotes Discussion
T15 1011-1141 Sentence denotes Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial.
T16 1142-1316 Sentence denotes Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies.
T17 1317-1503 Sentence denotes Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination.
T18 1504-1742 Sentence denotes Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury.
T19 1743-1882 Sentence denotes However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions.
T20 1883-1985 Sentence denotes The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established.
T21 1987-1998 Sentence denotes Conclusions
T22 1999-2073 Sentence denotes Acute symptomatic seizures are possible in patients with COVID-19 disease.
T23 2074-2265 Sentence denotes These seizures are likely multifactorial in origin, including cortical irritation due to blood–brain barrier breakdown, precipitated by the cytokine reaction as a part of the viral infection.
T24 2266-2436 Sentence denotes Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy.
T25 2437-2543 Sentence denotes Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population.