PMC:7252096 / 66545-68122
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T829 | 133-137 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T830 | 295-299 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T831 | 500-506 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T832 | 695-699 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T130 | 35-59 | Body_part | denotes | renin-angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
| T131 | 133-137 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T132 | 295-299 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T133 | 500-506 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T134 | 695-699 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T254 | 101-108 | Disease | denotes | sterile | http://purl.obolibrary.org/obo/MONDO_0005047 |
| T255 | 289-306 | Disease | denotes | acute lung injury | http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796 |
| T257 | 300-306 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T258 | 463-482 | Disease | denotes | influenza infection | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T259 | 473-482 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T260 | 597-605 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T261 | 597-601 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T262 | 883-893 | Disease | denotes | infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T263 | 907-915 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T264 | 907-911 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T265 | 972-990 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T266 | 972-976 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T267 | 981-990 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T268 | 1065-1074 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T269 | 1120-1128 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T270 | 1120-1124 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T271 | 1391-1399 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1197 | 8-9 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1198 | 67-70 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T1199 | 82-83 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1200 | 133-137 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T1201 | 133-137 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T1202 | 295-299 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T1203 | 295-299 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T1204 | 427-433 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T1205 | 611-616 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T1206 | 695-699 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T1207 | 695-699 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T1208 | 788-793 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T1209 | 852-857 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T1210 | 1285-1290 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T1211 | 1306-1307 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T24632 | 41-52 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T33897 | 191-202 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T17882 | 217-231 | Chemical | denotes | angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506 |
| T60637 | 217-228 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T26889 | 229-231 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T7395 | 255-269 | Chemical | denotes | Angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T96192 | 267-269 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T18207 | 409-423 | Chemical | denotes | angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506 |
| T40089 | 409-420 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T68878 | 421-423 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T79618 | 551-565 | Chemical | denotes | angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506 |
| T61732 | 551-562 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T71046 | 563-565 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T51966 | 671-675 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T70149 | 1341-1355 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T98979 | 1345-1355 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T432 | 0-168 | Sentence | denotes | ACE2 is a central component of the renin-angiotensin system, which has emerged as a key regulator of sterile- or microbially induced lung pathology (Imai et al., 2005). |
| T433 | 169-254 | Sentence | denotes | In brief, ACE cleaves angiotensin I to generate angiotensin II (Skeggs et al., 1980). |
