PMC:7252096 / 157-1339
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T26168 | 196-203 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T3086 | 312-318 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T96149 | 370-374 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T2013 | 414-421 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T71632 | 545-549 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T11 | 550-553 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T53995 | 660-666 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T53830 | 676-680 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T64083 | 733-738 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T86971 | 746-750 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T26959 | 759-770 | Body_part | denotes | pneumocytes | http://purl.org/sig/ont/fma/fma62499 |
| T62780 | 789-800 | Body_part | denotes | enterocytes | http://purl.org/sig/ont/fma/fma62122 |
| T95195 | 829-834 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T65890 | 905-909 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T10275 | 938-954 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T33745 | 949-954 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T94008 | 1114-1120 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T5618 | 1148-1152 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 660-666 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T2 | 746-750 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T3 | 1114-1120 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T4 | 1148-1152 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T3 | 72-105 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T4 | 127-135 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T5 | 127-131 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T6 | 165-173 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T7 | 175-183 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T8 | 175-179 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T9 | 395-403 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T10 | 395-399 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T11 | 643-651 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T12 | 643-647 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T13 | 990-1006 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T14 | 1030-1038 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T15 | 1030-1034 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T16 | 1153-1159 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T17 | 1172-1181 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T96846 | 370-374 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T15043 | 502-507 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T37543 | 513-518 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T21147 | 519-526 | http://purl.obolibrary.org/obo/NCBITaxon_9443 | denotes | primate |
| T70638 | 532-537 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T86612 | 545-549 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T89661 | 676-680 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T73493 | 733-738 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T73667 | 746-750 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T71495 | 746-750 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T8319 | 829-834 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T72936 | 875-876 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T31033 | 877-882 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T36407 | 905-909 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T42210 | 931-937 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airway |
| T32994 | 938-948 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T43681 | 949-954 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T73925 | 1112-1113 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T61785 | 1148-1152 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T98448 | 1148-1152 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 196-203 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T2 | 210-221 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T3 | 312-318 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T4 | 756-758 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T5 | 883-893 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T6 | 1072-1082 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T18072 | 52-64 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T57711 | 990-1006 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 0-7 | Sentence | denotes | Summary |
| T4 | 8-174 | Sentence | denotes | There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. |
| T5 | 175-365 | Sentence | denotes | SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cellular entry. |
| T6 | 366-483 | Sentence | denotes | The cell subsets targeted by SARS-CoV-2 in host tissues and the factors that regulate ACE2 expression remain unknown. |
| T7 | 484-689 | Sentence | denotes | Here, we leverage human, non-human primate, and mouse single-cell RNA-sequencing (scRNA-seq) datasets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. |
| T8 | 690-835 | Sentence | denotes | We identify ACE2 and TMPRSS2 co-expressing cells within lung type II pneumocytes, ileal absorptive enterocytes, and nasal goblet secretory cells. |
| T9 | 836-1007 | Sentence | denotes | Strikingly, we discovered that ACE2 is a human interferon-stimulated gene (ISG) in vitro using airway epithelial cells and extend our findings to in vivo viral infections. |
| T10 | 1008-1182 | Sentence | denotes | Our data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 35 | 186-191 | Gene | denotes | spike | Gene:43740568 |
| 36 | 193-203 | Gene | denotes | S) protein | Gene:43740568 |
| 37 | 210-241 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
| 38 | 243-247 | Gene | denotes | ACE2 | Gene:59272 |
| 39 | 298-329 | Gene | denotes | transmembrane serine protease 2 | Gene:7113 |
| 40 | 331-338 | Gene | denotes | TMPRSS2 | Gene:7113 |
| 41 | 452-456 | Gene | denotes | ACE2 | Gene:59272 |
| 42 | 702-706 | Gene | denotes | ACE2 | Gene:59272 |
| 43 | 711-718 | Gene | denotes | TMPRSS2 | Gene:7113 |
| 44 | 867-871 | Gene | denotes | ACE2 | Gene:59272 |
| 45 | 1072-1082 | Gene | denotes | interferon | Gene:3439 |
| 46 | 1106-1110 | Gene | denotes | ACE2 | Gene:59272 |
| 47 | 72-117 | Species | denotes | severe acute respiratory syndrome coronavirus | Tax:694009 |
| 48 | 127-137 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 49 | 175-185 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 50 | 395-405 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 51 | 502-507 | Species | denotes | human | Tax:9606 |
| 52 | 513-518 | Species | denotes | human | Tax:9606 |
| 53 | 532-537 | Species | denotes | mouse | Tax:10090 |
| 54 | 643-653 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 55 | 877-882 | Species | denotes | human | Tax:9606 |
| 56 | 1030-1040 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 57 | 883-893 | Gene | denotes | interferon | Gene:3439 |
| 58 | 165-173 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 59 | 990-1006 | Disease | denotes | viral infections | MESH:D001102 |
| 60 | 1148-1159 | Disease | denotes | lung injury | MESH:D055370 |
| 61 | 1172-1181 | Disease | denotes | infection | MESH:D007239 |