| T434 | 255-397 | Sentence | denotes | Angiotensin II then acts to drive acute lung injury through various mechanisms, including increased vascular permeability (Imai et al., 2005). |
| T435 | 398-585 | Sentence | denotes | Amounts of angiotensin II in humans and mice are elevated during influenza infection, and ACE2 exerts tissue-protective functions by reducing amounts of angiotensin II (Zou et al., 2014). |
| T436 | 586-728 | Sentence | denotes | Binding of SARS-CoV-S to mouse ACE2 in vivo reduced ACE2 expression leading to acute acid-aspiration-induced lung failure (Kuba et al., 2005). |
| T437 | 729-1233 | Sentence | denotes | Depending on the questions asked in future work, there are mouse models available on the basis of transgenic expression of human ACE2 (required for overt infectious pathology of SARS-CoV in mice), there are established NHP models available of SARS-CoV infection in M. fascicularis and C. aethiops, and early reports suggest symptomatic infection in M. mulatta and M. fascicularis models for SARS-CoV-2 (Bao et al., 2020, McCray et al., 2007, Munster et al., 2020, Rockx et al., 2020, Smits et al., 2011). |
| T438 | 1234-1577 | Sentence | denotes | For example, examining the efficacy of recombinant human ACE2 to act as a decoy receptor or the effect of “ACE inhibitors” in patients with, or at risk for, COVID-19 will require careful experimentation in appropriate models together with well-controlled clinical trials (Hofmann et al., 2004, Monteil et al., 2020, Vaduganathan et al., 2020). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T15 | 289-306 | Phenotype | denotes | acute lung injury | http://www.orpha.net/ORDO/Orphanet_178320 |
| T16 | 676-686 | Phenotype | denotes | aspiration | http://purl.obolibrary.org/obo/HP_0002835 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1969 | 0-4 | Gene | denotes | ACE2 | Gene:59272 |
| 1970 | 179-182 | Gene | denotes | ACE | Gene:1636 |
| 1971 | 191-204 | Gene | denotes | angiotensin I | Gene:183 |
| 1972 | 217-231 | Gene | denotes | angiotensin II | Gene:183 |
| 1973 | 255-269 | Gene | denotes | Angiotensin II | Gene:183 |
| 1974 | 409-423 | Gene | denotes | angiotensin II | Gene:183 |
| 1975 | 488-492 | Gene | denotes | ACE2 | Gene:59272 |
| 1976 | 551-565 | Gene | denotes | angiotensin II | Gene:183 |
| 1977 | 617-621 | Gene | denotes | ACE2 | Gene:70008 |
| 1978 | 638-642 | Gene | denotes | ACE2 | Gene:70008 |
| 1979 | 858-862 | Gene | denotes | ACE2 | Gene:59272 |
| 1980 | 1291-1295 | Gene | denotes | ACE2 | Gene:59272 |
| 1981 | 1341-1344 | Gene | denotes | ACE | Gene:1636 |
| 1982 | 427-433 | Species | denotes | humans | Tax:9606 |
| 1983 | 438-442 | Species | denotes | mice | Tax:10090 |
| 1984 | 597-605 | Species | denotes | SARS-CoV | Tax:694009 |
| 1985 | 611-616 | Species | denotes | mouse | Tax:10090 |
| 1986 | 788-793 | Species | denotes | mouse | Tax:10090 |
| 1987 | 852-857 | Species | denotes | human | Tax:9606 |
| 1988 | 907-915 | Species | denotes | SARS-CoV | Tax:694009 |
| 1989 | 919-923 | Species | denotes | mice | Tax:10090 |
| 1990 | 994-1009 | Species | denotes | M. fascicularis | Tax:9541 |
| 1991 | 1014-1025 | Species | denotes | C. aethiops | Tax:9534 |
| 1992 | 1078-1088 | Species | denotes | M. mulatta | Tax:9544 |
| 1993 | 1093-1108 | Species | denotes | M. fascicularis | Tax:9541 |
| 1994 | 1120-1130 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1995 | 1285-1290 | Species | denotes | human | Tax:9606 |
| 1996 | 1360-1368 | Species | denotes | patients | Tax:9606 |
| 1997 | 463-472 | Species | denotes | influenza | Tax:11520 |
| 1998 | 295-306 | Disease | denotes | lung injury | MESH:D055370 |
| 1999 | 473-482 | Disease | denotes | infection | MESH:D007239 |
| 2000 | 695-707 | Disease | denotes | lung failure | MESH:D012131 |
| 2001 | 972-990 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 2002 | 1065-1074 | Disease | denotes | infection | MESH:D007239 |
| 2003 | 1391-1399 | Disease | denotes | COVID-19 | MESH:C000657245 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32413319-16001071-20790533 | 162-166 | 16001071 | denotes | 2005 |
| 32413319-6250339-20790534 | 248-252 | 6250339 | denotes | 1980 |
| 32413319-16001071-20790535 | 391-395 | 16001071 | denotes | 2005 |
| 32413319-24800825-20790536 | 579-583 | 24800825 | denotes | 2014 |
| 32413319-16007097-20790537 | 722-726 | 16007097 | denotes | 2005 |
| 32413319-17079315-20790538 | 1165-1169 | 17079315 | denotes | 2007 |
| 32413319-21325418-20790539 | 1227-1231 | 21325418 | denotes | 2011 |
| 32413319-15194496-20790540 | 1522-1526 | 15194496 | denotes | 2004 |